iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000153207.14	ENST00000366508.5	ENSP00000355464.1
ENSG00000153207.14	ENST00000326225.3	ENSP00000355465.1
ENSG00000153207.14	ENST00000498601.1	ENSP00000418007.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
RepTar	miRNAMap	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Variation
GWASdb	GWAS Central	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosSNP	PhosphositePlus
dbPTM	HPRD	Phospho.ELM	UniProt
PHOSIDA	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	23.00	1.00e-05	51.20	IUUC-Ath-006911
E3 activity/RING/RING	20.57	6.00e-06	51.60	IUUC-Osa-086280

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Homo sapiens

Functional Description
(View)

Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis.

Protein Sequence
(Fasta)

MAAERRCGSM RDLRAQVTSG LLPFPEVTLQ ALGEDEITLE SVLRGKFAAG KNGLACLACG 60
PQLEVVNSIT GERLSAYRFS GVNEQPPVVL AVKEFSWQKR TGLLIGLEET EGSVLCLYDL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTCCCTCCC TTCCGGGGCG TGTGGAACTC GGTTTTGTCG GCGCAGGGTA ATGCGCAGAG 60
CGGGGCCGGC GCTGTCCGAG GCGAGCAGGC AGCGTTGCAA GGGGAAGGAC CCAGAAGCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0132--Cell division
KW-0137--Centromere
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0238--DNA-binding
KW-0995--Kinetochore
KW-0509--mRNA transport
KW-0906--Nuclear pore complex
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0811--Translocation
KW-0813--Transport

Interpro

IPR032040--ELYS-bb
IPR025151--ELYS_dom
IPR011047--Quinoprotein_ADH-like_supfam
IPR011990--TPR-like_helical_dom
IPR015943--WD40/YVTN_repeat-like_dom

Pfam

PF13934--ELYS
PF16687--ELYS-bb

Gene Ontology

GO:0000777--C:condensed chromosome kinetochore
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0016363--C:nuclear matrix
GO:0031965--C:nuclear membrane
GO:0034399--C:nuclear periphery
GO:0005643--C:nuclear pore
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0000910--P:cytokinesis
GO:0051028--P:mRNA transport
GO:0051292--P:nuclear pore complex assembly
GO:0015031--P:protein transport
GO:0007062--P:sister chromatid cohesion

KEGG

hsa:25909

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001495	Ailuropoda melanoleuca	70.25	0.00e+00	2966.00
IUUC-Atr-003128	Amborella trichopoda	22.39	3.00e-12	67.80
IUUC-Aca-004538	Anolis carolinensis	50.84	0.00e+00	2063.00
IUUC-Ath-006911	Arabidopsis thaliana	23.00	4.00e-07	50.80
IUUC-Bdi-014716	Brachypodium distachyon	20.07	1.00e-07	52.80
IUUC-Cja-019346	Callithrix jacchus	86.05	0.00e+00	3655.00
IUUC-Cfa-021184	Canis familiaris	70.55	0.00e+00	2948.00
IUUC-Cpo-021809	Cavia porcellus	73.28	0.00e+00	3164.00
IUUC-Csa-024229	Chlorocebus sabaeus	95.51	0.00e+00	4062.00
IUUC-Eeu-034782	Erinaceus europaeus	65.34	0.00e+00	1209.00
IUUC-Fca-036466	Felis catus	68.58	0.00e+00	2959.00
IUUC-Fal-036694	Ficedula albicollis	58.54	0.00e+00	2158.00
IUUC-Gmo-039692	Gadus morhua	59.30	0.00e+00	1440.00
IUUC-Ggo-045004	Gorilla gorilla	97.20	0.00e+00	4080.00
IUUC-Hvu-047462	Hordeum vulgare	20.55	3.00e-07	51.20
IUUC-Itr-048971	Ictidomys tridecemlineatus	77.20	0.00e+00	3403.00
IUUC-Lpe-051358	Leersia perrieri	18.75	1.00e-04	42.70
IUUC-Loc-052453	Lepisosteus oculatus	67.84	0.00e+00	1722.00
IUUC-Mcc-055404	Macaca mulatta	95.34	0.00e+00	4240.00
IUUC-Mmr-061515	Microcebus murinus	82.76	0.00e+00	3748.00
IUUC-Mmu-063425	Mus musculus	69.71	0.00e+00	2898.00
IUUC-Mac-065210	Musa acuminata	22.32	4.00e-07	50.40
IUUC-Nle-070006	Nomascus leucogenys	97.94	0.00e+00	3681.00
IUUC-Oba-075582	Oryza barthii	18.36	1.00e-03	39.30
IUUC-Obr-076132	Oryza brachyantha	21.53	8.00e-07	49.70
IUUC-Ogl-077653	Oryza glaberrima	20.57	2.00e-07	51.60
IUUC-Ogu-078815	Oryza glumaepatula	19.22	2.00e-05	45.10
IUUC-Osa-086280	Oryza sativa	23.00	4.00e-07	50.80
IUUC-Oga-089130	Otolemur garnettii	78.22	0.00e+00	3436.00
IUUC-Pan-092702	Papio anubis	94.57	0.00e+00	3749.00
IUUC-Ppa-095437	Physcomitrella patens	21.48	7.00e-11	62.80
IUUC-Pab-097569	Pongo abelii	96.31	0.00e+00	4364.00
IUUC-Pop-099913	Populus trichocarpa	22.22	2.00e-08	55.10
IUUC-Ppe-102080	Prunus persica	23.16	4.00e-10	60.80
IUUC-Smo-109433	Selaginella moellendorffii	22.69	1.00e-03	38.90
IUUC-Sit-110519	Setaria italica	20.68	3.00e-05	44.70
IUUC-Sly-111501	Solanum lycopersicum	22.22	4.00e-09	57.40
IUUC-Stu-112823	Solanum tuberosum	21.90	7.00e-09	56.60
IUUC-Sbi-113975	Sorghum bicolor	19.80	1.10e+00	28.10
IUUC-Sre-114890	Sporisorium reilianum	21.09	3.00e-04	41.20
IUUC-Tni-119734	Tetraodon nigroviridis	60.45	0.00e+00	1455.00
IUUC-Tca-121088	Theobroma cacao	23.44	2.00e-08	55.10
IUUC-Tae-123947	Triticum aestivum	20.57	6.00e-07	50.10
IUUC-Uma-129330	Ustilago maydis	20.69	2.00e-03	38.50
IUUC-Vvi-130863	Vitis vinifera	23.44	6.00e-11	63.50
IUUC-Xtr-132698	Xenopus tropicalis	69.29	0.00e+00	1561.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence