iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	6.10e-12	45.7	425	475

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
            +lydy+++ +deL++   dv++ i  e  degW++g    +g  GlfP+n+v+ 
   Q: 425  VALYDYQGEGSDELSFDPDDVITDI--EMVDEGWWRG--RCHGHFGLFPANYVKL 475
           68**********************9..9*********..8*************85 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MWKSVVGHNV SVSVETQGDD WDTDPDFVND ISEKEQRWGA KTIEGSGRTE HINIHQLRNK 60
VSEEHDILKK RELESGPKAS HGYGGRFGVE RDRMDKSAVG HEYVAEVEKH SSQTDAAKGF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGAAGAGCCA GAGTTTTAGC AACAAGGAAA GGTGGGTGCT CTGAACTGGG GGGGAGGGGG 60
TGCAGGGAAG TGTGGAAGAG AAATCTACCA AGCACTTAGT CCTTGTTAAG GGAGGTCTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR028534--HS1
IPR003134--Hs1_Cortactin
IPR001452--SH3_domain

PROSITE

PS51090--CORTACTIN
PS50002--SH3

Pfam

PF02218--HS1_rep
PF00018--SH3_1

PRINTS

PR00452--SH3DOMAIN

SMART

SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005667--C:transcription factor complex
GO:0030041--P:actin filament polymerization
GO:0071345--P:cellular response to cytokine stimulus
GO:0030218--P:erythrocyte differentiation
GO:2000107--P:negative regulation of leukocyte apoptotic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0008284--P:positive regulation of cell proliferation
GO:0030854--P:positive regulation of granulocyte differentiation
GO:0045651--P:positive regulation of macrophage differentiation
GO:0033138--P:positive regulation of peptidyl-serine phosphorylation
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0051897--P:positive regulation of protein kinase B signaling
GO:0042993--P:positive regulation of transcription factor import into nucleus
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0042531--P:positive regulation of tyrosine phosphorylation of STAT protein
GO:0030833--P:regulation of actin filament polymerization
GO:0009725--P:response to hormone

KEGG

rno:288077

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001194	Ailuropoda melanoleuca	82.89	0.00e+00	671.00
IUUC-Bta-012591	Bos taurus	88.27	1.00e-160	559.00
IUUC-Cja-019982	Callithrix jacchus	83.20	0.00e+00	656.00
IUUC-Cfa-020262	Canis familiaris	79.27	9.00e-174	603.00
IUUC-Cpo-021362	Cavia porcellus	84.70	0.00e+00	655.00
IUUC-Csa-023911	Chlorocebus sabaeus	88.52	6.00e-166	577.00
IUUC-Dor-030437	Dipodomys ordii	76.72	1.00e-170	592.00
IUUC-Ete-033160	Echinops telfairi	70.77	3.00e-140	491.00
IUUC-Eca-033269	Equus caballus	82.52	0.00e+00	686.00
IUUC-Eeu-035032	Erinaceus europaeus	72.51	4.00e-116	411.00
IUUC-Fca-035999	Felis catus	80.60	0.00e+00	711.00
IUUC-Fal-037107	Ficedula albicollis	50.74	4.00e-121	427.00
IUUC-Gga-040335	Gallus gallus	67.49	4.00e-106	378.00
IUUC-Ggo-044505	Gorilla gorilla	88.27	9.00e-165	573.00
IUUC-Hsa-046728	Homo sapiens	87.71	1.00e-163	569.00
IUUC-Itr-048592	Ictidomys tridecemlineatus	65.21	2.00e-157	548.00
IUUC-Laf-054202	Loxodonta africana	80.74	0.00e+00	634.00
IUUC-Mcc-055824	Macaca mulatta	87.99	2.00e-164	572.00
IUUC-Mmr-061281	Microcebus murinus	73.76	2.00e-156	545.00
IUUC-Mdo-062515	Monodelphis domestica	68.44	4.00e-145	507.00
IUUC-Mmu-064341	Mus musculus	91.15	0.00e+00	771.00
IUUC-Mpu-066565	Mustela putorius furo	81.25	0.00e+00	649.00
IUUC-Mlu-066942	Myotis lucifugus	80.44	0.00e+00	641.00
IUUC-Nle-069436	Nomascus leucogenys	84.13	0.00e+00	666.00
IUUC-Opr-070288	Ochotona princeps	78.01	4.00e-159	554.00
IUUC-Ocu-074686	Oryctolagus cuniculus	81.06	4.00e-175	607.00
IUUC-Ola-086894	Oryzias latipes	59.79	3.00e-94	339.00
IUUC-Oga-088585	Otolemur garnettii	76.02	3.00e-177	614.00
IUUC-Oar-089686	Ovis aries	83.88	0.00e+00	654.00
IUUC-Ptr-090461	Pan troglodytes	88.55	2.00e-165	575.00
IUUC-Pan-091887	Papio anubis	88.61	1.00e-165	576.00
IUUC-Psi-093785	Pelodiscus sinensis	70.32	2.00e-114	406.00
IUUC-Pab-098222	Pongo abelii	87.99	3.00e-164	571.00
IUUC-Pca-100668	Procavia capensis	76.10	1.00e-177	615.00
IUUC-Pva-102767	Pteropus vampyrus	70.45	9.00e-154	536.00
IUUC-Sar-113338	Sorex araneus	72.11	1.00e-162	565.00
IUUC-Ssc-116027	Sus scrofa	82.59	0.00e+00	682.00
IUUC-Tgu-117472	Taeniopygia guttata	57.81	3.00e-145	508.00
IUUC-Tni-119931	Tetraodon nigroviridis	57.95	9.00e-94	337.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence