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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Sce-106135
UUCD1 version UUC-SaC-00042
Ensembl Protein ID YDL190C
UniProt Accession P54860; D6VRG3; UFD2_YEAST
Genbank Protein ID AAC49024.1; CAA58257.1; CAA98767.1; DAA11673.2
Protein Name E4 ubiquitin-protein ligase UFD2; RING-type E3 ubiquitin transferase UFD2; Ubiquitin conjugation factor E4; Ubiquitin fusion degradation protein 2
Genbank Nucleotide ID U22154; X83276; Z74238; BK006938
Gene Name UFD2; YDL190C; D1255
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YDL190C YDL190C YDL190C
Annotation
mRNA Expression
GEOFFGED
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
IIDiRefIndexHINTMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
CPLMdbPAFBioGRID
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/U-box U-box 19887378; 20159987
Classification
Family E-value Score Start End
E3 activity/RING/U-box 7.00e-21 72.6 880 952
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/U-box
   S: 1    evpeeflCpIslelMrdPvvlp.sGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliqawceens 73
           +vp+efl+p+++++M+dPv+lp s + +drs+I+ +l s+ + +P++r pl+ ed++Pn +lr+ i  + ++++
   Q: 880  DVPDEFLDPLMYTIMKDPVILPaSKMNIDRSTIKAHLLSDST-DPFNRMPLKLEDVTPNEELRQKILCFKKQKK 952
           69**************************************98.*************************999987 PP
   
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     E4 ubiquitin chain-elongation enzyme specifically involved in polyubiquitin chain assembly. Binds to CDC48 and elongates mono- and diubiquitinated ERAD substrates presented by the UFD1-NPL4-CDC48/p97 (UNC) AAA ATPase complex to a chain length of 4 to 6 ubiquitin moieties. Delivers these polyubiquitinated substrates to RAD23 and DSK2, which target them to the proteasome. Has E3 ubiquitin-protein ligase activity, accepting ubiquitin from its cognate E2 ubiquitin-conjugating enzyme UBC4. Enhances ubiquitination at 'Lys-48', but not at 'Lys-29' of the Ub moiety. Promotes ubiquitin chain elongation at 'Lys-48' on the DOA10 substrate PEX29. Also involved in the proteolytic processing of the ER-bound transcription factor SPT23.
 E4 ubiquitin chain-elongation enzyme specifically involved in polyubiquitin chain assembly. Binds to CDC48 and elongates mono- and diubiquitinated ERAD substrates presented by the UFD1-NPL4-CDC48/p97 (UNC) AAA ATPase complex to a chain length of 4 to 6 ubiquitin moieties. Delivers these polyubiquitinated substrates to RAD23 and DSK2, which target them to the proteasome. Has E3 ubiquitin-protein ligase activity, accepting ubiquitin from its cognate E2 ubiquitin-conjugating enzyme UBC4. Enhances ubiquitination at 'Lys-48', but not at 'Lys-29' of the Ub moiety. Promotes ubiquitin chain elongation at 'Lys-48' on the DOA10 substrate PEX29. Also involved in the proteolytic processing of the ER-bound transcription factor SPT23.
Protein Sequence
(Fasta)
MTAIEDILQI TTDPSDTRGY SLLKSEEVPQ GSTLGVDFID TLLLYQLTEN EKLDKPFEYL 60
NDCFRRNQQQ KRITKNKPNA ESLHSTFQEI DRLVIGYGVV ALQIENFCMN GAFINYITGI 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Sce-106135|E3,U-box|Saccharomyces cerevisiae
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Nucleotide Sequence
(Fasta)
ATGACCGCCA TAGAAGATAT TTTACAAATC ACCACCGATC CTTCCGATAC CCGTGGCTAC 60
TCTCTATTGA AGTCCGAGGA AGTGCCTCAA GGCTCAACTC TTGGAGTTGA TTTTATTGAT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106135|E3,U-box|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR019474--Ub_conjug_fac_E4_core
IPR003613--Ubox_domain
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51698--U_BOX
Pfam

PF04564--U-box
PF10408--Ufd2P_core
SMART

SM00504--Ubox
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0071361--P:cellular response to ethanol
GO:0031398--P:positive regulation of protein ubiquitination
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0030433--P:ubiquitin-dependent ERAD pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG sce:YDL190C
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000585 Aegilops tauschii 30.17 3.00e-74 271.00
IUUC-Aml-002396 Ailuropoda melanoleuca 30.30 5.00e-81 294.00
IUUC-Atr-002479 Amborella trichopoda 28.91 1.00e-77 282.00
IUUC-Apl-003747 Anas platyrhynchos 30.25 1.00e-83 303.00
IUUC-Aca-004866 Anolis carolinensis 30.34 7.00e-87 313.00
IUUC-Aly-006300 Arabidopsis lyrata 29.74 3.00e-74 271.00
IUUC-Ath-006962 Arabidopsis thaliana 29.60 3.00e-71 261.00
IUUC-Ago-007880 Ashbya gossypii 65.28 0.00e+00 1254.00
IUUC-Acl-008289 Aspergillus clavatus 32.74 1.00e-124 439.00
IUUC-Afl-008711 Aspergillus flavus 33.06 9.00e-129 452.00
IUUC-Afu-008766 Aspergillus fumigatus 31.91 5.00e-125 440.00
IUUC-Ani-009126 Aspergillus nidulans 31.38 6.00e-127 446.00
IUUC-Ang-009837 Aspergillus niger 33.44 3.00e-131 460.00
IUUC-Aor-009919 Aspergillus oryzae 32.95 6.00e-128 449.00
IUUC-Ate-010300 Aspergillus terreus 32.84 8.00e-124 436.00
IUUC-Ame-011355 Astyanax mexicanus 30.79 4.00e-88 318.00
IUUC-Bgr-011995 Blumeria graminis 32.22 1.00e-125 442.00
IUUC-Bta-013056 Bos taurus 30.17 6.00e-81 294.00
IUUC-Bci-013605 Botrytis cinerea 30.15 2.00e-115 408.00
IUUC-Bdi-015032 Brachypodium distachyon 30.36 8.00e-73 266.00
IUUC-Bol-015172 Brassica oleracea 30.67 7.00e-79 286.00
IUUC-Bra-016633 Brassica rapa 30.67 7.00e-79 286.00
IUUC-Cel-018606 Caenorhabditis elegans 27.35 4.00e-58 217.00
IUUC-Cja-018872 Callithrix jacchus 29.82 5.00e-80 291.00
IUUC-Cfa-020045 Canis familiaris 30.17 2.00e-80 292.00
IUUC-Cpo-022309 Cavia porcellus 29.91 7.00e-81 293.00
IUUC-Cre-022726 Chlamydomonas reinhardtii 30.54 6.00e-36 142.00
IUUC-Csa-023765 Chlorocebus sabaeus 32.79 8.00e-59 220.00
IUUC-Cho-024614 Choloepus hoffmanni 35.61 2.00e-57 216.00
IUUC-Cin-025533 Ciona intestinalis 30.77 1.00e-86 312.00
IUUC-Csv-026081 Ciona savignyi 44.24 4.00e-34 135.00
IUUC-Cgl-026710 Colletotrichum gloeosporioides 31.06 4.00e-120 423.00
IUUC-Cne-027098 Cryptococcus neoformans 33.55 6.00e-110 390.00
IUUC-Cme-027352 Cyanidioschyzon merolae 34.84 5.00e-65 241.00
IUUC-Dre-027979 Danio rerio 30.43 2.00e-82 299.00
IUUC-Dno-029282 Dasypus novemcinctus 30.30 7.00e-81 294.00
IUUC-Dor-030421 Dipodomys ordii 29.88 4.00e-50 191.00
IUUC-Dse-031393 Dothistroma septosporum 31.73 3.00e-114 404.00
IUUC-Dme-031666 Drosophila melanogaster 28.72 9.00e-79 286.00
IUUC-Ete-032519 Echinops telfairi 39.63 7.00e-61 227.00
IUUC-Eca-033778 Equus caballus 29.70 1.00e-77 283.00
IUUC-Eeu-035315 Erinaceus europaeus 44.51 9.00e-38 150.00
IUUC-Fca-035658 Felis catus 30.13 4.00e-79 288.00
IUUC-Fal-037638 Ficedula albicollis 29.87 8.00e-86 310.00
IUUC-Fox-037909 Fusarium oxysporum 32.76 3.00e-103 367.00
IUUC-Fso-038406 Fusarium solani 33.20 7.00e-104 370.00
IUUC-Gmo-039379 Gadus morhua 30.51 7.00e-84 303.00
IUUC-Ggr-039851 Gaeumannomyces graminis 30.62 3.00e-113 401.00
IUUC-Gga-041136 Gallus gallus 30.13 9.00e-84 303.00
IUUC-Gac-041910 Gasterosteus aculeatus 30.43 9.00e-85 306.00
IUUC-Gma-043995 Glycine max 30.80 7.00e-81 293.00
IUUC-Ggo-045354 Gorilla gorilla 29.32 5.00e-72 264.00
IUUC-Hsa-046880 Homo sapiens 29.95 9.00e-81 293.00
IUUC-Hvu-047157 Hordeum vulgare 29.93 7.00e-72 263.00
IUUC-Itr-048213 Ictidomys tridecemlineatus 39.29 3.00e-62 229.00
IUUC-Kpa-049211 Komagataella pastoris 43.04 0.00e+00 700.00
IUUC-Lch-050534 Latimeria chalumnae 30.13 3.00e-83 301.00
IUUC-Lpe-051022 Leersia perrieri 29.25 3.00e-72 265.00
IUUC-Loc-052622 Lepisosteus oculatus 30.03 1.00e-82 300.00
IUUC-Lma-053241 Leptosphaeria maculans 29.86 1.00e-117 415.00
IUUC-Laf-053646 Loxodonta africana 30.30 4.00e-81 294.00
IUUC-Mcc-055588 Macaca mulatta 29.95 5.00e-81 294.00
IUUC-Meu-055991 Macropus eugenii 27.54 4.00e-59 221.00
IUUC-Mor-057064 Magnaporthe oryzae 30.96 8.00e-119 419.00
IUUC-Mpo-057452 Magnaporthe poae 30.73 5.00e-112 397.00
IUUC-Mtr-058016 Medicago truncatula 30.95 1.00e-81 296.00
IUUC-Mla-058887 Melampsora laricipopulina 35.01 6.00e-111 393.00
IUUC-Mga-059497 Meleagris gallopavo 30.07 2.00e-83 302.00
IUUC-Mvi-060343 Microbotryum violaceum 30.32 1.00e-107 382.00
IUUC-Mmr-061173 Microcebus murinus 36.45 6.00e-71 260.00
IUUC-Mdo-062102 Monodelphis domestica 30.35 4.00e-84 304.00
IUUC-Mmu-063223 Mus musculus 29.64 3.00e-82 298.00
IUUC-Mac-065531 Musa acuminata 29.09 2.00e-73 268.00
IUUC-Mpu-066624 Mustela putorius furo 34.62 1.00e-63 236.00
IUUC-Mlu-068018 Myotis lucifugus 29.87 7.00e-80 290.00
IUUC-Nfi-068590 Neosartorya fischeri 32.15 7.00e-125 439.00
IUUC-Ncr-068901 Neurospora crassa 34.26 4.00e-120 424.00
IUUC-Nle-069605 Nomascus leucogenys 29.95 5.00e-79 287.00
IUUC-Opr-071011 Ochotona princeps 36.97 7.00e-55 207.00
IUUC-Ont-072304 Oreochromis niloticus 30.19 7.00e-77 280.00
IUUC-Oan-073410 Ornithorhynchus anatinus 32.71 5.00e-76 276.00
IUUC-Ocu-074910 Oryctolagus cuniculus 30.30 9.00e-84 303.00
IUUC-Oba-075073 Oryza barthii 29.42 2.00e-78 285.00
IUUC-Obr-076452 Oryza brachyantha 29.97 6.00e-77 280.00
IUUC-Ogl-077141 Oryza glaberrima 29.42 4.00e-78 284.00
IUUC-Ogu-078116 Oryza glumaepatula 29.05 1.00e-77 283.00
IUUC-Oin-079066 Oryza indica 29.42 2.00e-78 285.00
IUUC-Olo-080253 Oryza longistaminata 27.67 2.00e-63 235.00
IUUC-Ome-081263 Oryza meridionalis 29.27 2.00e-78 285.00
IUUC-Oni-082019 Oryza nivara 29.18 4.00e-78 284.00
IUUC-Opu-083558 Oryza punctata 29.59 2.00e-78 285.00
IUUC-Oru-085002 Oryza rufipogon 29.42 6.00e-78 283.00
IUUC-Osa-085980 Oryza sativa 29.42 1.00e-78 286.00
IUUC-Ola-086323 Oryzias latipes 30.49 8.00e-85 306.00
IUUC-Olu-087901 Ostreococcus lucimarinus 29.66 3.00e-77 281.00
IUUC-Oga-087969 Otolemur garnettii 30.26 2.00e-77 282.00
IUUC-Oar-090020 Ovis aries 29.95 5.00e-81 294.00
IUUC-Ptr-091589 Pan troglodytes 29.95 1.00e-80 293.00
IUUC-Pan-091718 Papio anubis 36.07 4.00e-71 261.00
IUUC-Psi-093013 Pelodiscus sinensis 29.77 7.00e-82 297.00
IUUC-Pma-094627 Petromyzon marinus 37.89 9.00e-72 261.00
IUUC-Pno-094840 Phaeosphaeria nodorum 31.49 2.00e-131 461.00
IUUC-Ppa-095989 Physcomitrella patens 28.43 1.00e-75 276.00
IUUC-Pfo-096436 Poecilia formosa 30.39 3.00e-84 305.00
IUUC-Pab-098275 Pongo abelii 32.37 5.00e-74 271.00
IUUC-Pop-100005 Populus trichocarpa 28.18 7.00e-86 310.00
IUUC-Pca-100762 Procavia capensis 28.80 3.00e-53 202.00
IUUC-Ppe-101230 Prunus persica 30.71 9.00e-82 296.00
IUUC-Pva-102459 Pteropus vampyrus 30.04 3.00e-79 288.00
IUUC-Pgr-103485 Puccinia graminis 35.00 1.00e-111 395.00
IUUC-Ptt-104001 Puccinia triticina 37.30 5.00e-43 167.00
IUUC-Pte-104084 Pyrenophora teres 31.93 1.00e-131 462.00
IUUC-Pyt-104484 Pyrenophora triticirepentis 31.83 2.00e-131 461.00
IUUC-Rno-105719 Rattus norvegicus 30.04 3.00e-83 301.00
IUUC-Sha-106760 Sarcophilus harrisii 30.62 6.00e-85 307.00
IUUC-Sja-107698 Schizosaccharomyces japonicus 34.96 1.00e-133 469.00
IUUC-Spo-108076 Schizosaccharomyces pombe 35.21 2.00e-127 447.00
IUUC-Ssl-108624 Sclerotinia sclerotiorum 31.49 8.00e-125 439.00
IUUC-Smo-108769 Selaginella moellendorffii 26.82 1.00e-75 276.00
IUUC-Sit-109949 Setaria italica 30.08 6.00e-78 283.00
IUUC-Sly-110848 Solanum lycopersicum 37.50 5.00e-68 249.00
IUUC-Stu-112372 Solanum tuberosum 26.77 4.00e-79 287.00
IUUC-Sar-113131 Sorex araneus 32.37 3.00e-47 181.00
IUUC-Sbi-113828 Sorghum bicolor 29.63 4.00e-78 284.00
IUUC-Sre-114967 Sporisorium reilianum 33.25 1.00e-115 409.00
IUUC-Ssc-115841 Sus scrofa 32.11 5.00e-59 221.00
IUUC-Tgu-117290 Taeniopygia guttata 29.74 6.00e-83 300.00
IUUC-Tru-118193 Takifugu rubripes 30.58 5.00e-81 294.00
IUUC-Tsy-118926 Tarsius syrichta 30.04 7.00e-80 290.00
IUUC-Tni-120862 Tetraodon nigroviridis 30.45 4.00e-82 297.00
IUUC-Tca-121096 Theobroma cacao 29.40 2.00e-80 291.00
IUUC-Tre-122104 Trichoderma reesei 30.15 7.00e-111 394.00
IUUC-Tvi-122345 Trichoderma virens 34.72 4.00e-117 414.00
IUUC-Tae-123842 Triticum aestivum 30.65 4.00e-71 260.00
IUUC-Tur-126056 Triticum urartu 30.17 2.00e-74 271.00
IUUC-Tme-127074 Tuber melanosporum 31.26 1.00e-113 402.00
IUUC-Tbe-127533 Tupaia belangeri 29.91 5.00e-80 291.00
IUUC-Ttr-128757 Tursiops truncatus 29.91 2.00e-79 288.00
IUUC-Uma-129550 Ustilago maydis 34.48 2.00e-117 415.00
IUUC-Vda-129901 Verticillium dahliae 31.49 2.00e-122 431.00
IUUC-Vpa-130636 Vicugna pacos 36.22 3.00e-69 255.00
IUUC-Vvi-130891 Vitis vinifera 29.16 3.00e-76 278.00
IUUC-Xtr-132364 Xenopus tropicalis 30.53 8.00e-83 300.00
IUUC-Xma-133772 Xiphophorus maculatus 30.00 2.00e-83 302.00
IUUC-Yli-134506 Yarrowia lipolytica 34.34 1.00e-152 532.00
IUUC-Zma-135695 Zea mays 29.64 5.00e-78 283.00
Created Date 25-Jun-2017

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