• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Details
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046042
UUCD1 version UUC-HoS-00453
Ensembl Protein ID ENSP00000301924.4
UniProt Accession Q9UPQ4; Q86XQ0; Q8WVA4; TRI35_HUMAN
Genbank Protein ID AAO85480.1; BAA83050.1; AAH18337.1; AAH69226.1
Protein Name Tripartite motif-containing protein 35; Hemopoietic lineage switch protein 5
Genbank Nucleotide ID AF492463; AB029021; BC018337; BC069226
Gene Name TRIM35; HLS5; KIAA1098
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000104228.12 ENST00000305364.8 ENSP00000301924.4
ENSG00000104228.12 ENST00000521283.1 ENSP00000429356.1
ENSG00000104228.12 ENST00000521253.1 ENSP00000428770.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
AREsitecircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtPHOSIDA
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 18248090
Classification
Family E-value Score Start End
E3 activity/RING/U-box 1.10e-08 36.7 16 85
E3 activity/RING/RING 1.30e-06 30.5 21 61
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/U-box
   S: 3    peeflCpIslelMrdPvvlpsGitydrssIekwlasggk.tcPvtrqplteedlvPnltlrrliqawcee 71
            ee+lC++ ++++rd v+l +G+ + r ++ ++ + + + tcPv++ + ++ dl  n+tl +l+++ + e
   Q: 16   KEELLCAVCYDPFRDAVTLRCGHNFCRGCVSRCWEVQVSpTCPVCKDRASPADLRTNHTLNNLVEKLLRE 85
           689******************************97766669**********************9987765 PP
   

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           Ca+C+++f+d  ++l+CgH f++ C+  +w     + + + +CP+C+
   Q: 21   CAVCYDPFRD-AVTLRCGHNFCRGCVsRCW-----EVQVSPTCPVCK 61
           ********99.999************9999.....799999*****6 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Reduces FGFR1-dependent tyrosine phosphorylation of PKM, inhibiting PKM-dependent lactate production, glucose metabolism, and cell growth (PubMed:25263439). Involved in the cell death mechanism (By similarity).
 Reduces FGFR1-dependent tyrosine phosphorylation of PKM, inhibiting PKM-dependent lactate production, glucose metabolism, and cell growth (PubMed:25263439). Involved in the cell death mechanism (By similarity).
Protein Sequence
(Fasta)
MERSPDVSPG PSRSFKEELL CAVCYDPFRD AVTLRCGHNF CRGCVSRCWE VQVSPTCPVC 60
KDRASPADLR TNHTLNNLVE KLLREEAEGA RWTSYRFSRV CRLHRGQLSL FCLEDKELLC 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046042|E3,RING;E3,U-box|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CACTCGGGTC GCGGGCGTTG GCAGCCGGGC GGGTGGGAGG GGCCGGAGCA AAAGTTCCGG 60
GCGCCCGAGC CGGCTGCTCG TGCCATGGAG CGGAGTCCCG ACGTGTCCCC CGGGCCTTCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046042|E3,RING;E3,U-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box
PRINTS

PR01407--BUTYPHLNCDUF
SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0045087--P:innate immune response
GO:0045930--P:negative regulation of mitotic cell cycle
GO:1902187--P:negative regulation of viral release from host cell
GO:0043065--P:positive regulation of apoptotic process
KEGG hsa:23087
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001788 Ailuropoda melanoleuca 91.48 0.00e+00 941.00
IUUC-Apl-003958 Anas platyrhynchos 53.54 5.00e-133 468.00
IUUC-Aca-005199 Anolis carolinensis 47.52 3.00e-126 445.00
IUUC-Ame-011964 Astyanax mexicanus 36.33 9.00e-73 267.00
IUUC-Bta-013359 Bos taurus 88.98 0.00e+00 900.00
IUUC-Cja-018900 Callithrix jacchus 82.80 0.00e+00 843.00
IUUC-Cfa-020685 Canis familiaris 91.28 0.00e+00 940.00
IUUC-Cpo-022253 Cavia porcellus 81.54 0.00e+00 806.00
IUUC-Csa-023777 Chlorocebus sabaeus 99.59 0.00e+00 1019.00
IUUC-Dre-027686 Danio rerio 33.84 2.00e-59 223.00
IUUC-Dno-029065 Dasypus novemcinctus 85.74 0.00e+00 893.00
IUUC-Dor-030248 Dipodomys ordii 65.40 1.00e-102 366.00
IUUC-Ete-033183 Echinops telfairi 74.44 0.00e+00 733.00
IUUC-Eca-033263 Equus caballus 90.29 0.00e+00 819.00
IUUC-Eeu-034699 Erinaceus europaeus 80.75 4.00e-116 411.00
IUUC-Fca-036366 Felis catus 89.86 0.00e+00 926.00
IUUC-Fal-037257 Ficedula albicollis 56.58 4.00e-157 547.00
IUUC-Gmo-038512 Gadus morhua 35.37 4.00e-69 255.00
IUUC-Gga-041125 Gallus gallus 54.81 2.00e-106 379.00
IUUC-Gac-042136 Gasterosteus aculeatus 35.31 9.00e-71 260.00
IUUC-Ggo-045233 Gorilla gorilla 100.00 0.00e+00 653.00
IUUC-Itr-048751 Ictidomys tridecemlineatus 91.67 0.00e+00 921.00
IUUC-Lch-049548 Latimeria chalumnae 35.12 1.00e-81 297.00
IUUC-Loc-051729 Lepisosteus oculatus 35.89 2.00e-82 299.00
IUUC-Laf-054322 Loxodonta africana 90.79 0.00e+00 911.00
IUUC-Mcc-055555 Macaca mulatta 97.39 0.00e+00 1000.00
IUUC-Meu-055900 Macropus eugenii 80.46 0.00e+00 804.00
IUUC-Mga-059380 Meleagris gallopavo 56.23 3.00e-105 375.00
IUUC-Mmr-061296 Microcebus murinus 92.09 0.00e+00 935.00
IUUC-Mdo-062811 Monodelphis domestica 80.50 0.00e+00 804.00
IUUC-Mmu-063718 Mus musculus 79.42 0.00e+00 806.00
IUUC-Mpu-066219 Mustela putorius furo 90.44 0.00e+00 909.00
IUUC-Mlu-067033 Myotis lucifugus 85.77 0.00e+00 885.00
IUUC-Nle-069806 Nomascus leucogenys 99.13 0.00e+00 947.00
IUUC-Opr-070248 Ochotona princeps 82.61 0.00e+00 799.00
IUUC-Ont-072083 Oreochromis niloticus 32.79 5.00e-71 261.00
IUUC-Oan-073364 Ornithorhynchus anatinus 71.66 1.00e-99 355.00
IUUC-Ocu-074572 Oryctolagus cuniculus 93.90 0.00e+00 966.00
IUUC-Oga-088378 Otolemur garnettii 89.66 0.00e+00 905.00
IUUC-Oar-089516 Ovis aries 88.12 0.00e+00 886.00
IUUC-Ptr-091313 Pan troglodytes 100.00 0.00e+00 1021.00
IUUC-Pan-092877 Papio anubis 99.80 0.00e+00 1021.00
IUUC-Psi-093928 Pelodiscus sinensis 59.58 7.00e-164 570.00
IUUC-Pfo-096690 Poecilia formosa 34.95 2.00e-69 256.00
IUUC-Pab-098624 Pongo abelii 99.59 0.00e+00 1013.00
IUUC-Pca-100469 Procavia capensis 83.51 0.00e+00 838.00
IUUC-Pva-103227 Pteropus vampyrus 90.67 0.00e+00 934.00
IUUC-Rno-105778 Rattus norvegicus 79.22 0.00e+00 806.00
IUUC-Sha-107392 Sarcophilus harrisii 69.82 0.00e+00 690.00
IUUC-Sar-113297 Sorex araneus 72.09 4.00e-53 201.00
IUUC-Ssc-115739 Sus scrofa 89.81 0.00e+00 902.00
IUUC-Tru-117718 Takifugu rubripes 32.21 1.00e-63 237.00
IUUC-Tbe-127926 Tupaia belangeri 86.43 6.00e-138 484.00
IUUC-Ttr-129293 Tursiops truncatus 90.87 0.00e+00 927.00
IUUC-Vpa-130379 Vicugna pacos 91.28 3.00e-159 554.00
IUUC-Xma-134222 Xiphophorus maculatus 33.12 3.00e-62 233.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved