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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046605
UUCD1 version UUC-HoS-00155
Ensembl Protein ID ENSP00000310841.4
UniProt Accession Q5XUX0; Q5K680; Q8WYV1; Q96D73; Q9UFV4; FBX31_HUMAN
Genbank Protein ID AAU50679.1; AAQ04213.1; AAL55855.1; AAH12748.1; CAB55929.2
Protein Name F-box only protein 31
Genbank Nucleotide ID AY736035; AF428140; AF318348; AC010531; AL117444
Gene Name FBXO31; FBX14; FBX31; PP2386
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000103264.16 ENST00000311635.11 ENSP00000310841.4
ENSG00000103264.16 ENST00000565593.1 ENSP00000455772.1
ENSG00000103264.16 ENST00000636077.1 ENSP00000490402.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircRNADbCircNetmiRTarBase
microRNATRANSFACTargetScanRepTar
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProt
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box F-box 19412162; 23469015; 24936062
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/SCF/F-box 3.90e-05 25.4 12 109
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/SCF/F-box
   S: 45   parpraqrrasrrtprqpprgpsaaakpkaglrseaaaapapapaptptpeegpdaglldrlpeeilveilklldkeellraarvcrrwqel 136
           p+r  ++rr  rr p +     s         r ea+a      +  p+p   p + +l +lp e+lvei+  l++++l ++a+vc +++++
   Q: 12   PSRG-CRRRQQRRGPAETAAADSEPDTDPEEERIEASAGVGGGLCAGPSP--PPPRCSLLELPPELLVEIFASLPGTDLPSLAQVCTKFRRI 100
           5543.345555555555544444443333445666666655555555554..68899*********************************99 PP
   S: 137  asqkalwkt 145
            +++++w++
   Q: 101  LHTDTIWRR 109
           999999986 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. May act as a tumor suppressor.
 Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. May act as a tumor suppressor.
Protein Sequence
(Fasta)
MAVCARLCGV GPSRGCRRRQ QRRGPAETAA ADSEPDTDPE EERIEASAGV GGGLCAGPSP 60
PPPRCSLLEL PPELLVEIFA SLPGTDLPSL AQVCTKFRRI LHTDTIWRRR CREEYGVCEN 120
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Protein Fasta Sequence


>IUUC-Hsa-046605|E3,F-box|Homo sapiens
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Nucleotide Sequence
(Fasta)
GCATGCTCCC GGTCGTGCCC CAGCCCCGCC CAGCACCGCT GGGCGCCTGA GGCCCCTGAG 60
GTGACGGTTG TGGGCTGGGC CGCACCCCGG GTCTGTGGGC GCTCGGGAGC CTGCTGCCCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046605|E3,F-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0991--Mental retardation
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR001810--F-box_dom
IPR026941--FBXO31
PROSITE

PS50181--FBOX
Pfam

PF12937--F-box-like
SMART

SM00256--FBOX
Gene Ontology

GO:0005813--C:centrosome
GO:0005829--C:cytosol
GO:0043025--C:neuronal cell body
GO:0019005--C:SCF ubiquitin ligase complex
GO:0030332--F:cyclin binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0006974--P:cellular response to DNA damage stimulus
GO:0031571--P:mitotic G1 DNA damage checkpoint
GO:0050775--P:positive regulation of dendrite morphogenesis
GO:2001224--P:positive regulation of neuron migration
GO:0000209--P:protein polyubiquitination
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
KEGG hsa:79791
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000641 Aegilops tauschii 33.87 5.00e-04 38.50
IUUC-Aml-001283 Ailuropoda melanoleuca 80.20 0.00e+00 739.00
IUUC-Atr-003100 Amborella trichopoda 28.57 8.00e-04 39.30
IUUC-Apl-003209 Anas platyrhynchos 83.45 9.00e-143 500.00
IUUC-Aca-004894 Anolis carolinensis 83.08 4.00e-161 561.00
IUUC-Aly-005512 Arabidopsis lyrata 34.12 6.00e-04 39.70
IUUC-Ath-007284 Arabidopsis thaliana 31.53 1.00e-05 45.10
IUUC-Ame-011867 Astyanax mexicanus 64.96 0.00e+00 657.00
IUUC-Bta-012497 Bos taurus 77.51 0.00e+00 724.00
IUUC-Bdi-014535 Brachypodium distachyon 38.46 2.00e-03 37.70
IUUC-Cja-019896 Callithrix jacchus 91.18 0.00e+00 895.00
IUUC-Cfa-020183 Canis familiaris 87.38 0.00e+00 725.00
IUUC-Cpo-022420 Cavia porcellus 86.46 0.00e+00 871.00
IUUC-Cre-022968 Chlamydomonas reinhardtii 33.33 3.00e-04 40.40
IUUC-Csa-023606 Chlorocebus sabaeus 88.99 0.00e+00 910.00
IUUC-Dre-028579 Danio rerio 67.40 5.00e-148 517.00
IUUC-Dno-030013 Dasypus novemcinctus 82.04 8.00e-149 520.00
IUUC-Dor-030865 Dipodomys ordii 84.84 0.00e+00 794.00
IUUC-Eca-033625 Equus caballus 85.98 0.00e+00 714.00
IUUC-Eeu-034639 Erinaceus europaeus 76.26 0.00e+00 657.00
IUUC-Fca-036551 Felis catus 74.32 0.00e+00 703.00
IUUC-Fal-037031 Ficedula albicollis 80.60 0.00e+00 738.00
IUUC-Gmo-039215 Gadus morhua 70.34 2.00e-134 472.00
IUUC-Gga-040962 Gallus gallus 94.26 6.00e-171 593.00
IUUC-Gac-041683 Gasterosteus aculeatus 64.56 0.00e+00 641.00
IUUC-Ggo-044776 Gorilla gorilla 97.40 0.00e+00 900.00
IUUC-Hvu-047259 Hordeum vulgare 33.33 2.00e-03 37.70
IUUC-Itr-048607 Ictidomys tridecemlineatus 89.18 0.00e+00 714.00
IUUC-Lch-050047 Latimeria chalumnae 65.55 0.00e+00 683.00
IUUC-Lpe-051286 Leersia perrieri 34.69 2.00e-03 37.70
IUUC-Loc-052230 Lepisosteus oculatus 69.48 5.00e-179 620.00
IUUC-Laf-053797 Loxodonta africana 86.46 0.00e+00 845.00
IUUC-Mcc-055189 Macaca mulatta 97.82 0.00e+00 677.00
IUUC-Meu-055993 Macropus eugenii 74.21 2.00e-158 552.00
IUUC-Mga-059198 Meleagris gallopavo 85.71 2.00e-145 508.00
IUUC-Mvi-060509 Microbotryum violaceum 29.76 1.50e-02 35.00
IUUC-Mmr-061738 Microcebus murinus 92.42 0.00e+00 798.00
IUUC-Mdo-062753 Monodelphis domestica 88.54 3.00e-180 624.00
IUUC-Mmu-063936 Mus musculus 91.91 4.00e-179 621.00
IUUC-Mpu-066236 Mustela putorius furo 87.12 0.00e+00 719.00
IUUC-Mlu-068199 Myotis lucifugus 82.94 0.00e+00 815.00
IUUC-Nle-069835 Nomascus leucogenys 99.77 0.00e+00 774.00
IUUC-Opr-071142 Ochotona princeps 83.09 0.00e+00 795.00
IUUC-Ont-071669 Oreochromis niloticus 66.46 0.00e+00 640.00
IUUC-Oan-072716 Ornithorhynchus anatinus 85.48 0.00e+00 714.00
IUUC-Ocu-074345 Oryctolagus cuniculus 86.95 0.00e+00 733.00
IUUC-Oba-075322 Oryza barthii 32.00 4.00e-03 36.60
IUUC-Obr-076323 Oryza brachyantha 28.57 9.00e-04 37.70
IUUC-Ogu-078551 Oryza glumaepatula 32.00 4.00e-03 36.60
IUUC-Oin-079844 Oryza indica 32.00 8.00e-03 35.40
IUUC-Olo-080388 Oryza longistaminata 32.00 2.00e-03 36.20
IUUC-Ome-081606 Oryza meridionalis 32.00 5.00e-03 36.20
IUUC-Oni-082615 Oryza nivara 32.00 9.00e-03 35.40
IUUC-Opu-083870 Oryza punctata 32.00 5.00e-03 36.20
IUUC-Osa-086248 Oryza sativa 34.04 1.10e-02 35.00
IUUC-Ola-087311 Oryzias latipes 69.80 3.00e-164 571.00
IUUC-Oga-089001 Otolemur garnettii 82.69 0.00e+00 855.00
IUUC-Oar-089350 Ovis aries 78.14 0.00e+00 682.00
IUUC-Ptr-090976 Pan troglodytes 94.84 0.00e+00 894.00
IUUC-Pan-092129 Papio anubis 93.92 0.00e+00 924.00
IUUC-Psi-093747 Pelodiscus sinensis 76.38 4.00e-137 481.00
IUUC-Pma-094219 Petromyzon marinus 74.80 6.00e-100 357.00
IUUC-Pfo-096548 Poecilia formosa 68.03 0.00e+00 648.00
IUUC-Pab-098720 Pongo abelii 95.03 0.00e+00 940.00
IUUC-Pop-099194 Populus trichocarpa 30.67 3.00e-04 40.40
IUUC-Pca-101114 Procavia capensis 69.47 2.00e-108 386.00
IUUC-Pva-102268 Pteropus vampyrus 94.58 1.00e-169 589.00
IUUC-Pgr-103461 Puccinia graminis 45.45 5.00e-05 43.10
IUUC-Ptt-103780 Puccinia triticina 42.86 1.00e-03 38.10
IUUC-Rno-105274 Rattus norvegicus 85.53 0.00e+00 815.00
IUUC-Sha-107258 Sarcophilus harrisii 81.92 0.00e+00 680.00
IUUC-Sit-110285 Setaria italica 36.73 7.00e-03 35.80
IUUC-Stu-112846 Solanum tuberosum 26.32 1.60e-02 34.70
IUUC-Ssc-115393 Sus scrofa 78.43 0.00e+00 821.00
IUUC-Tgu-116622 Taeniopygia guttata 74.21 0.00e+00 753.00
IUUC-Tru-118647 Takifugu rubripes 63.56 0.00e+00 631.00
IUUC-Tni-120516 Tetraodon nigroviridis 65.12 0.00e+00 659.00
IUUC-Tae-122758 Triticum aestivum 36.23 5.00e-04 39.70
IUUC-Tur-126040 Triticum urartu 33.87 5.00e-04 38.10
IUUC-Tme-127118 Tuber melanosporum 39.13 2.00e-04 40.40
IUUC-Tbe-127269 Tupaia belangeri 85.35 0.00e+00 680.00
IUUC-Ttr-129258 Tursiops truncatus 83.45 0.00e+00 704.00
IUUC-Vpa-130056 Vicugna pacos 70.48 3.00e-39 155.00
IUUC-Vvi-131420 Vitis vinifera 33.33 6.00e-03 36.20
IUUC-Xtr-132268 Xenopus tropicalis 68.21 0.00e+00 695.00
IUUC-Xma-134200 Xiphophorus maculatus 67.60 0.00e+00 642.00
Created Date 25-Jun-2017

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