iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000055024.12	ENSMUST00000068387.10	ENSMUSP00000066789.4
ENSMUSG00000055024.12	ENSMUST00000185967.2	ENSMUSP00000139889.1
ENSMUSG00000055024.12	ENSMUST00000206936.1	ENSMUSP00000145639.1
ENSMUSG00000055024.12	ENSMUST00000206833.1	ENSMUSP00000146251.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	circBase	miRTarBase	microRNA
TRANSFAC	miRecords	RepTar	miRNAMap
RAID2
Protein-protein Interaction
IID	iRefIndex	HINT
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	UniProt
PHOSIDA	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/Other	94.53	0.00e+00	1896.00	IUUC-Hsa-046884

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Mus musculus

Functional Description
(View)

Functional Description

Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Mediates acetylation of histone H3 at 'Lys-27' (H3K27ac). Also functions as acetyltransferase for nonhistone targets. Acetylates 'Lys-131' of ALX1 and acts as its coactivator. Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function. Acetylates HDAC1 leading to its inactivation and modulation of transcription. Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2. Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement. Can also mediate transcriptional repression. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Acetylates FOXO1 and enhances its transcriptional activity. Acetylates BCL6 wich disrupts its ability to recruit histone deacetylases and hinders its transcriptional repressor activity. Participates in CLOCK or NPAS2-regulated rhythmic gene transcription; exhibits a circadian association with CLOCK or NPAS2, correlating with increase in PER1/2 mRNA and histone H3 acetylation on the PER1/2 promoter. Acetylates MTA1 at 'Lys-626' which is essential for its transcriptional coactivator activity (PubMed:14645221, PubMed:9512516). Acetylates XBP1 isoform 2; acetylation increases protein stability of XBP1 isoform 2 and enhances its transcriptional activity (PubMed:20955178). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (By similarity). Acetylates MEF2D (By similarity).

Protein Sequence
(Fasta)

MAENVVEPGP PSAKRPKLSS PALSASASDG TDFGSLFDLE HDLPDELINS TELGLTNGGD 60
ISQLQTSLGI VQDAASKHKQ LSELLRSGSS PNLNMGVGGP GQAMASQAQQ NSPGLSLINS 120

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Nucleotide Sequence
(Fasta)

ATCCTGTAAG GAGGATTCGG CAGAGGCAAG AAACAACAGC CGCCATCTTG TTTGTGTGCT 60
AGCCTGTGGG GGGGGTGGGG GGAGGAGGAG AGAGAGCGGA GAGGGACCGG GAGAGAGAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0012--Acyltransferase
KW-0090--Biological rhythms
KW-0103--Bromodomain
KW-0131--Cell cycle
KW-0164--Citrullination
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0221--Differentiation
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR031162--CBP_P300_HAT
IPR013178--Histone_AcTrfase_Rtt109/CBP
IPR003101--KIX_dom
IPR009110--Nuc_rcpt_coact
IPR014744--Nuc_rcpt_coact_CREBbp
IPR010303--RING_CBP-p300
IPR001781--Znf_LIM
IPR000197--Znf_TAZ
IPR000433--Znf_ZZ

PROSITE

PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS51727--CBP_P300_HAT
PS50952--KIX
PS50134--ZF_TAZ
PS01357--ZF_ZZ_1
PS50135--ZF_ZZ_2

Pfam

PF00439--Bromodomain
PF09030--Creb_binding
PF06001--DUF902
PF08214--HAT_KAT11
PF02172--KIX
PF02135--zf-TAZ
PF00569--ZZ

PRINTS

PR00503--BROMODOMAIN

SMART

SM00297--BROMO
SM01250--KAT11
SM00551--ZnF_TAZ
SM00291--ZnF_ZZ

Gene Ontology

GO:0005829--C:cytosol
GO:0000123--C:histone acetyltransferase complex
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0043234--C:protein complex
GO:0005667--C:transcription factor complex
GO:0016407--F:acetyltransferase activity
GO:0033613--F:activating transcription factor binding
GO:0050681--F:androgen receptor binding
GO:0008013--F:beta-catenin binding
GO:0003682--F:chromatin binding
GO:0031490--F:chromatin DNA binding
GO:0001047--F:core promoter binding
GO:0003684--F:damaged DNA binding
GO:0003677--F:DNA binding
GO:0004402--F:histone acetyltransferase activity
GO:0004468--F:lysine N-acetyltransferase activity, acting on acetyl phosphate as donor
GO:0035257--F:nuclear hormone receptor binding
GO:0002039--F:p53 binding
GO:0097157--F:pre-mRNA intronic binding
GO:0008022--F:protein C-terminus binding
GO:0001102--F:RNA polymerase II activating transcription factor binding
GO:0000979--F:RNA polymerase II core promoter sequence-specific DNA binding
GO:0001085--F:RNA polymerase II transcription factor binding
GO:0003713--F:transcription coactivator activity
GO:0008134--F:transcription factor binding
GO:0001228--F:transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0016746--F:transferase activity, transferring acyl groups
GO:0008270--F:zinc ion binding
GO:0009887--P:animal organ morphogenesis
GO:0006915--P:apoptotic process
GO:0030183--P:B cell differentiation
GO:0051216--P:cartilage development
GO:0007049--P:cell cycle
GO:0034644--P:cellular response to UV
GO:0007623--P:circadian rhythm
GO:0045444--P:fat cell differentiation
GO:0007507--P:heart development
GO:0043969--P:histone H2B acetylation
GO:0043967--P:histone H4 acetylation
GO:0018393--P:internal peptidyl-lysine acetylation
GO:0006475--P:internal protein amino acid acetylation
GO:0042771--P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0030324--P:lung development
GO:0010742--P:macrophage derived foam cell differentiation
GO:0035855--P:megakaryocyte development
GO:0018076--P:N-terminal peptidyl-lysine acetylation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0007219--P:Notch signaling pathway
GO:0030220--P:platelet formation
GO:0043923--P:positive regulation by host of viral transcription
GO:0010628--P:positive regulation of gene expression
GO:0032092--P:positive regulation of protein binding
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0006990--P:positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006473--P:protein acetylation
GO:0050821--P:protein stabilization
GO:0060765--P:regulation of androgen receptor signaling pathway
GO:0006355--P:regulation of transcription, DNA-templated
GO:0090043--P:regulation of tubulin deacetylation
GO:0043627--P:response to estrogen
GO:0001666--P:response to hypoxia
GO:0007519--P:skeletal muscle tissue development
GO:0001756--P:somitogenesis

KEGG

mmu:328572

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002027	Ailuropoda melanoleuca	94.64	0.00e+00	1896.00
IUUC-Aca-005040	Anolis carolinensis	80.00	0.00e+00	1835.00
IUUC-Ame-011395	Astyanax mexicanus	88.57	0.00e+00	1460.00
IUUC-Bta-012649	Bos taurus	94.45	0.00e+00	1865.00
IUUC-Bdi-014481	Brachypodium distachyon	39.41	6.00e-72	266.00
IUUC-Cel-018691	Caenorhabditis elegans	50.31	0.00e+00	844.00
IUUC-Cja-019649	Callithrix jacchus	93.01	0.00e+00	2091.00
IUUC-Cfa-020764	Canis familiaris	96.13	0.00e+00	1785.00
IUUC-Cpo-022345	Cavia porcellus	89.00	0.00e+00	3291.00
IUUC-Cre-022852	Chlamydomonas reinhardtii	34.84	9.00e-65	242.00
IUUC-Csa-023866	Chlorocebus sabaeus	95.18	0.00e+00	2043.00
IUUC-Cho-024951	Choloepus hoffmanni	96.48	0.00e+00	1227.00
IUUC-Csv-026122	Ciona savignyi	65.08	0.00e+00	675.00
IUUC-Dre-028500	Danio rerio	78.62	0.00e+00	1455.00
IUUC-Ete-032979	Echinops telfairi	89.63	0.00e+00	1753.00
IUUC-Eca-034048	Equus caballus	96.30	0.00e+00	1896.00
IUUC-Fca-035891	Felis catus	94.57	0.00e+00	2017.00
IUUC-Fal-037585	Ficedula albicollis	84.65	0.00e+00	1892.00
IUUC-Gmo-039348	Gadus morhua	84.60	0.00e+00	1438.00
IUUC-Gga-040916	Gallus gallus	84.23	0.00e+00	1904.00
IUUC-Gac-041642	Gasterosteus aculeatus	87.32	0.00e+00	1411.00
IUUC-Ggo-045189	Gorilla gorilla	94.90	0.00e+00	2039.00
IUUC-Hsa-046884	Homo sapiens	94.41	0.00e+00	2043.00
IUUC-Itr-048564	Ictidomys tridecemlineatus	96.43	0.00e+00	1852.00
IUUC-Laf-054423	Loxodonta africana	94.05	0.00e+00	2170.00
IUUC-Mcc-054847	Macaca mulatta	94.62	0.00e+00	2052.00
IUUC-Meu-056217	Macropus eugenii	83.96	0.00e+00	1903.00
IUUC-Mga-059250	Meleagris gallopavo	80.58	0.00e+00	1933.00
IUUC-Mmr-061496	Microcebus murinus	95.66	0.00e+00	2058.00
IUUC-Mdo-062478	Monodelphis domestica	86.53	0.00e+00	1931.00
IUUC-Mac-064767	Musa acuminata	39.35	7.00e-76	280.00
IUUC-Mpu-065963	Mustela putorius furo	93.71	0.00e+00	1869.00
IUUC-Mlu-067185	Myotis lucifugus	95.26	0.00e+00	1883.00
IUUC-Ncr-068795	Neurospora crassa	37.97	1.00e-13	71.60
IUUC-Nle-069907	Nomascus leucogenys	94.93	0.00e+00	1853.00
IUUC-Opr-070324	Ochotona princeps	86.43	0.00e+00	1170.00
IUUC-Ont-072211	Oreochromis niloticus	78.75	0.00e+00	1453.00
IUUC-Oan-073723	Ornithorhynchus anatinus	88.55	0.00e+00	1843.00
IUUC-Ocu-074707	Oryctolagus cuniculus	95.25	0.00e+00	1873.00
IUUC-Oba-075590	Oryza barthii	33.61	1.00e-103	372.00
IUUC-Ogu-078580	Oryza glumaepatula	33.47	6.00e-104	373.00
IUUC-Ome-081615	Oryza meridionalis	33.61	1.00e-103	372.00
IUUC-Oni-082636	Oryza nivara	33.61	1.00e-103	372.00
IUUC-Opu-084073	Oryza punctata	33.20	1.00e-103	372.00
IUUC-Oru-084994	Oryza rufipogon	33.61	1.00e-103	372.00
IUUC-Olu-087701	Ostreococcus lucimarinus	31.23	9.00e-93	335.00
IUUC-Oga-088700	Otolemur garnettii	95.11	0.00e+00	2033.00
IUUC-Oar-089787	Ovis aries	92.79	0.00e+00	1901.00
IUUC-Ptr-091620	Pan troglodytes	93.79	0.00e+00	2040.00
IUUC-Pan-092166	Papio anubis	93.59	0.00e+00	2066.00
IUUC-Psi-093992	Pelodiscus sinensis	83.79	0.00e+00	1970.00
IUUC-Ppa-095569	Physcomitrella patens	38.48	8.00e-72	266.00
IUUC-Pfo-097342	Poecilia formosa	84.89	0.00e+00	1375.00
IUUC-Pab-098235	Pongo abelii	93.93	0.00e+00	2034.00
IUUC-Pop-098947	Populus trichocarpa	40.00	8.00e-74	273.00
IUUC-Pca-100780	Procavia capensis	87.86	0.00e+00	1445.00
IUUC-Pva-103071	Pteropus vampyrus	93.91	0.00e+00	2165.00
IUUC-Sha-106736	Sarcophilus harrisii	91.32	0.00e+00	1663.00
IUUC-Smo-109420	Selaginella moellendorffii	38.27	6.00e-72	266.00
IUUC-Sar-113162	Sorex araneus	93.94	0.00e+00	843.00
IUUC-Ssc-116077	Sus scrofa	96.30	0.00e+00	1925.00
IUUC-Tgu-116872	Taeniopygia guttata	84.94	0.00e+00	1921.00
IUUC-Tsy-119451	Tarsius syrichta	92.68	0.00e+00	1308.00
IUUC-Tca-121835	Theobroma cacao	33.22	9.00e-74	273.00
IUUC-Tvi-122536	Trichoderma virens	43.04	2.00e-15	77.40
IUUC-Tae-124383	Triticum aestivum	38.73	5.00e-69	256.00
IUUC-Tbe-127772	Tupaia belangeri	85.98	0.00e+00	1281.00
IUUC-Vpa-130766	Vicugna pacos	90.85	0.00e+00	1301.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence