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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Cel-018334
UUCD1 version UUC-CaE-00417
Ensembl Protein ID T12E12.1
UniProt Accession Q22431; ARI2_CAEEL
Genbank Protein ID CCD70522.1
Protein Name Potential E3 ubiquitin-protein ligase ariadne-2; Protein ariadne-2; RING-type E3 ubiquitin transferase ariadne-2
Genbank Nucleotide ID FO081292
Gene Name T12E12.1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00020462 T12E12.1 T12E12.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNAmiRNAMapRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAFdbPTMPhospho.ELM
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RBR 1.30e-43 149.8 129 316
Active Site
Position(s) Description Evidence
300 N/A {ECO:0000250|UniProtKB:Q9Y4X5}
Domain Profile

   E3 activity/RBR
   S: 1    CkvCllelsveeltvlleCehtfCkeClkqylelkikegqvteiscpaaecpekleeseikellveeelyk.ryekllleevveadaalk 89
           C+vC +   + el+  l+C h fC++C+k+++e +++eg +++i c++ ec   ++++ + +++ ++ ++k +ye++ll+++v+++++lk
   Q: 129  CSVCAMDGYT-ELP-HLTCGHCFCEHCWKSHVESRLSEGVASRIECMESECEVYAPSEFVLSIIKNSPVIKlKYERFLLRDMVNSHPHLK 216
           9999976655.444.679********************************************98876655439***************** PP
   S: 90   wcpapdCslvvllekeaeklevecekcgkefCveCkeewHeglsCkelkeklakteeekeeaeskelleanskkCpkCkvyieknegCnh 179
           +c   +C ++++ ++ ++ ++v+c +c++ fCv+C + +H+++sC+++k++++k++   +++e++++++a++k+Cp+C+++iek +gCnh
   Q: 217  FCVGNECPVIIRSTE-VKPKRVTCMQCHTSFCVKCGADYHAPTSCETIKQWMTKCA---DDSETANYISAHTKDCPQCHSCIEKAGGCNH 302
           *********999999.599*************************************...99***************************** PP
   S: 180  mtCakCkaefCwlC 193
           ++C++C+++fCw+C
   Q: 303  IQCTRCRHHFCWMC 316
           ************** PP
   
Organism Caenorhabditis elegans
Functional Description
(View)

Functional Description


     Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBC-2/UBE2L3, and then transfers it to substrates.
 Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBC-2/UBE2L3, and then transfers it to substrates.
Protein Sequence
(Fasta)
MDDEDMSCTS GDDYAGYGDE DYYNEADVDA ADDVAVTPTH SEEADYECLS VNQVERVFID 60
GVNSLVSRIS INEKFARILL QANHWDVDKI ARLVRNDRND FLRKCHIDAK PEPKRKLSST 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Cel-018334|E3,RBR|Caenorhabditis elegans
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AAAAGCAGAA AATGGACGAT GAAGACATGA GCTGCACGTC CGGGGATGAT TATGCCGGTT 60
ATGGAGATGG TTAGATTTAA GCTGATTTAA AAAAAAATAT TTATCGCCAA ACATAATTGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cel-018334|E3,RBR|Caenorhabditis elegans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR016150--Casein_kin_II_reg-sub_b-sht
IPR031127--E3_UB_ligase_RBR
IPR002867--IBR_dom
Pfam

PF01485--IBR
SMART

SM00647--IBR
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0046872--F:metal ion binding
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
KEGG cel:CELE_T12E12.1
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001557 Ailuropoda melanoleuca 48.64 2.00e-121 427.00
IUUC-Apl-003878 Anas platyrhynchos 48.86 6.00e-121 426.00
IUUC-Aca-004865 Anolis carolinensis 49.09 5.00e-121 426.00
IUUC-Bta-012901 Bos taurus 48.86 1.00e-121 428.00
IUUC-Cja-019728 Callithrix jacchus 48.86 3.00e-122 430.00
IUUC-Cfa-020953 Canis familiaris 48.64 2.00e-121 427.00
IUUC-Cpo-021445 Cavia porcellus 48.86 9.00e-122 429.00
IUUC-Csa-023769 Chlorocebus sabaeus 48.64 6.00e-122 429.00
IUUC-Cho-024650 Choloepus hoffmanni 43.41 4.00e-96 343.00
IUUC-Cin-025577 Ciona intestinalis 48.92 3.00e-119 421.00
IUUC-Csv-025849 Ciona savignyi 46.23 4.00e-99 353.00
IUUC-Dre-028490 Danio rerio 48.45 2.00e-122 431.00
IUUC-Dno-029942 Dasypus novemcinctus 48.64 2.00e-121 427.00
IUUC-Dor-030134 Dipodomys ordii 46.62 2.00e-81 295.00
IUUC-Dme-031853 Drosophila melanogaster 49.89 3.00e-130 457.00
IUUC-Ete-032355 Echinops telfairi 45.23 3.00e-106 377.00
IUUC-Eca-033440 Equus caballus 48.41 5.00e-121 426.00
IUUC-Eeu-035230 Erinaceus europaeus 58.19 2.00e-74 271.00
IUUC-Fca-036308 Felis catus 47.27 4.00e-114 403.00
IUUC-Fal-036974 Ficedula albicollis 48.86 6.00e-121 426.00
IUUC-Gmo-038642 Gadus morhua 51.63 5.00e-116 409.00
IUUC-Gga-041019 Gallus gallus 48.86 6.00e-121 426.00
IUUC-Gac-042014 Gasterosteus aculeatus 48.88 1.00e-122 431.00
IUUC-Ggo-045329 Gorilla gorilla 48.64 8.00e-122 429.00
IUUC-Hsa-046712 Homo sapiens 48.64 8.00e-122 429.00
IUUC-Itr-048370 Ictidomys tridecemlineatus 50.24 9.00e-120 422.00
IUUC-Lch-049584 Latimeria chalumnae 48.86 1.00e-117 415.00
IUUC-Loc-051826 Lepisosteus oculatus 43.13 9.00e-74 269.00
IUUC-Laf-054567 Loxodonta africana 47.84 1.00e-119 422.00
IUUC-Mcc-054919 Macaca mulatta 48.64 6.00e-122 429.00
IUUC-Meu-056332 Macropus eugenii 47.73 2.00e-116 410.00
IUUC-Mga-060132 Meleagris gallopavo 48.30 9.00e-121 425.00
IUUC-Mmr-061599 Microcebus murinus 47.11 7.00e-116 409.00
IUUC-Mdo-062186 Monodelphis domestica 48.82 3.00e-117 413.00
IUUC-Mmu-064271 Mus musculus 49.09 6.00e-122 429.00
IUUC-Mpu-066827 Mustela putorius furo 48.58 2.00e-117 414.00
IUUC-Mlu-067528 Myotis lucifugus 47.61 7.00e-119 419.00
IUUC-Nle-068995 Nomascus leucogenys 48.64 8.00e-122 429.00
IUUC-Opr-070518 Ochotona princeps 48.41 8.00e-120 422.00
IUUC-Ont-071650 Oreochromis niloticus 48.78 2.00e-120 424.00
IUUC-Oan-073676 Ornithorhynchus anatinus 50.36 2.00e-114 404.00
IUUC-Ocu-073761 Oryctolagus cuniculus 48.64 1.00e-121 428.00
IUUC-Ola-087204 Oryzias latipes 47.02 5.00e-119 420.00
IUUC-Oga-088098 Otolemur garnettii 48.86 4.00e-122 430.00
IUUC-Oar-089205 Ovis aries 48.86 1.00e-121 428.00
IUUC-Ptr-091514 Pan troglodytes 48.64 8.00e-122 429.00
IUUC-Pan-092493 Papio anubis 45.78 1.00e-109 389.00
IUUC-Pfo-097256 Poecilia formosa 48.87 1.00e-121 428.00
IUUC-Pab-098504 Pongo abelii 43.18 1.00e-97 348.00
IUUC-Pca-100700 Procavia capensis 44.55 2.00e-102 364.00
IUUC-Pva-103105 Pteropus vampyrus 47.73 9.00e-117 412.00
IUUC-Rno-105289 Rattus norvegicus 49.32 1.00e-122 431.00
IUUC-Sha-107417 Sarcophilus harrisii 47.38 4.00e-118 416.00
IUUC-Sar-113042 Sorex araneus 48.86 1.00e-121 428.00
IUUC-Ssc-115362 Sus scrofa 48.64 3.00e-121 427.00
IUUC-Tgu-117469 Taeniopygia guttata 48.33 4.00e-114 403.00
IUUC-Tru-117976 Takifugu rubripes 47.17 6.00e-119 419.00
IUUC-Tni-119831 Tetraodon nigroviridis 47.17 7.00e-118 416.00
IUUC-Tbe-127386 Tupaia belangeri 39.26 5.00e-56 210.00
IUUC-Ttr-128315 Tursiops truncatus 48.86 2.00e-121 427.00
IUUC-Vpa-130383 Vicugna pacos 44.77 1.00e-103 368.00
IUUC-Xtr-132945 Xenopus tropicalis 48.87 2.00e-120 424.00
Created Date 25-Jun-2017

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