• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063229
UUCD1 version UUC-MuM-00258
Ensembl Protein ID ENSMUSP00000140609.1
UniProt Accession O35618; Q9CYG1; MDM4_MOUSE
Genbank Protein ID AAB62927.1; ACB69756.1; BAB30893.1; BAC38879.1; EDL39660.1; EDL39662.1
Protein Name Protein Mdm4; Double minute 4 protein; Mdm2-like p53-binding protein; Protein Mdmx; p53-binding protein Mdm4
Genbank Nucleotide ID AF007110; EU568360; AK017719; AK083349; CH466520; CH466520
Gene Name Mdm4; Mdmx
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000054387.13 ENSMUST00000186617.6 ENSMUSP00000140812.1
ENSMUSG00000054387.13 ENSMUST00000188090.6 ENSMUSP00000140609.1
ENSMUSG00000054387.13 ENSMUST00000191212.6 ENSMUSP00000140006.1
ENSMUSG00000054387.13 ENSMUST00000185398.6 ENSMUSP00000140090.1
ENSMUSG00000054387.13 ENSMUST00000067398.12 ENSMUSP00000068661.6
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 83.91 0.00e+00 770.00 IUUC-Hsa-046950
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Found in a trimeric complex with USP2, MDM2 and MDM4. Interacts with USP2. Interacts (phosphorylated) with YWHAG; negatively regulates MDM4 activity toward TP53 (By similarity). Interacts with MDM2, TP53 and TP73.
 Found in a trimeric complex with USP2, MDM2 and MDM4. Interacts with USP2. Interacts (phosphorylated) with YWHAG; negatively regulates MDM4 activity toward TP53 (By similarity). Interacts with MDM2, TP53 and TP73.
Protein Sequence
(Fasta)
MTSHSTSAQC SASDSACRIS SEQISQVRPK LQLLKILHAA GAQGEVFTMK EVMHYLGQYI 60
MVKQLYDQQE QHMVYCGGDL LGDLLGCQSF SVKDPSPLYD MLRKNLVTSA SINTDAAQTL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063229|E3,RING|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCAGCAGTGG TCAAAGAAGA AACAAAGGTA AGAAGTTAGG TTCCGGGGTT TTCATAATTC 60
CTCTCTCCCC TCTATCCTTG TTTCCATTCT ATCTAGTGTT AGGAGTGGGG GGGGGGGGAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063229|E3,RING|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR015458--MDM4
IPR016495--p53_neg-reg_MDM_2/4
IPR003121--SWIB_MDM2_domain
IPR001876--Znf_RanBP2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2
PS50089--ZF_RING_2
Pfam

PF02201--SWIB
PF00641--zf-RanBP
Gene Ontology

GO:0005634--C:nucleus
GO:0019899--F:enzyme binding
GO:0008270--F:zinc ion binding
GO:0003283--P:atrial septum development
GO:0003181--P:atrioventricular valve morphogenesis
GO:0008283--P:cell proliferation
GO:0030330--P:DNA damage response, signal transduction by p53 class mediator
GO:0003203--P:endocardial cushion morphogenesis
GO:0045023--P:G0 to G1 transition
GO:0003170--P:heart valve development
GO:0043066--P:negative regulation of apoptotic process
GO:0071157--P:negative regulation of cell cycle arrest
GO:0042177--P:negative regulation of protein catabolic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0008284--P:positive regulation of cell proliferation
GO:0006461--P:protein complex assembly
GO:0002027--P:regulation of heart rate
GO:0003281--P:ventricular septum development
KEGG mmu:17248
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001467 Ailuropoda melanoleuca 83.13 0.00e+00 701.00
IUUC-Apl-003800 Anas platyrhynchos 59.15 4.00e-151 528.00
IUUC-Aca-004608 Anolis carolinensis 56.14 3.00e-136 478.00
IUUC-Ame-010869 Astyanax mexicanus 45.62 4.00e-102 365.00
IUUC-Bta-013287 Bos taurus 80.45 0.00e+00 752.00
IUUC-Cja-019305 Callithrix jacchus 82.28 0.00e+00 723.00
IUUC-Cfa-020393 Canis familiaris 82.52 0.00e+00 718.00
IUUC-Cpo-022166 Cavia porcellus 81.97 0.00e+00 678.00
IUUC-Csa-023654 Chlorocebus sabaeus 83.10 0.00e+00 705.00
IUUC-Cho-024403 Choloepus hoffmanni 82.02 2.00e-110 392.00
IUUC-Dre-027754 Danio rerio 45.74 3.00e-111 395.00
IUUC-Dno-029630 Dasypus novemcinctus 80.08 0.00e+00 731.00
IUUC-Dor-031064 Dipodomys ordii 64.49 2.00e-171 595.00
IUUC-Ete-032901 Echinops telfairi 72.56 0.00e+00 673.00
IUUC-Eca-034234 Equus caballus 83.71 0.00e+00 809.00
IUUC-Eeu-035015 Erinaceus europaeus 75.00 1.00e-74 273.00
IUUC-Fca-036587 Felis catus 82.69 0.00e+00 739.00
IUUC-Fal-036906 Ficedula albicollis 51.63 1.00e-127 449.00
IUUC-Gmo-038646 Gadus morhua 44.83 9.00e-101 360.00
IUUC-Gga-040124 Gallus gallus 57.18 3.00e-109 388.00
IUUC-Gac-042397 Gasterosteus aculeatus 45.21 1.00e-107 383.00
IUUC-Ggo-045505 Gorilla gorilla 83.71 0.00e+00 722.00
IUUC-Hsa-046950 Homo sapiens 83.91 0.00e+00 726.00
IUUC-Itr-048886 Ictidomys tridecemlineatus 81.26 0.00e+00 725.00
IUUC-Lch-050141 Latimeria chalumnae 53.59 1.00e-120 426.00
IUUC-Loc-051921 Lepisosteus oculatus 49.50 9.00e-111 394.00
IUUC-Laf-054281 Loxodonta africana 78.82 0.00e+00 698.00
IUUC-Mcc-055462 Macaca mulatta 80.04 0.00e+00 660.00
IUUC-Meu-056294 Macropus eugenii 69.79 2.00e-144 505.00
IUUC-Mga-059924 Meleagris gallopavo 58.82 1.00e-162 566.00
IUUC-Mmr-061428 Microcebus murinus 82.69 0.00e+00 772.00
IUUC-Mdo-062643 Monodelphis domestica 71.37 0.00e+00 671.00
IUUC-Mpu-065782 Mustela putorius furo 81.95 0.00e+00 706.00
IUUC-Mlu-068105 Myotis lucifugus 74.19 0.00e+00 685.00
IUUC-Nle-069549 Nomascus leucogenys 83.91 0.00e+00 726.00
IUUC-Opr-070568 Ochotona princeps 81.51 0.00e+00 685.00
IUUC-Ont-072276 Oreochromis niloticus 46.86 5.00e-119 421.00
IUUC-Oan-072787 Ornithorhynchus anatinus 69.38 3.00e-178 618.00
IUUC-Ocu-074912 Oryctolagus cuniculus 81.87 0.00e+00 726.00
IUUC-Ola-087037 Oryzias latipes 45.14 2.00e-95 343.00
IUUC-Oga-088953 Otolemur garnettii 81.21 0.00e+00 728.00
IUUC-Oar-089202 Ovis aries 80.65 0.00e+00 759.00
IUUC-Ptr-090964 Pan troglodytes 83.71 0.00e+00 724.00
IUUC-Pan-091975 Papio anubis 83.30 0.00e+00 724.00
IUUC-Psi-093558 Pelodiscus sinensis 61.02 4.00e-156 544.00
IUUC-Pfo-096454 Poecilia formosa 47.55 1.00e-113 403.00
IUUC-Pab-098123 Pongo abelii 83.50 0.00e+00 726.00
IUUC-Pca-101112 Procavia capensis 72.51 0.00e+00 653.00
IUUC-Pva-103098 Pteropus vampyrus 74.54 0.00e+00 685.00
IUUC-Rno-105930 Rattus norvegicus 94.90 0.00e+00 866.00
IUUC-Sha-107512 Sarcophilus harrisii 70.67 5.00e-178 617.00
IUUC-Sar-113584 Sorex araneus 74.29 0.00e+00 630.00
IUUC-Tgu-116766 Taeniopygia guttata 55.80 6.00e-98 350.00
IUUC-Tru-117829 Takifugu rubripes 47.64 6.00e-113 400.00
IUUC-Tsy-119268 Tarsius syrichta 69.86 4.00e-170 590.00
IUUC-Tni-120204 Tetraodon nigroviridis 47.34 1.00e-111 396.00
IUUC-Tbe-127840 Tupaia belangeri 78.81 2.00e-115 409.00
IUUC-Ttr-128863 Tursiops truncatus 79.63 0.00e+00 716.00
IUUC-Vpa-130718 Vicugna pacos 81.94 0.00e+00 703.00
IUUC-Xtr-132320 Xenopus tropicalis 46.43 2.00e-89 323.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved