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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063133
UUCD1 version UUC-MuM-00305
Ensembl Protein ID ENSMUSP00000028311.6
UniProt Accession P39429; A2AJA3; O54896; TRAF2_MOUSE
Genbank Protein ID AAC37662.1; AAC53545.1; AAF59928.1; AAF59928.1; AAF59928.1; AAF59928.1; AAF59928.1; AAF59928.1; AAF59928.1; CAM25164.1; AAH03801.1
Protein Name TNF receptor-associated factor 2; E3 ubiquitin-protein ligase TRAF2; RING-type E3 ubiquitin transferase TRAF2
Genbank Nucleotide ID L35303; AF027570; AF233332; AF233326; AF233327; AF233328; AF233329; AF233330; AF233331; AL732590; BC003801
Gene Name Traf2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000026942.13 ENSMUST00000028311.12 ENSMUSP00000028311.6
ENSMUSG00000026942.13 ENSMUST00000114234.1 ENSMUSP00000109872.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMPHOSIDA
BioGRID
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 86.83 0.00e+00 873.00 IUUC-Hsa-046952
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain. Isoform 2 does not seem to mediate activation of NF-kappa-B but inhibits isoform 1 activity. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE.
 Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain. Isoform 2 does not seem to mediate activation of NF-kappa-B but inhibits isoform 1 activity. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE.
Protein Sequence
(Fasta)
MAAASVTSPG SLELLQPGFS KTLLGTRLEA KYLCSACKNI LRRPFQAQCG HRYCSFCLTS 60
ILSSGPQNCA ACVYEGLYEE GISILESSSA FPDNAARREV ESLPAVCPND GCTWKGTLKE 120
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Protein Fasta Sequence


>IUUC-Mmu-063133|E3,RING|Mus musculus
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Nucleotide Sequence
(Fasta)
GTCCGTCAGA CGGGGCGGGC CGCGGCAGCG GGGGTGTTTC CCGGCGAGCG CTGAGTTCCG 60
GGCGCGCGAA GACCGTTGGG TGAGGCGGCG CGGATCTAAG CGGGGGGTCT ACTCTCAGCG 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-063133|E3,RING|Mus musculus
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Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-1017--Isopeptide bond
KW-0446--Lipid-binding
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR002083--MATH/TRAF_dom
IPR012227--TNF_rcpt--assoc_TRAF
IPR008974--TRAF-like
IPR027133--TRAF2
IPR032070--TRAF_BIRC3-bd
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
IPR001293--Znf_TRAF
PROSITE

PS50144--MATH
PS00518--ZF_RING_1
PS50089--ZF_RING_2
PS50145--ZF_TRAF
Pfam

PF16673--TRAF_BIRC3_bd
PF00097--zf-C3HC4
PF02176--zf-TRAF
SMART

SM00061--MATH
SM00184--RING
Gene Ontology

GO:0035631--C:CD40 receptor complex
GO:0005938--C:cell cortex
GO:0005737--C:cytoplasm
GO:0009898--C:cytoplasmic side of plasma membrane
GO:0005829--C:cytosol
GO:1990604--C:IRE1-TRAF2-ASK1 complex
GO:0045121--C:membrane raft
GO:0097057--C:TRAF2-GSTP1 complex
GO:0000151--C:ubiquitin ligase complex
GO:0012506--C:vesicle membrane
GO:0005174--F:CD40 receptor binding
GO:0019899--F:enzyme binding
GO:0042802--F:identical protein binding
GO:0019901--F:protein kinase binding
GO:0019903--F:protein phosphatase binding
GO:0046625--F:sphingolipid binding
GO:0031996--F:thioesterase binding
GO:0005164--F:tumor necrosis factor receptor binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007250--P:activation of NF-kappaB-inducing kinase activity
GO:0006915--P:apoptotic process
GO:0043623--P:cellular protein complex assembly
GO:0071732--P:cellular response to nitric oxide
GO:0043066--P:negative regulation of apoptotic process
GO:0034351--P:negative regulation of glial cell apoptotic process
GO:2001238--P:positive regulation of extrinsic apoptotic signaling pathway
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:1903721--P:positive regulation of I-kappaB phosphorylation
GO:0032743--P:positive regulation of interleukin-2 production
GO:0043507--P:positive regulation of JUN kinase activity
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0090073--P:positive regulation of protein homodimerization activity
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0002726--P:positive regulation of T cell cytokine production
GO:1903265--P:positive regulation of tumor necrosis factor-mediated signaling pathway
GO:0097300--P:programmed necrotic cell death
GO:0051865--P:protein autoubiquitination
GO:0030163--P:protein catabolic process
GO:0051291--P:protein heterooligomerization
GO:0070207--P:protein homotrimerization
GO:0070534--P:protein K63-linked ubiquitination
GO:0042981--P:regulation of apoptotic process
GO:0051023--P:regulation of immunoglobulin secretion
GO:0046328--P:regulation of JNK cascade
GO:0007165--P:signal transduction
GO:0033209--P:tumor necrosis factor-mediated signaling pathway
KEGG mmu:22030
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000744 Aegilops tauschii 26.27 3.00e-05 45.10
IUUC-Aml-002344 Ailuropoda melanoleuca 80.88 0.00e+00 866.00
IUUC-Apl-004202 Anas platyrhynchos 71.67 0.00e+00 803.00
IUUC-Aca-005029 Anolis carolinensis 55.61 3.00e-142 498.00
IUUC-Ame-011841 Astyanax mexicanus 55.59 0.00e+00 667.00
IUUC-Bta-013180 Bos taurus 82.65 0.00e+00 864.00
IUUC-Cja-019813 Callithrix jacchus 86.43 0.00e+00 910.00
IUUC-Cfa-021205 Canis familiaris 85.83 0.00e+00 877.00
IUUC-Cpo-021346 Cavia porcellus 88.22 0.00e+00 910.00
IUUC-Csa-023809 Chlorocebus sabaeus 85.65 0.00e+00 797.00
IUUC-Dre-027669 Danio rerio 57.94 5.00e-177 614.00
IUUC-Dno-029458 Dasypus novemcinctus 78.49 0.00e+00 851.00
IUUC-Dor-030338 Dipodomys ordii 86.03 0.00e+00 833.00
IUUC-Eca-034401 Equus caballus 86.14 0.00e+00 904.00
IUUC-Eeu-034668 Erinaceus europaeus 91.45 1.00e-81 297.00
IUUC-Fca-036057 Felis catus 82.22 0.00e+00 889.00
IUUC-Fal-037560 Ficedula albicollis 70.67 0.00e+00 708.00
IUUC-Gmo-038964 Gadus morhua 61.83 0.00e+00 659.00
IUUC-Gga-040425 Gallus gallus 72.30 0.00e+00 802.00
IUUC-Gac-041908 Gasterosteus aculeatus 62.90 0.00e+00 669.00
IUUC-Gma-043859 Glycine max 33.05 4.00e-06 47.80
IUUC-Ggo-044606 Gorilla gorilla 79.64 0.00e+00 820.00
IUUC-Hsa-046952 Homo sapiens 86.83 0.00e+00 912.00
IUUC-Hvu-047095 Hordeum vulgare 27.97 6.00e-05 43.90
IUUC-Itr-049016 Ictidomys tridecemlineatus 77.80 0.00e+00 792.00
IUUC-Lch-049571 Latimeria chalumnae 57.34 0.00e+00 684.00
IUUC-Loc-051973 Lepisosteus oculatus 62.58 0.00e+00 632.00
IUUC-Laf-053815 Loxodonta africana 79.37 0.00e+00 814.00
IUUC-Mcc-054888 Macaca mulatta 87.03 0.00e+00 910.00
IUUC-Meu-056547 Macropus eugenii 71.00 0.00e+00 650.00
IUUC-Mga-059819 Meleagris gallopavo 72.84 0.00e+00 768.00
IUUC-Mdo-062570 Monodelphis domestica 79.48 0.00e+00 833.00
IUUC-Mac-064547 Musa acuminata 33.67 4.00e-06 47.80
IUUC-Mpu-065802 Mustela putorius furo 81.64 0.00e+00 872.00
IUUC-Nle-070155 Nomascus leucogenys 87.23 0.00e+00 917.00
IUUC-Opr-070856 Ochotona princeps 78.07 2.00e-104 372.00
IUUC-Ont-071930 Oreochromis niloticus 62.72 0.00e+00 696.00
IUUC-Ola-087397 Oryzias latipes 59.40 0.00e+00 676.00
IUUC-Oga-088109 Otolemur garnettii 85.83 0.00e+00 908.00
IUUC-Oar-090310 Ovis aries 72.85 0.00e+00 763.00
IUUC-Ptr-090643 Pan troglodytes 87.03 0.00e+00 915.00
IUUC-Pan-091933 Papio anubis 87.23 0.00e+00 911.00
IUUC-Psi-093681 Pelodiscus sinensis 70.39 0.00e+00 764.00
IUUC-Pfo-096148 Poecilia formosa 58.85 0.00e+00 679.00
IUUC-Pab-098631 Pongo abelii 87.03 0.00e+00 915.00
IUUC-Pca-100582 Procavia capensis 63.18 1.00e-83 303.00
IUUC-Pva-102396 Pteropus vampyrus 71.86 0.00e+00 720.00
IUUC-Rno-106120 Rattus norvegicus 95.01 0.00e+00 936.00
IUUC-Sha-106493 Sarcophilus harrisii 79.88 0.00e+00 859.00
IUUC-Sar-113570 Sorex araneus 93.37 1.00e-100 359.00
IUUC-Ssc-115843 Sus scrofa 81.35 0.00e+00 885.00
IUUC-Tgu-117144 Taeniopygia guttata 68.25 0.00e+00 686.00
IUUC-Tru-117853 Takifugu rubripes 59.85 0.00e+00 676.00
IUUC-Tni-120256 Tetraodon nigroviridis 63.87 0.00e+00 705.00
IUUC-Tae-123531 Triticum aestivum 26.27 3.00e-05 44.70
IUUC-Tbe-127943 Tupaia belangeri 64.98 5.00e-96 343.00
IUUC-Ttr-129246 Tursiops truncatus 84.92 0.00e+00 864.00
IUUC-Xtr-132279 Xenopus tropicalis 58.00 1.00e-166 579.00
Created Date 25-Jun-2017

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