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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046674
Ensembl Protein ID ENSP00000265565.5
UniProt Accession Q12770; Q8N2E0; Q8WUA1; SCAP_HUMAN
Genbank Protein ID BAA12111.2; BAB55088.1; AAH20987.1; BAC11673.1
Protein Name Sterol regulatory element-binding protein cleavage-activating protein
Genbank Nucleotide ID D83782; AK027402; BC020987; AK075528
Gene Name SCAP; KIAA0199; PSEC0227
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000114650.18 ENST00000320017.10 ENSP00000324296.6
ENSG00000114650.18 ENST00000441517.6 ENSP00000416847.3
ENSG00000114650.18 ENST00000265565.9 ENSP00000265565.5
ENSG00000114650.18 ENST00000416208.5 ENSP00000409183.1
ENSG00000114650.18 ENST00000448217.2 ENSP00000415195.1
ENSG00000114650.18 ENST00000545718.2 ENSP00000438956.2
ENSG00000114650.18 ENST00000428413.5 ENSP00000401819.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarmiRNAMapSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
GWASdbOMIM
Drug and target
TTD
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtBioGRID
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.70e-14 55.0 1117 1150
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclafsd.tl.lvsGsdDgtikvWDlrtg 33
           gH++ +t +   d t+ l+sG+ Dg i +WD+ tg
   Q: 1117 GHSGAITTVYI-DqTMvLASGGQDGAICLWDVLTG 1150
           8********88.446648*************9887 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of SREBF in the Golgi, release of the transcription factor fragment of SREBF from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway (By similarity).
 Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of SREBF in the Golgi, release of the transcription factor fragment of SREBF from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway (By similarity).
Protein Sequence
(Fasta)
MTLTERLREK ISRAFYNHGL LCASYPIPII LFTGFCILAC CYPLLKLPLP GTGPVEFTTP 60
VKDYSPPPVD SDRKQGEPTE QPEWYVGAPV AYVQQIFVKS SVFPWHKNLL AVDVFRSPLS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046674|E3,WD_repeat|Homo sapiens
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Nucleotide Sequence
(Fasta)
AGAGTCCGGT GGGAACTGGG TTTTAGGAGG AGGTATCTGA AGAATGTGTA GTGGGTCGGG 60
GGCTGGTGCG GTCAGAAGGG CCACCTCTAA TTTCTGCCTT GCATTGGTGA CTAGATCTGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046674|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0153--Cholesterol metabolism
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0256--Endoplasmic reticulum
KW-0325--Glycoprotein
KW-0333--Golgi apparatus
KW-0443--Lipid metabolism
KW-0472--Membrane
KW-0488--Methylation
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0753--Steroid metabolism
KW-1207--Sterol metabolism
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0853--WD repeat
Interpro

IPR030225--SCAP
IPR000731--SSD
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS50156--SSD
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF12349--Sterol-sensing
PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0012507--C:ER to Golgi transport vesicle membrane
GO:0005794--C:Golgi apparatus
GO:0000139--C:Golgi membrane
GO:0016021--C:integral component of membrane
GO:0043234--C:protein complex
GO:0015485--F:cholesterol binding
GO:0051082--F:unfolded protein binding
GO:0007568--P:aging
GO:0008203--P:cholesterol metabolic process
GO:0045541--P:negative regulation of cholesterol biosynthetic process
GO:0045716--P:positive regulation of low-density lipoprotein particle receptor biosynthetic process
GO:0042304--P:regulation of fatty acid biosynthetic process
GO:0001666--P:response to hypoxia
GO:0032868--P:response to insulin
GO:0032933--P:SREBP signaling pathway
KEGG hsa:22937
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001802 Ailuropoda melanoleuca 94.43 0.00e+00 1092.00
IUUC-Apl-003294 Anas platyrhynchos 76.42 0.00e+00 1726.00
IUUC-Aca-004424 Anolis carolinensis 69.92 0.00e+00 1521.00
IUUC-Bta-013478 Bos taurus 92.58 0.00e+00 2100.00
IUUC-Cel-018160 Caenorhabditis elegans 29.78 3.00e-64 240.00
IUUC-Cja-019123 Callithrix jacchus 95.54 0.00e+00 2179.00
IUUC-Cfa-021082 Canis familiaris 91.16 0.00e+00 2043.00
IUUC-Cpo-022477 Cavia porcellus 84.71 0.00e+00 1901.00
IUUC-Csa-023176 Chlorocebus sabaeus 95.07 0.00e+00 2162.00
IUUC-Cin-025490 Ciona intestinalis 38.35 1.00e-91 331.00
IUUC-Csv-026115 Ciona savignyi 37.35 1.00e-133 471.00
IUUC-Dre-028008 Danio rerio 68.27 0.00e+00 1524.00
IUUC-Dno-028887 Dasypus novemcinctus 91.46 0.00e+00 1216.00
IUUC-Dor-030467 Dipodomys ordii 92.90 0.00e+00 878.00
IUUC-Dme-032087 Drosophila melanogaster 32.88 1.00e-109 391.00
IUUC-Ete-032372 Echinops telfairi 77.55 0.00e+00 1731.00
IUUC-Eca-033896 Equus caballus 93.44 0.00e+00 2180.00
IUUC-Eeu-035099 Erinaceus europaeus 85.44 0.00e+00 1222.00
IUUC-Fca-035616 Felis catus 87.27 0.00e+00 1948.00
IUUC-Fal-037231 Ficedula albicollis 74.11 0.00e+00 1650.00
IUUC-Gmo-039439 Gadus morhua 74.28 0.00e+00 679.00
IUUC-Gac-041516 Gasterosteus aculeatus 67.46 0.00e+00 1518.00
IUUC-Itr-048879 Ictidomys tridecemlineatus 93.12 0.00e+00 2164.00
IUUC-Lch-049689 Latimeria chalumnae 70.37 0.00e+00 1646.00
IUUC-Loc-052417 Lepisosteus oculatus 52.77 5.00e-135 474.00
IUUC-Laf-053795 Loxodonta africana 90.68 0.00e+00 2100.00
IUUC-Mcc-055502 Macaca mulatta 98.12 0.00e+00 2283.00
IUUC-Mga-059805 Meleagris gallopavo 77.35 0.00e+00 1741.00
IUUC-Mmr-060997 Microcebus murinus 94.14 0.00e+00 2215.00
IUUC-Mdo-062940 Monodelphis domestica 81.08 0.00e+00 1830.00
IUUC-Mmu-063255 Mus musculus 91.95 0.00e+00 2125.00
IUUC-Mpu-066158 Mustela putorius furo 92.18 0.00e+00 2099.00
IUUC-Mlu-067201 Myotis lucifugus 88.49 0.00e+00 2051.00
IUUC-Nle-069145 Nomascus leucogenys 98.75 0.00e+00 1438.00
IUUC-Opr-070797 Ochotona princeps 88.12 0.00e+00 1971.00
IUUC-Ont-071553 Oreochromis niloticus 67.00 0.00e+00 1512.00
IUUC-Ocu-074598 Oryctolagus cuniculus 93.59 0.00e+00 2103.00
IUUC-Ola-086650 Oryzias latipes 84.23 1.00e-112 398.00
IUUC-Oar-089287 Ovis aries 85.99 0.00e+00 1115.00
IUUC-Pan-092004 Papio anubis 98.11 0.00e+00 2259.00
IUUC-Psi-093028 Pelodiscus sinensis 71.79 0.00e+00 1516.00
IUUC-Pma-094145 Petromyzon marinus 51.86 0.00e+00 1135.00
IUUC-Pfo-096320 Poecilia formosa 67.30 0.00e+00 1515.00
IUUC-Pab-097862 Pongo abelii 99.06 0.00e+00 2345.00
IUUC-Pca-100862 Procavia capensis 78.91 0.00e+00 1663.00
IUUC-Pva-103050 Pteropus vampyrus 92.71 0.00e+00 1340.00
IUUC-Rno-105852 Rattus norvegicus 92.49 0.00e+00 2150.00
IUUC-Sha-107312 Sarcophilus harrisii 81.64 0.00e+00 1846.00
IUUC-Sar-113311 Sorex araneus 89.26 0.00e+00 850.00
IUUC-Ssc-116356 Sus scrofa 92.66 0.00e+00 2151.00
IUUC-Tgu-116896 Taeniopygia guttata 61.83 6.00e-150 525.00
IUUC-Tru-118197 Takifugu rubripes 68.09 0.00e+00 1516.00
IUUC-Tni-119823 Tetraodon nigroviridis 65.24 0.00e+00 1486.00
IUUC-Ttr-129164 Tursiops truncatus 93.05 0.00e+00 2115.00
IUUC-Xtr-132819 Xenopus tropicalis 68.76 0.00e+00 1625.00
Created Date 25-Jun-2017

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