iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000162643.12	ENST00000370596.5	ENSP00000359628.1
ENSG00000162643.12	ENST00000294664.10	ENSP00000294664.6
ENSG00000162643.12	ENST00000528899.5	ENSP00000435102.1
ENSG00000162643.12	ENST00000464801.1	ENSP00000433294.1
ENSG00000162643.12	ENST00000484007.1	ENSP00000435544.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circRNADb	CircNet
microRNA	TRANSFAC	RepTar	miRNAMap
SomamiR	miRcode	RAID2
Protein-protein Interaction
iRefIndex	PINA	Mentha
Disease-associated Variation
GWASdb	GWAS Central
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	6.40e-10	40.6	477	529

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sdtl..................lvsGsdDgtikvWDlrtgv 34
           gH+  +t++++ sdt+                  lv++s D+ti  WD+r ++
   Q: 477  GHKKVITDIHWlSDTFeinrmgsvfenrsgiccqLVTCSADCTICFWDIRPQK 529
           8999********5544555566666666666667**************98766 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MAPKQKKKTS RGKKRLKPVL AASEDMEPVN MESMGHPEIY PLVLTTKTQE IFNCRIDEDV 60
TDEQPYKLIN KEDIFEDLRN RAAVSDFHPV KKIVQEYPGN ELLLVYDKDF KYGLNFYLIA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGGAGCCCGG GGTTTGGGGA CCCCTGCAGA CGGAGAAATA GTTTCAAAAG GGAGATCTGA 60
GGATCTCAAA CATTAATGTG CATATGAGTC ACCAGAGTTT TTATTGAAGC AGACTGATTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1

SMART

SM00320--WD40

KEGG

hsa:126820

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001318	Ailuropoda melanoleuca	84.40	0.00e+00	1456.00
IUUC-Apl-003772	Anas platyrhynchos	54.99	0.00e+00	879.00
IUUC-Aca-004627	Anolis carolinensis	59.66	0.00e+00	1045.00
IUUC-Ame-011396	Astyanax mexicanus	43.36	0.00e+00	671.00
IUUC-Bta-012977	Bos taurus	87.31	0.00e+00	1481.00
IUUC-Cja-018966	Callithrix jacchus	94.16	0.00e+00	1625.00
IUUC-Cfa-021086	Canis familiaris	85.17	0.00e+00	1513.00
IUUC-Cpo-021919	Cavia porcellus	83.64	0.00e+00	1444.00
IUUC-Cre-022793	Chlamydomonas reinhardtii	31.57	2.00e-54	207.00
IUUC-Csa-023175	Chlorocebus sabaeus	96.22	0.00e+00	1623.00
IUUC-Cin-025511	Ciona intestinalis	44.41	0.00e+00	776.00
IUUC-Csv-026346	Ciona savignyi	48.55	0.00e+00	798.00
IUUC-Dre-027474	Danio rerio	41.35	0.00e+00	727.00
IUUC-Dme-031619	Drosophila melanogaster	24.06	4.00e-43	170.00
IUUC-Ete-032560	Echinops telfairi	80.11	0.00e+00	851.00
IUUC-Eca-033342	Equus caballus	87.51	0.00e+00	1481.00
IUUC-Eeu-035108	Erinaceus europaeus	80.52	0.00e+00	1310.00
IUUC-Fca-036352	Felis catus	84.95	0.00e+00	1500.00
IUUC-Fal-037291	Ficedula albicollis	49.30	0.00e+00	779.00
IUUC-Gga-040503	Gallus gallus	52.51	0.00e+00	839.00
IUUC-Gac-041827	Gasterosteus aculeatus	40.72	3.00e-168	585.00
IUUC-Ggo-044831	Gorilla gorilla	99.43	0.00e+00	1675.00
IUUC-Lch-050243	Latimeria chalumnae	55.76	0.00e+00	970.00
IUUC-Loc-052614	Lepisosteus oculatus	56.22	0.00e+00	983.00
IUUC-Laf-053513	Loxodonta africana	85.73	0.00e+00	1311.00
IUUC-Mcc-055678	Macaca mulatta	96.11	0.00e+00	1620.00
IUUC-Meu-056375	Macropus eugenii	75.68	7.00e-179	621.00
IUUC-Mga-060015	Meleagris gallopavo	53.23	0.00e+00	816.00
IUUC-Mmr-060598	Microcebus murinus	84.16	0.00e+00	1436.00
IUUC-Mdo-062125	Monodelphis domestica	68.40	0.00e+00	1161.00
IUUC-Mmu-063162	Mus musculus	80.02	0.00e+00	1421.00
IUUC-Mpu-066891	Mustela putorius furo	87.16	0.00e+00	1504.00
IUUC-Mlu-068017	Myotis lucifugus	81.59	0.00e+00	1462.00
IUUC-Nle-069396	Nomascus leucogenys	95.60	0.00e+00	1624.00
IUUC-Opr-070226	Ochotona princeps	84.89	0.00e+00	1013.00
IUUC-Ont-072684	Oreochromis niloticus	42.12	0.00e+00	662.00
IUUC-Oan-073141	Ornithorhynchus anatinus	65.25	3.00e-176	611.00
IUUC-Ocu-074198	Oryctolagus cuniculus	87.74	0.00e+00	1541.00
IUUC-Ola-087453	Oryzias latipes	40.12	8.00e-164	571.00
IUUC-Oga-089138	Otolemur garnettii	80.96	0.00e+00	1432.00
IUUC-Oar-090322	Ovis aries	84.40	0.00e+00	1469.00
IUUC-Ptr-091250	Pan troglodytes	99.43	0.00e+00	1677.00
IUUC-Pan-092051	Papio anubis	96.89	0.00e+00	1553.00
IUUC-Psi-093273	Pelodiscus sinensis	62.21	0.00e+00	1068.00
IUUC-Ppa-095837	Physcomitrella patens	30.76	3.00e-72	266.00
IUUC-Pfo-096244	Poecilia formosa	40.00	2.00e-168	586.00
IUUC-Pab-098623	Pongo abelii	98.63	0.00e+00	1664.00
IUUC-Pca-100831	Procavia capensis	73.12	0.00e+00	1042.00
IUUC-Rno-105015	Rattus norvegicus	79.61	0.00e+00	1381.00
IUUC-Sha-107109	Sarcophilus harrisii	67.45	0.00e+00	937.00
IUUC-Smo-109594	Selaginella moellendorffii	26.41	8.00e-37	148.00
IUUC-Sar-113575	Sorex araneus	68.99	0.00e+00	1136.00
IUUC-Ssc-115610	Sus scrofa	83.74	0.00e+00	1479.00
IUUC-Tgu-116483	Taeniopygia guttata	50.13	0.00e+00	745.00
IUUC-Tru-117765	Takifugu rubripes	38.79	7.00e-173	601.00
IUUC-Tsy-118826	Tarsius syrichta	85.35	0.00e+00	1500.00
IUUC-Ttr-129263	Tursiops truncatus	77.27	0.00e+00	1300.00
IUUC-Vpa-130416	Vicugna pacos	80.59	0.00e+00	854.00
IUUC-Xtr-131930	Xenopus tropicalis	57.89	0.00e+00	994.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence