iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
FBgn0264493	FBtr0100361	FBpp0099767
FBgn0264493	FBtr0301632	FBpp0290846
FBgn0264493	FBtr0301634	FBpp0290848

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/BCR/BTB_Other	BTB_Other	16740475; 19164706

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	2.30e-26	92.0	655	722

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgkldene 69
           +Dv+l vgg+ef+ahk++Laa+S+vF a+f++e+ee+k  ++v i dv++ev++++l+F+Ytgk+++ e
   Q: 655  SDVTLSVGGREFQAHKAILAARSDVFAAMFEHEMEERK-LNRVAITDVDHEVLKEMLRFIYTGKAPNLE 722
           6************************************9.**************************9976 PP

Organism

Drosophila melanogaster

Functional Description
(View)

Involved in segment polarity. In complex with gft/CUL3, promotes ubiquitination of ci and its subsequent degradation by the proteasome, which results in hh signaling attenuation. This regulation may be important during eye formation for proper packing of ommatidia into a hexagonal array.

Protein Sequence
(Fasta)

MFEPYVKIKK KRSVNEIYEN ENLEQQQHHL QQQQQQPATS DNCCCENGEP QNAPEVATAT 60
VAATSVAATS AAATVATGAA ASSSSSGNCS RLQQLISTPP VLLRRSSLQQ QQHQQQQHHP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGTTCGTGT GGGTGGTAGC GTGTGAGTGT GTGCCGCAGC ATGGGAAGCG AGTGATTCGC 60
TGATTCGCCA AATTCGTCGT ATTTACTTGG AAATTTGCAA ACTAATAGCC AAGGGTCGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0709--Segmentation polarity protein
KW-0833--Ubl conjugation pathway

Interpro

IPR000210--BTB/POZ_dom
IPR002083--MATH/TRAF_dom
IPR011333--SKP1/BTB/POZ
IPR034089--SPOP_C
IPR008974--TRAF-like
IPR015943--WD40/YVTN_repeat-like_dom

PROSITE

PS50097--BTB
PS50144--MATH

Pfam

PF00651--BTB
PF00917--MATH

SMART

SM00225--BTB
SM00061--MATH

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0042803--F:protein homodimerization activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0042067--P:establishment of ommatidial planar polarity
GO:0001654--P:eye development
GO:0048592--P:eye morphogenesis
GO:0046331--P:lateral inhibition
GO:0042308--P:negative regulation of protein import into nucleus
GO:0045879--P:negative regulation of smoothened signaling pathway
GO:0043065--P:positive regulation of apoptotic process
GO:0046330--P:positive regulation of JNK cascade
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0031648--P:protein destabilization
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030162--P:regulation of proteolysis
GO:0007367--P:segment polarity determination

KEGG

dme:Dmel_CG12537

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000421	Aegilops tauschii	36.91	2.00e-36	144.00
IUUC-Aml-002307	Ailuropoda melanoleuca	75.83	2.00e-158	550.00
IUUC-Atr-002922	Amborella trichopoda	28.78	7.00e-39	153.00
IUUC-Apl-003488	Anas platyrhynchos	79.95	1.00e-163	567.00
IUUC-Aca-005010	Anolis carolinensis	79.95	1.00e-163	568.00
IUUC-Aly-005813	Arabidopsis lyrata	27.68	4.00e-35	141.00
IUUC-Ath-007670	Arabidopsis thaliana	27.97	4.00e-36	144.00
IUUC-Afu-008999	Aspergillus fumigatus	29.63	1.00e-07	49.70
IUUC-Ani-009467	Aspergillus nidulans	26.49	3.00e-07	48.50
IUUC-Ate-010494	Aspergillus terreus	34.85	2.00e-07	48.90
IUUC-Ame-011843	Astyanax mexicanus	75.00	6.00e-169	585.00
IUUC-Bta-012931	Bos taurus	79.68	4.00e-163	566.00
IUUC-Bci-013825	Botrytis cinerea	26.39	1.00e-06	47.00
IUUC-Bdi-014743	Brachypodium distachyon	33.72	1.00e-43	169.00
IUUC-Bol-015218	Brassica oleracea	31.76	5.00e-40	157.00
IUUC-Bra-016833	Brassica rapa	31.76	3.00e-40	158.00
IUUC-Cel-018671	Caenorhabditis elegans	69.34	4.00e-142	497.00
IUUC-Cja-019981	Callithrix jacchus	79.47	1.00e-161	561.00
IUUC-Cfa-020115	Canis familiaris	79.68	4.00e-163	566.00
IUUC-Cpo-021366	Cavia porcellus	79.20	4.00e-161	559.00
IUUC-Cre-022892	Chlamydomonas reinhardtii	36.84	9.00e-06	45.10
IUUC-Csa-023569	Chlorocebus sabaeus	78.12	7.00e-129	452.00
IUUC-Cho-024732	Choloepus hoffmanni	65.82	4.00e-139	486.00
IUUC-Cin-025636	Ciona intestinalis	75.68	2.00e-160	556.00
IUUC-Csv-026167	Ciona savignyi	71.28	2.00e-157	547.00
IUUC-Cgl-026729	Colletotrichum gloeosporioides	31.31	2.00e-05	42.70
IUUC-Dre-027603	Danio rerio	79.14	5.00e-163	566.00
IUUC-Dno-029399	Dasypus novemcinctus	74.24	3.00e-168	583.00
IUUC-Dor-030503	Dipodomys ordii	80.00	5.00e-162	562.00
IUUC-Dse-031465	Dothistroma septosporum	29.11	3.00e-07	48.50
IUUC-Ete-032328	Echinops telfairi	80.17	1.00e-152	531.00
IUUC-Eca-033238	Equus caballus	79.68	4.00e-163	566.00
IUUC-Eeu-035156	Erinaceus europaeus	75.08	3.00e-136	476.00
IUUC-Fca-035435	Felis catus	79.68	4.00e-163	566.00
IUUC-Fal-037023	Ficedula albicollis	76.53	1.00e-171	594.00
IUUC-Fox-037845	Fusarium oxysporum	32.63	5.00e-10	57.00
IUUC-Fso-038419	Fusarium solani	41.67	6.00e-07	47.40
IUUC-Gmo-038605	Gadus morhua	77.04	1.00e-172	598.00
IUUC-Ggr-039747	Gaeumannomyces graminis	31.03	2.00e-09	55.80
IUUC-Gga-040441	Gallus gallus	79.95	1.00e-163	567.00
IUUC-Gac-041911	Gasterosteus aculeatus	78.07	1.00e-160	558.00
IUUC-Gma-044158	Glycine max	33.33	6.00e-41	160.00
IUUC-Ggo-045160	Gorilla gorilla	75.00	3.00e-169	586.00
IUUC-Hsa-045835	Homo sapiens	79.68	4.00e-163	566.00
IUUC-Hvu-047528	Hordeum vulgare	30.81	4.00e-40	157.00
IUUC-Itr-048153	Ictidomys tridecemlineatus	75.26	7.00e-170	588.00
IUUC-Lch-050241	Latimeria chalumnae	79.68	4.00e-163	566.00
IUUC-Lpe-050805	Leersia perrieri	33.54	1.00e-46	179.00
IUUC-Loc-052374	Lepisosteus oculatus	79.41	4.00e-163	566.00
IUUC-Lma-052959	Leptosphaeria maculans	27.85	3.00e-07	48.50
IUUC-Laf-054192	Loxodonta africana	79.47	1.00e-161	561.00
IUUC-Mcc-055322	Macaca mulatta	79.68	4.00e-163	566.00
IUUC-Meu-056330	Macropus eugenii	74.33	6.00e-150	522.00
IUUC-Mor-057237	Magnaporthe oryzae	29.41	7.00e-08	50.10
IUUC-Mpo-057466	Magnaporthe poae	34.29	2.00e-09	55.10
IUUC-Mtr-058558	Medicago truncatula	32.13	3.00e-39	155.00
IUUC-Mla-059110	Melampsora laricipopulina	33.33	1.00e-03	38.10
IUUC-Mga-059990	Meleagris gallopavo	76.53	1.00e-171	594.00
IUUC-Mmr-061309	Microcebus murinus	79.68	4.00e-163	566.00
IUUC-Mdo-062472	Monodelphis domestica	76.18	2.00e-169	587.00
IUUC-Mmu-064227	Mus musculus	79.68	4.00e-163	566.00
IUUC-Mac-065018	Musa acuminata	31.39	3.00e-35	141.00
IUUC-Mpu-065693	Mustela putorius furo	79.68	4.00e-163	566.00
IUUC-Mlu-067827	Myotis lucifugus	79.47	3.00e-161	560.00
IUUC-Ncr-068938	Neurospora crassa	34.78	1.00e-05	43.90
IUUC-Nle-069393	Nomascus leucogenys	79.68	4.00e-163	566.00
IUUC-Opr-070490	Ochotona princeps	78.34	4.00e-160	556.00
IUUC-Ont-072569	Oreochromis niloticus	77.04	1.00e-172	598.00
IUUC-Oan-073449	Ornithorhynchus anatinus	74.23	1.00e-165	574.00
IUUC-Ocu-074932	Oryctolagus cuniculus	79.68	4.00e-163	566.00
IUUC-Oba-075513	Oryza barthii	35.29	1.00e-40	159.00
IUUC-Obr-076031	Oryza brachyantha	28.61	1.00e-31	129.00
IUUC-Ogl-077235	Oryza glaberrima	35.29	1.00e-40	159.00
IUUC-Ogu-077969	Oryza glumaepatula	35.51	9.00e-39	153.00
IUUC-Oin-079531	Oryza indica	35.60	3.00e-41	161.00
IUUC-Olo-080583	Oryza longistaminata	30.94	4.00e-40	157.00
IUUC-Ome-081184	Oryza meridionalis	31.76	3.00e-37	149.00
IUUC-Oni-082862	Oryza nivara	35.60	4.00e-41	162.00
IUUC-Opu-083557	Oryza punctata	31.39	1.00e-35	143.00
IUUC-Oru-084513	Oryza rufipogon	34.05	8.00e-33	134.00
IUUC-Osa-085702	Oryza sativa	34.98	1.00e-39	156.00
IUUC-Ola-086989	Oryzias latipes	78.13	2.00e-159	554.00
IUUC-Olu-087691	Ostreococcus lucimarinus	29.61	1.00e-31	129.00
IUUC-Oga-089107	Otolemur garnettii	79.68	4.00e-163	566.00
IUUC-Oar-089943	Ovis aries	79.47	1.00e-161	561.00
IUUC-Ptr-091201	Pan troglodytes	79.68	4.00e-163	566.00
IUUC-Pan-092504	Papio anubis	79.68	4.00e-163	566.00
IUUC-Psi-093063	Pelodiscus sinensis	79.95	1.00e-163	567.00
IUUC-Pma-094310	Petromyzon marinus	80.50	1.00e-157	548.00
IUUC-Ppa-095322	Physcomitrella patens	31.64	2.00e-38	152.00
IUUC-Pfo-096411	Poecilia formosa	78.34	9.00e-161	558.00
IUUC-Pab-098640	Pongo abelii	79.68	4.00e-163	566.00
IUUC-Pop-099525	Populus trichocarpa	31.07	5.00e-29	120.00
IUUC-Pca-100243	Procavia capensis	65.80	1.00e-98	352.00
IUUC-Ppe-101816	Prunus persica	31.16	5.00e-36	144.00
IUUC-Pva-102660	Pteropus vampyrus	74.74	1.00e-164	571.00
IUUC-Pgr-103295	Puccinia graminis	21.71	1.10e-02	34.70
IUUC-Pte-104298	Pyrenophora teres	28.17	7.00e-07	48.10
IUUC-Pyt-104494	Pyrenophora triticirepentis	26.92	8.00e-07	47.00
IUUC-Rno-105399	Rattus norvegicus	79.68	4.00e-163	566.00
IUUC-Sha-106700	Sarcophilus harrisii	79.68	6.00e-163	565.00
IUUC-Spo-108262	Schizosaccharomyces pombe	38.60	1.00e-02	34.70
IUUC-Smo-108684	Selaginella moellendorffii	28.91	8.00e-26	110.00
IUUC-Sit-110335	Setaria italica	33.99	2.00e-39	155.00
IUUC-Sly-110886	Solanum lycopersicum	30.54	2.00e-31	129.00
IUUC-Stu-112678	Solanum tuberosum	30.54	2.00e-31	129.00
IUUC-Sar-113489	Sorex araneus	79.68	4.00e-163	566.00
IUUC-Sbi-114217	Sorghum bicolor	33.23	3.00e-43	168.00
IUUC-Ssc-116199	Sus scrofa	78.34	6.00e-168	582.00
IUUC-Tgu-116755	Taeniopygia guttata	76.92	8.00e-172	595.00
IUUC-Tru-117832	Takifugu rubripes	77.33	4.00e-159	553.00
IUUC-Tsy-118969	Tarsius syrichta	75.67	3.00e-152	530.00
IUUC-Tni-120221	Tetraodon nigroviridis	77.33	4.00e-159	553.00
IUUC-Tca-121578	Theobroma cacao	29.79	7.00e-35	140.00
IUUC-Tre-122160	Trichoderma reesei	32.88	9.00e-08	49.70
IUUC-Tvi-122498	Trichoderma virens	33.00	5.00e-09	53.90
IUUC-Tae-124322	Triticum aestivum	33.33	3.00e-39	154.00
IUUC-Tur-126567	Triticum urartu	33.33	2.00e-37	148.00
IUUC-Tme-126982	Tuber melanosporum	35.80	2.00e-09	56.20
IUUC-Tbe-127298	Tupaia belangeri	79.68	7.00e-160	555.00
IUUC-Ttr-128952	Tursiops truncatus	79.41	9.00e-163	565.00
IUUC-Vda-129835	Verticillium dahliae	37.93	1.00e-07	50.80
IUUC-Vpa-130735	Vicugna pacos	75.07	4.00e-146	509.00
IUUC-Vvi-130854	Vitis vinifera	31.14	4.00e-28	118.00
IUUC-Xtr-132806	Xenopus tropicalis	79.26	4.00e-161	560.00
IUUC-Xma-134130	Xiphophorus maculatus	76.79	2.00e-172	597.00
IUUC-Zma-135896	Zea mays	32.07	2.00e-35	142.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence