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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046959
Ensembl Protein ID ENSP00000263904.4
UniProt Accession O75886; A8K8A0; D3DPA1; Q7LDQ0; Q9UF58; STAM2_HUMAN
Genbank Protein ID AAC63963.1; AAC63964.1; CAB63735.1; BAF84954.1; BAF85536.1; AAY14712.1; EAX11490.1; EAX11492.1; AAH28740.1
Protein Name Signal transducing adapter molecule 2; Hrs-binding protein
Genbank Nucleotide ID AF042273; AF042274; AL133600; AK292265; AK292847; AC079790; CH471058; CH471058; BC028740
Gene Name STAM2; HBP
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000115145.9 ENST00000263904.4 ENSP00000263904.4
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkTargetScanRepTarSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMPHOSIDABioGRID
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UIM UIM 12551915; 22841719
UBD/Alpha-Helix/VHS VHS 22841719
Classification
Family E-value Score Start End
UBD/Alpha-Helix/VHS 1.30e-55 188.7 16 144
UBD/Alpha-Helix/UIM 0.0027 19.2 165 183
UBD/SH3 1.60e-16 61.6 204 257
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/VHS
   S: 1    atselvtsedwelileicdliqetkegakdalralrkrinnknphvalraLtlLdscvsnCgkkfhvevaskdlleelrellknenepkvie 92
           at+e++t+edw+li++icd++++t +gakd+l+a++kr+n+k phval+aLtlL++cv+nCgk+fh+ev+s+d+++e+r+++kn+++pkv+e
   Q: 16   ATNEYNTTEDWSLIMDICDKVGSTPNGAKDCLKAIMKRVNHKVPHVALQALTLLGACVANCGKIFHLEVCSRDFATEVRAVIKNKAHPKVCE 107
           799***************************************************************************************** PP
   S: 93   KlkalivsWadelknepalslivaliktlkeeGlefp 129
           Klk+l+v+W++e++++p++sli+a+ik++keeG++fp
   Q: 108  KLKSLMVEWSEEFQKDPQFSLISATIKSMKEEGITFP 144
           ************************************8 PP
   

   UBD/Alpha-Helix/UIM
   S: 1    dEdeeLqlAlalSlqEeee 19
           +Ede++++A++lSlqE+ +
   Q: 165  KEDEDIAKAIELSLQEQKQ 183
           69**************976 PP
   

   UBD/SH3
   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFve 60
            +kv++lyd+ea++d+eLt+k+G+++ v+  ++ d++W+kg  e +   GlfP+nFv+
   Q: 204  ARKVRALYDFEAVEDNELTFKHGEIIIVL--DDSDANWWKG--ENHRGIGLFPSNFVT 257
           689*************************9..99********..899999*******97 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity).
 Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity).
Protein Sequence
(Fasta)
MPLFTANPFE QDVEKATNEY NTTEDWSLIM DICDKVGSTP NGAKDCLKAI MKRVNHKVPH 60
VALQALTLLG ACVANCGKIF HLEVCSRDFA TEVRAVIKNK AHPKVCEKLK SLMVEWSEEF 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046959|UBD,UIM;UBD,VHS;UBD,SH3|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GAAGGTCCCC GGCTTCGTGG CTAGCCGGGG TCCTAGCGCT GGAAAGGTGG CCGTAGCGGC 60
CGCCTGACCC CTACAAAAGT CTGGGACAGG GGCAGCGACA AAGGCCTTGG GAGGACGCCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046959|UBD,UIM;UBD,VHS;UBD,SH3|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0967--Endosome
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0813--Transport
Interpro

IPR008942--ENTH_VHS
IPR001452--SH3_domain
IPR003903--UIM_dom
IPR002014--VHS_dom
PROSITE

PS50002--SH3
PS50330--UIM
PS50179--VHS
Pfam

PF00018--SH3_1
PF02809--UIM
PF00790--VHS
PRINTS

PR00452--SH3DOMAIN
SMART

SM00326--SH3
SM00726--UIM
SM00288--VHS
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0031901--C:early endosome membrane
GO:0033565--C:ESCRT-0 complex
GO:0043231--C:intracellular membrane-bounded organelle
GO:0005654--C:nucleoplasm
GO:0016197--P:endosomal transport
GO:0006886--P:intracellular protein transport
GO:0016236--P:macroautophagy
GO:0061024--P:membrane organization
GO:0036258--P:multivesicular body assembly
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0016579--P:protein deubiquitination
KEGG hsa:10254
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002079 Ailuropoda melanoleuca 92.16 0.00e+00 979.00
IUUC-Apl-003548 Anas platyrhynchos 78.95 0.00e+00 788.00
IUUC-Aca-004991 Anolis carolinensis 77.80 0.00e+00 732.00
IUUC-Ago-007874 Ashbya gossypii 24.89 3.00e-31 129.00
IUUC-Acl-008046 Aspergillus clavatus 26.46 2.00e-36 147.00
IUUC-Afl-008621 Aspergillus flavus 26.65 2.00e-39 157.00
IUUC-Afu-008826 Aspergillus fumigatus 26.30 2.00e-32 133.00
IUUC-Ani-009419 Aspergillus nidulans 27.53 1.00e-37 150.00
IUUC-Ang-009580 Aspergillus niger 27.30 1.00e-38 154.00
IUUC-Ate-010532 Aspergillus terreus 26.32 3.00e-37 150.00
IUUC-Ame-011913 Astyanax mexicanus 60.26 2.00e-169 588.00
IUUC-Bgr-012113 Blumeria graminis 26.72 6.00e-41 162.00
IUUC-Bta-013115 Bos taurus 92.33 0.00e+00 682.00
IUUC-Bci-013955 Botrytis cinerea 31.62 3.00e-34 140.00
IUUC-Cja-018846 Callithrix jacchus 94.76 0.00e+00 1049.00
IUUC-Cfa-020589 Canis familiaris 94.34 0.00e+00 981.00
IUUC-Cpo-021460 Cavia porcellus 87.48 0.00e+00 941.00
IUUC-Csa-023912 Chlorocebus sabaeus 99.43 0.00e+00 1089.00
IUUC-Cho-024297 Choloepus hoffmanni 94.72 0.00e+00 983.00
IUUC-Cne-027007 Cryptococcus neoformans 32.87 5.00e-18 86.30
IUUC-Cme-027127 Cyanidioschyzon merolae 28.69 2.30e-02 35.00
IUUC-Dre-027454 Danio rerio 61.63 5.00e-170 590.00
IUUC-Dno-029182 Dasypus novemcinctus 94.29 0.00e+00 1030.00
IUUC-Dor-030949 Dipodomys ordii 83.96 0.00e+00 746.00
IUUC-Dse-031527 Dothistroma septosporum 31.40 3.00e-35 143.00
IUUC-Eca-033544 Equus caballus 95.97 0.00e+00 957.00
IUUC-Eeu-035224 Erinaceus europaeus 79.24 0.00e+00 844.00
IUUC-Fca-035958 Felis catus 95.62 0.00e+00 1026.00
IUUC-Fal-037193 Ficedula albicollis 71.35 0.00e+00 697.00
IUUC-Ggr-040048 Gaeumannomyces graminis 26.57 7.00e-38 152.00
IUUC-Gga-041158 Gallus gallus 75.63 0.00e+00 783.00
IUUC-Ggo-044661 Gorilla gorilla 95.54 0.00e+00 1016.00
IUUC-Itr-048399 Ictidomys tridecemlineatus 95.54 0.00e+00 758.00
IUUC-Lch-050505 Latimeria chalumnae 70.67 0.00e+00 751.00
IUUC-Loc-051737 Lepisosteus oculatus 62.22 0.00e+00 649.00
IUUC-Laf-053943 Loxodonta africana 93.33 0.00e+00 1028.00
IUUC-Mcc-055609 Macaca mulatta 99.43 0.00e+00 1089.00
IUUC-Meu-056575 Macropus eugenii 69.42 0.00e+00 672.00
IUUC-Mor-056972 Magnaporthe oryzae 31.71 2.00e-35 144.00
IUUC-Mpo-057476 Magnaporthe poae 26.75 2.00e-38 154.00
IUUC-Mla-059162 Melampsora laricipopulina 26.88 3.00e-25 110.00
IUUC-Mga-059462 Meleagris gallopavo 76.02 0.00e+00 773.00
IUUC-Mvi-060560 Microbotryum violaceum 27.66 2.00e-27 118.00
IUUC-Mmr-061756 Microcebus murinus 80.79 0.00e+00 771.00
IUUC-Mdo-062314 Monodelphis domestica 88.40 0.00e+00 975.00
IUUC-Mmu-064020 Mus musculus 86.48 0.00e+00 934.00
IUUC-Mpu-066320 Mustela putorius furo 94.77 0.00e+00 946.00
IUUC-Mlu-067472 Myotis lucifugus 91.74 0.00e+00 990.00
IUUC-Nfi-068568 Neosartorya fischeri 27.53 1.00e-35 145.00
IUUC-Ncr-068765 Neurospora crassa 27.17 1.00e-38 154.00
IUUC-Nle-070035 Nomascus leucogenys 97.52 0.00e+00 1063.00
IUUC-Opr-070584 Ochotona princeps 70.48 0.00e+00 741.00
IUUC-Ont-072419 Oreochromis niloticus 61.15 5.00e-166 577.00
IUUC-Oan-072727 Ornithorhynchus anatinus 81.97 1.00e-149 522.00
IUUC-Ocu-074576 Oryctolagus cuniculus 84.37 0.00e+00 921.00
IUUC-Oga-089079 Otolemur garnettii 76.55 0.00e+00 770.00
IUUC-Oar-089306 Ovis aries 94.12 0.00e+00 995.00
IUUC-Ptr-090536 Pan troglodytes 99.62 0.00e+00 1089.00
IUUC-Pan-092172 Papio anubis 99.05 0.00e+00 1082.00
IUUC-Psi-094026 Pelodiscus sinensis 76.61 0.00e+00 732.00
IUUC-Pno-094911 Phaeosphaeria nodorum 33.33 4.00e-36 145.00
IUUC-Pfo-096200 Poecilia formosa 60.47 4.00e-164 571.00
IUUC-Pab-098151 Pongo abelii 99.60 0.00e+00 1038.00
IUUC-Pca-100361 Procavia capensis 71.62 0.00e+00 720.00
IUUC-Pva-103093 Pteropus vampyrus 94.48 0.00e+00 1001.00
IUUC-Rno-105275 Rattus norvegicus 84.57 0.00e+00 889.00
IUUC-Sce-106209 Saccharomyces cerevisiae 27.00 8.00e-27 114.00
IUUC-Sha-107090 Sarcophilus harrisii 85.02 0.00e+00 937.00
IUUC-Sja-107859 Schizosaccharomyces japonicus 27.00 3.00e-28 119.00
IUUC-Spo-108333 Schizosaccharomyces pombe 29.86 8.00e-31 127.00
IUUC-Ssl-108525 Sclerotinia sclerotiorum 30.63 7.00e-33 135.00
IUUC-Sar-113125 Sorex araneus 80.30 0.00e+00 833.00
IUUC-Sre-115010 Sporisorium reilianum 39.29 9.00e-22 98.60
IUUC-Ssc-116366 Sus scrofa 93.64 0.00e+00 947.00
IUUC-Tgu-117414 Taeniopygia guttata 78.76 0.00e+00 714.00
IUUC-Tru-117683 Takifugu rubripes 56.41 2.00e-151 528.00
IUUC-Tsy-119199 Tarsius syrichta 95.62 0.00e+00 1043.00
IUUC-Tni-120765 Tetraodon nigroviridis 66.41 8.00e-149 520.00
IUUC-Tre-122061 Trichoderma reesei 26.15 1.00e-37 151.00
IUUC-Tbe-127343 Tupaia belangeri 91.44 0.00e+00 775.00
IUUC-Ttr-128960 Tursiops truncatus 92.98 0.00e+00 955.00
IUUC-Uma-129613 Ustilago maydis 40.00 2.00e-22 100.00
IUUC-Vda-129759 Verticillium dahliae 30.22 1.00e-35 144.00
IUUC-Vpa-130600 Vicugna pacos 89.56 0.00e+00 939.00
IUUC-Xtr-132472 Xenopus tropicalis 68.97 0.00e+00 710.00
IUUC-Xma-133716 Xiphophorus maculatus 60.16 6.00e-160 557.00
Created Date 25-Jun-2017

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