iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046269

UUCD1 version

UUC-HoS-00296

Ensembl Protein ID

ENSP00000315112.6

UniProt Accession

Q96EP0; A0A962; Q86VI2; Q8TEI0; Q96GB4; Q96NF1; Q9H5F1; Q9NWD2; RNF31_HUMAN

Genbank Protein ID

AAP12522.1; BAF35583.1; BAA91450.1; BAB15675.1; BAB70948.1; BAF83936.1; EAW66098.1; AAH09821.3; AAH12077.1; AAH17376.3; BAB84970.1

Protein Name

E3 ubiquitin-protein ligase RNF31; HOIL-1-interacting protein; RING finger protein 31; RING-type E3 ubiquitin transferase RNF31; Zinc in-between-RING-finger ubiquitin-associated domain protein

Genbank Nucleotide ID

AY256461; AB265810; AK000973; AK027154; AK055542; AK291247; AL136295; BC009821; BC012077; BC017376; AK074144

Gene Name

RNF31; ZIBRA; HOIP

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000092098.16	ENST00000559275.5	ENSP00000453574.1
ENSG00000092098.16	ENST00000324103.10	ENSP00000315112.6
ENSG00000092098.16	ENST00000491351.5	ENSP00000453595.1
ENSG00000092098.16	ENST00000558907.5	ENSP00000453601.1
ENSG00000092098.16	ENST00000560787.5	ENSP00000452972.1
ENSG00000092098.16	ENST00000559449.5	ENSP00000454140.1
ENSG00000092098.16	ENST00000483895.5	ENSP00000453672.1
ENSG00000092098.16	ENST00000559719.1	ENSP00000452820.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	CircNet	microRNA
TRANSFAC	TargetScan	RepTar	miRNAMap
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	GWASdb	OMIM
Drug and target
TTD
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RBR	RBR	21455180; 19237537; 21292167; 20614026
UBD/ZnF/NZF	NZF	21455181

Classification

Family	E-value	Score	Start	End
UBD/ZnF/NZF	3.90e-27	95.1	351	377
UBD/Alpha-Helix/UBA	0.00014	23.5	579	612

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/ZnF/NZF

   S: 2    eaqWaCsaCTflNePeavkCemCsrpR 28
           ++ WaC++CTf+Ne++av C++C+rpR
   Q: 351  RGRWACQSCTFENEAAAVLCSICERPR 377
           578***********************9 PP

UBD/Alpha-Helix/UBA

   S: 6    kleqlveMGF.dreealqaLraannnleaAveyL 38
           k+++l++ GF ++e  lqaL ++++++ +A++ L
   Q: 579  KVQELQSLGFgPEEGSLQALFQHGGDVSRALTEL 612
           8*****************************9987 PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:21455173). LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (PubMed:20005846). Together with otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. Binds polyubiquitin of different linkage types (PubMed:23708998).

Protein Sequence
(Fasta)

MPGEEEERAF LVAREELASA LRRDSGQAFS LEQLRPLLAS SLPLAARYLQ LDAARLVRCN 60
AHGEPRNYLN TLSTALNILE KYGRNLLSPQ RPRYWRGVKF NNPVFRSTVD AVQGGRDVLR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTCTTTCCGC CCCCCTCCTC CCGCTGGCAG GCCGCAAGCA GTAGGTAGCC CCTCAGCCAT 60
TCCCAGCCAG TTGCCACTAG GAGAGGCGGT GCTGGCTGGG TCACAGTCCA GGGGCTGCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR016150--Casein_kin_II_reg-sub_b-sht
IPR002867--IBR_dom
IPR018997--PUB_domain
IPR026254--RNF31
IPR032065--RNF31-UBA
IPR015940--UBA
IPR001876--Znf_RanBP2
IPR017907--Znf_RING_CS

PROSITE

PS50030--UBA
PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2
PS00518--ZF_RING_1

Pfam

PF16678--HOIP-UBA
PF01485--IBR
PF09409--PUB

SMART

SM00647--IBR
SM00547--ZnF_RBZ

Gene Ontology

GO:0035631--C:CD40 receptor complex
GO:0009898--C:cytoplasmic side of plasma membrane
GO:0005829--C:cytosol
GO:0071797--C:LUBAC complex
GO:0043130--F:ubiquitin binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0023035--P:CD40 signaling pathway
GO:0007249--P:I-kappaB kinase/NF-kappaB signaling
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:0097039--P:protein linear polyubiquitination
GO:0000209--P:protein polyubiquitination
GO:0010803--P:regulation of tumor necrosis factor-mediated signaling pathway
GO:0050852--P:T cell receptor signaling pathway

KEGG

hsa:55072

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002017	Ailuropoda melanoleuca	92.67	0.00e+00	1811.00
IUUC-Aca-004719	Anolis carolinensis	56.67	0.00e+00	900.00
IUUC-Ame-011924	Astyanax mexicanus	38.41	5.00e-122	432.00
IUUC-Bta-012795	Bos taurus	88.25	0.00e+00	1702.00
IUUC-Cja-019168	Callithrix jacchus	96.10	0.00e+00	1900.00
IUUC-Cfa-020767	Canis familiaris	92.55	0.00e+00	1828.00
IUUC-Cpo-022291	Cavia porcellus	87.78	0.00e+00	1792.00
IUUC-Csa-024246	Chlorocebus sabaeus	97.90	0.00e+00	1644.00
IUUC-Cho-024866	Choloepus hoffmanni	60.51	0.00e+00	881.00
IUUC-Cin-025568	Ciona intestinalis	34.36	1.00e-94	341.00
IUUC-Dre-027426	Danio rerio	45.21	0.00e+00	782.00
IUUC-Dno-029925	Dasypus novemcinctus	88.81	0.00e+00	1724.00
IUUC-Dor-030389	Dipodomys ordii	84.08	0.00e+00	1599.00
IUUC-Dme-031816	Drosophila melanogaster	40.31	7.00e-88	320.00
IUUC-Ete-032383	Echinops telfairi	96.13	0.00e+00	735.00
IUUC-Eca-033807	Equus caballus	91.90	0.00e+00	1856.00
IUUC-Eeu-034745	Erinaceus europaeus	77.96	0.00e+00	850.00
IUUC-Fca-036464	Felis catus	92.66	0.00e+00	1831.00
IUUC-Gmo-039121	Gadus morhua	44.65	0.00e+00	637.00
IUUC-Gac-041766	Gasterosteus aculeatus	46.69	0.00e+00	841.00
IUUC-Ggo-045259	Gorilla gorilla	99.44	0.00e+00	1933.00
IUUC-Itr-048764	Ictidomys tridecemlineatus	91.42	0.00e+00	1956.00
IUUC-Lch-049622	Latimeria chalumnae	52.63	0.00e+00	1098.00
IUUC-Laf-054027	Loxodonta africana	90.39	0.00e+00	1759.00
IUUC-Mcc-054906	Macaca mulatta	98.13	0.00e+00	1958.00
IUUC-Meu-056354	Macropus eugenii	70.97	0.00e+00	1388.00
IUUC-Mmr-060835	Microcebus murinus	93.24	0.00e+00	1798.00
IUUC-Mdo-061883	Monodelphis domestica	77.93	0.00e+00	1588.00
IUUC-Mmu-064014	Mus musculus	85.54	0.00e+00	1719.00
IUUC-Mlu-067075	Myotis lucifugus	89.47	0.00e+00	1756.00
IUUC-Nle-069954	Nomascus leucogenys	99.07	0.00e+00	1946.00
IUUC-Opr-070399	Ochotona princeps	84.05	0.00e+00	1729.00
IUUC-Ont-071593	Oreochromis niloticus	47.29	0.00e+00	870.00
IUUC-Oan-073591	Ornithorhynchus anatinus	91.21	6.00e-47	179.00
IUUC-Ocu-073785	Oryctolagus cuniculus	72.86	0.00e+00	1372.00
IUUC-Ogl-077291	Oryza glaberrima	26.55	2.00e-04	40.00
IUUC-Oin-079800	Oryza indica	26.72	3.00e-04	39.30
IUUC-Oni-082829	Oryza nivara	26.72	3.00e-04	39.30
IUUC-Ola-087261	Oryzias latipes	47.15	0.00e+00	848.00
IUUC-Oga-088724	Otolemur garnettii	94.38	0.00e+00	1840.00
IUUC-Oar-089318	Ovis aries	89.00	0.00e+00	1828.00
IUUC-Ptr-091249	Pan troglodytes	99.53	0.00e+00	1950.00
IUUC-Pan-092080	Papio anubis	97.86	0.00e+00	1981.00
IUUC-Pma-094655	Petromyzon marinus	50.63	3.00e-67	248.00
IUUC-Pfo-096097	Poecilia formosa	44.92	0.00e+00	847.00
IUUC-Pab-098380	Pongo abelii	97.11	0.00e+00	1879.00
IUUC-Pca-101024	Procavia capensis	83.80	0.00e+00	1685.00
IUUC-Pva-102289	Pteropus vampyrus	91.23	0.00e+00	1784.00
IUUC-Rno-105864	Rattus norvegicus	86.46	0.00e+00	1719.00
IUUC-Sha-107428	Sarcophilus harrisii	78.19	0.00e+00	1518.00
IUUC-Sar-113745	Sorex araneus	86.94	0.00e+00	1742.00
IUUC-Ssc-116246	Sus scrofa	92.19	0.00e+00	1774.00
IUUC-Tru-118704	Takifugu rubripes	45.24	0.00e+00	821.00
IUUC-Tsy-119077	Tarsius syrichta	91.67	0.00e+00	1524.00
IUUC-Tni-120343	Tetraodon nigroviridis	45.64	0.00e+00	825.00
IUUC-Tbe-127822	Tupaia belangeri	92.78	0.00e+00	838.00
IUUC-Ttr-129179	Tursiops truncatus	86.75	0.00e+00	1708.00
IUUC-Xtr-132864	Xenopus tropicalis	50.86	0.00e+00	968.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence