iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	miRNAMap	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.80e-79	267.1	88	474

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle....kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEfla 97
           +Gl N+  tCY+NS++Q+L+++pe+r+++ +    +++ +++e+ +k+ ++++ ++lqklf  l++s++ + ++++l+++++++++e   y+q+D+qE+++
   Q: 88   VGLVNQAMTCYLNSLVQSLYMTPEFRNAMYDweyvQQPAHIKEQ-RKKAEQSIPCQLQKLFLLLQTSENDSLETKDLTQSFGWTSNE--AYDQHDVQELCR 185
           6*******************************999899999876.689*************************************98..9*********** PP
   S: 98   flldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgk.eetkkeslqdcLesftke 197
            ++d+le +                           k +++++li+dl++g++++ + cl+c+++s++++ fldl+l+v+      + +s++++L +f+++
   Q: 186  LMFDALEHKW--------------------------KGTEHEKLIQDLYRGTMEDFVACLKCGRESVKTDYFLDLPLAVKPFgAIHAYKSVEEALTAFVQP 260
           **********..........................78999**************************************9541345678************ PP
   S: 198  eelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqke........................ 274
           e l+g+n+y ce+ck+kq+a k l+++++P  L+++LkRf f+ ++++r+k+n+k++fp+ Ldl+ ++++++++ ++                        
   Q: 261  ELLDGSNQYMCENCKSKQDAHKGLRITQFPYLLTIQLKRFDFDYNTMHRIKLNDKMTFPDVLDLNDYVNKEKRSTTSsawqqigknkseneeddmelgspn 361
           **********************************************************************7766655778888888888888999999999 PP
   S: 275  .......................................kkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetg........ 327
                                                  ++ YeL++v+vHsG++ +GHY+ay+kn +++ W+ f+D++V   +  e++++ g        
   Q: 362  pkrctpgvqspnryqgsenvcvgqpidhaavddivktsgDNVYELFSVMVHSGNAAGGHYFAYIKNLDQDrWYVFNDTRVDFATPLEIEKSFGghpsgwnq 462
           99999999999999999999999999999999****999***************************66656*******************988******** PP
   S: 328  ..staYvlfYkr 337
             ++aY+l+Y+r
   Q: 463  snTNAYMLMYRR 474
           **********98 PP

Organism

Caenorhabditis elegans

Protein Sequence
(Fasta)

MVRVEDSNGA DTDTNPEGES SGYVRLAGNG LPGGEQQQAS SSGVAAAPSV DSSPGRSVPL 60
AIASSSSPAN VANNQYAIPV DENGHRYVGL VNQAMTCYLN SLVQSLYMTP EFRNAMYDWE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGTACGGG TCGAGGACTC GAACGGCGCA GATACAGATA CCAATCCAGA AGGTGAATCC 60
TCAGGTTATG TCCGTTTGGC TGGCAACGGA CTTCCTGGCG GCGAGCAACA ACAAGCAAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008595--P:anterior/posterior axis specification, embryo
GO:0006284--P:base-excision repair
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0016579--P:protein deubiquitination
GO:0042981--P:regulation of apoptotic process
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

cel:CELE_T05H10.1

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002228	Ailuropoda melanoleuca	35.89	4.00e-114	405.00
IUUC-Apl-003486	Anas platyrhynchos	37.47	9.00e-114	404.00
IUUC-Aca-005061	Anolis carolinensis	38.25	8.00e-117	414.00
IUUC-Ame-011206	Astyanax mexicanus	38.25	4.00e-115	408.00
IUUC-Bta-012942	Bos taurus	37.04	7.00e-114	404.00
IUUC-Cja-018950	Callithrix jacchus	37.72	1.00e-114	407.00
IUUC-Cfa-020299	Canis familiaris	36.51	9.00e-114	404.00
IUUC-Cpo-021943	Cavia porcellus	37.58	1.00e-115	409.00
IUUC-Csa-023285	Chlorocebus sabaeus	37.62	5.00e-115	408.00
IUUC-Cho-025006	Choloepus hoffmanni	49.16	1.00e-103	370.00
IUUC-Cin-025145	Ciona intestinalis	31.13	1.00e-108	386.00
IUUC-Csv-025839	Ciona savignyi	50.12	2.00e-104	372.00
IUUC-Dre-027959	Danio rerio	38.56	1.00e-115	409.00
IUUC-Dno-030023	Dasypus novemcinctus	51.07	1.00e-113	403.00
IUUC-Dme-031604	Drosophila melanogaster	41.37	3.00e-111	395.00
IUUC-Eca-033913	Equus caballus	37.18	1.00e-113	403.00
IUUC-Eeu-034518	Erinaceus europaeus	50.23	4.00e-114	405.00
IUUC-Fca-035997	Felis catus	36.19	1.00e-114	406.00
IUUC-Fal-037088	Ficedula albicollis	37.79	2.00e-112	399.00
IUUC-Gmo-038920	Gadus morhua	49.05	2.00e-113	403.00
IUUC-Gga-040953	Gallus gallus	37.74	9.00e-115	407.00
IUUC-Gac-042400	Gasterosteus aculeatus	38.06	3.00e-114	405.00
IUUC-Ggo-044820	Gorilla gorilla	37.62	7.00e-115	407.00
IUUC-Hsa-046634	Homo sapiens	37.62	2.00e-115	409.00
IUUC-Lch-050440	Latimeria chalumnae	37.34	1.00e-115	410.00
IUUC-Loc-051904	Lepisosteus oculatus	37.19	3.00e-110	392.00
IUUC-Laf-053760	Loxodonta africana	37.31	2.00e-114	406.00
IUUC-Mcc-054637	Macaca mulatta	37.62	5.00e-115	408.00
IUUC-Meu-056904	Macropus eugenii	36.65	2.00e-96	346.00
IUUC-Mga-059556	Meleagris gallopavo	52.04	1.00e-113	403.00
IUUC-Mmr-061192	Microcebus murinus	51.07	2.00e-113	402.00
IUUC-Mdo-061929	Monodelphis domestica	36.72	2.00e-116	412.00
IUUC-Mmu-063726	Mus musculus	37.02	3.00e-114	405.00
IUUC-Mpu-066014	Mustela putorius furo	49.43	1.00e-113	404.00
IUUC-Mlu-067232	Myotis lucifugus	37.11	2.00e-114	406.00
IUUC-Nle-069619	Nomascus leucogenys	37.62	5.00e-115	408.00
IUUC-Opr-070224	Ochotona princeps	48.38	4.00e-110	392.00
IUUC-Ont-071384	Oreochromis niloticus	52.98	3.00e-114	405.00
IUUC-Oan-073208	Ornithorhynchus anatinus	36.86	2.00e-112	399.00
IUUC-Ocu-074285	Oryctolagus cuniculus	37.31	3.00e-114	405.00
IUUC-Ola-087051	Oryzias latipes	38.64	4.00e-114	405.00
IUUC-Oga-088928	Otolemur garnettii	37.76	6.00e-114	404.00
IUUC-Oar-090215	Ovis aries	36.98	7.00e-114	404.00
IUUC-Ptr-091035	Pan troglodytes	37.62	4.00e-115	408.00
IUUC-Pan-092377	Papio anubis	37.35	1.00e-111	397.00
IUUC-Pma-094428	Petromyzon marinus	37.65	3.00e-39	154.00
IUUC-Pfo-096722	Poecilia formosa	52.77	1.00e-114	407.00
IUUC-Pab-098723	Pongo abelii	37.48	1.00e-114	407.00
IUUC-Pca-100105	Procavia capensis	34.60	4.00e-91	328.00
IUUC-Pva-102514	Pteropus vampyrus	52.13	6.00e-90	325.00
IUUC-Rno-105384	Rattus norvegicus	37.50	3.00e-114	405.00
IUUC-Sha-106982	Sarcophilus harrisii	36.50	3.00e-116	412.00
IUUC-Sar-113723	Sorex araneus	44.41	3.00e-77	282.00
IUUC-Ssc-115671	Sus scrofa	31.84	3.00e-74	272.00
IUUC-Tgu-116722	Taeniopygia guttata	37.99	4.00e-114	405.00
IUUC-Tru-118380	Takifugu rubripes	37.64	1.00e-112	400.00
IUUC-Tsy-119646	Tarsius syrichta	48.34	2.00e-86	313.00
IUUC-Tni-120762	Tetraodon nigroviridis	37.77	5.00e-115	408.00
IUUC-Tbe-127861	Tupaia belangeri	36.60	4.00e-108	385.00
IUUC-Ttr-129254	Tursiops truncatus	33.70	3.00e-90	326.00
IUUC-Vpa-130141	Vicugna pacos	51.07	3.00e-113	402.00
IUUC-Xtr-132700	Xenopus tropicalis	48.54	1.00e-116	413.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence