iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.20e-18	66.5	881	916

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclafsd.tllvsGsdDgtikvWDlrtgvll 36
           gH+ ++ cl  sd  +++s++  g+i+vWD r+g +l
   Q: 881  GHKHRIECL-VSDgAYIISCCLKGQIRVWDARSGEQL 916
           799999997.577799***************999876 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MAAATDVSAR AAAAASSTSP RTAASNSSGL AGKPPGPAPS SAGVAGAAGA SSTGLPASVS 60
HFYYKHGLFL SSYPTCASSI AFMAILLSCY PLINIPLPGT IPTKIVVPYE TGSGSLSWHS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTTTGTTCT AACGTGTGTG GTGGCGCAGG GCGCATCCAA TTTTGCGGTT CGGTAAAACG 60
TGCTTAACGA AAAGCTGCAT ATTAAACTGC TTGCCGGACT CGTCTGATCG CCGTTACCTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0677--Repeat
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR011047--Quinoprotein_ADH-like_supfam
IPR030225--SCAP
IPR000731--SSD
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50156--SSD
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12349--Sterol-sensing
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0016021--C:integral component of membrane
GO:0015485--F:cholesterol binding
GO:0008203--P:cholesterol metabolic process
GO:0016485--P:protein processing
GO:0035103--P:sterol regulatory element binding protein cleavage

KEGG

dme:Dmel_CG33131

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001802	Ailuropoda melanoleuca	38.70	3.00e-85	309.00
IUUC-Apl-003294	Anas platyrhynchos	32.47	1.00e-98	354.00
IUUC-Aca-004424	Anolis carolinensis	30.79	2.00e-82	300.00
IUUC-Bta-013478	Bos taurus	33.11	6.00e-99	355.00
IUUC-Cel-018160	Caenorhabditis elegans	21.64	9.00e-66	244.00
IUUC-Cja-019123	Callithrix jacchus	35.14	1.00e-74	274.00
IUUC-Cfa-021082	Canis familiaris	33.74	3.00e-98	352.00
IUUC-Cpo-022477	Cavia porcellus	34.01	2.00e-90	327.00
IUUC-Csa-023176	Chlorocebus sabaeus	36.59	1.00e-83	304.00
IUUC-Cin-025490	Ciona intestinalis	27.92	2.00e-62	233.00
IUUC-Csv-026115	Ciona savignyi	30.59	2.00e-92	333.00
IUUC-Dre-028008	Danio rerio	31.03	8.00e-100	358.00
IUUC-Dno-028887	Dasypus novemcinctus	34.15	6.00e-90	325.00
IUUC-Dor-030467	Dipodomys ordii	36.22	2.00e-78	286.00
IUUC-Ete-032372	Echinops telfairi	34.23	4.00e-43	169.00
IUUC-Eca-033896	Equus caballus	31.73	1.00e-99	357.00
IUUC-Eeu-035099	Erinaceus europaeus	33.33	9.00e-66	244.00
IUUC-Fca-035616	Felis catus	38.11	4.00e-83	302.00
IUUC-Fal-037231	Ficedula albicollis	33.33	2.00e-81	297.00
IUUC-Gmo-039439	Gadus morhua	37.92	1.00e-76	281.00
IUUC-Gac-041516	Gasterosteus aculeatus	33.06	8.00e-85	308.00
IUUC-Hsa-046674	Homo sapiens	32.66	2.00e-98	353.00
IUUC-Itr-048879	Ictidomys tridecemlineatus	32.67	4.00e-102	365.00
IUUC-Lch-049689	Latimeria chalumnae	31.17	1.00e-95	344.00
IUUC-Loc-051906	Lepisosteus oculatus	36.11	2.00e-21	94.00
IUUC-Laf-053795	Loxodonta africana	33.26	1.00e-100	360.00
IUUC-Mcc-055502	Macaca mulatta	32.60	3.00e-96	346.00
IUUC-Mga-059805	Meleagris gallopavo	33.41	8.00e-99	354.00
IUUC-Mmr-060997	Microcebus murinus	32.89	5.00e-99	355.00
IUUC-Mdo-062940	Monodelphis domestica	33.26	5.00e-100	358.00
IUUC-Mmu-063255	Mus musculus	32.96	8.00e-99	354.00
IUUC-Mpu-066158	Mustela putorius furo	32.70	3.00e-99	356.00
IUUC-Mlu-067201	Myotis lucifugus	33.22	5.00e-89	322.00
IUUC-Nle-069145	Nomascus leucogenys	31.15	6.00e-127	448.00
IUUC-Opr-070797	Ochotona princeps	41.92	9.00e-43	168.00
IUUC-Ont-071553	Oreochromis niloticus	30.95	1.00e-98	353.00
IUUC-Ocu-074598	Oryctolagus cuniculus	39.05	9.00e-83	301.00
IUUC-Ola-086650	Oryzias latipes	38.35	1.00e-34	138.00
IUUC-Oar-089287	Ovis aries	36.30	2.00e-81	296.00
IUUC-Pan-092004	Papio anubis	32.60	3.00e-96	346.00
IUUC-Psi-093028	Pelodiscus sinensis	32.90	4.00e-102	365.00
IUUC-Pma-094145	Petromyzon marinus	32.78	2.00e-107	383.00
IUUC-Pfo-096320	Poecilia formosa	31.93	1.00e-101	364.00
IUUC-Pab-097862	Pongo abelii	32.74	4.00e-99	355.00
IUUC-Pca-100862	Procavia capensis	35.89	4.00e-49	189.00
IUUC-Pva-103050	Pteropus vampyrus	34.32	5.00e-95	342.00
IUUC-Rno-105852	Rattus norvegicus	32.93	7.00e-98	351.00
IUUC-Sha-107312	Sarcophilus harrisii	32.23	6.00e-102	365.00
IUUC-Sar-113311	Sorex araneus	32.63	4.00e-44	172.00
IUUC-Ssc-116356	Sus scrofa	32.89	2.00e-102	367.00
IUUC-Tgu-116896	Taeniopygia guttata	39.45	2.00e-16	80.50
IUUC-Tru-118197	Takifugu rubripes	31.48	5.00e-95	342.00
IUUC-Tni-119823	Tetraodon nigroviridis	31.43	1.00e-103	370.00
IUUC-Ttr-129164	Tursiops truncatus	33.48	1.00e-101	363.00
IUUC-Xtr-132819	Xenopus tropicalis	32.79	2.00e-103	370.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence