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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-064170
Ensembl Protein ID ENSMUSP00000005234.9
UniProt Accession O88342; WDR1_MOUSE
Genbank Protein ID AAD05043.1
Protein Name WD repeat-containing protein 1; Actin-interacting protein 1
Genbank Nucleotide ID AF020055
Gene Name Wdr1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000005103.12 ENSMUST00000005234.12 ENSMUSP00000005234.9
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
circBasemiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
Phospho.ELMUniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.90e-39 133.0 233 263
UBD/Beta-Prp 4.70e-61 207.7 55 276
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDl 30
           H ++++++++ +d t+l+s+s+D+t k+WD+
   Q: 233  HDGGIYAISWsPDsTHLLSASGDKTSKIWDV 263
           99*********999****************7 PP
   

   UBD/Beta-Prp
   S: 7    ghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrsl..sgheaevtavkfspdgkilvtgseD..rtikvwdlstgkcvhtlk 91
           ++h +++ + k++p++ ++a+g  +g++++wd+t++  l ++  +   ++++++ + +d+k ++ ++e   ++  v+  +tg+ v  ++
   Q: 55   TEHAHQVVVAKYAPSGFYIASGDISGKLRIWDTTQKEHLLKYeyQPFAGKIKDIAWTEDSKRIAVVGEGreKFGAVFLWDTGSSVGEIT 143
           4566667778*************************998777742334567***********9999999988777888888********* PP
   S: 92   ghedsvlslsfspsg.dklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl..tg 177
           gh++ + s+++ +++ ++l++Gs+d+ +  ++ +  +    t   h+++vncv+++pdgn ++++s+D+++ ++d ktg+ +  l  ++
   Q: 144  GHNKVINSVDIKQTRpYRLATGSDDNCAAFFEGPPFKFKF-TIGDHSRFVNCVRFSPDGNRFATASADGQIFIYDGKTGEKVCALgeSK 231
           *************999*****************9999998.99********************************************88 PP
   S: 178  ghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnght 222
           +h++ +y +s+++++++l+s+s d+t k+wd+  +++v t+   +
   Q: 232  AHDGGIYAISWSPDSTHLLSASGDKTSKIWDVNVNSVVSTFPMGS 276
           8***********************************999997655 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (By similarity). Enhances cofilin-mediated actin severing (PubMed:25915128). Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions (By similarity). Involved in myocardium sarcomere organization. Required for cardiomyocyte growth at the postnatal and maintenance at the adult stage (PubMed:24840128). Involved in neutrophil actin dynamics and migration. Involved in megakaryocyte maturation and platelet shedding (PubMed:17515402). Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension (PubMed:25915128). Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (By similarity).
 Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (By similarity). Enhances cofilin-mediated actin severing (PubMed:25915128). Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions (By similarity). Involved in myocardium sarcomere organization. Required for cardiomyocyte growth at the postnatal and maintenance at the adult stage (PubMed:24840128). Involved in neutrophil actin dynamics and migration. Involved in megakaryocyte maturation and platelet shedding (PubMed:17515402). Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension (PubMed:25915128). Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (By similarity).
Protein Sequence
(Fasta)
MPYEIKKVFA SLPQVERGVS KILGGDPKGD HFLYTNGKCV ILRNIDNPAI ADIYTEHAHQ 60
VVVAKYAPSG FYIASGDISG KLRIWDTTQK EHLLKYEYQP FAGKIKDIAW TEDSKRIAVV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064170|E3,WD_repeat;UBD,Beta-Prp|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCAGTGTAAA GGCTGGGACA GACAGGTGAA TCATTGAGAT AGTAGCTGGA AGTCACCACT 60
TTTGAGAGAA ATTAACCAGG TGGTACTGGC ATTCCTTCTA GGCACCACCC CACAGTTCCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064170|E3,WD_repeat;UBD,Beta-Prp|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0009--Actin-binding
KW-0965--Cell junction
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0903--Direct protein sequencing
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR011045--N2O_reductase_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0042643--C:actomyosin, actin portion
GO:0042995--C:cell projection
GO:0005911--C:cell-cell junction
GO:0030864--C:cortical actin cytoskeleton
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0043209--C:myelin sheath
GO:0002102--C:podosome
GO:0003779--F:actin binding
GO:0051015--F:actin filament binding
GO:0030036--P:actin cytoskeleton organization
GO:0030043--P:actin filament fragmentation
GO:0043297--P:apical junction assembly
GO:0030865--P:cortical cytoskeleton organization
GO:0042247--P:establishment of planar polarity of follicular epithelium
GO:0045199--P:maintenance of epithelial cell apical/basal polarity
GO:0002446--P:neutrophil mediated immunity
GO:1990266--P:neutrophil migration
GO:0030220--P:platelet formation
GO:0030836--P:positive regulation of actin filament depolymerization
GO:0030834--P:regulation of actin filament depolymerization
GO:0008360--P:regulation of cell shape
GO:0048713--P:regulation of oligodendrocyte differentiation
GO:0060307--P:regulation of ventricular cardiac muscle cell membrane repolarization
GO:0045214--P:sarcomere organization
GO:0007605--P:sensory perception of sound
KEGG mmu:22388
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000457 Aegilops tauschii 35.27 7.00e-82 298.00
IUUC-Aml-002368 Ailuropoda melanoleuca 95.01 0.00e+00 1169.00
IUUC-Atr-003160 Amborella trichopoda 36.76 2.00e-113 402.00
IUUC-Apl-004012 Anas platyrhynchos 87.95 0.00e+00 1080.00
IUUC-Aca-004707 Anolis carolinensis 83.50 0.00e+00 1054.00
IUUC-Aly-006465 Arabidopsis lyrata 37.07 2.00e-110 393.00
IUUC-Ath-006740 Arabidopsis thaliana 36.42 8.00e-110 390.00
IUUC-Ago-007920 Ashbya gossypii 28.00 8.00e-74 271.00
IUUC-Acl-008262 Aspergillus clavatus 36.59 2.00e-108 386.00
IUUC-Afl-008471 Aspergillus flavus 30.72 5.00e-69 255.00
IUUC-Afu-008989 Aspergillus fumigatus 38.89 5.00e-98 351.00
IUUC-Ani-009167 Aspergillus nidulans 37.97 4.00e-117 415.00
IUUC-Ang-009595 Aspergillus niger 38.36 5.00e-106 378.00
IUUC-Aor-009908 Aspergillus oryzae 36.47 2.00e-103 370.00
IUUC-Ate-010580 Aspergillus terreus 37.85 7.00e-110 392.00
IUUC-Ame-011269 Astyanax mexicanus 60.00 3.00e-133 468.00
IUUC-Bgr-011996 Blumeria graminis 34.47 1.00e-108 387.00
IUUC-Bta-013278 Bos taurus 95.21 0.00e+00 1206.00
IUUC-Bci-013925 Botrytis cinerea 35.34 6.00e-108 384.00
IUUC-Bdi-014659 Brachypodium distachyon 35.90 4.00e-104 372.00
IUUC-Bol-016043 Brassica oleracea 35.62 6.00e-108 384.00
IUUC-Bra-017139 Brassica rapa 36.16 1.00e-109 390.00
IUUC-Cel-018417 Caenorhabditis elegans 41.39 3.00e-124 439.00
IUUC-Cja-019952 Callithrix jacchus 94.72 0.00e+00 1153.00
IUUC-Cfa-020225 Canis familiaris 95.21 0.00e+00 1181.00
IUUC-Cpo-021900 Cavia porcellus 94.68 0.00e+00 1167.00
IUUC-Csa-023028 Chlorocebus sabaeus 95.71 0.00e+00 1162.00
IUUC-Cho-025030 Choloepus hoffmanni 67.50 0.00e+00 748.00
IUUC-Cin-025152 Ciona intestinalis 56.03 2.00e-81 295.00
IUUC-Csv-025986 Ciona savignyi 37.85 9.00e-94 337.00
IUUC-Cgl-026597 Colletotrichum gloeosporioides 37.95 4.00e-112 398.00
IUUC-Cne-026814 Cryptococcus neoformans 33.93 3.00e-98 352.00
IUUC-Dre-027498 Danio rerio 81.03 8.00e-96 342.00
IUUC-Dno-029383 Dasypus novemcinctus 93.73 0.00e+00 1136.00
IUUC-Dor-030633 Dipodomys ordii 95.01 0.00e+00 1097.00
IUUC-Dse-031526 Dothistroma septosporum 37.90 8.00e-118 417.00
IUUC-Dme-031597 Drosophila melanogaster 48.34 1.00e-168 586.00
IUUC-Ete-032780 Echinops telfairi 82.62 0.00e+00 1026.00
IUUC-Eca-034306 Equus caballus 93.51 0.00e+00 1137.00
IUUC-Eeu-034531 Erinaceus europaeus 72.90 7.00e-135 474.00
IUUC-Fca-036301 Felis catus 95.17 0.00e+00 1195.00
IUUC-Fal-037361 Ficedula albicollis 87.44 0.00e+00 1123.00
IUUC-Fox-037924 Fusarium oxysporum 34.81 3.00e-101 362.00
IUUC-Fso-038199 Fusarium solani 34.36 2.00e-97 350.00
IUUC-Gmo-039238 Gadus morhua 71.00 0.00e+00 880.00
IUUC-Ggr-039830 Gaeumannomyces graminis 34.83 7.00e-95 341.00
IUUC-Gga-040235 Gallus gallus 88.78 0.00e+00 1105.00
IUUC-Gac-042363 Gasterosteus aculeatus 71.66 0.00e+00 922.00
IUUC-Gma-044189 Glycine max 36.29 5.00e-112 398.00
IUUC-Ggo-044632 Gorilla gorilla 93.25 0.00e+00 1127.00
IUUC-Hsa-045792 Homo sapiens 95.21 0.00e+00 1184.00
IUUC-Hvu-047517 Hordeum vulgare 35.35 2.00e-108 386.00
IUUC-Itr-048076 Ictidomys tridecemlineatus 96.34 0.00e+00 1179.00
IUUC-Kpa-049183 Komagataella pastoris 33.44 7.00e-88 318.00
IUUC-Lch-050428 Latimeria chalumnae 76.28 0.00e+00 999.00
IUUC-Lpe-051306 Leersia perrieri 36.11 2.00e-109 390.00
IUUC-Loc-052096 Lepisosteus oculatus 72.40 0.00e+00 904.00
IUUC-Lma-053313 Leptosphaeria maculans 38.95 1.00e-116 416.00
IUUC-Laf-054060 Loxodonta africana 92.74 0.00e+00 1135.00
IUUC-Mcc-055619 Macaca mulatta 93.62 0.00e+00 1133.00
IUUC-Meu-056689 Macropus eugenii 77.89 0.00e+00 630.00
IUUC-Mor-056940 Magnaporthe oryzae 35.01 1.00e-96 347.00
IUUC-Mpo-057557 Magnaporthe poae 30.56 9.00e-70 258.00
IUUC-Mtr-057922 Medicago truncatula 35.84 3.00e-110 392.00
IUUC-Mla-059103 Melampsora laricipopulina 34.33 1.00e-78 287.00
IUUC-Mga-060150 Meleagris gallopavo 88.41 0.00e+00 1095.00
IUUC-Mvi-060448 Microbotryum violaceum 30.78 6.00e-73 268.00
IUUC-Mmr-061226 Microcebus murinus 94.06 0.00e+00 1150.00
IUUC-Mdo-062674 Monodelphis domestica 91.25 0.00e+00 1143.00
IUUC-Mac-065124 Musa acuminata 37.12 2.00e-114 406.00
IUUC-Mpu-066001 Mustela putorius furo 91.26 0.00e+00 1155.00
IUUC-Mlu-067253 Myotis lucifugus 94.34 0.00e+00 1170.00
IUUC-Nfi-068550 Neosartorya fischeri 39.03 2.00e-113 403.00
IUUC-Ncr-068948 Neurospora crassa 36.98 1.00e-115 410.00
IUUC-Nle-070115 Nomascus leucogenys 91.48 0.00e+00 1065.00
IUUC-Opr-070254 Ochotona princeps 92.17 0.00e+00 1102.00
IUUC-Ont-071666 Oreochromis niloticus 75.08 0.00e+00 953.00
IUUC-Oan-073594 Ornithorhynchus anatinus 91.59 6.00e-167 579.00
IUUC-Ocu-074824 Oryctolagus cuniculus 94.06 0.00e+00 1136.00
IUUC-Oba-075010 Oryza barthii 36.33 9.00e-111 394.00
IUUC-Obr-076364 Oryza brachyantha 37.19 4.00e-112 398.00
IUUC-Ogl-077019 Oryza glaberrima 36.33 9.00e-111 394.00
IUUC-Ogu-078496 Oryza glumaepatula 36.33 9.00e-111 394.00
IUUC-Oin-080116 Oryza indica 36.50 3.00e-111 395.00
IUUC-Olo-080290 Oryza longistaminata 36.33 2.00e-110 392.00
IUUC-Ome-081969 Oryza meridionalis 36.33 1.00e-110 394.00
IUUC-Oni-082075 Oryza nivara 36.33 7.00e-111 394.00
IUUC-Opu-083959 Oryza punctata 36.54 1.00e-110 393.00
IUUC-Oru-084711 Oryza rufipogon 36.33 9.00e-111 394.00
IUUC-Osa-085958 Oryza sativa 36.50 3.00e-111 395.00
IUUC-Ola-086968 Oryzias latipes 76.24 0.00e+00 971.00
IUUC-Oga-089108 Otolemur garnettii 94.27 0.00e+00 1204.00
IUUC-Oar-089986 Ovis aries 89.02 0.00e+00 1108.00
IUUC-Ptr-091281 Pan troglodytes 95.33 0.00e+00 1172.00
IUUC-Pan-092585 Papio anubis 95.87 0.00e+00 1165.00
IUUC-Psi-093811 Pelodiscus sinensis 87.21 0.00e+00 1119.00
IUUC-Pma-094396 Petromyzon marinus 71.06 0.00e+00 910.00
IUUC-Pno-095086 Phaeosphaeria nodorum 36.98 8.00e-109 387.00
IUUC-Ppa-095876 Physcomitrella patens 35.74 1.00e-110 393.00
IUUC-Pfo-096973 Poecilia formosa 74.92 0.00e+00 990.00
IUUC-Pab-098391 Pongo abelii 95.21 0.00e+00 1161.00
IUUC-Pop-098850 Populus trichocarpa 36.32 5.00e-111 395.00
IUUC-Pca-100257 Procavia capensis 59.60 1.00e-89 323.00
IUUC-Ppe-101578 Prunus persica 38.07 2.00e-115 410.00
IUUC-Pva-102872 Pteropus vampyrus 88.96 0.00e+00 1118.00
IUUC-Pgr-103593 Puccinia graminis 33.06 5.00e-79 288.00
IUUC-Pte-104365 Pyrenophora teres 38.67 9.00e-112 397.00
IUUC-Pyt-104689 Pyrenophora triticirepentis 38.35 2.00e-114 406.00
IUUC-Rno-105737 Rattus norvegicus 98.02 0.00e+00 1232.00
IUUC-Sce-106383 Saccharomyces cerevisiae 28.91 5.00e-69 255.00
IUUC-Sha-107084 Sarcophilus harrisii 88.95 0.00e+00 1004.00
IUUC-Sja-107688 Schizosaccharomyces japonicus 35.86 4.00e-112 398.00
IUUC-Spo-108309 Schizosaccharomyces pombe 33.33 2.00e-96 346.00
IUUC-Ssl-108408 Sclerotinia sclerotiorum 35.34 2.00e-108 386.00
IUUC-Smo-109255 Selaginella moellendorffii 34.75 5.00e-101 361.00
IUUC-Sit-109962 Setaria italica 37.58 1.00e-112 400.00
IUUC-Sly-110897 Solanum lycopersicum 37.68 1.00e-114 407.00
IUUC-Stu-111971 Solanum tuberosum 37.68 2.00e-114 406.00
IUUC-Sar-113415 Sorex araneus 71.96 2.00e-108 386.00
IUUC-Sbi-114857 Sorghum bicolor 37.09 2.00e-110 393.00
IUUC-Sre-114900 Sporisorium reilianum 33.44 2.00e-91 330.00
IUUC-Tgu-117256 Taeniopygia guttata 87.21 0.00e+00 1118.00
IUUC-Tru-117871 Takifugu rubripes 69.75 0.00e+00 888.00
IUUC-Tsy-119172 Tarsius syrichta 95.83 4.00e-138 484.00
IUUC-Tni-120339 Tetraodon nigroviridis 70.13 0.00e+00 922.00
IUUC-Tca-121609 Theobroma cacao 36.73 9.00e-112 397.00
IUUC-Tre-122076 Trichoderma reesei 35.53 3.00e-94 339.00
IUUC-Tvi-122528 Trichoderma virens 34.65 1.00e-96 347.00
IUUC-Tae-124549 Triticum aestivum 35.68 3.00e-109 389.00
IUUC-Tur-126845 Triticum urartu 35.25 5.00e-81 295.00
IUUC-Tme-127217 Tuber melanosporum 34.92 2.00e-105 376.00
IUUC-Tbe-127526 Tupaia belangeri 92.24 0.00e+00 1149.00
IUUC-Ttr-128898 Tursiops truncatus 86.82 0.00e+00 1087.00
IUUC-Uma-129631 Ustilago maydis 31.97 7.00e-94 338.00
IUUC-Vda-129732 Verticillium dahliae 35.50 5.00e-94 338.00
IUUC-Vvi-131217 Vitis vinifera 37.40 3.00e-112 399.00
IUUC-Xtr-132860 Xenopus tropicalis 73.91 0.00e+00 942.00
IUUC-Xma-133830 Xiphophorus maculatus 74.92 0.00e+00 990.00
IUUC-Yli-134335 Yarrowia lipolytica 33.33 8.00e-77 281.00
IUUC-Zma-135907 Zea mays 37.25 3.00e-111 395.00
Created Date 25-Jun-2017

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