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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045747
UUCD1 version UUC-HoS-01143
Ensembl Protein ID ENSP00000327197.5
UniProt Accession Q96HI0; B4DY82; Q96SA5; SENP5_HUMAN
Genbank Protein ID BAG63644.1; AAH08589.1; AAH30705.1; AAK69630.1
Protein Name Sentrin-specific protease 5; Sentrin/SUMO-specific protease SENP5
Genbank Nucleotide ID AK302305; AC011322; BC030705; AF335474
Gene Name SENP5; FKSG45
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000119231.10 ENST00000445299.6 ENSP00000390231.2
ENSG00000119231.10 ENST00000323460.9 ENSP00000327197.5
ENSG00000119231.10 ENST00000448068.5 ENSP00000405663.1
ENSG00000119231.10 ENST00000434433.1 ENSP00000415227.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
InWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRD
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
DUB/ULP ULP 16738315
Classification
Family E-value Score Start End
DUB/ULP 2.50e-51 176.0 568 723
Active Site
Position(s) Description Evidence
646 N/A {ECO:0000250}
663 {ECO:0000250}
713 {ECO:0000305}
Domain Profile

   DUB/ULP
   S: 2    svtnedlkcLeegeflnDviidfylkylvleklkkekverihifssffykklkqkerrrvktwtrkvdlfekdlifvpineaaHWslavvcf 93
           +++++dl +L+ +++lnD++i++y + l+++ +     +++h+f+sff+++l +k+++ vk+wt+kvdlf+k+l+++pi+ ++HWsl+ v++
   Q: 568  MLDMDDLATLDGQNWLNDQVINMYGE-LIMDAVP----DKVHFFNSFFHRQLVTKGYNGVKRWTKKVDLFKKSLLLIPIHLEVHWSLITVTL 654
           6789**********************.******7....9***************************************************** PP
   S: 94   kkksilllDSlrgasksnvvkklreylevevkkkskrefskeklkgsnpk.vpqQkNssDCGvyvlqyves 163
           +++ i ++DS+ g + + +v+++r+yl +e+++k++ ef +  ++++++k +pqQkN+sDCGv+vlqy+++
   Q: 655  SNRIISFYDSQ-GIHFKFCVENIRKYLLTEAREKNRPEFLQ-GWQTAVTKcIPQQKNDSDCGVFVLQYCKC 723
           ***********.****************************9.999999999******************97 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division.
 Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division.
Protein Sequence
(Fasta)
MKKQRKILWR KGIHLAFSEK WNTGFGGFKK FYFHQHLCIL KAKLGRPVTW NRQLRHFQGR 60
KKALQIQKTW IKDEPLCAKT KFNVATQNVS TLSSKVKRKD AKHFISSSKT LLRLQAEKLL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045747|DUB,ULP|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCAGGCGGAA GGGCGCGGAG GAGGTGACGC GATAGGCCAG CGCCGGCGTC GCGGCAGCCG 60
CTTCAGAGGA AGCTCGGCGG CTGTGGCCGC GGCGAACAGG CCGGACGCCT CGTCGCTGGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045747|DUB,ULP|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
Interpro

IPR003653--Peptidase_C48_C
IPR033465--SENP5
PROSITE

PS50600--ULP_PROTEASE
Pfam

PF02902--Peptidase_C48
Gene Ontology

GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0004175--F:endopeptidase activity
GO:0070139--F:SUMO-specific endopeptidase activity
GO:0016929--F:SUMO-specific protease activity
GO:0007049--P:cell cycle
GO:0051301--P:cell division
GO:0016926--P:protein desumoylation
GO:0016925--P:protein sumoylation
KEGG hsa:205564
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002198 Ailuropoda melanoleuca 90.73 0.00e+00 1430.00
IUUC-Apl-003396 Anas platyrhynchos 60.53 0.00e+00 635.00
IUUC-Aca-004954 Anolis carolinensis 48.47 3.00e-170 592.00
IUUC-Ame-011963 Astyanax mexicanus 49.72 2.00e-97 349.00
IUUC-Bta-013424 Bos taurus 89.01 0.00e+00 1395.00
IUUC-Cja-019271 Callithrix jacchus 95.36 0.00e+00 1504.00
IUUC-Cfa-020809 Canis familiaris 90.33 0.00e+00 1429.00
IUUC-Cpo-021633 Cavia porcellus 78.81 0.00e+00 1217.00
IUUC-Csa-023353 Chlorocebus sabaeus 95.10 0.00e+00 1461.00
IUUC-Cho-024452 Choloepus hoffmanni 81.89 1.00e-119 424.00
IUUC-Dre-027542 Danio rerio 45.82 1.00e-89 323.00
IUUC-Dno-029354 Dasypus novemcinctus 87.81 0.00e+00 1390.00
IUUC-Dor-030333 Dipodomys ordii 72.45 0.00e+00 1059.00
IUUC-Ete-033044 Echinops telfairi 82.52 0.00e+00 1258.00
IUUC-Eca-033652 Equus caballus 90.20 0.00e+00 1420.00
IUUC-Eeu-035194 Erinaceus europaeus 75.63 0.00e+00 1165.00
IUUC-Fca-035818 Felis catus 89.14 0.00e+00 1395.00
IUUC-Fal-036870 Ficedula albicollis 59.30 1.00e-178 619.00
IUUC-Gmo-039618 Gadus morhua 55.36 2.00e-90 325.00
IUUC-Gga-040485 Gallus gallus 59.44 4.00e-178 617.00
IUUC-Gac-041779 Gasterosteus aculeatus 55.16 1.00e-89 323.00
IUUC-Ggo-044587 Gorilla gorilla 99.47 0.00e+00 1570.00
IUUC-Itr-048302 Ictidomys tridecemlineatus 88.74 0.00e+00 1401.00
IUUC-Lch-049644 Latimeria chalumnae 59.48 6.00e-122 431.00
IUUC-Loc-052661 Lepisosteus oculatus 61.04 4.00e-107 380.00
IUUC-Laf-054540 Loxodonta africana 86.77 0.00e+00 1328.00
IUUC-Mcc-054914 Macaca mulatta 94.57 0.00e+00 1456.00
IUUC-Meu-056903 Macropus eugenii 62.20 7.00e-178 617.00
IUUC-Mga-059450 Meleagris gallopavo 50.85 0.00e+00 646.00
IUUC-Mmr-061697 Microcebus murinus 89.67 0.00e+00 1410.00
IUUC-Mdo-062859 Monodelphis domestica 54.42 0.00e+00 670.00
IUUC-Mmu-063127 Mus musculus 81.88 0.00e+00 1212.00
IUUC-Mpu-066657 Mustela putorius furo 91.13 0.00e+00 1439.00
IUUC-Mlu-067515 Myotis lucifugus 87.68 0.00e+00 1372.00
IUUC-Nle-070025 Nomascus leucogenys 97.48 0.00e+00 1511.00
IUUC-Ont-071806 Oreochromis niloticus 60.38 4.00e-92 331.00
IUUC-Oan-073271 Ornithorhynchus anatinus 57.60 0.00e+00 754.00
IUUC-Ocu-074334 Oryctolagus cuniculus 89.01 0.00e+00 1377.00
IUUC-Ola-086926 Oryzias latipes 53.78 6.00e-81 293.00
IUUC-Oga-088748 Otolemur garnettii 88.74 0.00e+00 1386.00
IUUC-Oar-089661 Ovis aries 88.74 0.00e+00 1395.00
IUUC-Ptr-090815 Pan troglodytes 99.60 0.00e+00 1573.00
IUUC-Pan-091869 Papio anubis 94.97 0.00e+00 1463.00
IUUC-Psi-093629 Pelodiscus sinensis 51.14 0.00e+00 686.00
IUUC-Pfo-096553 Poecilia formosa 58.10 2.00e-84 305.00
IUUC-Pab-098245 Pongo abelii 98.54 0.00e+00 1556.00
IUUC-Pca-101132 Procavia capensis 75.36 0.00e+00 1161.00
IUUC-Pva-102530 Pteropus vampyrus 89.67 0.00e+00 1408.00
IUUC-Rno-105307 Rattus norvegicus 83.36 0.00e+00 1259.00
IUUC-Sha-107362 Sarcophilus harrisii 85.20 1.00e-147 515.00
IUUC-Ssc-115758 Sus scrofa 88.08 0.00e+00 1382.00
IUUC-Tgu-116496 Taeniopygia guttata 60.78 0.00e+00 630.00
IUUC-Tsy-119395 Tarsius syrichta 83.33 0.00e+00 1296.00
IUUC-Tni-120025 Tetraodon nigroviridis 62.20 6.00e-92 330.00
IUUC-Tbe-127305 Tupaia belangeri 83.91 6.00e-158 551.00
IUUC-Ttr-129053 Tursiops truncatus 86.89 0.00e+00 1349.00
IUUC-Vpa-130688 Vicugna pacos 88.74 0.00e+00 1398.00
IUUC-Xtr-132040 Xenopus tropicalis 63.53 5.00e-149 521.00
Created Date 25-Jun-2017

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