iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000038425.17	ENSMUST00000121674.8	ENSMUSP00000112563.2
ENSMUSG00000038425.17	ENSMUST00000159389.7	ENSMUSP00000123964.1
ENSMUSG00000038425.17	ENSMUST00000160713.1	ENSMUSP00000125467.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UBM	UBM	16357261; 18923427

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UBM	1.40e-25	89.2	701	728

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBM

   S: 1    lPsqvDpeVfsqLPeeiQeEvmaelrqq 28
           +P+++Dp+Vf++LPee+Q+E+mae++++
   Q: 701  FPPDIDPQVFYELPEEVQKELMAEWERA 728
           8*************************98 PP

Organism

Mus musculus

Functional Description
(View)

Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity (By similarity).

Protein Sequence
(Fasta)

MGVESEEEGG PAEEEDAPRA MEPLHAGAAG SSRAVCSQGP PTQISSSRVI VHVDLDCFYA 60
QVEMISNPEL KDRPLGVQQK YLVVTCNYEA RKLGVRKLMN VRDAKEKCPQ LVLVNGEDLS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACAAACCCCA GTTAATTCCA GTTAACTCCA GTTCCTGGGG ATCCAACGCT CTTTTCTGGC 60
TTTTGTGGGC GCTTGCATTC ACACAGCATA CACTCTCACA CACATGTTTA AAAAAAGAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0235--DNA replication
KW-0237--DNA synthesis
KW-0238--DNA-binding
KW-0239--DNA-directed DNA polymerase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0515--Mutator protein
KW-0548--Nucleotidyltransferase
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0704--Schiff base
KW-0808--Transferase

Interpro

IPR017961--DNA_pol_Y-fam_little_finger
IPR013981--PFK_a-hlx
IPR024728--PolY_HhH_motif
IPR001126--UmuC

PROSITE

PS50173--UMUC

Pfam

PF00817--IMS
PF11799--IMS_C
PF11798--IMS_HHH

Gene Ontology

GO:0005622--C:intracellular
GO:0016607--C:nuclear speck
GO:0000932--C:P-body
GO:0003684--F:damaged DNA binding
GO:0003887--F:DNA-directed DNA polymerase activity
GO:0046872--F:metal ion binding
GO:0071494--P:cellular response to UV-C
GO:0006260--P:DNA replication
GO:0019985--P:translesion synthesis

KEGG

mmu:26447

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002144	Ailuropoda melanoleuca	76.39	0.00e+00	1061.00
IUUC-Apl-003303	Anas platyrhynchos	58.57	1.00e-135	476.00
IUUC-Aca-004883	Anolis carolinensis	59.92	9.00e-163	566.00
IUUC-Acl-008010	Aspergillus clavatus	30.33	2.00e-45	177.00
IUUC-Afu-008874	Aspergillus fumigatus	30.82	8.00e-49	188.00
IUUC-Ani-009354	Aspergillus nidulans	32.98	1.00e-44	174.00
IUUC-Ang-009584	Aspergillus niger	30.39	2.00e-40	160.00
IUUC-Ate-010413	Aspergillus terreus	32.69	1.00e-47	184.00
IUUC-Bgr-012031	Blumeria graminis	29.56	3.00e-40	159.00
IUUC-Bta-012393	Bos taurus	72.75	0.00e+00	969.00
IUUC-Bci-013960	Botrytis cinerea	31.06	3.00e-47	182.00
IUUC-Cja-019032	Callithrix jacchus	74.90	0.00e+00	1040.00
IUUC-Cfa-020560	Canis familiaris	75.53	0.00e+00	1076.00
IUUC-Cpo-021756	Cavia porcellus	68.34	0.00e+00	807.00
IUUC-Cre-022555	Chlamydomonas reinhardtii	46.45	4.00e-35	140.00
IUUC-Csa-023102	Chlorocebus sabaeus	77.70	0.00e+00	1028.00
IUUC-Cho-024983	Choloepus hoffmanni	81.60	2.00e-97	349.00
IUUC-Cgl-026717	Colletotrichum gloeosporioides	32.10	4.00e-50	192.00
IUUC-Cme-027310	Cyanidioschyzon merolae	31.63	8.00e-39	155.00
IUUC-Dre-027407	Danio rerio	59.90	4.00e-130	458.00
IUUC-Dno-029723	Dasypus novemcinctus	69.20	0.00e+00	937.00
IUUC-Dor-030274	Dipodomys ordii	69.46	0.00e+00	937.00
IUUC-Dse-031261	Dothistroma septosporum	32.51	2.00e-41	163.00
IUUC-Dme-031707	Drosophila melanogaster	40.59	1.00e-81	297.00
IUUC-Ete-032374	Echinops telfairi	68.67	4.00e-113	402.00
IUUC-Eca-034334	Equus caballus	73.69	0.00e+00	1022.00
IUUC-Eeu-034857	Erinaceus europaeus	80.42	3.00e-171	594.00
IUUC-Fca-036361	Felis catus	67.63	0.00e+00	943.00
IUUC-Fox-037933	Fusarium oxysporum	29.59	2.00e-45	176.00
IUUC-Fso-038328	Fusarium solani	31.26	1.00e-42	168.00
IUUC-Gmo-039026	Gadus morhua	49.39	6.00e-100	357.00
IUUC-Ggr-039773	Gaeumannomyces graminis	28.66	4.00e-37	149.00
IUUC-Gac-041577	Gasterosteus aculeatus	56.40	7.00e-129	454.00
IUUC-Ggo-045651	Gorilla gorilla	76.84	0.00e+00	1076.00
IUUC-Hsa-045715	Homo sapiens	77.34	0.00e+00	1073.00
IUUC-Itr-048408	Ictidomys tridecemlineatus	76.45	0.00e+00	1088.00
IUUC-Lch-050019	Latimeria chalumnae	53.58	3.00e-159	555.00
IUUC-Loc-052755	Lepisosteus oculatus	50.57	6.00e-136	478.00
IUUC-Lma-053204	Leptosphaeria maculans	29.76	3.00e-47	183.00
IUUC-Laf-053413	Loxodonta africana	74.06	0.00e+00	1014.00
IUUC-Mcc-055581	Macaca mulatta	77.25	0.00e+00	1042.00
IUUC-Meu-056476	Macropus eugenii	80.00	4.00e-70	258.00
IUUC-Mor-057059	Magnaporthe oryzae	34.24	1.00e-32	134.00
IUUC-Mpo-057505	Magnaporthe poae	31.78	2.00e-40	160.00
IUUC-Mmr-060808	Microcebus murinus	75.17	0.00e+00	1039.00
IUUC-Mdo-062650	Monodelphis domestica	72.28	0.00e+00	1008.00
IUUC-Mpu-065972	Mustela putorius furo	66.37	1.00e-119	422.00
IUUC-Mlu-067868	Myotis lucifugus	73.14	0.00e+00	1020.00
IUUC-Nfi-068273	Neosartorya fischeri	27.70	4.00e-38	152.00
IUUC-Nle-068968	Nomascus leucogenys	76.98	0.00e+00	1076.00
IUUC-Opr-070343	Ochotona princeps	64.98	0.00e+00	786.00
IUUC-Ont-071538	Oreochromis niloticus	51.30	3.00e-137	482.00
IUUC-Oan-073027	Ornithorhynchus anatinus	64.44	0.00e+00	899.00
IUUC-Ocu-074858	Oryctolagus cuniculus	75.61	0.00e+00	1055.00
IUUC-Ola-086502	Oryzias latipes	48.79	2.00e-137	483.00
IUUC-Oga-088433	Otolemur garnettii	73.13	0.00e+00	990.00
IUUC-Oar-090109	Ovis aries	76.22	0.00e+00	1034.00
IUUC-Ptr-091289	Pan troglodytes	77.20	0.00e+00	1071.00
IUUC-Pan-092101	Papio anubis	76.94	0.00e+00	1081.00
IUUC-Psi-093115	Pelodiscus sinensis	55.66	0.00e+00	686.00
IUUC-Pno-094836	Phaeosphaeria nodorum	28.61	1.00e-30	128.00
IUUC-Pfo-096290	Poecilia formosa	50.59	9.00e-136	477.00
IUUC-Pab-098022	Pongo abelii	82.85	1.00e-179	623.00
IUUC-Pca-100696	Procavia capensis	63.38	0.00e+00	838.00
IUUC-Pva-102750	Pteropus vampyrus	84.34	0.00e+00	635.00
IUUC-Pte-104179	Pyrenophora teres	33.64	2.00e-39	157.00
IUUC-Rno-105560	Rattus norvegicus	86.99	0.00e+00	1269.00
IUUC-Sha-107266	Sarcophilus harrisii	64.59	1.00e-141	496.00
IUUC-Smo-109490	Selaginella moellendorffii	39.06	2.00e-53	202.00
IUUC-Sar-113566	Sorex araneus	59.48	0.00e+00	717.00
IUUC-Sre-114907	Sporisorium reilianum	35.29	2.00e-36	147.00
IUUC-Ssc-116055	Sus scrofa	64.50	0.00e+00	840.00
IUUC-Tru-118294	Takifugu rubripes	48.46	1.00e-133	470.00
IUUC-Tsy-119086	Tarsius syrichta	76.10	0.00e+00	1054.00
IUUC-Tni-120067	Tetraodon nigroviridis	48.49	1.00e-131	463.00
IUUC-Tre-122247	Trichoderma reesei	28.79	6.00e-40	158.00
IUUC-Tvi-122417	Trichoderma virens	30.79	1.00e-46	181.00
IUUC-Tbe-127278	Tupaia belangeri	72.55	0.00e+00	979.00
IUUC-Ttr-129147	Tursiops truncatus	72.45	0.00e+00	808.00
IUUC-Uma-129397	Ustilago maydis	37.50	2.00e-37	150.00
IUUC-Vda-129773	Verticillium dahliae	32.39	4.00e-41	162.00
IUUC-Vpa-130771	Vicugna pacos	71.57	0.00e+00	981.00
IUUC-Xtr-132975	Xenopus tropicalis	47.54	2.00e-164	573.00
IUUC-Xma-133429	Xiphophorus maculatus	49.81	1.00e-135	477.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence