iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Mmu-063197

UUCD1 version

UUC-MuM-00994

Ensembl Protein ID

ENSMUSP00000005064.7

UniProt Accession

Q9JM05; Q8R165; PIAS4_MOUSE

Genbank Protein ID

AAF72040.1; AAH25159.1

Protein Name

E3 SUMO-protein ligase PIAS4; PIASy; Protein inhibitor of activated STAT protein 4; Protein inhibitor of activated STAT protein gamma; RING-type E3 ubiquitin transferase PIAS4

Genbank Nucleotide ID

AF109174; BC025159

Gene Name

Pias4; Piasg

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000004934.13	ENSMUST00000005064.13	ENSMUSP00000005064.7
ENSMUSG00000004934.13	ENSMUST00000146764.1	ENSMUSP00000122183.1
ENSMUSG00000004934.13	ENSMUST00000135765.1	ENSMUSP00000121361.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
miRNAMap	RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Post-translational Modifications (PTMs)
PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	86.80	0.00e+00	853.00	IUUC-Hsa-045784
E3 activity/RING/RING	32.37	2.00e-27	118.00	IUUC-Sce-106398

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Mus musculus

Functional Description
(View)

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (By similarity).

Protein Sequence
(Fasta)

MAAELVEAKN MVMSFRVSDL QMLLGFVGRS KSGLKHELVT RALQLVQFDC SPELFKKIKE 60
LYETRYAKKS AEPGPQAPRP LDPLALHSMP RTPLSGPTVD YPVLYGKYLN GLGRLPTKTL 120

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Nucleotide Sequence
(Fasta)

CAATTGTCCG TTGTGATTGG TCAGATCCTC GGGCGGGGTT CCTGTAGGCG CGTGCGCGTG 60
ATGCATCCTC CCGCCTCTCA GACGCGGGGG CGTGGAGGAA GGAGCCAGCA CTCGCTTTTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0945--Host-virus interaction
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0879--Wnt signaling pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR027224--PIAS4
IPR023321--PINIT
IPR003034--SAP_dom
IPR004181--Znf_MIZ

PROSITE

PS51466--PINIT
PS50800--SAP
PS51044--ZF_SP_RING

Pfam

PF14324--PINIT
PF02891--zf-MIZ

SMART

SM00513--SAP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0016363--C:nuclear matrix
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0016605--C:PML body
GO:1990234--C:transferase complex
GO:0003677--F:DNA binding
GO:0061665--F:SUMO ligase activity
GO:0019789--F:SUMO transferase activity
GO:0003714--F:transcription corepressor activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0008270--F:zinc ion binding
GO:0007259--P:JAK-STAT cascade
GO:0007275--P:multicellular organism development
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0010804--P:negative regulation of tumor necrosis factor-mediated signaling pathway
GO:1902231--P:positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:1902174--P:positive regulation of keratinocyte apoptotic process
GO:0033235--P:positive regulation of protein sumoylation
GO:0016925--P:protein sumoylation
GO:0006351--P:transcription, DNA-templated
GO:0016032--P:viral process
GO:0016055--P:Wnt signaling pathway

KEGG

mmu:59004

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001745	Ailuropoda melanoleuca	85.74	0.00e+00	817.00
IUUC-Apl-003765	Anas platyrhynchos	78.19	0.00e+00	766.00
IUUC-Ame-010763	Astyanax mexicanus	60.18	2.00e-146	512.00
IUUC-Bta-012369	Bos taurus	88.18	0.00e+00	847.00
IUUC-Bol-015380	Brassica oleracea	29.48	3.00e-18	87.00
IUUC-Bra-017443	Brassica rapa	29.48	1.00e-18	88.60
IUUC-Cja-019450	Callithrix jacchus	86.60	0.00e+00	842.00
IUUC-Cfa-020933	Canis familiaris	87.57	0.00e+00	842.00
IUUC-Cpo-022112	Cavia porcellus	89.05	0.00e+00	821.00
IUUC-Csa-023913	Chlorocebus sabaeus	75.34	0.00e+00	683.00
IUUC-Cgl-026533	Colletotrichum gloeosporioides	27.20	2.00e-32	133.00
IUUC-Dre-027609	Danio rerio	59.45	6.00e-143	500.00
IUUC-Dno-029664	Dasypus novemcinctus	73.11	4.00e-150	525.00
IUUC-Ete-032988	Echinops telfairi	89.91	1.00e-165	576.00
IUUC-Eca-034430	Equus caballus	84.05	0.00e+00	813.00
IUUC-Fca-035968	Felis catus	91.78	8.00e-157	546.00
IUUC-Fal-037449	Ficedula albicollis	78.94	0.00e+00	758.00
IUUC-Gmo-038925	Gadus morhua	61.35	5.00e-139	488.00
IUUC-Gga-040362	Gallus gallus	80.39	0.00e+00	793.00
IUUC-Gac-042353	Gasterosteus aculeatus	59.50	1.00e-134	473.00
IUUC-Ggo-044810	Gorilla gorilla	84.66	0.00e+00	810.00
IUUC-Hsa-045784	Homo sapiens	86.99	0.00e+00	857.00
IUUC-Itr-048486	Ictidomys tridecemlineatus	87.35	0.00e+00	838.00
IUUC-Lch-049727	Latimeria chalumnae	71.43	3.00e-151	527.00
IUUC-Loc-052354	Lepisosteus oculatus	53.74	2.00e-123	436.00
IUUC-Laf-054261	Loxodonta africana	87.38	0.00e+00	856.00
IUUC-Mcc-054931	Macaca mulatta	86.80	0.00e+00	843.00
IUUC-Meu-056468	Macropus eugenii	81.59	0.00e+00	814.00
IUUC-Mpo-057405	Magnaporthe poae	32.92	2.00e-28	120.00
IUUC-Mtr-058267	Medicago truncatula	33.93	4.00e-19	90.50
IUUC-Mga-059981	Meleagris gallopavo	86.77	0.00e+00	673.00
IUUC-Mvi-060421	Microbotryum violaceum	28.22	5.00e-27	116.00
IUUC-Mmr-061181	Microcebus murinus	85.38	0.00e+00	805.00
IUUC-Mdo-062345	Monodelphis domestica	82.17	0.00e+00	814.00
IUUC-Mpu-066275	Mustela putorius furo	85.63	0.00e+00	825.00
IUUC-Mlu-067194	Myotis lucifugus	86.85	0.00e+00	841.00
IUUC-Ont-072227	Oreochromis niloticus	59.50	2.00e-140	492.00
IUUC-Obr-076179	Oryza brachyantha	33.52	1.00e-20	95.10
IUUC-Ola-086865	Oryzias latipes	58.22	8.00e-139	486.00
IUUC-Oga-088945	Otolemur garnettii	87.96	0.00e+00	861.00
IUUC-Oar-089412	Ovis aries	85.35	0.00e+00	810.00
IUUC-Ptr-091550	Pan troglodytes	80.79	2.00e-173	600.00
IUUC-Pan-092183	Papio anubis	86.80	0.00e+00	853.00
IUUC-Psi-093003	Pelodiscus sinensis	79.81	0.00e+00	786.00
IUUC-Ppa-095583	Physcomitrella patens	39.20	2.00e-21	97.80
IUUC-Pfo-096704	Poecilia formosa	59.04	4.00e-142	498.00
IUUC-Pab-097923	Pongo abelii	93.44	0.00e+00	730.00
IUUC-Pca-100249	Procavia capensis	75.41	4.00e-139	487.00
IUUC-Pva-102562	Pteropus vampyrus	82.18	0.00e+00	778.00
IUUC-Rno-105762	Rattus norvegicus	98.62	0.00e+00	924.00
IUUC-Sce-106398	Saccharomyces cerevisiae	32.37	9.00e-28	118.00
IUUC-Sha-107253	Sarcophilus harrisii	81.40	0.00e+00	806.00
IUUC-Sja-107662	Schizosaccharomyces japonicus	28.50	5.00e-30	126.00
IUUC-Smo-109174	Selaginella moellendorffii	35.90	6.00e-15	76.60
IUUC-Sit-110527	Setaria italica	40.91	1.00e-19	92.00
IUUC-Sar-113149	Sorex araneus	85.82	8.00e-128	450.00
IUUC-Ssc-115241	Sus scrofa	87.79	0.00e+00	850.00
IUUC-Tgu-116884	Taeniopygia guttata	79.09	0.00e+00	760.00
IUUC-Tru-118031	Takifugu rubripes	59.50	2.00e-144	505.00
IUUC-Tni-119766	Tetraodon nigroviridis	59.32	6.00e-140	490.00
IUUC-Ttr-128556	Tursiops truncatus	79.04	0.00e+00	686.00
IUUC-Xtr-131866	Xenopus tropicalis	74.19	0.00e+00	731.00
IUUC-Xma-133963	Xiphophorus maculatus	59.08	2.00e-135	475.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence