iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
iRefIndex	PINA	Mentha
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box	F-box	17697379

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/SCF/F-box	0.0048	17.0	10	48

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/SCF/F-box

   S: 107  peeilveilklldkeellraarvcrrwqelas..qkalw 143
           ++++l  i+++l+ ++l ++++vc++w+++ +  ++ +w
   Q: 10   NYNVLEVIFSYLELDDLSHCSQVCKSWYHFLNdeNSDVW 48
           578999**********************77763345555 PP

Organism

Drosophila melanogaster

Functional Description
(View)

Required in the presynaptic motoneuron to down-regulate the levels of wnd and restrain synaptic terminal growth at the neuromuscular junction (NMJ). Negatively regulates the localization of vas to the posterior pole of the oocyte. Involved in primordial germ cell formation.

Protein Sequence
(Fasta)

MVDPVAALCN YNVLEVIFSY LELDDLSHCS QVCKSWYHFL NDENSDVWRW HCLNKLPKES 60
LKSDLLASVS TYKTKLRAYF HAWSPNDCSR NVYIKPNGFT LHRNPVAQST DAARGKIGFR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCAGACAGT GCGCGCCAAT TTACGCATCA ATTTACGCAG TGTTGTAAGC AGCTGTGTGC 60
GACAGTCGCT ATCGCACACT GGTCGCGGAT GTAAACAAAG TTGCCACTTT GTCCAGGTGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0965--Cell junction
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0903--Direct protein sequencing
KW-0524--Neurogenesis
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0770--Synapse
KW-0833--Ubl conjugation pathway

Interpro

IPR001870--B30.2/SPRY
IPR013320--ConA-like_dom
IPR001810--F-box_dom
IPR003877--SPRY_dom

PROSITE

PS50188--B302_SPRY

Pfam

PF12937--F-box-like
PF00622--SPRY

SMART

SM00449--SPRY

Gene Ontology

GO:0030424--C:axon
GO:0005938--C:cell cortex
GO:0030054--C:cell junction
GO:0005737--C:cytoplasm
GO:0031594--C:neuromuscular junction
GO:0005634--C:nucleus
GO:0043204--C:perikaryon
GO:0045495--C:pole plasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0010629--P:negative regulation of gene expression
GO:0045886--P:negative regulation of synaptic growth at neuromuscular junction
GO:0007399--P:nervous system development
GO:0007274--P:neuromuscular synaptic transmission
GO:0045732--P:positive regulation of protein catabolic process
GO:0016567--P:protein ubiquitination
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

KEGG

dme:Dmel_CG4643

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001815	Ailuropoda melanoleuca	71.31	6.00e-104	369.00
IUUC-Apl-003739	Anas platyrhynchos	80.16	1.00e-58	216.00
IUUC-Aca-005393	Anolis carolinensis	70.08	3.00e-97	346.00
IUUC-Ani-009348	Aspergillus nidulans	27.78	3.70e-02	31.20
IUUC-Ame-011341	Astyanax mexicanus	69.96	2.00e-102	364.00
IUUC-Bta-013136	Bos taurus	70.49	1.00e-102	364.00
IUUC-Bdi-014637	Brachypodium distachyon	31.11	1.40e-02	33.90
IUUC-Bol-015482	Brassica oleracea	39.13	6.00e-04	37.40
IUUC-Bra-016658	Brassica rapa	39.13	4.00e-04	37.40
IUUC-Cel-018377	Caenorhabditis elegans	56.56	7.00e-80	289.00
IUUC-Cja-019860	Callithrix jacchus	71.31	5.00e-104	369.00
IUUC-Cfa-020372	Canis familiaris	69.39	7.00e-101	358.00
IUUC-Cpo-022254	Cavia porcellus	71.31	7.00e-104	369.00
IUUC-Csa-023427	Chlorocebus sabaeus	71.31	4.00e-104	369.00
IUUC-Cho-024723	Choloepus hoffmanni	70.00	2.00e-71	260.00
IUUC-Cin-025644	Ciona intestinalis	64.68	9.00e-101	358.00
IUUC-Csv-025822	Ciona savignyi	66.67	7.00e-101	358.00
IUUC-Dre-028352	Danio rerio	69.96	8.00e-102	362.00
IUUC-Dno-029763	Dasypus novemcinctus	71.31	3.00e-104	370.00
IUUC-Dor-030984	Dipodomys ordii	71.31	4.00e-104	370.00
IUUC-Eca-034006	Equus caballus	72.40	3.00e-95	340.00
IUUC-Eeu-035294	Erinaceus europaeus	78.33	3.00e-84	302.00
IUUC-Fca-035599	Felis catus	71.31	2.00e-104	370.00
IUUC-Fal-037304	Ficedula albicollis	71.60	6.00e-100	355.00
IUUC-Gmo-038969	Gadus morhua	67.73	3.00e-100	357.00
IUUC-Gga-040625	Gallus gallus	78.50	3.00e-48	182.00
IUUC-Gac-041926	Gasterosteus aculeatus	68.31	3.00e-101	360.00
IUUC-Ggo-045114	Gorilla gorilla	71.12	2.00e-98	351.00
IUUC-Hsa-046619	Homo sapiens	71.31	5.00e-104	369.00
IUUC-Itr-049037	Ictidomys tridecemlineatus	71.31	4.00e-104	369.00
IUUC-Lch-049702	Latimeria chalumnae	69.26	8.00e-103	365.00
IUUC-Loc-052199	Lepisosteus oculatus	70.49	9.00e-103	365.00
IUUC-Lma-053079	Leptosphaeria maculans	27.14	6.50e-01	28.50
IUUC-Laf-054069	Loxodonta africana	71.31	3.00e-104	370.00
IUUC-Mcc-055362	Macaca mulatta	71.31	5.00e-104	369.00
IUUC-Meu-056400	Macropus eugenii	67.21	2.00e-71	260.00
IUUC-Mga-059682	Meleagris gallopavo	71.98	9.00e-96	341.00
IUUC-Mmr-061545	Microcebus murinus	71.31	6.00e-104	369.00
IUUC-Mdo-063044	Monodelphis domestica	71.31	8.00e-104	369.00
IUUC-Mmu-063211	Mus musculus	71.31	3.00e-104	370.00
IUUC-Mac-064570	Musa acuminata	34.62	5.00e-04	38.10
IUUC-Mpu-065969	Mustela putorius furo	71.31	5.00e-104	369.00
IUUC-Mlu-067484	Myotis lucifugus	71.83	2.00e-90	323.00
IUUC-Nle-069299	Nomascus leucogenys	71.31	6.00e-104	369.00
IUUC-Ont-071824	Oreochromis niloticus	70.37	4.00e-102	363.00
IUUC-Ocu-074917	Oryctolagus cuniculus	71.31	5.00e-104	369.00
IUUC-Ola-087014	Oryzias latipes	71.19	8.00e-103	365.00
IUUC-Oga-089176	Otolemur garnettii	71.31	2.00e-104	370.00
IUUC-Oar-089517	Ovis aries	68.85	5.00e-100	356.00
IUUC-Ptr-091318	Pan troglodytes	78.33	6.00e-84	301.00
IUUC-Pan-092627	Papio anubis	71.31	5.00e-104	369.00
IUUC-Psi-093937	Pelodiscus sinensis	78.33	3.00e-84	302.00
IUUC-Pfo-097200	Poecilia formosa	70.25	7.00e-101	359.00
IUUC-Pop-099387	Populus trichocarpa	33.87	5.00e-04	37.00
IUUC-Pva-102717	Pteropus vampyrus	71.31	4.00e-104	370.00
IUUC-Rno-105956	Rattus norvegicus	67.22	8.00e-96	342.00
IUUC-Sha-107117	Sarcophilus harrisii	78.33	7.00e-84	301.00
IUUC-Sly-111564	Solanum lycopersicum	51.85	1.00e-03	33.10
IUUC-Sar-113757	Sorex araneus	78.33	3.00e-84	302.00
IUUC-Tgu-117169	Taeniopygia guttata	78.02	5.00e-85	305.00
IUUC-Tru-118146	Takifugu rubripes	69.96	3.00e-101	360.00
IUUC-Tni-120858	Tetraodon nigroviridis	69.96	3.00e-100	357.00
IUUC-Tae-124485	Triticum aestivum	32.22	6.00e-04	38.10
IUUC-Tur-126336	Triticum urartu	31.11	6.00e-04	38.90
IUUC-Tbe-128110	Tupaia belangeri	68.38	5.00e-91	326.00
IUUC-Ttr-128569	Tursiops truncatus	71.31	3.00e-104	370.00
IUUC-Uma-129396	Ustilago maydis	40.00	4.00e-02	32.70
IUUC-Vpa-130507	Vicugna pacos	71.31	6.00e-104	369.00
IUUC-Xtr-132793	Xenopus tropicalis	70.49	2.00e-102	364.00
IUUC-Xma-133910	Xiphophorus maculatus	70.25	7.00e-101	359.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence