iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000040455.17	ENSMUST00000065111.14	ENSMUSP00000067109.8
ENSMUSG00000040455.17	ENSMUST00000040429.11	ENSMUSP00000048324.5
ENSMUSG00000040455.17	ENSMUST00000148304.7	ENSMUSP00000127194.1
ENSMUSG00000040455.17	ENSMUST00000137293.7	ENSMUSP00000125982.1
ENSMUSG00000040455.17	ENSMUST00000148647.2	ENSMUSP00000128859.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	miRNAMap	RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	UniProt
PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.90e-85	287.1	191	811

Active Site

Position(s)	Description	Evidence
200	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
745	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle......kkkeklneenp.............kepkgellkslqklfeelwkskkkavsp 70
           +G++NlgNtC++N+v+Q L+++  l el++e      k       + +              ++ g+l+++l  +++++ + +k+  sp
   Q: 191  KGITNLGNTCFFNAVIQNLAQTYILFELMNEikedgtK------FKISlssapqleplvveLSSPGPLTSALFLFLHSMKEAEKGPLSP 273
           59*****************************5544442......3333444555777777788888*********************** PP
   S: 71   rellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde......aeekkkkknkslisdlFqgqlksq 153
           + l+++l+++a++f+g++qqD+qE+l++lld++++e +k+ + ++ +++++ ++++ d+      + + k+  + ++i+++F g+l+s+
   Q: 274  KVLFNQLCQKAPRFKGFQQQDSQELLHHLLDAVRTEETKRIQASILKAFNNPTTKTADDetrkkvKAYGKEGVKMNFIDRIFIGELTST 362
           *************************************99888888888888877777773443335555555555************** PP
   S: 154  ikclecdnvssreepfldlslpvpgkeetkke......................................................... 185
           ++c+ec+n+s+ ++pf+d+slp+ +++ +k+                                                          
   Q: 363  VMCEECANISTMKDPFIDISLPIIEERVSKPVllgkmskcrslqetdqdhnkgtvtvgnahqprasrkhsspndknqlshdrkhlrkwp 451
           ***************************98777********************************************************* PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 452  seeektvvthpkndnleasppastlsteaslnesltdgserdaslessvdadseasepeiaskqpvllrsrgdscghaeqhphlplase 540
           ***************************************************************************************** PP
   S: 186  .............................................................................slqdcLesftke 197
                                                                                        s+q+cL +ft+ 
   Q: 541  lpqakethggeeemaeaiaelhlsgtvtgnrdfhrekqplnvpnnlcfsegkhtrlhsaqnafqtlsqsyvttskecSVQSCLYQFTSM 629
           ***************************************************************************************** PP
   S: 198  eelegenkyycekckkkqe...................aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts 267
           e l g+nk+ ce c++k++                   a+k+l ++ +P +LilhLkRf  ++++ s +k+n++v+fpl+Ldl+pfc+ 
   Q: 630  ELLMGNNKLLCEDCTEKRRkchketssaekkaggvytnARKQLLISAVPAILILHLKRF--HQAGLSLRKVNRHVDFPLTLDLAPFCAA 716
           ***************99999999999999999999999*********************..9999************************ PP
   S: 268  peekqke..kkkYeLiavvvHsGslssGHYvayvkn..........................ekgkWllfdDskVtevkeeevleetgs 328
           ++++ ++  k+ Y L+++v HsGs+++GHY+ayvk                             g+W++++D++V++v+e++ l+   +
   Q: 717  TCKNISVgeKVLYGLYGIVEHSGSMRGGHYTAYVKVrvpsrklsecitgrktaaglkepdgeLGGHWVHVSDTYVQVVPESRALS---A 802
           8887765669**************************999999999999998888888765544555*******************...* PP
   S: 329  taYvlfYkr 337
           +aY+lfY+r
   Q: 803  QAYLLFYER 811
           *******98 PP

Organism

Mus musculus

Protein Sequence
(Fasta)

MRVKDPSKDL PEKGKRNKRP LLPHDEDSSD DIAVGLTCQH VSYAVSVNHV KKAVAESLWS 60
VCSECLKERR FCDGQPVLPA DVWLCLKCGL QGCGKNSESQ HSLRHFKSSG TESHCVVISL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACTTCCTTTC CTCGGCTCCT TCCTGCTCTT CTTCCTACAG GCGCTGTCCA GGCTCTTGAG 60
CGCCCCGCAG CCAGCACCGG CAGAAAGAGG TACTGCCACA CAGTTACTGT TTTACTTTAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0006281--P:DNA repair
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mmu:77593

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002331	Ailuropoda melanoleuca	69.38	0.00e+00	1041.00
IUUC-Apl-003512	Anas platyrhynchos	63.47	0.00e+00	1019.00
IUUC-Aca-004284	Anolis carolinensis	58.82	0.00e+00	939.00
IUUC-Ame-010735	Astyanax mexicanus	61.67	1.00e-84	306.00
IUUC-Bta-012880	Bos taurus	76.41	0.00e+00	1190.00
IUUC-Cja-019144	Callithrix jacchus	78.24	0.00e+00	1264.00
IUUC-Cfa-020971	Canis familiaris	78.04	0.00e+00	723.00
IUUC-Cpo-022497	Cavia porcellus	81.24	0.00e+00	706.00
IUUC-Csa-023910	Chlorocebus sabaeus	76.74	0.00e+00	1138.00
IUUC-Cho-024358	Choloepus hoffmanni	58.91	7.00e-106	377.00
IUUC-Dre-028106	Danio rerio	52.65	0.00e+00	793.00
IUUC-Dno-029456	Dasypus novemcinctus	67.46	0.00e+00	646.00
IUUC-Dor-030438	Dipodomys ordii	63.45	0.00e+00	948.00
IUUC-Dme-031870	Drosophila melanogaster	47.31	1.00e-36	148.00
IUUC-Ete-032736	Echinops telfairi	64.47	0.00e+00	937.00
IUUC-Eca-034211	Equus caballus	78.39	0.00e+00	1251.00
IUUC-Eeu-034797	Erinaceus europaeus	77.32	7.00e-85	308.00
IUUC-Fca-035947	Felis catus	73.06	0.00e+00	1087.00
IUUC-Fal-037199	Ficedula albicollis	63.84	0.00e+00	887.00
IUUC-Gmo-039228	Gadus morhua	62.53	4.00e-142	498.00
IUUC-Gga-040823	Gallus gallus	57.09	1.00e-155	543.00
IUUC-Gac-042406	Gasterosteus aculeatus	52.25	0.00e+00	772.00
IUUC-Ggo-045402	Gorilla gorilla	77.56	0.00e+00	1216.00
IUUC-Hsa-046430	Homo sapiens	77.53	0.00e+00	1221.00
IUUC-Itr-048855	Ictidomys tridecemlineatus	80.28	0.00e+00	731.00
IUUC-Lch-049547	Latimeria chalumnae	59.06	0.00e+00	884.00
IUUC-Loc-052842	Lepisosteus oculatus	57.61	0.00e+00	891.00
IUUC-Laf-053988	Loxodonta africana	77.68	0.00e+00	1241.00
IUUC-Mcc-055491	Macaca mulatta	73.72	0.00e+00	1155.00
IUUC-Meu-056256	Macropus eugenii	61.11	1.00e-173	603.00
IUUC-Mla-059026	Melampsora laricipopulina	31.22	5.00e-17	82.80
IUUC-Mga-059833	Meleagris gallopavo	54.51	9.00e-159	553.00
IUUC-Mmr-060952	Microcebus murinus	77.26	0.00e+00	1211.00
IUUC-Mdo-062642	Monodelphis domestica	68.60	0.00e+00	1056.00
IUUC-Mpu-065944	Mustela putorius furo	74.69	0.00e+00	1142.00
IUUC-Mlu-067049	Myotis lucifugus	76.83	0.00e+00	1183.00
IUUC-Nle-069828	Nomascus leucogenys	77.05	0.00e+00	1219.00
IUUC-Opr-070672	Ochotona princeps	68.38	3.00e-134	472.00
IUUC-Ont-072121	Oreochromis niloticus	52.92	3.00e-135	476.00
IUUC-Oan-073656	Ornithorhynchus anatinus	64.21	0.00e+00	1003.00
IUUC-Ocu-074323	Oryctolagus cuniculus	76.90	0.00e+00	1185.00
IUUC-Ola-087238	Oryzias latipes	54.17	2.00e-151	529.00
IUUC-Oga-088379	Otolemur garnettii	72.50	0.00e+00	1137.00
IUUC-Oar-089718	Ovis aries	76.22	0.00e+00	1183.00
IUUC-Ptr-091358	Pan troglodytes	77.53	0.00e+00	1221.00
IUUC-Pan-092023	Papio anubis	77.87	0.00e+00	1231.00
IUUC-Psi-093256	Pelodiscus sinensis	63.85	0.00e+00	959.00
IUUC-Pfo-097285	Poecilia formosa	48.68	0.00e+00	705.00
IUUC-Pab-098539	Pongo abelii	77.51	0.00e+00	1221.00
IUUC-Pca-100610	Procavia capensis	62.74	0.00e+00	844.00
IUUC-Pva-102985	Pteropus vampyrus	85.95	0.00e+00	661.00
IUUC-Rno-105538	Rattus norvegicus	93.23	0.00e+00	1517.00
IUUC-Sha-107022	Sarcophilus harrisii	69.78	3.00e-177	615.00
IUUC-Sja-107712	Schizosaccharomyces japonicus	27.35	9.00e-20	92.40
IUUC-Spo-108149	Schizosaccharomyces pombe	29.41	3.00e-20	94.00
IUUC-Sar-113637	Sorex araneus	66.26	0.00e+00	1003.00
IUUC-Ssc-115870	Sus scrofa	75.18	0.00e+00	1224.00
IUUC-Tgu-116907	Taeniopygia guttata	64.11	0.00e+00	1019.00
IUUC-Tru-117835	Takifugu rubripes	46.27	5.00e-108	385.00
IUUC-Tsy-118869	Tarsius syrichta	71.39	0.00e+00	1079.00
IUUC-Tni-119716	Tetraodon nigroviridis	51.15	3.00e-94	339.00
IUUC-Tbe-128041	Tupaia belangeri	61.49	0.00e+00	892.00
IUUC-Ttr-128901	Tursiops truncatus	74.57	0.00e+00	1201.00
IUUC-Vpa-130331	Vicugna pacos	77.36	0.00e+00	1115.00
IUUC-Xtr-131794	Xenopus tropicalis	51.04	0.00e+00	747.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence