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Basic Information Integrated Annotations

Tag Content
iUUCD ID IUUC-Rno-105532
Ensembl Protein ID ENSRNOP00000007476.4
UniProt Accession Q498T3; ING3_RAT
Genbank Protein ID EDM15142.1; AAI00083.1
Protein Name Inhibitor of growth protein 3
Genbank Nucleotide ID CH473959; BC100082
Gene Name Ing3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000005496.5 ENSRNOT00000007476.5 ENSRNOP00000007476.4
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNATRANSFACRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/PHD 1.90e-09 37.9 364 411
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCek..Cr.ewfHpaClklsveeelpnsekwiCpkCrs 53
    ++C +C + + +e +v C++ C ewfH++C++l+ e p+ + w+Cp+C++
   Q: 364 RYC-ICNQVSYGE--MVGCDNqdCPiEWFHYGCVGLT---EAPKGK-WFCPQCTA 411
    69*.*******99..*****999*99***********...999997.******86 PP
   

Organism Rattus norvegicus
Functional Description
(View)

Functional Description



     Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome (By similarity).
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome (By similarity).
Protein Sequence
(Fasta)
MLYLEDYLEM IEQLPMDLRD RFTEMREMDL QVQNAMDQLE QRVSEFFMNA KKNKPEWREE 60
QMASIKKDYY KALEDADEKV QLANQIYDLV DRHLRKLDQE LAKFKMELEA DNAGITEILE 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Rno-105532|E3,PHD|Rattus norvegicus
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Nucleotide Sequence
(Fasta)
CTCCGGCGAC AGCGAGTGAC ACAAATAAAC CCCTGGACCC GTTCGTCTCC GCAGCACTCA 60
GGGCCGCGAT GTTGTACCTA GAAGACTATT TGGAAAGTGA GTGCGCGGCG CCGGCAACGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Rno-105532|E3,PHD|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0341--Growth regulation
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR028651--ING_fam
IPR024610--ING_N_histone_binding
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF12998--ING

SMART

SM01408--ING
SM00249--PHD

Gene Ontology

GO:0035267--C:NuA4 histone acetyltransferase complex
GO:0032777--C:Piccolo NuA4 histone acetyltransferase complex
GO:0000812--C:Swr1 complex
GO:0004402--F:histone acetyltransferase activity
GO:0008270--F:zinc ion binding
GO:0043968--P:histone H2A acetylation
GO:0043967--P:histone H4 acetylation
GO:0043065--P:positive regulation of apoptotic process
GO:0040008--P:regulation of growth
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG rno:312154
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002275 Ailuropoda melanoleuca 94.06 0.00e+00 682.00
IUUC-Apl-003660 Anas platyrhynchos 85.43 9.00e-155 539.00
IUUC-Aca-005206 Anolis carolinensis 83.14 1.00e-161 562.00
IUUC-Ate-010297 Aspergillus terreus 60.38 1.00e-18 88.60
IUUC-Ame-011952 Astyanax mexicanus 81.09 2.00e-156 545.00
IUUC-Bta-012562 Bos taurus 93.11 0.00e+00 681.00
IUUC-Cja-019646 Callithrix jacchus 92.40 0.00e+00 671.00
IUUC-Cfa-020874 Canis familiaris 94.06 0.00e+00 684.00
IUUC-Cpo-022530 Cavia porcellus 93.59 0.00e+00 666.00
IUUC-Csa-024232 Chlorocebus sabaeus 93.11 0.00e+00 676.00
IUUC-Cho-025039 Choloepus hoffmanni 91.69 0.00e+00 656.00
IUUC-Cin-025233 Ciona intestinalis 58.29 5.00e-52 198.00
IUUC-Csv-025900 Ciona savignyi 62.42 2.00e-52 199.00
IUUC-Dre-027397 Danio rerio 77.54 2.00e-147 515.00
IUUC-Dno-029289 Dasypus novemcinctus 93.59 0.00e+00 680.00
IUUC-Dse-031323 Dothistroma septosporum 54.24 8.00e-18 85.50
IUUC-Ete-032510 Echinops telfairi 84.32 1.00e-154 539.00
IUUC-Eca-033770 Equus caballus 94.30 0.00e+00 684.00
IUUC-Fca-035661 Felis catus 93.35 0.00e+00 677.00
IUUC-Fal-037051 Ficedula albicollis 82.22 2.00e-149 521.00
IUUC-Gmo-039123 Gadus morhua 77.07 2.00e-160 558.00
IUUC-Gga-040794 Gallus gallus 86.22 5.00e-171 593.00
IUUC-Gac-042167 Gasterosteus aculeatus 80.94 2.00e-110 392.00
IUUC-Ggo-044586 Gorilla gorilla 97.71 7.00e-114 403.00
IUUC-Hsa-046035 Homo sapiens 93.59 0.00e+00 677.00
IUUC-Itr-048783 Ictidomys tridecemlineatus 94.30 0.00e+00 684.00
IUUC-Lch-049419 Latimeria chalumnae 81.95 3.00e-177 614.00
IUUC-Loc-052246 Lepisosteus oculatus 84.16 2.00e-165 575.00
IUUC-Lma-053234 Leptosphaeria maculans 52.31 7.00e-17 82.80
IUUC-Laf-053617 Loxodonta africana 95.49 0.00e+00 655.00
IUUC-Mcc-055192 Macaca mulatta 90.50 0.00e+00 641.00
IUUC-Meu-056848 Macropus eugenii 77.91 1.00e-140 492.00
IUUC-Mga-059899 Meleagris gallopavo 84.79 1.00e-149 522.00
IUUC-Mmr-061435 Microcebus murinus 90.02 0.00e+00 647.00
IUUC-Mmu-064032 Mus musculus 98.81 0.00e+00 709.00
IUUC-Mpu-066530 Mustela putorius furo 93.59 0.00e+00 684.00
IUUC-Mlu-067790 Myotis lucifugus 94.06 0.00e+00 682.00
IUUC-Nle-070171 Nomascus leucogenys 93.59 0.00e+00 677.00
IUUC-Opr-070865 Ochotona princeps 74.65 2.00e-75 276.00
IUUC-Ont-072045 Oreochromis niloticus 80.47 2.00e-158 551.00
IUUC-Oan-073641 Ornithorhynchus anatinus 81.40 2.00e-150 525.00
IUUC-Ocu-074613 Oryctolagus cuniculus 93.82 0.00e+00 682.00
IUUC-Oga-088624 Otolemur garnettii 93.60 0.00e+00 669.00
IUUC-Oar-089442 Ovis aries 92.64 0.00e+00 674.00
IUUC-Ptr-091208 Pan troglodytes 93.59 0.00e+00 677.00
IUUC-Pan-092715 Papio anubis 93.35 0.00e+00 676.00
IUUC-Psi-093455 Pelodiscus sinensis 84.56 2.00e-168 585.00
IUUC-Pma-094144 Petromyzon marinus 78.65 4.00e-44 169.00
IUUC-Pfo-096573 Poecilia formosa 80.85 8.00e-159 553.00
IUUC-Pab-097549 Pongo abelii 93.59 0.00e+00 677.00
IUUC-Pca-100198 Procavia capensis 91.45 0.00e+00 659.00
IUUC-Pva-102440 Pteropus vampyrus 92.64 0.00e+00 674.00
IUUC-Pte-104284 Pyrenophora teres 52.54 8.00e-17 82.80
IUUC-Pyt-104787 Pyrenophora triticirepentis 54.24 6.00e-17 83.20
IUUC-Sha-107475 Sarcophilus harrisii 85.51 3.00e-178 617.00
IUUC-Sar-113193 Sorex araneus 91.69 0.00e+00 660.00
IUUC-Ssc-115795 Sus scrofa 93.35 0.00e+00 679.00
IUUC-Tgu-117305 Taeniopygia guttata 87.63 7.00e-152 530.00
IUUC-Tru-117691 Takifugu rubripes 76.89 4.00e-150 524.00
IUUC-Tsy-119035 Tarsius syrichta 86.24 6.00e-95 340.00
IUUC-Tni-120738 Tetraodon nigroviridis 84.12 7.00e-114 403.00
IUUC-Tre-121950 Trichoderma reesei 59.26 8.00e-19 89.40
IUUC-Ttr-128512 Tursiops truncatus 91.45 0.00e+00 682.00
IUUC-Xma-133522 Xiphophorus maculatus 81.09 2.00e-159 555.00
Created Date 25-Jun-2017

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