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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046943
Ensembl Protein ID ENSP00000351100.5
UniProt Accession Q9H6Y2; Q9NXK4; WDR55_HUMAN
Genbank Protein ID BAA91006.1; BAB15118.1; AAH68485.1
Protein Name WD repeat-containing protein 55
Genbank Nucleotide ID AK000202; AK025355; AC116353
Gene Name WDR55
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000120314.18 ENST00000358337.9 ENSP00000351100.5
ENSG00000120314.18 ENST00000506393.5 ENSP00000426304.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPMSZDB
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
InWeb_IM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtBioGRID
mUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 8.80e-22 77.9 126 157
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf.sdtllvsGsdDgtikvWDlrt 32
           H +++++l + +++ l++G d g i +WD r+
   Q: 126  HGAPINSLLLvDENVLATGDDTGGICLWDQRK 157
           999*****77555****************765 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis (By similarity).
 Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis (By similarity).
Protein Sequence
(Fasta)
MDRTCEERPA EDGSDEEDPD SMEAPTRIRD TPEDIVLEAP ASGLAFHPAR DLLAAGDVDG 60
DVFVFSYSCQ EGETKELWSS GHHLKACRAV AFSEDGQKLI TVSKDKAIHV LDVEQGQLER 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046943|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AAACGGGGTC ACAGCAGGAC AAGGAAGTAG CCGATCTCCC AGATGCGGTC TCTTCGCTCC 60
GCTCCACCCG CACCAGCAGC GGCCCACCCA CCTCTCCTGT AAGAGGAAGA ACGTCCCGGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046943|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0698--rRNA processing
KW-0853--WD repeat
Interpro

IPR024977--Apc4_WD40_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR017422--WDR55
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF12894--ANAPC4_WD40
PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005730--C:nucleolus
GO:0042273--P:ribosomal large subunit biogenesis
GO:0006364--P:rRNA processing
KEGG hsa:54853
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000562 Aegilops tauschii 36.64 4.00e-47 182.00
IUUC-Aml-001768 Ailuropoda melanoleuca 93.47 0.00e+00 741.00
IUUC-Atr-002764 Amborella trichopoda 35.53 8.00e-22 96.30
IUUC-Apl-003880 Anas platyrhynchos 64.36 5.00e-116 412.00
IUUC-Aca-005060 Anolis carolinensis 66.58 8.00e-150 524.00
IUUC-Aly-006484 Arabidopsis lyrata 36.15 5.00e-49 188.00
IUUC-Ath-006652 Arabidopsis thaliana 37.97 3.00e-57 215.00
IUUC-Bta-013497 Bos taurus 92.95 0.00e+00 708.00
IUUC-Bdi-014378 Brachypodium distachyon 38.11 4.00e-56 211.00
IUUC-Bol-016352 Brassica oleracea 38.31 5.00e-59 221.00
IUUC-Bra-017103 Brassica rapa 38.31 2.00e-59 222.00
IUUC-Cel-018192 Caenorhabditis elegans 23.86 6.00e-14 72.00
IUUC-Cja-018792 Callithrix jacchus 94.53 0.00e+00 703.00
IUUC-Cfa-020739 Canis familiaris 93.06 0.00e+00 708.00
IUUC-Cpo-022331 Cavia porcellus 91.91 0.00e+00 701.00
IUUC-Cre-022921 Chlamydomonas reinhardtii 39.89 6.00e-37 147.00
IUUC-Csa-023414 Chlorocebus sabaeus 97.13 0.00e+00 763.00
IUUC-Cho-024600 Choloepus hoffmanni 92.56 0.00e+00 638.00
IUUC-Cin-025565 Ciona intestinalis 38.36 3.00e-62 232.00
IUUC-Csv-026294 Ciona savignyi 39.59 1.00e-61 230.00
IUUC-Cne-026979 Cryptococcus neoformans 33.33 4.00e-40 158.00
IUUC-Cme-027192 Cyanidioschyzon merolae 25.83 5.00e-20 92.00
IUUC-Dre-028492 Danio rerio 63.33 1.00e-127 449.00
IUUC-Dno-030050 Dasypus novemcinctus 89.10 0.00e+00 639.00
IUUC-Dor-030386 Dipodomys ordii 81.54 1.00e-171 595.00
IUUC-Dse-031203 Dothistroma septosporum 24.92 1.00e-11 64.70
IUUC-Dme-032012 Drosophila melanogaster 34.58 2.00e-59 223.00
IUUC-Ete-032491 Echinops telfairi 88.53 0.00e+00 679.00
IUUC-Eca-033583 Equus caballus 94.77 0.00e+00 719.00
IUUC-Eeu-034976 Erinaceus europaeus 94.48 1.00e-175 608.00
IUUC-Fca-036417 Felis catus 89.82 0.00e+00 687.00
IUUC-Gmo-039505 Gadus morhua 65.48 5.00e-138 484.00
IUUC-Ggr-039978 Gaeumannomyces graminis 23.75 2.00e-11 63.50
IUUC-Gga-040732 Gallus gallus 69.82 4.00e-145 507.00
IUUC-Gac-041313 Gasterosteus aculeatus 63.99 3.00e-134 471.00
IUUC-Gma-044122 Glycine max 40.00 1.00e-57 217.00
IUUC-Ggo-044748 Gorilla gorilla 98.96 0.00e+00 776.00
IUUC-Hvu-047659 Hordeum vulgare 37.19 3.00e-54 206.00
IUUC-Itr-048110 Ictidomys tridecemlineatus 91.74 0.00e+00 667.00
IUUC-Lch-050331 Latimeria chalumnae 58.77 3.00e-113 401.00
IUUC-Lpe-051193 Leersia perrieri 39.44 2.00e-58 219.00
IUUC-Loc-051946 Lepisosteus oculatus 66.28 1.00e-133 470.00
IUUC-Lma-052960 Leptosphaeria maculans 22.69 4.00e-10 59.30
IUUC-Laf-054035 Loxodonta africana 91.99 0.00e+00 686.00
IUUC-Mcc-055285 Macaca mulatta 97.30 2.00e-103 367.00
IUUC-Meu-056596 Macropus eugenii 83.78 1.00e-169 589.00
IUUC-Mor-056995 Magnaporthe oryzae 23.74 8.00e-12 64.70
IUUC-Mtr-058637 Medicago truncatula 40.07 3.00e-57 216.00
IUUC-Mga-059839 Meleagris gallopavo 70.61 2.00e-94 340.00
IUUC-Mdo-062868 Monodelphis domestica 82.22 2.00e-173 603.00
IUUC-Mmu-064305 Mus musculus 88.27 0.00e+00 674.00
IUUC-Mac-065041 Musa acuminata 38.73 2.00e-57 216.00
IUUC-Mpu-066779 Mustela putorius furo 92.95 0.00e+00 692.00
IUUC-Mlu-067223 Myotis lucifugus 92.27 0.00e+00 665.00
IUUC-Ncr-068919 Neurospora crassa 24.68 4.00e-08 52.80
IUUC-Nle-069852 Nomascus leucogenys 98.17 0.00e+00 721.00
IUUC-Ont-072452 Oreochromis niloticus 66.67 5.00e-139 487.00
IUUC-Oan-073163 Ornithorhynchus anatinus 82.76 4.00e-65 239.00
IUUC-Ocu-074628 Oryctolagus cuniculus 94.49 0.00e+00 712.00
IUUC-Oba-075868 Oryza barthii 38.73 2.00e-55 209.00
IUUC-Obr-076768 Oryza brachyantha 39.08 5.00e-57 214.00
IUUC-Ogl-077424 Oryza glaberrima 39.44 3.00e-58 219.00
IUUC-Ogu-078847 Oryza glumaepatula 39.08 6.00e-56 211.00
IUUC-Oin-079495 Oryza indica 39.44 3.00e-58 219.00
IUUC-Olo-080268 Oryza longistaminata 39.08 7.00e-56 211.00
IUUC-Ome-081709 Oryza meridionalis 38.85 2.00e-49 189.00
IUUC-Oni-082749 Oryza nivara 39.44 3.00e-58 219.00
IUUC-Opu-084023 Oryza punctata 32.75 5.00e-39 154.00
IUUC-Oru-084764 Oryza rufipogon 39.08 6.00e-56 211.00
IUUC-Osa-086009 Oryza sativa 39.44 3.00e-58 218.00
IUUC-Ola-086463 Oryzias latipes 61.26 7.00e-129 453.00
IUUC-Olu-087897 Ostreococcus lucimarinus 31.93 2.00e-42 166.00
IUUC-Oga-089114 Otolemur garnettii 92.18 0.00e+00 709.00
IUUC-Ptr-090556 Pan troglodytes 99.22 0.00e+00 778.00
IUUC-Pan-092828 Papio anubis 97.65 0.00e+00 766.00
IUUC-Psi-093609 Pelodiscus sinensis 72.92 6.00e-120 425.00
IUUC-Pma-094413 Petromyzon marinus 53.54 1.00e-100 360.00
IUUC-Ppa-095422 Physcomitrella patens 38.84 9.00e-66 243.00
IUUC-Pfo-096389 Poecilia formosa 65.18 3.00e-131 461.00
IUUC-Pab-098095 Pongo abelii 97.91 0.00e+00 769.00
IUUC-Pop-099612 Populus trichocarpa 39.22 4.00e-54 205.00
IUUC-Pca-100408 Procavia capensis 90.88 0.00e+00 678.00
IUUC-Ppe-101931 Prunus persica 35.49 8.00e-55 207.00
IUUC-Pva-102549 Pteropus vampyrus 92.84 0.00e+00 693.00
IUUC-Rno-105079 Rattus norvegicus 91.46 0.00e+00 700.00
IUUC-Sha-107299 Sarcophilus harrisii 84.07 4.00e-161 561.00
IUUC-Sja-107829 Schizosaccharomyces japonicus 28.28 3.00e-21 95.90
IUUC-Spo-108122 Schizosaccharomyces pombe 29.82 2.00e-27 116.00
IUUC-Smo-109613 Selaginella moellendorffii 39.65 2.00e-51 196.00
IUUC-Sit-110263 Setaria italica 38.38 3.00e-56 212.00
IUUC-Sly-110988 Solanum lycopersicum 37.10 8.00e-53 201.00
IUUC-Stu-112713 Solanum tuberosum 37.46 9.00e-54 204.00
IUUC-Sbi-114617 Sorghum bicolor 37.32 5.00e-54 204.00
IUUC-Sre-115136 Sporisorium reilianum 30.00 8.00e-12 65.10
IUUC-Ssc-116268 Sus scrofa 92.45 0.00e+00 718.00
IUUC-Tgu-116720 Taeniopygia guttata 61.26 4.00e-88 319.00
IUUC-Tru-117977 Takifugu rubripes 66.07 3.00e-131 461.00
IUUC-Tsy-119121 Tarsius syrichta 92.27 6.00e-118 417.00
IUUC-Tni-119904 Tetraodon nigroviridis 68.75 2.00e-133 468.00
IUUC-Tca-121718 Theobroma cacao 40.64 5.00e-59 221.00
IUUC-Tae-124364 Triticum aestivum 37.54 2.00e-54 206.00
IUUC-Tme-126922 Tuber melanosporum 22.44 2.00e-12 67.80
IUUC-Tbe-127276 Tupaia belangeri 92.26 2.00e-154 538.00
IUUC-Uma-129505 Ustilago maydis 32.52 3.00e-13 70.10
IUUC-Vpa-130276 Vicugna pacos 94.02 7.00e-138 482.00
IUUC-Vvi-131377 Vitis vinifera 39.22 7.00e-57 216.00
IUUC-Xtr-132529 Xenopus tropicalis 68.71 1.00e-145 510.00
IUUC-Xma-134177 Xiphophorus maculatus 64.88 1.00e-123 436.00
IUUC-Yli-134665 Yarrowia lipolytica 23.66 7.00e-08 51.60
Created Date 25-Jun-2017

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