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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064100
UUCD1 version UUC-MuM-00422
Ensembl Protein ID ENSMUSP00000006377.6
UniProt Accession Q60821; A2ADB9; Q60699; ZBT17_MOUSE
Genbank Protein ID AAA64848.1; AAA85493.1; CAM20401.1; EDL13378.1
Protein Name Zinc finger and BTB domain-containing protein 17; LP-1; Polyomavirus late initiator promoter-binding protein; Zinc finger protein 100; Zinc finger protein 151; Zinc finger protein Z13
Genbank Nucleotide ID U22396; U14556; AL670285; CH466615
Gene Name Zbtb17; Zfp100; Znf151
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000006215.12 ENSMUST00000006377.12 ENSMUSP00000006377.6
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
miRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTM
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB 1.10e-11 46.1 24 85
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_Other: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklden 68
           +D+++vv+g+ f+ahk+vLaa+S++F+ lf     +  +k+ v+++   +  + ++l+F+Yt kl+++
   Q: 24   CDCTFVVDGVDFKAHKAVLAACSEYFKMLFV----D--QKDVVHLDISNAAGLGQVLEFMYTAKLSLS 85
           9*****************************2....2..26788888678999************9875 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Represses RB1 transcription; this repression can be blocked by interaction with ZBTB49 (By similarity).
 Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Represses RB1 transcription; this repression can be blocked by interaction with ZBTB49 (By similarity).
Protein Sequence
(Fasta)
MDFPQHSQRV LEQLNQQRQL GLLCDCTFVV DGVDFKAHKA VLAACSEYFK MLFVDQKDVV 60
HLDISNAAGL GQVLEFMYTA KLSLSPENVD DVLAVASFLQ MQDIVTACHT LKSLAEPSST 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064100|E3,BTB_Other|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGCGACGGAA GTCCCAGCCG GGAAGCCAGC GAGGTCGGTT CCGCCCGGTT CTAACATGGC 60
GGCGCCCTTT GTCTGCTGTG AAGCGCTGCC CCCGGCCTTC TCGCGGCCGT GATGCACCTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064100|E3,BTB_Other|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0238--DNA-binding
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR000210--BTB/POZ_dom
IPR004039--Rubredoxin-type_fold
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type
IPR001781--Znf_LIM
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2
Pfam

PF00651--BTB
SMART

SM00225--BTB
SM00355--ZnF_C2H2
Gene Ontology

GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0046872--F:metal ion binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0007398--P:ectoderm development
GO:0001702--P:gastrulation with mouth forming second
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:1903146--P:regulation of mitophagy
KEGG mmu:22642
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002207 Ailuropoda melanoleuca 76.25 0.00e+00 985.00
IUUC-Apl-003789 Anas platyrhynchos 76.04 0.00e+00 1028.00
IUUC-Ame-010978 Astyanax mexicanus 78.63 0.00e+00 822.00
IUUC-Bta-012571 Bos taurus 97.46 0.00e+00 1004.00
IUUC-Cja-018730 Callithrix jacchus 88.15 0.00e+00 1341.00
IUUC-Cfa-020463 Canis familiaris 92.14 0.00e+00 1242.00
IUUC-Cpo-022120 Cavia porcellus 91.20 0.00e+00 1311.00
IUUC-Csa-024263 Chlorocebus sabaeus 83.15 7.00e-86 310.00
IUUC-Dre-027469 Danio rerio 78.38 0.00e+00 817.00
IUUC-Dno-029237 Dasypus novemcinctus 90.09 0.00e+00 1280.00
IUUC-Ete-033053 Echinops telfairi 82.12 0.00e+00 1200.00
IUUC-Eca-033861 Equus caballus 91.24 0.00e+00 1300.00
IUUC-Fca-036528 Felis catus 81.79 5.00e-133 468.00
IUUC-Fal-037166 Ficedula albicollis 90.57 0.00e+00 894.00
IUUC-Gmo-038904 Gadus morhua 75.25 0.00e+00 806.00
IUUC-Gga-040721 Gallus gallus 74.38 0.00e+00 1096.00
IUUC-Gac-041298 Gasterosteus aculeatus 74.31 0.00e+00 789.00
IUUC-Ggo-045394 Gorilla gorilla 88.48 0.00e+00 1347.00
IUUC-Hsa-046073 Homo sapiens 88.27 0.00e+00 1343.00
IUUC-Itr-048299 Ictidomys tridecemlineatus 92.44 0.00e+00 1371.00
IUUC-Lch-050218 Latimeria chalumnae 73.83 0.00e+00 731.00
IUUC-Loc-052153 Lepisosteus oculatus 76.55 0.00e+00 785.00
IUUC-Laf-053829 Loxodonta africana 90.81 0.00e+00 1348.00
IUUC-Mcc-055270 Macaca mulatta 77.56 0.00e+00 1117.00
IUUC-Meu-056271 Macropus eugenii 87.65 0.00e+00 981.00
IUUC-Mga-059305 Meleagris gallopavo 69.38 0.00e+00 993.00
IUUC-Mmr-060760 Microcebus murinus 92.28 0.00e+00 1354.00
IUUC-Mdo-062280 Monodelphis domestica 79.08 0.00e+00 1203.00
IUUC-Mpu-066286 Mustela putorius furo 79.50 9.00e-174 603.00
IUUC-Mlu-067394 Myotis lucifugus 90.69 0.00e+00 1294.00
IUUC-Nle-069713 Nomascus leucogenys 89.99 0.00e+00 1187.00
IUUC-Opr-071195 Ochotona princeps 88.06 0.00e+00 1284.00
IUUC-Ont-071808 Oreochromis niloticus 66.45 0.00e+00 991.00
IUUC-Oan-072892 Ornithorhynchus anatinus 89.43 0.00e+00 918.00
IUUC-Ocu-074812 Oryctolagus cuniculus 91.45 0.00e+00 1329.00
IUUC-Oga-088345 Otolemur garnettii 92.03 0.00e+00 1360.00
IUUC-Oar-089992 Ovis aries 98.64 1.00e-114 407.00
IUUC-Ptr-091414 Pan troglodytes 91.50 0.00e+00 1369.00
IUUC-Pan-091888 Papio anubis 91.88 0.00e+00 1380.00
IUUC-Psi-094055 Pelodiscus sinensis 84.70 0.00e+00 861.00
IUUC-Pfo-096787 Poecilia formosa 79.42 0.00e+00 797.00
IUUC-Pab-098341 Pongo abelii 88.85 0.00e+00 1354.00
IUUC-Pca-100832 Procavia capensis 90.51 0.00e+00 1236.00
IUUC-Pva-102905 Pteropus vampyrus 90.69 0.00e+00 1259.00
IUUC-Rno-105884 Rattus norvegicus 96.75 0.00e+00 1452.00
IUUC-Sha-107460 Sarcophilus harrisii 65.08 0.00e+00 912.00
IUUC-Sar-113442 Sorex araneus 83.38 0.00e+00 1120.00
IUUC-Ssc-115342 Sus scrofa 84.43 0.00e+00 1171.00
IUUC-Tgu-117348 Taeniopygia guttata 91.95 0.00e+00 833.00
IUUC-Tru-118668 Takifugu rubripes 74.18 0.00e+00 805.00
IUUC-Tni-120159 Tetraodon nigroviridis 74.13 0.00e+00 797.00
IUUC-Tbe-127424 Tupaia belangeri 76.69 4.00e-115 408.00
IUUC-Ttr-128620 Tursiops truncatus 88.75 0.00e+00 1110.00
Created Date 25-Jun-2017

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