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Basic Information Integrated Annotations

Tag Content
iUUCD ID IUUC-Rno-105583
Ensembl Protein ID ENSRNOP00000012137.3
UniProt Accession O88275; Q9QWG0; Q9R197; PPARG_RAT
Genbank Protein ID AAD40119.1; AAD40118.1; BAA36485.1; CAA73382.2; BAA32540.1; AAF63385.1; AAF63386.1
Protein Name Peroxisome proliferator-activated receptor gamma; Nuclear receptor subfamily 1 group C member 3
Genbank Nucleotide ID AF156666; AF156665; AB019561; Y12882; AB011365; AF246457; AF246458
Gene Name Pparg; Nr1c3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000008839.7 ENSRNOT00000012137.5 ENSRNOP00000012137.3
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNATRANSFACmiRNAMapRAID2
Protein-protein Interaction
IIDiRefIndex
Drug and target
GRAC
Post-translational Modifications (PTMs)
dbPAFdbPTMUniProt
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 95.84 0.00e+00 982.00 IUUC-Hsa-046916
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Rattus norvegicus
Functional Description
(View)

Functional Description



     Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels.
Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels.
Protein Sequence
(Fasta)
MGETLGDPPV DPEHGAFADA LPMSTSQEIT MVDTEMPFWP TNFGISSVDL SVMDDHSHSF 60
DIKPFTTVDF SSISAPHYED IPFTRADPMV ADYKYDLKLQ EYQSAIKVEP ASPPYYSEKT 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Rno-105583|E3,RING|Rattus norvegicus
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Nucleotide Sequence
(Fasta)
CGGGTCGGCC GCACGGACGC ACATTGCCCG CCAAGCCGCC GCCTCAGGTC AGAGTCGCCC 60
CGGGCCACAA GGCCCGCCGC AGGGACGCTG AAGAAGAGAC CTGGGGCGCC GCACTGGGGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Rno-105583|E3,RING|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0010--Activator
KW-0025--Alternative splicing
KW-0090--Biological rhythms
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0238--DNA-binding
KW-0325--Glycoprotein
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0675--Receptor
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003074--1Cnucl_rcpt
IPR003077--1Cnucl_rcpt_G
IPR000536--Nucl_hrmn_rcpt_lig-bd
IPR001723--Nuclear_hrmn_rcpt
IPR022590--PPARgamma_N
IPR001628--Znf_hrmn_rcpt
IPR013088--Znf_NHR/GATA

PROSITE

PS00031--NUCLEAR_REC_DBD_1
PS51030--NUCLEAR_REC_DBD_2

Pfam

PF00104--Hormone_recep
PF12577--PPARgamma_N
PF00105--zf-C4

PRINTS

PR01288--PROXISOMEPAR
PR01291--PROXISOMPAGR
PR00398--STRDHORMONER
PR00047--STROIDFINGER

SMART

SM00430--HOLI
SM00399--ZnF_C4

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0090575--C:RNA polymerase II transcription factor complex
GO:0003682--F:chromatin binding
GO:0001046--F:core promoter sequence-specific DNA binding
GO:0003677--F:DNA binding
GO:0008144--F:drug binding
GO:0030331--F:estrogen receptor binding
GO:0030374--F:ligand-dependent nuclear receptor transcription coactivator activity
GO:0019903--F:protein phosphatase binding
GO:0004879--F:RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
GO:0003707--F:steroid hormone receptor activity
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0008134--F:transcription factor binding
GO:0044212--F:transcription regulatory region DNA binding
GO:0008270--F:zinc ion binding
GO:0006919--P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0031100--P:animal organ regeneration
GO:0048469--P:cell maturation
GO:0071455--P:cellular response to hyperoxia
GO:0032869--P:cellular response to insulin stimulus
GO:0071380--P:cellular response to prostaglandin E stimulus
GO:0071379--P:cellular response to prostaglandin stimulus
GO:0071300--P:cellular response to retinoic acid
GO:0071306--P:cellular response to vitamin E
GO:0006631--P:fatty acid metabolic process
GO:0019395--P:fatty acid oxidation
GO:0042593--P:glucose homeostasis
GO:0007507--P:heart development
GO:0042953--P:lipoprotein transport
GO:0045713--P:low-density lipoprotein particle receptor biosynthetic process
GO:0010742--P:macrophage derived foam cell differentiation
GO:0030224--P:monocyte differentiation
GO:0002674--P:negative regulation of acute inflammatory response
GO:0030308--P:negative regulation of cell growth
GO:0008285--P:negative regulation of cell proliferation
GO:0010887--P:negative regulation of cholesterol storage
GO:0032966--P:negative regulation of collagen biosynthetic process
GO:0060336--P:negative regulation of interferon-gamma-mediated signaling pathway
GO:0010745--P:negative regulation of macrophage derived foam cell differentiation
GO:2000230--P:negative regulation of pancreatic stellate cell proliferation
GO:0010871--P:negative regulation of receptor biosynthetic process
GO:0010891--P:negative regulation of sequestering of triglyceride
GO:0048662--P:negative regulation of smooth muscle cell proliferation
GO:0051974--P:negative regulation of telomerase activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0035357--P:peroxisome proliferator activated receptor signaling pathway
GO:0043065--P:positive regulation of apoptotic process
GO:0045600--P:positive regulation of fat cell differentiation
GO:0046321--P:positive regulation of fatty acid oxidation
GO:0048714--P:positive regulation of oligodendrocyte differentiation
GO:0060100--P:positive regulation of phagocytosis, engulfment
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0008217--P:regulation of blood pressure
GO:0042752--P:regulation of circadian rhythm
GO:0045598--P:regulation of fat cell differentiation
GO:0019216--P:regulation of lipid metabolic process
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0060850--P:regulation of transcription involved in cell fate commitment
GO:0031000--P:response to caffeine
GO:0009409--P:response to cold
GO:0042493--P:response to drug
GO:0043627--P:response to estrogen
GO:0035902--P:response to immobilization stress
GO:0033993--P:response to lipid
GO:0055098--P:response to low-density lipoprotein particle
GO:0009612--P:response to mechanical stimulus
GO:1901558--P:response to metformin
GO:0014070--P:response to organic cyclic compound
GO:0010033--P:response to organic substance
GO:0032526--P:response to retinoic acid
GO:0042594--P:response to starvation
GO:0033189--P:response to vitamin A
GO:0048511--P:rhythmic process
GO:0006351--P:transcription, DNA-templated
GO:0050872--P:white fat cell differentiation

KEGG rno:25664
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001214 Ailuropoda melanoleuca 94.46 0.00e+00 955.00
IUUC-Aca-005129 Anolis carolinensis 88.64 0.00e+00 870.00
IUUC-Ame-010818 Astyanax mexicanus 65.38 0.00e+00 640.00
IUUC-Bta-013226 Bos taurus 95.25 0.00e+00 969.00
IUUC-Cja-019236 Callithrix jacchus 96.04 0.00e+00 981.00
IUUC-Cfa-020281 Canis familiaris 96.63 0.00e+00 986.00
IUUC-Cpo-021587 Cavia porcellus 95.45 0.00e+00 932.00
IUUC-Csa-023400 Chlorocebus sabaeus 98.53 0.00e+00 946.00
IUUC-Cho-024593 Choloepus hoffmanni 84.55 0.00e+00 838.00
IUUC-Dre-028176 Danio rerio 60.82 2.00e-153 535.00
IUUC-Dno-029063 Dasypus novemcinctus 93.28 0.00e+00 940.00
IUUC-Ete-032520 Echinops telfairi 93.07 0.00e+00 940.00
IUUC-Fca-035935 Felis catus 96.44 0.00e+00 985.00
IUUC-Fal-037524 Ficedula albicollis 91.58 0.00e+00 879.00
IUUC-Gga-041223 Gallus gallus 92.63 0.00e+00 887.00
IUUC-Gac-042156 Gasterosteus aculeatus 61.75 0.00e+00 632.00
IUUC-Ggo-045265 Gorilla gorilla 96.24 0.00e+00 985.00
IUUC-Hsa-046916 Homo sapiens 95.84 0.00e+00 982.00
IUUC-Lch-049759 Latimeria chalumnae 80.05 0.00e+00 677.00
IUUC-Loc-051870 Lepisosteus oculatus 73.76 0.00e+00 743.00
IUUC-Laf-054483 Loxodonta africana 94.46 0.00e+00 962.00
IUUC-Meu-056587 Macropus eugenii 94.00 0.00e+00 917.00
IUUC-Mga-059530 Meleagris gallopavo 92.63 0.00e+00 887.00
IUUC-Mmr-060576 Microcebus murinus 94.85 0.00e+00 971.00
IUUC-Mdo-061854 Monodelphis domestica 97.89 0.00e+00 932.00
IUUC-Mmu-063724 Mus musculus 99.60 0.00e+00 1016.00
IUUC-Mpu-066888 Mustela putorius furo 98.53 0.00e+00 979.00
IUUC-Mlu-067978 Myotis lucifugus 95.64 0.00e+00 1011.00
IUUC-Nle-070069 Nomascus leucogenys 96.24 0.00e+00 985.00
IUUC-Opr-070630 Ochotona princeps 93.62 0.00e+00 790.00
IUUC-Ont-071399 Oreochromis niloticus 58.70 6.00e-178 617.00
IUUC-Ocu-074862 Oryctolagus cuniculus 97.48 0.00e+00 942.00
IUUC-Ola-087266 Oryzias latipes 56.05 2.00e-158 552.00
IUUC-Oga-089143 Otolemur garnettii 94.85 0.00e+00 974.00
IUUC-Oar-089725 Ovis aries 95.84 0.00e+00 976.00
IUUC-Ptr-091580 Pan troglodytes 96.04 0.00e+00 984.00
IUUC-Psi-093041 Pelodiscus sinensis 90.15 0.00e+00 862.00
IUUC-Pfo-097438 Poecilia formosa 58.55 1.00e-176 612.00
IUUC-Pab-098333 Pongo abelii 97.48 0.00e+00 934.00
IUUC-Pca-100861 Procavia capensis 96.65 0.00e+00 930.00
IUUC-Pva-102186 Pteropus vampyrus 86.14 0.00e+00 858.00
IUUC-Sha-107484 Sarcophilus harrisii 97.08 0.00e+00 936.00
IUUC-Sar-112996 Sorex araneus 84.29 0.00e+00 643.00
IUUC-Ssc-115945 Sus scrofa 96.04 0.00e+00 975.00
IUUC-Tsy-119098 Tarsius syrichta 86.93 0.00e+00 858.00
IUUC-Tni-120902 Tetraodon nigroviridis 58.93 3.00e-171 595.00
IUUC-Tbe-127225 Tupaia belangeri 74.85 0.00e+00 706.00
IUUC-Ttr-129292 Tursiops truncatus 96.24 0.00e+00 980.00
IUUC-Vpa-130378 Vicugna pacos 91.33 0.00e+00 783.00
Created Date 25-Jun-2017

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