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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046121
Ensembl Protein ID ENSP00000368887.3
UniProt Accession Q9NWT1; Q5T4J2; Q96QJ8; Q96T87; PK1IP_HUMAN
Genbank Protein ID AAK57477.1; BAA91296.1; AAH10907.1
Protein Name p21-activated protein kinase-interacting protein 1; PAK/PLC-interacting protein 1; PAK1-interacting protein 1; WD repeat-containing protein 84
Genbank Nucleotide ID AF283303; AK000631; AL358777
Gene Name PAK1IP1; PIP1; WDR84
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000111845.4 ENST00000379568.3 ENSP00000368887.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
InWeb_IM
Disease-associated Variation
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtBioGRID
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.50e-26 93.0 81 117
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf.sdtllvsGsdDgtikvWDlrtgvllk 37
           H++ +tcl+f  +++l+sG+ Dg i +WD ++  +lk
   Q: 81   HSGTITCLKFyGNRHLISGAEDGLICIWDAKKWECLK 117
           9*********9559***************77766665 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which have been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42.
 Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which have been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42.
Protein Sequence
(Fasta)
MELVAGCYEQ VLFGFAVHPE PEACGDHEQW TLVADFTHHA HTASLSAVAV NSRFVVTGSK 60
DETIHIYDMK KKIEHGALVH HSGTITCLKF YGNRHLISGA EDGLICIWDA KKWECLKSIK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046121|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCTGGCACCT TCCTGAGATA TGCCTGCTTG CCCCCGATTT TTTTCTCCTT GCAGTGAGAA 60
CCTCCTCATG TGGCATCTTT ACTTATTCTC TTCTTGGAAA ATCCATGTGA CCTCCCCGCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046121|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0734--Signal transduction inhibitor
KW-0853--WD repeat
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0005730--C:nucleolus
GO:0008283--P:cell proliferation
GO:0009968--P:negative regulation of signal transduction
GO:0060021--P:palate development
KEGG hsa:55003
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001803 Ailuropoda melanoleuca 85.48 0.00e+00 669.00
IUUC-Atr-003018 Amborella trichopoda 33.86 2.00e-46 179.00
IUUC-Apl-004199 Anas platyrhynchos 67.38 2.00e-133 468.00
IUUC-Aca-005157 Anolis carolinensis 63.31 7.00e-124 437.00
IUUC-Aly-006245 Arabidopsis lyrata 33.64 2.00e-42 166.00
IUUC-Ath-007309 Arabidopsis thaliana 33.33 5.00e-42 164.00
IUUC-Ago-007878 Ashbya gossypii 31.01 5.00e-34 138.00
IUUC-Acl-008015 Aspergillus clavatus 22.03 7.00e-20 92.00
IUUC-Afu-008760 Aspergillus fumigatus 21.99 8.00e-20 92.00
IUUC-Ani-009358 Aspergillus nidulans 21.96 5.00e-17 82.40
IUUC-Ate-010411 Aspergillus terreus 21.35 3.00e-15 76.60
IUUC-Ame-011121 Astyanax mexicanus 54.34 8.00e-112 396.00
IUUC-Bgr-012152 Blumeria graminis 24.67 2.00e-16 80.50
IUUC-Bta-012383 Bos taurus 81.63 0.00e+00 642.00
IUUC-Bci-013752 Botrytis cinerea 23.74 5.00e-17 82.40
IUUC-Bdi-014505 Brachypodium distachyon 27.44 3.00e-17 82.40
IUUC-Bol-015458 Brassica oleracea 33.12 2.00e-43 169.00
IUUC-Bra-017790 Brassica rapa 33.33 5.00e-45 174.00
IUUC-Cja-018803 Callithrix jacchus 91.25 3.00e-178 617.00
IUUC-Cfa-020178 Canis familiaris 84.95 0.00e+00 665.00
IUUC-Cpo-021785 Cavia porcellus 76.64 2.00e-170 592.00
IUUC-Cre-022703 Chlamydomonas reinhardtii 28.62 3.00e-35 143.00
IUUC-Csa-023179 Chlorocebus sabaeus 96.22 0.00e+00 741.00
IUUC-Cho-025088 Choloepus hoffmanni 82.99 3.00e-139 487.00
IUUC-Cin-025484 Ciona intestinalis 34.48 5.00e-21 94.40
IUUC-Csv-025887 Ciona savignyi 35.84 1.00e-49 190.00
IUUC-Cgl-026525 Colletotrichum gloeosporioides 24.45 1.00e-18 87.80
IUUC-Cne-027021 Cryptococcus neoformans 34.39 5.00e-27 117.00
IUUC-Dre-027360 Danio rerio 64.03 6.00e-118 417.00
IUUC-Dno-029836 Dasypus novemcinctus 83.15 1.00e-177 615.00
IUUC-Dor-030677 Dipodomys ordii 88.93 3.00e-150 523.00
IUUC-Dse-031177 Dothistroma septosporum 24.20 4.00e-20 93.20
IUUC-Dme-032004 Drosophila melanogaster 30.64 3.00e-32 132.00
IUUC-Ete-032837 Echinops telfairi 86.07 2.00e-147 514.00
IUUC-Eca-033291 Equus caballus 85.83 0.00e+00 685.00
IUUC-Eeu-035347 Erinaceus europaeus 86.69 4.00e-148 516.00
IUUC-Fca-036577 Felis catus 86.25 0.00e+00 635.00
IUUC-Fal-036810 Ficedula albicollis 65.83 2.00e-133 468.00
IUUC-Fox-037844 Fusarium oxysporum 24.15 1.00e-16 81.30
IUUC-Fso-038338 Fusarium solani 24.09 2.00e-20 94.00
IUUC-Gmo-038537 Gadus morhua 61.97 9.00e-113 399.00
IUUC-Gga-040566 Gallus gallus 65.74 2.00e-142 498.00
IUUC-Gac-042422 Gasterosteus aculeatus 61.66 1.00e-120 426.00
IUUC-Gma-044199 Glycine max 30.16 3.00e-34 139.00
IUUC-Ggo-045365 Gorilla gorilla 85.41 0.00e+00 641.00
IUUC-Itr-048361 Ictidomys tridecemlineatus 84.87 1.00e-171 595.00
IUUC-Kpa-049407 Komagataella pastoris 32.74 2.00e-41 163.00
IUUC-Lch-049767 Latimeria chalumnae 66.34 3.00e-128 451.00
IUUC-Lpe-051569 Leersia perrieri 28.35 1.00e-20 94.00
IUUC-Loc-051940 Lepisosteus oculatus 59.03 7.00e-119 420.00
IUUC-Lma-053288 Leptosphaeria maculans 25.94 2.00e-20 94.00
IUUC-Laf-054463 Loxodonta africana 85.09 0.00e+00 666.00
IUUC-Mcc-055412 Macaca mulatta 96.22 0.00e+00 740.00
IUUC-Mor-056986 Magnaporthe oryzae 23.24 2.00e-14 73.90
IUUC-Mtr-057886 Medicago truncatula 32.05 7.00e-34 137.00
IUUC-Mla-058862 Melampsora laricipopulina 23.44 2.00e-18 87.40
IUUC-Mga-060109 Meleagris gallopavo 67.69 4.00e-133 467.00
IUUC-Mvi-060326 Microbotryum violaceum 26.98 2.00e-28 120.00
IUUC-Mmr-060681 Microcebus murinus 84.91 0.00e+00 645.00
IUUC-Mdo-063004 Monodelphis domestica 75.76 3.00e-164 571.00
IUUC-Mmu-064184 Mus musculus 72.63 2.00e-168 585.00
IUUC-Mac-064987 Musa acuminata 32.70 2.00e-39 156.00
IUUC-Mpu-065847 Mustela putorius furo 84.55 0.00e+00 679.00
IUUC-Mlu-067608 Myotis lucifugus 85.71 0.00e+00 690.00
IUUC-Nfi-068531 Neosartorya fischeri 23.54 9.00e-21 95.10
IUUC-Nle-069302 Nomascus leucogenys 98.21 0.00e+00 759.00
IUUC-Ont-072591 Oreochromis niloticus 64.90 9.00e-108 383.00
IUUC-Oan-073558 Ornithorhynchus anatinus 66.12 3.00e-119 421.00
IUUC-Ocu-074558 Oryctolagus cuniculus 83.56 2.00e-176 611.00
IUUC-Ogl-076960 Oryza glaberrima 27.27 2.00e-23 103.00
IUUC-Ogu-078660 Oryza glumaepatula 28.53 2.00e-21 96.70
IUUC-Oin-079790 Oryza indica 27.67 9.00e-28 117.00
IUUC-Ome-081631 Oryza meridionalis 26.11 3.00e-14 72.80
IUUC-Oni-083082 Oryza nivara 27.67 2.00e-22 99.80
IUUC-Opu-083394 Oryza punctata 28.93 9.00e-28 117.00
IUUC-Oru-084461 Oryza rufipogon 28.12 3.00e-22 99.40
IUUC-Osa-085655 Oryza sativa 28.22 1.00e-22 100.00
IUUC-Ola-086955 Oryzias latipes 61.86 3.00e-123 434.00
IUUC-Olu-087657 Ostreococcus lucimarinus 28.35 9.00e-26 111.00
IUUC-Oga-088108 Otolemur garnettii 86.58 0.00e+00 647.00
IUUC-Oar-090019 Ovis aries 80.53 3.00e-178 617.00
IUUC-Ptr-091544 Pan troglodytes 99.23 0.00e+00 763.00
IUUC-Pan-092562 Papio anubis 96.22 0.00e+00 740.00
IUUC-Psi-094025 Pelodiscus sinensis 65.99 1.00e-105 376.00
IUUC-Pma-094322 Petromyzon marinus 57.66 4.00e-99 354.00
IUUC-Ppa-095541 Physcomitrella patens 33.23 9.00e-41 161.00
IUUC-Pfo-096667 Poecilia formosa 65.35 3.00e-98 352.00
IUUC-Pab-098064 Pongo abelii 97.84 0.00e+00 753.00
IUUC-Pop-099969 Populus trichocarpa 32.49 1.00e-40 160.00
IUUC-Pca-101053 Procavia capensis 84.42 4.00e-169 587.00
IUUC-Ppe-101839 Prunus persica 33.12 1.00e-44 173.00
IUUC-Pva-102963 Pteropus vampyrus 86.02 0.00e+00 644.00
IUUC-Pgr-103276 Puccinia graminis 24.06 9.00e-17 81.60
IUUC-Pte-104117 Pyrenophora teres 26.02 2.00e-20 94.40
IUUC-Pyt-104649 Pyrenophora triticirepentis 26.33 4.00e-20 92.80
IUUC-Rno-105975 Rattus norvegicus 75.53 2.00e-168 585.00
IUUC-Sce-106226 Saccharomyces cerevisiae 25.43 6.00e-30 125.00
IUUC-Sha-106907 Sarcophilus harrisii 70.05 6.00e-160 556.00
IUUC-Sja-107867 Schizosaccharomyces japonicus 26.06 2.00e-23 102.00
IUUC-Spo-108377 Schizosaccharomyces pombe 27.03 2.00e-25 110.00
IUUC-Ssl-108647 Sclerotinia sclerotiorum 23.98 1.00e-18 87.80
IUUC-Smo-109068 Selaginella moellendorffii 29.90 2.00e-35 142.00
IUUC-Sit-110114 Setaria italica 28.08 1.00e-22 100.00
IUUC-Sly-111581 Solanum lycopersicum 33.33 3.00e-40 159.00
IUUC-Stu-112770 Solanum tuberosum 33.12 5.00e-40 158.00
IUUC-Sbi-114797 Sorghum bicolor 25.85 2.00e-16 80.10
IUUC-Sre-114941 Sporisorium reilianum 28.31 2.00e-34 140.00
IUUC-Ssc-116346 Sus scrofa 82.21 1.00e-175 609.00
IUUC-Tgu-116628 Taeniopygia guttata 71.17 8.00e-137 479.00
IUUC-Tru-117646 Takifugu rubripes 62.38 2.00e-110 392.00
IUUC-Tsy-119593 Tarsius syrichta 70.26 8.00e-152 530.00
IUUC-Tni-119872 Tetraodon nigroviridis 62.25 3.00e-117 414.00
IUUC-Tca-121500 Theobroma cacao 34.49 3.00e-44 172.00
IUUC-Tre-122151 Trichoderma reesei 23.89 6.00e-20 92.40
IUUC-Tvi-122619 Trichoderma virens 22.77 5.00e-18 85.90
IUUC-Tae-124450 Triticum aestivum 28.71 2.00e-21 96.30
IUUC-Tbe-127959 Tupaia belangeri 86.30 7.00e-150 522.00
IUUC-Ttr-129125 Tursiops truncatus 84.78 0.00e+00 650.00
IUUC-Uma-129567 Ustilago maydis 27.47 7.00e-36 145.00
IUUC-Vda-129955 Verticillium dahliae 22.55 3.00e-15 76.60
IUUC-Vpa-130157 Vicugna pacos 94.55 3.00e-91 328.00
IUUC-Vvi-131065 Vitis vinifera 32.59 6.00e-37 147.00
IUUC-Xtr-132601 Xenopus tropicalis 60.74 1.00e-117 416.00
IUUC-Xma-133142 Xiphophorus maculatus 61.09 3.00e-105 374.00
IUUC-Yli-134580 Yarrowia lipolytica 29.76 2.00e-35 143.00
IUUC-Zma-135330 Zea mays 29.69 3.00e-29 122.00
Created Date 25-Jun-2017

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