iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt	BioGRID	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	19631635; 19546213; 19423641; 11786535; 15064394; 15221006; 9334332; 15466852; 12072443; 14654780; 14645235; 11483518; 10747903; 9637679; 16141343; 20691163; 17716627

Reviewed

Classification

Family	Identity	E-value	Score	Source Orthology
E3 activity/RING/RING	97.53	3.00e-154	541.00	IUUC-Mmu-063206
E3 activity/RING/RING	97.84	2.00e-154	541.00	IUUC-Rno-105477

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a protein involved in synaptic vesicle function in neurons (SYP). Mediates ubiquitination and proteasomal degradation of DYRK2 in response to hypoxia. It is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes. Has some overlapping function with SIAH1. Triggers the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 does not. Promotes monoubiquitination of SNCA.

Protein Sequence
(Fasta)

MSRPSSTGPS ANKPCSKQPP PQPQHTPSPA APPAAATISA AGPGSSAVPA AAAVISGPGG 60
GGGAGPVSPQ HHELTSLFEC PVCFDYVLPP ILQCQAGHLV CNQCRQKLSC CPTCRGALTP 120

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Nucleotide Sequence
(Fasta)

GAGCTGAGGG ACGCGTCAGC CAGGCACCCC GGGGTGTGGC CAGAGGACTT CGGCGACGCT 60
TCCCCGAGAG TAGCCCCCCT CCTCAACCCA GAAAAGACAA CCCCGCGGGG CTGCAGCGAG 120

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Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0053--Apoptosis
KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR018121--7-in-absentia-prot_TRAF-dom
IPR001370--BIR_rpt
IPR004162--SINA-like
IPR008974--TRAF-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR013010--Znf_SIAH

PROSITE

PS50089--ZF_RING_2
PS51081--ZF_SIAH

Pfam

PF03145--Sina

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0043231--C:intracellular membrane-bounded organelle
GO:0043005--C:neuron projection
GO:0043025--C:neuronal cell body
GO:0005654--C:nucleoplasm
GO:0003714--F:transcription corepressor activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0007411--P:axon guidance
GO:0007049--P:cell cycle
GO:0044257--P:cellular protein catabolic process
GO:0044267--P:cellular protein metabolic process
GO:0043066--P:negative regulation of apoptotic process
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway
GO:0016579--P:protein deubiquitination
GO:0000209--P:protein polyubiquitination
GO:0031396--P:regulation of protein ubiquitination
GO:0007264--P:small GTPase mediated signal transduction
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:6478

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001409	Ailuropoda melanoleuca	100.00	2.00e-156	544.00
IUUC-Ame-011678	Astyanax mexicanus	92.09	2.00e-141	494.00
IUUC-Bta-012750	Bos taurus	99.61	2.00e-153	535.00
IUUC-Cja-019800	Callithrix jacchus	100.00	6.00e-158	550.00
IUUC-Cfa-020505	Canis familiaris	99.61	2.00e-154	538.00
IUUC-Cpo-021394	Cavia porcellus	88.69	8.00e-157	546.00
IUUC-Csa-023374	Chlorocebus sabaeus	100.00	6.00e-158	550.00
IUUC-Cho-024933	Choloepus hoffmanni	100.00	5.00e-155	539.00
IUUC-Dre-027711	Danio rerio	91.70	4.00e-141	493.00
IUUC-Dno-029260	Dasypus novemcinctus	100.00	6.00e-148	516.00
IUUC-Dor-030489	Dipodomys ordii	96.22	9.00e-108	382.00
IUUC-Ete-032946	Echinops telfairi	91.05	2.00e-159	554.00
IUUC-Eca-033546	Equus caballus	99.61	7.00e-156	542.00
IUUC-Eeu-034861	Erinaceus europaeus	96.12	1.00e-148	518.00
IUUC-Fal-037160	Ficedula albicollis	88.05	1.00e-132	465.00
IUUC-Gmo-039091	Gadus morhua	89.72	3.00e-139	488.00
IUUC-Gga-040252	Gallus gallus	86.73	9.00e-153	532.00
IUUC-Gac-041673	Gasterosteus aculeatus	89.72	1.00e-139	488.00
IUUC-Ggo-044618	Gorilla gorilla	100.00	6.00e-158	550.00
IUUC-Itr-048976	Ictidomys tridecemlineatus	98.45	3.00e-154	537.00
IUUC-Lch-049496	Latimeria chalumnae	81.73	4.00e-152	530.00
IUUC-Loc-052107	Lepisosteus oculatus	92.80	1.00e-141	495.00
IUUC-Laf-054257	Loxodonta africana	99.61	1.00e-153	535.00
IUUC-Mcc-055023	Macaca mulatta	100.00	6.00e-158	550.00
IUUC-Meu-055922	Macropus eugenii	97.25	2.00e-149	521.00
IUUC-Mga-060070	Meleagris gallopavo	96.11	6.00e-148	516.00
IUUC-Mmr-061494	Microcebus murinus	99.69	6.00e-158	550.00
IUUC-Mdo-061971	Monodelphis domestica	98.82	1.00e-153	535.00
IUUC-Mmu-063206	Mus musculus	87.96	2.00e-154	538.00
IUUC-Mpu-066597	Mustela putorius furo	99.38	6.00e-158	550.00
IUUC-Mlu-067199	Myotis lucifugus	99.61	3.00e-154	537.00
IUUC-Nle-069342	Nomascus leucogenys	100.00	6.00e-158	550.00
IUUC-Opr-070341	Ochotona princeps	56.86	4.00e-50	191.00
IUUC-Ont-071906	Oreochromis niloticus	90.12	2.00e-140	491.00
IUUC-Oan-073701	Ornithorhynchus anatinus	53.85	7.00e-50	190.00
IUUC-Ocu-073950	Oryctolagus cuniculus	99.61	1.00e-156	545.00
IUUC-Oga-089154	Otolemur garnettii	99.69	6.00e-158	550.00
IUUC-Oar-089446	Ovis aries	98.85	7.00e-157	546.00
IUUC-Ptr-091088	Pan troglodytes	100.00	6.00e-158	550.00
IUUC-Psi-093079	Pelodiscus sinensis	99.24	3.00e-159	553.00
IUUC-Pfo-097007	Poecilia formosa	85.38	4.00e-133	467.00
IUUC-Pab-098092	Pongo abelii	100.00	6.00e-158	550.00
IUUC-Pca-100328	Procavia capensis	97.22	1.00e-152	531.00
IUUC-Pva-102368	Pteropus vampyrus	100.00	3.00e-64	238.00
IUUC-Rno-105477	Rattus norvegicus	87.96	2.00e-154	538.00
IUUC-Sha-107630	Sarcophilus harrisii	98.86	6.00e-159	552.00
IUUC-Ssc-116441	Sus scrofa	99.07	4.00e-157	547.00
IUUC-Tru-118004	Takifugu rubripes	87.35	7.00e-135	473.00
IUUC-Tsy-119548	Tarsius syrichta	89.47	1.00e-67	249.00
IUUC-Tni-120846	Tetraodon nigroviridis	88.93	3.00e-137	480.00
IUUC-Vpa-130799	Vicugna pacos	99.42	4.00e-104	369.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence