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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Rno-106005
UUCD1 version UUC-RaN-00520
Ensembl Protein ID ENSRNOP00000037772.3
UniProt Accession Q62623; O70380; Q5U360; CDC20_RAT
Genbank Protein ID AAA19018.1; AAC14741.1; AAH85691.1
Protein Name Cell division cycle protein 20 homolog; p55CDC
Genbank Nucleotide ID U05341; AF052695; BC085691
Gene Name Cdc20
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000028415.4 ENSRNOT00000036151.4 ENSRNOP00000037772.3
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTM
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 2.00e-29 100.8 307 336
E3 adaptor/Cullin RING/APC_C/CDC20 4.20e-147 489.7 172 477
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvW 28
           gH+ +v++l++ +d ++l+sG++D+ + vW
   Q: 307  GHSQEVCGLRWaPDgRHLASGGNDNIVNVW 336
           8***********999*************** PP
   

   E3 adaptor/Cullin RING/APC_C/CDC20
   S: 1    pekvldapelrddfylnLldWssknvlavaLgssvylwsaktgdvskladl.eekdlvtsvswieegtllavGtkkgeveiyDveekkk 88
           p+++ldape+r+d+ylnL+dWss nvlavaL++svylw+a +gd+ +l ++ +++d+++sv+wi+eg++lavGt+++ev+++Dv+++k+
   Q: 172  PDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWNAGSGDILQLLQMeQPGDYISSVAWIKEGNYLAVGTSNAEVQLWDVQQQKR 260
           689************************************************899*********************************** PP
   S: 89   vrtltghsarvgaLsWnaevlssGsrdgeilhrdvrvkelklstlqahaqevCGlkwnedaklLasGGnDnsvsvwdassse....Plk 173
           +r++t+hsarv++LsWn+++lssGsr+g+i+h+dvrv+e++++tl++h+qevCGl+w+ d+++LasGGnDn v+vw +   e    Pl+
   Q: 261  LRNMTSHSARVSSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNIVNVWPSGPGEsgwvPLQ 349
           ******************************************************************************9998899**** PP
   S: 174  kfkehkaavkaiawsPwqkslLasGGGtaDrcikfwntltgalleeidtgsqvcsllwskkskelvsthGfaenkitlwkypslskvae 262
           +f++h++avka+aw+Pwq+++La+GGGt+Dr+i++wn+++ga+l+++d++sqvcs+lws+++kel+s+hGfa+n++++wkyp+++kvae
   Q: 350  TFTQHQGAVKAVAWCPWQSNILATGGGTSDRHIRIWNVCSGACLSAVDVHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAE 438
           ***************************************************************************************** PP
   S: 263  lkgheaRvlslalspdgeaivtaagDetlrfwklfdkkk 301
           lkgh+aRvlsl++spdg+++++aa+Detlr+w++f+ ++
   Q: 439  LKGHTARVLSLTMSPDGATVASAAADETLRLWRCFELDP 477
           ***********************************9876 PP
   
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation (By similarity). Interacts with NEK2 (By similarity).
 Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation (By similarity). Interacts with NEK2 (By similarity).
Protein Sequence
(Fasta)
MAQFVFESDL HSLLQLDAPI PNAPIARWQR KAKEATGPAP SPMRAANRSH SAGRTPGRTP 60
GKSNSKVQTT PSKPGGDRYI PQRSASQMEV ASFLLSKENQ PEDGGTPTKK EHQKAWARNL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-106005|E3,WD_repeat;E3,CDC20|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AATCGACAAA GGCGACGGTT AAGACAGTTG GGTTTTGAAG GAGCCAATGA ACACTAGCAG 60
CGGAGAGTTT AAGAATAACT GTTCGGCGTG CCTTTAGCCG GTCAGAAAAG AACGCATTCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-106005|E3,WD_repeat;E3,CDC20|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-1017--Isopeptide bond
KW-0498--Mitosis
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
Interpro

IPR024977--Apc4_WD40_dom
IPR033187--CDC20
IPR033010--Cdc20/Fizzy
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF12894--ANAPC4_WD40
PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0005680--C:anaphase-promoting complex
GO:0005813--C:centrosome
GO:0048471--C:perinuclear region of cytoplasm
GO:0043234--C:protein complex
GO:0000922--C:spindle pole
GO:0042826--F:histone deacetylase binding
GO:0097027--F:ubiquitin-protein transferase activator activity
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0051301--P:cell division
GO:0007064--P:mitotic sister chromatid cohesion
GO:0090307--P:mitotic spindle assembly
GO:0008284--P:positive regulation of cell proliferation
GO:0090129--P:positive regulation of synapse maturation
GO:0031915--P:positive regulation of synaptic plasticity
GO:1904668--P:positive regulation of ubiquitin protein ligase activity
GO:0016567--P:protein ubiquitination
GO:0050773--P:regulation of dendrite development
GO:0040020--P:regulation of meiotic nuclear division
KEGG rno:64515
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000638 Aegilops tauschii 44.51 4.00e-109 388.00
IUUC-Aml-001545 Ailuropoda melanoleuca 95.19 0.00e+00 930.00
IUUC-Atr-003103 Amborella trichopoda 46.68 9.00e-109 387.00
IUUC-Apl-003255 Anas platyrhynchos 80.23 0.00e+00 750.00
IUUC-Aca-004920 Anolis carolinensis 76.23 0.00e+00 771.00
IUUC-Aly-006012 Arabidopsis lyrata 47.99 2.00e-109 389.00
IUUC-Ath-006795 Arabidopsis thaliana 44.10 4.00e-108 384.00
IUUC-Ate-010479 Aspergillus terreus 48.41 8.00e-91 328.00
IUUC-Ame-010850 Astyanax mexicanus 60.00 3.00e-90 324.00
IUUC-Bgr-012059 Blumeria graminis 48.89 2.00e-94 339.00
IUUC-Bta-012625 Bos taurus 94.39 0.00e+00 924.00
IUUC-Bci-013607 Botrytis cinerea 46.78 7.00e-97 347.00
IUUC-Bdi-014344 Brachypodium distachyon 46.51 3.00e-108 385.00
IUUC-Bol-015368 Brassica oleracea 45.63 8.00e-107 382.00
IUUC-Bra-016738 Brassica rapa 46.36 2.00e-106 380.00
IUUC-Cja-019132 Callithrix jacchus 94.19 0.00e+00 929.00
IUUC-Cfa-020780 Canis familiaris 94.59 0.00e+00 924.00
IUUC-Cpo-022223 Cavia porcellus 95.79 0.00e+00 889.00
IUUC-Cre-022701 Chlamydomonas reinhardtii 50.70 4.00e-119 421.00
IUUC-Csa-023666 Chlorocebus sabaeus 94.79 0.00e+00 928.00
IUUC-Cho-024920 Choloepus hoffmanni 92.91 5.00e-154 537.00
IUUC-Cin-025675 Ciona intestinalis 50.80 5.00e-136 477.00
IUUC-Csv-026019 Ciona savignyi 50.85 3.00e-132 465.00
IUUC-Cgl-026465 Colletotrichum gloeosporioides 40.35 2.00e-95 343.00
IUUC-Cme-027234 Cyanidioschyzon merolae 51.91 8.00e-106 377.00
IUUC-Dre-028026 Danio rerio 60.36 0.00e+00 632.00
IUUC-Dno-028865 Dasypus novemcinctus 93.20 0.00e+00 908.00
IUUC-Dor-030958 Dipodomys ordii 95.59 0.00e+00 934.00
IUUC-Dse-031391 Dothistroma septosporum 48.28 2.00e-95 343.00
IUUC-Dme-031905 Drosophila melanogaster 48.88 1.00e-142 499.00
IUUC-Ete-032387 Echinops telfairi 88.38 0.00e+00 873.00
IUUC-Eca-033522 Equus caballus 85.97 0.00e+00 837.00
IUUC-Eeu-035059 Erinaceus europaeus 83.40 0.00e+00 781.00
IUUC-Fca-036346 Felis catus 94.78 0.00e+00 841.00
IUUC-Fal-037558 Ficedula albicollis 79.17 0.00e+00 785.00
IUUC-Fox-037850 Fusarium oxysporum 48.09 3.00e-96 345.00
IUUC-Fso-038375 Fusarium solani 48.39 1.00e-96 347.00
IUUC-Gmo-039284 Gadus morhua 63.17 0.00e+00 630.00
IUUC-Ggr-039864 Gaeumannomyces graminis 48.26 1.00e-98 353.00
IUUC-Gga-040790 Gallus gallus 79.13 0.00e+00 810.00
IUUC-Gac-041431 Gasterosteus aculeatus 62.62 3.00e-180 624.00
IUUC-Gma-043489 Glycine max 46.25 4.00e-107 381.00
IUUC-Ggo-045052 Gorilla gorilla 94.99 0.00e+00 928.00
IUUC-Hsa-046305 Homo sapiens 94.99 0.00e+00 928.00
IUUC-Hvu-047476 Hordeum vulgare 44.67 8.00e-109 387.00
IUUC-Itr-048461 Ictidomys tridecemlineatus 96.39 0.00e+00 897.00
IUUC-Lch-050174 Latimeria chalumnae 60.62 5.00e-172 597.00
IUUC-Lpe-050954 Leersia perrieri 46.97 9.00e-100 357.00
IUUC-Loc-052638 Lepisosteus oculatus 62.72 1.00e-180 626.00
IUUC-Lma-052998 Leptosphaeria maculans 42.89 5.00e-99 355.00
IUUC-Laf-053742 Loxodonta africana 93.99 0.00e+00 918.00
IUUC-Mcc-054948 Macaca mulatta 94.79 0.00e+00 928.00
IUUC-Meu-056013 Macropus eugenii 84.81 4.00e-139 488.00
IUUC-Mor-057277 Magnaporthe oryzae 51.82 4.00e-96 345.00
IUUC-Mpo-057624 Magnaporthe poae 51.14 8.00e-97 347.00
IUUC-Mtr-057725 Medicago truncatula 45.80 2.00e-100 359.00
IUUC-Mga-060102 Meleagris gallopavo 79.37 0.00e+00 811.00
IUUC-Mmr-061615 Microcebus murinus 93.89 0.00e+00 922.00
IUUC-Mdo-061982 Monodelphis domestica 86.85 0.00e+00 758.00
IUUC-Mmu-063864 Mus musculus 97.60 0.00e+00 959.00
IUUC-Mac-064861 Musa acuminata 47.10 2.00e-109 389.00
IUUC-Mpu-066502 Mustela putorius furo 94.99 0.00e+00 919.00
IUUC-Mlu-067277 Myotis lucifugus 87.23 0.00e+00 857.00
IUUC-Ncr-068951 Neurospora crassa 45.07 5.00e-94 338.00
IUUC-Nle-070149 Nomascus leucogenys 94.59 0.00e+00 922.00
IUUC-Opr-070778 Ochotona princeps 93.59 0.00e+00 674.00
IUUC-Ont-071660 Oreochromis niloticus 61.16 3.00e-177 614.00
IUUC-Oan-073677 Ornithorhynchus anatinus 75.50 0.00e+00 692.00
IUUC-Ocu-073797 Oryctolagus cuniculus 95.57 0.00e+00 928.00
IUUC-Oba-075946 Oryza barthii 47.10 1.00e-106 379.00
IUUC-Obr-076018 Oryza brachyantha 45.62 4.00e-107 381.00
IUUC-Ogl-077254 Oryza glaberrima 46.97 7.00e-100 357.00
IUUC-Ogu-078521 Oryza glumaepatula 47.32 7.00e-107 381.00
IUUC-Oin-080094 Oryza indica 46.97 7.00e-100 357.00
IUUC-Olo-080449 Oryza longistaminata 47.19 6.00e-100 357.00
IUUC-Ome-081186 Oryza meridionalis 47.07 7.00e-107 382.00
IUUC-Oni-082243 Oryza nivara 46.97 7.00e-100 357.00
IUUC-Opu-084007 Oryza punctata 46.97 1.00e-99 356.00
IUUC-Oru-084562 Oryza rufipogon 47.32 2.00e-106 380.00
IUUC-Osa-086094 Oryza sativa 46.97 8.00e-100 357.00
IUUC-Ola-086907 Oryzias latipes 60.87 5.00e-165 574.00
IUUC-Olu-087647 Ostreococcus lucimarinus 48.96 9.00e-118 416.00
IUUC-Oga-088184 Otolemur garnettii 93.60 0.00e+00 914.00
IUUC-Oar-090023 Ovis aries 88.91 0.00e+00 816.00
IUUC-Ptr-090935 Pan troglodytes 94.08 0.00e+00 865.00
IUUC-Pan-091845 Papio anubis 94.79 0.00e+00 928.00
IUUC-Psi-093188 Pelodiscus sinensis 80.16 0.00e+00 838.00
IUUC-Pma-094187 Petromyzon marinus 54.36 1.00e-148 520.00
IUUC-Pno-094809 Phaeosphaeria nodorum 41.36 5.00e-100 358.00
IUUC-Ppa-095457 Physcomitrella patens 48.58 2.00e-111 395.00
IUUC-Pfo-097429 Poecilia formosa 58.96 1.00e-161 562.00
IUUC-Pab-098603 Pongo abelii 94.79 0.00e+00 928.00
IUUC-Pop-099654 Populus trichocarpa 45.63 7.00e-103 367.00
IUUC-Pca-101062 Procavia capensis 92.99 0.00e+00 896.00
IUUC-Ppe-101865 Prunus persica 46.05 1.00e-96 346.00
IUUC-Pva-102925 Pteropus vampyrus 93.79 0.00e+00 944.00
IUUC-Pte-104142 Pyrenophora teres 42.16 6.00e-98 351.00
IUUC-Pyt-104693 Pyrenophora triticirepentis 42.16 7.00e-98 351.00
IUUC-Sha-107472 Sarcophilus harrisii 87.60 0.00e+00 871.00
IUUC-Sja-107919 Schizosaccharomyces japonicus 42.79 9.00e-95 340.00
IUUC-Spo-108075 Schizosaccharomyces pombe 51.72 3.00e-96 345.00
IUUC-Ssl-108507 Sclerotinia sclerotiorum 48.09 4.00e-96 345.00
IUUC-Smo-108922 Selaginella moellendorffii 48.60 6.00e-123 434.00
IUUC-Sit-110732 Setaria italica 45.81 7.00e-108 384.00
IUUC-Sly-111202 Solanum lycopersicum 43.48 1.00e-105 376.00
IUUC-Stu-112024 Solanum tuberosum 42.12 4.00e-106 378.00
IUUC-Sar-113092 Sorex araneus 89.98 0.00e+00 862.00
IUUC-Sbi-114558 Sorghum bicolor 44.84 7.00e-108 384.00
IUUC-Ssc-115710 Sus scrofa 95.19 0.00e+00 931.00
IUUC-Tgu-117100 Taeniopygia guttata 78.57 0.00e+00 786.00
IUUC-Tru-118184 Takifugu rubripes 57.81 9.00e-138 483.00
IUUC-Tsy-118892 Tarsius syrichta 95.39 4.00e-159 553.00
IUUC-Tni-120474 Tetraodon nigroviridis 59.16 4.00e-166 577.00
IUUC-Tca-120949 Theobroma cacao 45.54 1.00e-105 377.00
IUUC-Tre-122211 Trichoderma reesei 40.49 1.00e-96 347.00
IUUC-Tvi-122531 Trichoderma virens 41.19 3.00e-98 352.00
IUUC-Tae-123765 Triticum aestivum 45.34 3.00e-109 389.00
IUUC-Tur-126018 Triticum urartu 44.52 1.00e-102 366.00
IUUC-Tbe-127384 Tupaia belangeri 95.96 3.00e-173 601.00
IUUC-Ttr-128511 Tursiops truncatus 94.59 0.00e+00 920.00
IUUC-Vda-129993 Verticillium dahliae 40.39 2.00e-96 346.00
IUUC-Vpa-130775 Vicugna pacos 46.36 1.00e-78 287.00
IUUC-Vvi-131245 Vitis vinifera 45.45 3.00e-94 338.00
IUUC-Xtr-131993 Xenopus tropicalis 73.68 0.00e+00 756.00
IUUC-Xma-133332 Xiphophorus maculatus 62.18 2.00e-177 615.00
IUUC-Zma-135135 Zea mays 46.63 4.00e-106 378.00
Created Date 25-Jun-2017

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