iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	miRNAMap	RAID2
Protein-protein Interaction
IID	PINA
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	3.70e-64	217.6	2	222

Active Site

Position(s)	Description	Evidence
90	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10091}
161	Proton donor	ECO:0000255\|PROSITE-ProRule:PRU10091}

Domain Profile

DUB/UCH

   S: 7    ewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakqvi 95
           ++ ++e +P+++++++ ++gv +++++ ++ +L++e+lg+++ p ++llllF+++ ++e++rk+q++    e +++++  +++f+kq+i
   Q: 2    QLKPMEINPEMLNKVLAKLGVAGQWRFADVLGLEEETLGSVPSPACALLLLFPLTAQHENFRKKQIE----ELKGQEVSPKVYFMKQTI 86
           5789*************************************************************99....99**************** PP
   S: 96   gNsCatyAllsvllncedkl.ldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfvsy 183
           gNsC+t++l+++++n++dkl ++ G+ l++++++t++ spe++a++++++++++++h+s+a++++++ +          +k +fhf+++
   Q: 87   GNSCGTIGLIHAVANNQDKLeFEDGSVLKQFLSETEKLSPEDRAKCFEKNEAIQAAHDSVAQEGQCRVD----------DKVNFHFILF 165
           *******************************************************************99..........5679****** PP
   S: 184  vningrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesdeirfnllaivad 244
            n++g+lyeldg++pfP+++g+++e+  l+d++kv+r+f+er    e++e+rf+++a++++
   Q: 166  NNVDGHLYELDGRMPFPVNHGASSEDSLLQDAAKVCREFTER----EQGEVRFSAVALCKA 222
           ******************************************....************987 PP

Organism

Rattus norvegicus

Functional Description
(View)

Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity (By similarity).

Protein Sequence
(Fasta)

MQLKPMEINP EMLNKVLAKL GVAGQWRFAD VLGLEEETLG SVPSPACALL LLFPLTAQHE 60
NFRKKQIEEL KGQEVSPKVY FMKQTIGNSC GTIGLIHAVA NNQDKLEFED GSVLKQFLSE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTTTATAGC AGCCGCCTGG GCGGCTCCAC CGGCTGTTTT TTGGCTCCTG CGCTTGTTCT 60
TCCCTGTGCA CTCCGCAAAG ATGCAGCTGA AACCGATGGA GATTAACCCC GAGGTAAATG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0256--Endoplasmic reticulum
KW-0325--Glycoprotein
KW-0378--Hydrolase
KW-0436--Ligase
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0636--Prenylation
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR030297--UCHL1

PROSITE

PS00140--UCH_1

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:1904115--C:axon cytoplasm
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005789--C:endoplasmic reticulum membrane
GO:0070062--C:extracellular exosome
GO:0043209--C:myelin sheath
GO:0044306--C:neuron projection terminus
GO:0043025--C:neuronal cell body
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0004197--F:cysteine-type endopeptidase activity
GO:0016874--F:ligase activity
GO:0008242--F:omega peptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0007628--P:adult walking behavior
GO:0007412--P:axon target recognition
GO:0019896--P:axonal transport of mitochondrion
GO:0008283--P:cell proliferation
GO:0042755--P:eating behavior
GO:0048747--P:muscle fiber development
GO:0043407--P:negative regulation of MAP kinase activity
GO:0050905--P:neuromuscular process
GO:0016579--P:protein deubiquitination
GO:0002931--P:response to ischemia
GO:0019233--P:sensory perception of pain
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

rno:29545

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001376	Ailuropoda melanoleuca	81.71	1.00e-114	405.00
IUUC-Apl-003693	Anas platyrhynchos	70.09	3.00e-91	327.00
IUUC-Aca-004716	Anolis carolinensis	75.00	7.00e-101	359.00
IUUC-Ame-011806	Astyanax mexicanus	67.26	2.00e-85	308.00
IUUC-Bta-013521	Bos taurus	81.75	3.00e-115	407.00
IUUC-Cja-018752	Callithrix jacchus	95.09	8.00e-117	412.00
IUUC-Cfa-020442	Canis familiaris	96.88	3.00e-118	417.00
IUUC-Cpo-021723	Cavia porcellus	97.59	4.00e-95	339.00
IUUC-Csa-023626	Chlorocebus sabaeus	95.52	1.00e-117	415.00
IUUC-Cho-024548	Choloepus hoffmanni	85.19	6.00e-41	160.00
IUUC-Dre-027854	Danio rerio	65.18	4.00e-84	303.00
IUUC-Dno-029325	Dasypus novemcinctus	95.96	9.00e-119	419.00
IUUC-Dor-030114	Dipodomys ordii	95.52	1.00e-127	448.00
IUUC-Ete-033092	Echinops telfairi	77.58	5.00e-97	346.00
IUUC-Eca-033854	Equus caballus	97.89	2.00e-80	290.00
IUUC-Eeu-034493	Erinaceus europaeus	93.27	2.00e-114	404.00
IUUC-Fal-036693	Ficedula albicollis	73.81	7.00e-92	329.00
IUUC-Gmo-038848	Gadus morhua	62.26	1.00e-75	275.00
IUUC-Gga-041078	Gallus gallus	74.55	9.00e-101	358.00
IUUC-Gac-042064	Gasterosteus aculeatus	62.27	1.00e-78	285.00
IUUC-Ggo-044827	Gorilla gorilla	95.52	5.00e-118	416.00
IUUC-Hsa-045820	Homo sapiens	95.52	5.00e-118	416.00
IUUC-Itr-048496	Ictidomys tridecemlineatus	96.41	2.00e-118	418.00
IUUC-Lch-050121	Latimeria chalumnae	72.52	4.00e-97	347.00
IUUC-Loc-052342	Lepisosteus oculatus	70.35	5.00e-93	333.00
IUUC-Laf-053916	Loxodonta africana	94.22	1.00e-116	411.00
IUUC-Mcc-054838	Macaca mulatta	95.52	1.00e-117	415.00
IUUC-Meu-056478	Macropus eugenii	88.34	4.00e-120	423.00
IUUC-Mga-059878	Meleagris gallopavo	73.27	1.00e-94	338.00
IUUC-Mdo-062544	Monodelphis domestica	86.55	5.00e-109	386.00
IUUC-Mmu-063300	Mus musculus	100.00	2.00e-131	460.00
IUUC-Mpu-066128	Mustela putorius furo	96.50	5.00e-105	373.00
IUUC-Mlu-067778	Myotis lucifugus	94.62	3.00e-126	443.00
IUUC-Nle-069686	Nomascus leucogenys	95.52	8.00e-118	416.00
IUUC-Opr-070535	Ochotona princeps	78.92	4.00e-100	357.00
IUUC-Ont-071510	Oreochromis niloticus	62.61	5.00e-80	290.00
IUUC-Ocu-074590	Oryctolagus cuniculus	95.96	4.00e-119	420.00
IUUC-Oga-089013	Otolemur garnettii	82.14	2.00e-114	404.00
IUUC-Oar-089861	Ovis aries	81.75	4.00e-115	407.00
IUUC-Ptr-091536	Pan troglodytes	93.72	1.00e-115	408.00
IUUC-Pan-092909	Papio anubis	95.52	1.00e-117	415.00
IUUC-Psi-093818	Pelodiscus sinensis	78.12	3.00e-103	367.00
IUUC-Pfo-097335	Poecilia formosa	59.11	4.00e-78	283.00
IUUC-Pab-098048	Pongo abelii	95.52	5.00e-118	416.00
IUUC-Pca-100818	Procavia capensis	73.33	5.00e-68	249.00
IUUC-Pva-102954	Pteropus vampyrus	95.07	2.00e-113	401.00
IUUC-Pyt-104587	Pyrenophora triticirepentis	37.98	2.00e-31	129.00
IUUC-Sha-107111	Sarcophilus harrisii	87.27	3.00e-87	313.00
IUUC-Sar-113190	Sorex araneus	75.44	2.00e-38	150.00
IUUC-Ssc-115908	Sus scrofa	79.11	2.00e-100	357.00
IUUC-Tgu-117465	Taeniopygia guttata	69.19	3.00e-85	307.00
IUUC-Tru-118565	Takifugu rubripes	60.29	2.00e-69	254.00
IUUC-Tsy-119561	Tarsius syrichta	78.03	2.00e-97	347.00
IUUC-Tbe-128048	Tupaia belangeri	95.15	6.00e-93	332.00
IUUC-Ttr-128494	Tursiops truncatus	95.50	1.00e-115	408.00
IUUC-Vda-129850	Verticillium dahliae	34.20	1.00e-28	119.00
IUUC-Xtr-132286	Xenopus tropicalis	69.51	4.00e-92	330.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence