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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046895
Ensembl Protein ID ENSP00000348089.5
UniProt Accession Q03468; D3DX94; E7EV46; Q5W0L9; ERCC6_HUMAN
Genbank Protein ID AAA52397.1; AAO13487.1; CAH70291.1; EAW93094.1; EAW93097.1
Protein Name DNA excision repair protein ERCC-6; ATP-dependent helicase ERCC6; Cockayne syndrome protein CSB
Genbank Nucleotide ID L04791; AY204752; AC073366; CH471187; CH471187
Gene Name ERCC6; CSB
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000225830.11 ENST00000624341.3 ENSP00000485163.1
ENSG00000225830.11 ENST00000355832.9 ENSP00000348089.5
ENSG00000225830.11 ENST00000447839.6 ENSP00000387966.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
AREsitecircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/CUE CUE 20541997
UBD/Alpha-Helix/UBA UBA 20541997
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Isoform 2: Like isoform 1, it is involved in repair of DNA damage, acting on its own or synergistically with isoform 1. May bind to PiggyBac transposable elements known as MER85 scattered in the genome and may therefore regulate the expression of nearby genes. Able to stimulate the antiviral response and modulate the expression of genes involved in metabolism regulation.
 Isoform 2: Like isoform 1, it is involved in repair of DNA damage, acting on its own or synergistically with isoform 1. May bind to PiggyBac transposable elements known as MER85 scattered in the genome and may therefore regulate the expression of nearby genes. Able to stimulate the antiviral response and modulate the expression of genes involved in metabolism regulation.
Protein Sequence
(Fasta)
MPNEGIPHSS QTQEQDCLQS QPVSNNEEMA IKQESGGDGE VEEYLSFRSV GDGLSTSAVG 60
CASAAPRRGP ALLHIDRHQI QAVEPSAQAL ELQGLGVDVY DQDVLEQGVL QQVDNAIHEA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046895|UBD,CUE;UBD,UBA|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGGTGCGCGC GTGGCGGAGG GGGAACAGAG AAGCAGGACA GCTCTCCATC CTTCCCGTGT 60
TCAGTCGTGG GAGACAACAA GAGAGGTCAC AGCCTGGCGA CCAAAAAGTG CGGCTAACTT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046895|UBD,CUE;UBD,UBA|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0913--Age-related macular degeneration
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0898--Cataract
KW-0172--Cockayne syndrome
KW-0181--Complete proteome
KW-0209--Deafness
KW-0225--Disease mutation
KW-0227--DNA damage
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0242--Dwarfism
KW-0347--Helicase
KW-0378--Hydrolase
KW-0991--Mental retardation
KW-0488--Methylation
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1066--Premature ovarian failure
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0857--Xeroderma pigmentosum
Interpro

IPR014001--Helicase_ATP-bd
IPR001650--Helicase_C
IPR027417--P-loop_NTPase
IPR000330--SNF2_N
PROSITE

PS51192--HELICASE_ATP_BIND_1
PS51194--HELICASE_CTER
Pfam

PF00271--Helicase_C
PF00176--SNF2_N
SMART

SM00487--DEXDc
SM00490--HELICc
Gene Ontology

GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0008023--C:transcription elongation factor complex
GO:0005524--F:ATP binding
GO:0003682--F:chromatin binding
GO:0003677--F:DNA binding
GO:0008094--F:DNA-dependent ATPase activity
GO:0004386--F:helicase activity
GO:0008022--F:protein C-terminus binding
GO:0032403--F:protein complex binding
GO:0047485--F:protein N-terminus binding
GO:0030296--F:protein tyrosine kinase activator activity
GO:0070063--F:RNA polymerase binding
GO:0007256--P:activation of JNKK activity
GO:0007257--P:activation of JUN kinase activity
GO:0006284--P:base-excision repair
GO:0006281--P:DNA repair
GO:0008630--P:intrinsic apoptotic signaling pathway in response to DNA damage
GO:0035264--P:multicellular organism growth
GO:0045494--P:photoreceptor cell maintenance
GO:0032786--P:positive regulation of DNA-templated transcription, elongation
GO:0045815--P:positive regulation of gene expression, epigenetic
GO:0006290--P:pyrimidine dimer repair
GO:0032784--P:regulation of DNA-templated transcription, elongation
GO:0010332--P:response to gamma radiation
GO:0006979--P:response to oxidative stress
GO:0000303--P:response to superoxide
GO:0009636--P:response to toxic substance
GO:0009411--P:response to UV
GO:0010224--P:response to UV-B
GO:0010165--P:response to X-ray
GO:0006362--P:transcription elongation from RNA polymerase I promoter
GO:0006366--P:transcription from RNA polymerase II promoter
GO:0006283--P:transcription-coupled nucleotide-excision repair
KEGG hsa:2074
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000518 Aegilops tauschii 53.09 0.00e+00 642.00
IUUC-Aml-002021 Ailuropoda melanoleuca 82.47 0.00e+00 2335.00
IUUC-Atr-002868 Amborella trichopoda 52.63 0.00e+00 633.00
IUUC-Apl-003989 Anas platyrhynchos 65.51 0.00e+00 1798.00
IUUC-Aca-004609 Anolis carolinensis 65.40 0.00e+00 1373.00
IUUC-Aly-005912 Arabidopsis lyrata 52.79 0.00e+00 632.00
IUUC-Ath-006812 Arabidopsis thaliana 52.44 0.00e+00 630.00
IUUC-Ago-007719 Ashbya gossypii 52.78 2.00e-179 623.00
IUUC-Acl-008050 Aspergillus clavatus 49.77 2.00e-179 623.00
IUUC-Afl-008677 Aspergillus flavus 51.84 2.00e-171 596.00
IUUC-Afu-008975 Aspergillus fumigatus 51.84 8.00e-179 621.00
IUUC-Ani-009464 Aspergillus nidulans 50.80 2.00e-178 620.00
IUUC-Ang-009516 Aspergillus niger 50.64 8.00e-168 584.00
IUUC-Aor-010057 Aspergillus oryzae 50.15 2.00e-173 603.00
IUUC-Ate-010307 Aspergillus terreus 51.95 6.00e-170 592.00
IUUC-Ame-011055 Astyanax mexicanus 63.23 0.00e+00 1259.00
IUUC-Bgr-012211 Blumeria graminis 49.68 2.00e-168 586.00
IUUC-Bta-012761 Bos taurus 76.35 0.00e+00 2101.00
IUUC-Bci-013603 Botrytis cinerea 51.93 0.00e+00 638.00
IUUC-Bdi-014031 Brachypodium distachyon 52.91 0.00e+00 638.00
IUUC-Bol-015096 Brassica oleracea 53.54 0.00e+00 641.00
IUUC-Bra-017583 Brassica rapa 53.53 0.00e+00 635.00
IUUC-Cel-018275 Caenorhabditis elegans 35.85 2.00e-105 377.00
IUUC-Cja-019733 Callithrix jacchus 93.84 0.00e+00 2594.00
IUUC-Cfa-020631 Canis familiaris 81.60 0.00e+00 2319.00
IUUC-Cpo-022218 Cavia porcellus 75.96 0.00e+00 1540.00
IUUC-Cre-022710 Chlamydomonas reinhardtii 49.73 4.00e-153 536.00
IUUC-Csa-023723 Chlorocebus sabaeus 97.12 0.00e+00 2704.00
IUUC-Cho-024312 Choloepus hoffmanni 79.15 0.00e+00 967.00
IUUC-Cin-025376 Ciona intestinalis 52.68 0.00e+00 836.00
IUUC-Cgl-026654 Colletotrichum gloeosporioides 46.55 3.00e-164 573.00
IUUC-Cme-027109 Cyanidioschyzon merolae 52.12 7.00e-157 548.00
IUUC-Dre-028672 Danio rerio 61.87 0.00e+00 1217.00
IUUC-Dno-028893 Dasypus novemcinctus 80.52 0.00e+00 2182.00
IUUC-Dor-031114 Dipodomys ordii 71.93 0.00e+00 1891.00
IUUC-Dse-031225 Dothistroma septosporum 49.84 0.00e+00 632.00
IUUC-Ete-032713 Echinops telfairi 74.29 0.00e+00 997.00
IUUC-Eca-034071 Equus caballus 80.88 0.00e+00 2269.00
IUUC-Eeu-034781 Erinaceus europaeus 82.39 0.00e+00 1766.00
IUUC-Fca-036561 Felis catus 82.31 0.00e+00 2324.00
IUUC-Fal-037343 Ficedula albicollis 61.00 0.00e+00 1674.00
IUUC-Fox-037667 Fusarium oxysporum 49.34 6.00e-158 551.00
IUUC-Fso-038331 Fusarium solani 51.69 2.00e-159 556.00
IUUC-Gmo-039132 Gadus morhua 82.37 0.00e+00 981.00
IUUC-Gga-040376 Gallus gallus 65.37 0.00e+00 1821.00
IUUC-Gac-042326 Gasterosteus aculeatus 76.81 0.00e+00 989.00
IUUC-Gma-043401 Glycine max 51.58 1.00e-180 627.00
IUUC-Ggo-044844 Gorilla gorilla 99.13 0.00e+00 2776.00
IUUC-Itr-048071 Ictidomys tridecemlineatus 82.08 0.00e+00 2332.00
IUUC-Kpa-049261 Komagataella pastoris 52.08 0.00e+00 658.00
IUUC-Lch-049934 Latimeria chalumnae 59.46 0.00e+00 1370.00
IUUC-Lpe-051249 Leersia perrieri 48.81 5.00e-148 518.00
IUUC-Loc-052591 Lepisosteus oculatus 61.99 0.00e+00 1536.00
IUUC-Lma-053210 Leptosphaeria maculans 49.08 5.00e-169 588.00
IUUC-Laf-054403 Loxodonta africana 80.95 0.00e+00 2229.00
IUUC-Mcc-054876 Macaca mulatta 96.86 0.00e+00 2733.00
IUUC-Meu-056545 Macropus eugenii 61.47 5.00e-136 479.00
IUUC-Mor-057145 Magnaporthe oryzae 49.12 5.00e-173 602.00
IUUC-Mpo-057493 Magnaporthe poae 49.51 2.00e-170 593.00
IUUC-Mtr-057734 Medicago truncatula 51.29 5.00e-180 625.00
IUUC-Mga-059402 Meleagris gallopavo 65.01 0.00e+00 1809.00
IUUC-Mmr-061791 Microcebus murinus 88.18 0.00e+00 2488.00
IUUC-Mdo-062148 Monodelphis domestica 70.66 0.00e+00 1926.00
IUUC-Mmu-063238 Mus musculus 78.19 0.00e+00 2180.00
IUUC-Mac-064440 Musa acuminata 50.89 1.00e-172 600.00
IUUC-Mpu-066112 Mustela putorius furo 82.15 0.00e+00 2296.00
IUUC-Mlu-067057 Myotis lucifugus 81.15 0.00e+00 2277.00
IUUC-Nfi-068617 Neosartorya fischeri 51.36 2.00e-179 623.00
IUUC-Ncr-068920 Neurospora crassa 48.04 3.00e-173 602.00
IUUC-Nle-069992 Nomascus leucogenys 97.86 0.00e+00 2738.00
IUUC-Opr-070929 Ochotona princeps 70.51 0.00e+00 1947.00
IUUC-Ont-071740 Oreochromis niloticus 62.73 0.00e+00 1253.00
IUUC-Oan-073380 Ornithorhynchus anatinus 68.48 0.00e+00 850.00
IUUC-Ocu-074143 Oryctolagus cuniculus 75.98 0.00e+00 2054.00
IUUC-Oba-075626 Oryza barthii 52.94 2.00e-179 623.00
IUUC-Obr-076240 Oryza brachyantha 52.35 0.00e+00 638.00
IUUC-Ogl-077187 Oryza glaberrima 52.60 8.00e-180 624.00
IUUC-Ogu-078629 Oryza glumaepatula 49.60 1.00e-143 504.00
IUUC-Oin-079268 Oryza indica 52.77 9.00e-180 624.00
IUUC-Olo-080567 Oryza longistaminata 49.01 9.00e-144 504.00
IUUC-Oni-082122 Oryza nivara 53.11 7.00e-180 624.00
IUUC-Opu-083477 Oryza punctata 52.42 0.00e+00 638.00
IUUC-Oru-084783 Oryza rufipogon 52.77 6.00e-180 625.00
IUUC-Osa-086206 Oryza sativa 52.77 1.00e-178 620.00
IUUC-Oga-088414 Otolemur garnettii 84.10 0.00e+00 2361.00
IUUC-Oar-089697 Ovis aries 80.01 0.00e+00 2286.00
IUUC-Ptr-090856 Pan troglodytes 99.33 0.00e+00 2789.00
IUUC-Pan-092521 Papio anubis 97.46 0.00e+00 2741.00
IUUC-Psi-093037 Pelodiscus sinensis 67.93 0.00e+00 1620.00
IUUC-Pma-094456 Petromyzon marinus 66.67 0.00e+00 838.00
IUUC-Pno-094861 Phaeosphaeria nodorum 48.78 2.00e-170 593.00
IUUC-Ppa-095711 Physcomitrella patens 50.33 0.00e+00 639.00
IUUC-Pfo-096223 Poecilia formosa 61.52 0.00e+00 1235.00
IUUC-Pab-098595 Pongo abelii 97.39 0.00e+00 2719.00
IUUC-Pop-099531 Populus trichocarpa 51.44 0.00e+00 634.00
IUUC-Pca-100770 Procavia capensis 81.93 0.00e+00 824.00
IUUC-Ppe-101528 Prunus persica 51.39 0.00e+00 630.00
IUUC-Pva-102247 Pteropus vampyrus 82.03 0.00e+00 1271.00
IUUC-Pte-104217 Pyrenophora teres 50.25 6.00e-171 595.00
IUUC-Pyt-104797 Pyrenophora triticirepentis 49.59 2.00e-172 600.00
IUUC-Rno-105742 Rattus norvegicus 76.42 0.00e+00 2107.00
IUUC-Sce-106234 Saccharomyces cerevisiae 51.05 0.00e+00 635.00
IUUC-Sha-106622 Sarcophilus harrisii 67.40 0.00e+00 1821.00
IUUC-Sja-107874 Schizosaccharomyces japonicus 51.17 0.00e+00 649.00
IUUC-Spo-108021 Schizosaccharomyces pombe 52.24 0.00e+00 654.00
IUUC-Ssl-108500 Sclerotinia sclerotiorum 52.40 0.00e+00 634.00
IUUC-Smo-109132 Selaginella moellendorffii 51.52 2.00e-175 610.00
IUUC-Sit-110066 Setaria italica 52.84 0.00e+00 638.00
IUUC-Sly-111833 Solanum lycopersicum 53.54 0.00e+00 644.00
IUUC-Stu-112189 Solanum tuberosum 53.71 0.00e+00 642.00
IUUC-Sar-113511 Sorex araneus 77.32 0.00e+00 1258.00
IUUC-Sbi-114606 Sorghum bicolor 53.19 0.00e+00 639.00
IUUC-Ssc-116374 Sus scrofa 83.50 0.00e+00 2423.00
IUUC-Tgu-117153 Taeniopygia guttata 60.29 0.00e+00 1564.00
IUUC-Tru-118178 Takifugu rubripes 61.96 0.00e+00 1249.00
IUUC-Tsy-119524 Tarsius syrichta 86.15 0.00e+00 2456.00
IUUC-Tni-120546 Tetraodon nigroviridis 55.82 0.00e+00 1388.00
IUUC-Tca-121065 Theobroma cacao 52.15 0.00e+00 635.00
IUUC-Tre-121868 Trichoderma reesei 48.93 2.00e-161 563.00
IUUC-Tvi-122455 Trichoderma virens 49.26 3.00e-158 553.00
IUUC-Tae-123249 Triticum aestivum 52.42 0.00e+00 642.00
IUUC-Tur-126107 Triticum urartu 53.37 0.00e+00 643.00
IUUC-Tbe-127967 Tupaia belangeri 81.10 0.00e+00 1080.00
IUUC-Ttr-128768 Tursiops truncatus 81.48 0.00e+00 2362.00
IUUC-Vda-129884 Verticillium dahliae 50.17 4.00e-175 608.00
IUUC-Vpa-130521 Vicugna pacos 82.04 0.00e+00 1099.00
IUUC-Vvi-130838 Vitis vinifera 51.55 3.00e-180 626.00
IUUC-Xtr-132056 Xenopus tropicalis 56.69 0.00e+00 1117.00
IUUC-Xma-133113 Xiphophorus maculatus 61.49 0.00e+00 1236.00
IUUC-Yli-134344 Yarrowia lipolytica 53.52 0.00e+00 644.00
IUUC-Zma-134837 Zea mays 51.55 1.00e-180 627.00
Created Date 25-Jun-2017

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