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Basic Information Integrated Annotations

Tag Content
iUUCD ID IUUC-Hsa-046924
UUCD1 version UUC-HoS-01106
Ensembl Protein ID ENSP00000362179.5
UniProt Accession Q5D1E8; D3DPT0; Q6I9Z1; Q9H5P1; ZC12A_HUMAN
Genbank Protein ID AAX14017.1; BAB15581.1; CAG33645.1; CAI20551.1; CAI20551.1; CAH73689.1; CAH73689.1; EAX07346.1; EAX07347.1; AAH05001.1
Protein Name Endoribonuclease ZC3H12A; Monocyte chemotactic protein-induced protein 1; Regnase-1; Zinc finger CCCH domain-containing protein 12A
Genbank Nucleotide ID AY920403; AK026884; CR457364; AL034379; AL449284; AL449284; AL034379; CH471059; CH471059; BC005001
Gene Name ZC3H12A; MCPIP; MCPIP1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000163874.9 ENST00000373087.6 ENSP00000362179.5
ENSG00000163874.9 ENST00000471012.1 ENSP00000473447.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBaseCircNetTRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2LncRNADisease
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWAS CentralOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtPHOSIDA
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
DUB/Other DUB/Other 21115689
UBD/Other/Other UBD/Other/Other 22771441
Organism Homo sapiens
Functional Description
(View)

Functional Description



     (Microbial infection) Exhibits broad antiviral activity by cleaving viral RNAs (PubMed:23355615). Binds to Japanese encephalitis virus (JEV) and dengue virus (DEN) RNAs (PubMed:23355615). Exhibits antiviral activity against HIV-1 in lymphocytes by decreasing the abundance of HIV-1 viral RNA species (PubMed:24191027).
(Microbial infection) Exhibits broad antiviral activity by cleaving viral RNAs (PubMed:23355615). Binds to Japanese encephalitis virus (JEV) and dengue virus (DEN) RNAs (PubMed:23355615). Exhibits antiviral activity against HIV-1 in lymphocytes by decreasing the abundance of HIV-1 viral RNA species (PubMed:24191027).
Protein Sequence
(Fasta)
MSGPCGEKPV LEASPTMSLW EFEDSHSRQG TPRPGQELAA EEASALELQM KVDFFRKLGY 60
SSTEIHSVLQ KLGVQADTNT VLGELVKHGT ATERERQTSP DPCPQLPLVP RGGGTPKAPN 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Hsa-046924|DUB,DUB/Other;UBD,UBD/Other/Other|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATATAAAGGC GCCGCCGTCC TTACCCCCAG GACTCGGCCC CATGGAGACG CCGCCGGCCG 60
CCGCTGGCGC ATGGCGGGGT GAGGCGCGGC GGGGAGGGTG CGGGCCTCGG CGGGGAAGCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Hsa-046924|DUB,DUB/Other;UBD,UBD/Other/Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0037--Angiogenesis
KW-0051--Antiviral defense
KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0227--DNA damage
KW-0238--DNA-binding
KW-0255--Endonuclease
KW-0256--Endoplasmic reticulum
KW-0378--Hydrolase
KW-0391--Immunity
KW-0395--Inflammatory response
KW-0460--Magnesium
KW-0472--Membrane
KW-0479--Metal-binding
KW-0524--Neurogenesis
KW-0540--Nuclease
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0678--Repressor
KW-0694--RNA-binding
KW-0346--Stress response
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR021869--RNase_Zc3h12_NYN

Pfam

PF11977--RNase_Zc3h12a

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005856--C:cytoskeleton
GO:0042406--C:extrinsic component of endoplasmic reticulum membrane
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0000932--C:P-body
GO:0043234--C:protein complex
GO:0005791--C:rough endoplasmic reticulum
GO:0030867--C:rough endoplasmic reticulum membrane
GO:0003682--F:chromatin binding
GO:0003677--F:DNA binding
GO:0004521--F:endoribonuclease activity
GO:0004532--F:exoribonuclease activity
GO:0046872--F:metal ion binding
GO:0035198--F:miRNA binding
GO:0035925--F:mRNA 3'-UTR AU-rich region binding
GO:0003730--F:mRNA 3'-UTR binding
GO:0003729--F:mRNA binding
GO:0004540--F:ribonuclease activity
GO:0043022--F:ribosome binding
GO:0003723--F:RNA binding
GO:0035613--F:RNA stem-loop binding
GO:0061158--P:3'-UTR-mediated mRNA destabilization
GO:0001525--P:angiogenesis
GO:0006915--P:apoptotic process
GO:0030154--P:cell differentiation
GO:1990869--P:cellular response to chemokine
GO:0006974--P:cellular response to DNA damage stimulus
GO:0042149--P:cellular response to glucose starvation
GO:0071347--P:cellular response to interleukin-1
GO:1904637--P:cellular response to ionomycin
GO:0071222--P:cellular response to lipopolysaccharide
GO:0034599--P:cellular response to oxidative stress
GO:1904628--P:cellular response to phorbol 13-acetate 12-myristate
GO:1903936--P:cellular response to sodium arsenite
GO:0071356--P:cellular response to tumor necrosis factor
GO:0098586--P:cellular response to virus
GO:0051607--P:defense response to virus
GO:0006954--P:inflammatory response
GO:0044828--P:negative regulation by host of viral genome replication
GO:0055118--P:negative regulation of cardiac muscle contraction
GO:1900016--P:negative regulation of cytokine production involved in inflammatory response
GO:0010629--P:negative regulation of gene expression
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:1902714--P:negative regulation of interferon-gamma secretion
GO:0050713--P:negative regulation of interleukin-1 beta secretion
GO:0032715--P:negative regulation of interleukin-6 production
GO:1900165--P:negative regulation of interleukin-6 secretion
GO:0043031--P:negative regulation of macrophage activation
GO:0010656--P:negative regulation of muscle cell apoptotic process
GO:0042347--P:negative regulation of NF-kappaB import into nucleus
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0045019--P:negative regulation of nitric oxide biosynthetic process
GO:1903799--P:negative regulation of production of miRNAs involved in gene silencing by miRNA
GO:0001933--P:negative regulation of protein phosphorylation
GO:0032720--P:negative regulation of tumor necrosis factor production
GO:1904468--P:negative regulation of tumor necrosis factor secretion
GO:0007399--P:nervous system development
GO:0000294--P:nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay
GO:0045766--P:positive regulation of angiogenesis
GO:0010508--P:positive regulation of autophagy
GO:0010942--P:positive regulation of cell death
GO:0002230--P:positive regulation of defense response to virus by host
GO:0010595--P:positive regulation of endothelial cell migration
GO:1900119--P:positive regulation of execution phase of apoptosis
GO:0045600--P:positive regulation of fat cell differentiation
GO:0010628--P:positive regulation of gene expression
GO:0010884--P:positive regulation of lipid storage
GO:2000627--P:positive regulation of miRNA catabolic process
GO:0061014--P:positive regulation of mRNA catabolic process
GO:1900745--P:positive regulation of p38MAPK cascade
GO:1903003--P:positive regulation of protein deubiquitination
GO:0042307--P:positive regulation of protein import into nucleus
GO:2000379--P:positive regulation of reactive oxygen species metabolic process
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0016579--P:protein deubiquitination
GO:0051259--P:protein oligomerization
GO:0010468--P:regulation of gene expression
GO:0090501--P:RNA phosphodiester bond hydrolysis
GO:0090502--P:RNA phosphodiester bond hydrolysis, endonucleolytic
GO:0006351--P:transcription, DNA-templated

KEGG hsa:80149
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002223 Ailuropoda melanoleuca 86.36 0.00e+00 823.00
IUUC-Apl-003631 Anas platyrhynchos 66.51 4.00e-150 524.00
IUUC-Aca-005301 Anolis carolinensis 55.59 7.00e-149 520.00
IUUC-Aly-005403 Arabidopsis lyrata 31.82 1.20e-01 32.30
IUUC-Ate-010342 Aspergillus terreus 31.25 2.40e-01 29.60
IUUC-Ame-010867 Astyanax mexicanus 69.48 1.00e-121 430.00
IUUC-Bta-012505 Bos taurus 86.79 0.00e+00 873.00
IUUC-Bol-016598 Brassica oleracea 30.99 1.40e-01 32.00
IUUC-Bra-016919 Brassica rapa 30.99 1.40e-01 32.30
IUUC-Cja-019490 Callithrix jacchus 92.32 0.00e+00 911.00
IUUC-Cfa-021149 Canis familiaris 80.68 0.00e+00 785.00
IUUC-Cpo-021301 Cavia porcellus 86.41 0.00e+00 831.00
IUUC-Csa-023367 Chlorocebus sabaeus 96.34 0.00e+00 961.00
IUUC-Cin-025756 Ciona intestinalis 65.33 6.00e-17 80.50
IUUC-Dre-027579 Danio rerio 68.40 1.00e-120 426.00
IUUC-Dno-030064 Dasypus novemcinctus 84.62 0.00e+00 791.00
IUUC-Dor-031093 Dipodomys ordii 75.93 0.00e+00 737.00
IUUC-Ete-032302 Echinops telfairi 72.06 1.00e-173 602.00
IUUC-Eca-033237 Equus caballus 88.34 0.00e+00 899.00
IUUC-Eeu-035130 Erinaceus europaeus 81.77 0.00e+00 687.00
IUUC-Fca-035416 Felis catus 87.14 0.00e+00 815.00
IUUC-Fal-037281 Ficedula albicollis 56.05 4.00e-166 578.00
IUUC-Fso-038424 Fusarium solani 29.79 2.50e-02 32.70
IUUC-Gmo-039204 Gadus morhua 64.78 4.00e-107 382.00
IUUC-Gac-041980 Gasterosteus aculeatus 55.08 1.00e-117 417.00
IUUC-Ggo-044933 Gorilla gorilla 99.33 0.00e+00 1002.00
IUUC-Itr-048614 Ictidomys tridecemlineatus 86.48 0.00e+00 856.00
IUUC-Lch-050063 Latimeria chalumnae 54.96 4.00e-166 578.00
IUUC-Loc-051993 Lepisosteus oculatus 52.07 7.00e-147 514.00
IUUC-Laf-053400 Loxodonta africana 87.25 0.00e+00 865.00
IUUC-Mcc-054768 Macaca mulatta 97.00 0.00e+00 959.00
IUUC-Meu-056059 Macropus eugenii 56.01 5.00e-128 451.00
IUUC-Mga-059707 Meleagris gallopavo 59.22 6.00e-171 594.00
IUUC-Mvi-060339 Microbotryum violaceum 38.30 7.80e-02 30.00
IUUC-Mmr-061391 Microcebus murinus 88.65 0.00e+00 882.00
IUUC-Mdo-062040 Monodelphis domestica 63.54 0.00e+00 658.00
IUUC-Mmu-064420 Mus musculus 82.14 0.00e+00 815.00
IUUC-Mpu-066099 Mustela putorius furo 85.25 0.00e+00 809.00
IUUC-Mlu-067979 Myotis lucifugus 84.76 0.00e+00 861.00
IUUC-Nle-069830 Nomascus leucogenys 94.49 0.00e+00 927.00
IUUC-Opr-071005 Ochotona princeps 84.48 0.00e+00 629.00
IUUC-Ont-072306 Oreochromis niloticus 47.03 3.00e-128 452.00
IUUC-Oan-073138 Ornithorhynchus anatinus 64.50 5.00e-169 587.00
IUUC-Ocu-073908 Oryctolagus cuniculus 88.68 0.00e+00 637.00
IUUC-Ola-087280 Oryzias latipes 45.61 5.00e-122 431.00
IUUC-Oga-088418 Otolemur garnettii 88.31 0.00e+00 882.00
IUUC-Oar-090414 Ovis aries 86.01 0.00e+00 679.00
IUUC-Ptr-091275 Pan troglodytes 99.33 0.00e+00 1006.00
IUUC-Pan-092541 Papio anubis 97.17 0.00e+00 939.00
IUUC-Psi-094002 Pelodiscus sinensis 60.14 2.00e-177 615.00
IUUC-Pab-098538 Pongo abelii 98.16 0.00e+00 964.00
IUUC-Pca-100137 Procavia capensis 84.27 0.00e+00 688.00
IUUC-Pva-102367 Pteropus vampyrus 86.03 0.00e+00 701.00
IUUC-Rno-105133 Rattus norvegicus 82.47 0.00e+00 872.00
IUUC-Sha-106603 Sarcophilus harrisii 66.05 9.00e-156 543.00
IUUC-Tgu-117358 Taeniopygia guttata 60.30 8.00e-148 516.00
IUUC-Tru-118112 Takifugu rubripes 48.36 4.00e-122 431.00
IUUC-Tsy-119005 Tarsius syrichta 78.43 1.00e-153 535.00
IUUC-Ttr-129314 Tursiops truncatus 87.65 0.00e+00 912.00
Created Date 25-Jun-2017

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