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Basic Information Integrated Annotations

Tag Content
UUCD2 ID IUUC-Cel-018459
UUCD1 version UUC-CaE-00578
Ensembl Protein ID T03F6.5
UniProt Accession Q9NDC9; O45742; LIS1_CAEEL
Genbank Protein ID AAF82632.1; CAB03282.3
Protein Name Lissencephaly-1 homolog; Pronuclear migration abnormal protein 1
Genbank Nucleotide ID AF164430; Z81113
Gene Name lis-1; pnm-1; T03F6.5
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00003047 T03F6.5 T03F6.5
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
IIDiRefIndexMentha
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 4.50e-49 162.5 331 368
UBD/Beta-Prp 1.40e-76 257.8 105 404
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
    H+++v++laf + ++l+s +dD+t++vW+l+ +++ k
   Q: 331 HENWVRGLAFhPKgKYLISVADDKTLRVWELSAQRCMK 368
    9**********777******************999976 PP
   


   UBD/Beta-Prp

   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdls.tgkcvhtlkghedsvlslsfspsgdk 108
    h +it v f+p +++a+ s+d+tikvwd++tg+l r+l+gh+++v+++ ++ gk lv++s+D ik+wd+ t++c+ +lkghe++v s++f p+gd+
   Q: 105 HRLPITRVIFHPLWTIMASCSEDATIKVWDYETGQLERTLKGHTDAVNDIAIDAAGKQLVSCSSDLSIKLWDFGqTYDCLKSLKGHEHTVSSVTFLPTGDF 205
    7789*******************************************************************9955************************** PP
   S: 109 lvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsng...............ke 194
    ++s+s+d ti+ wd++tg+c++ t++gh+++v++++++ dg l++s+slD+tv +W+ +t++ l+ h+++v+++++ ++
   Q: 206 VLSASRDHTIKQWDISTGYCVY-TFRGHNDWVRMIRISNDGTLFASASLDQTVTVWSFATKSAKLVLRD-HEHAVECVEWAPDTaytnvtgqqpegnstHI 304
    **********************.********************************************98.*********99999999999999*****999 PP
   S: 195 lvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvisvavlsfgdnvlvlgsedskvniwklk 295
    l sgs+d+++k w++ tg+++ tl +h+++v+ ++f+p++++l+s+++D+++r+W l + ++k+++ h++ v+ va+ + + + +++gs d + ++w+++
   Q: 305 LFSGSRDRSIKAWNINTGDVLFTLLAHENWVRGLAFHPKGKYLISVADDKTLRVWELSAQRCMKAIEAHEHFVSTVAF-HQTSPFVITGSVDMSCKVWECR 404
    99**************************************************************************99.999****************985 PP
   

Organism Caenorhabditis elegans
Functional Description
(View)

Functional Description



     Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as nuclear migration during cell division. Required for neuronal cell differentiation.
Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as nuclear migration during cell division. Required for neuronal cell differentiation.
Protein Sequence
(Fasta)
MSLSERQKEE INRAIAEYMQ NNGYSESFSV FLKESSLSEN DIKPLGGILE KKWTTVLRLQ 60
RKVNDLESKL QESQREINHG APTRDKRQAA DWIPRPPETQ KLTGHRLPIT RVIFHPLWTI 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Cel-018459|E3,WD_repeat;UBD,Beta-Prp|Caenorhabditis elegans
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATTCTCTCCA AAACTTCTTC TCTTCCCCAC TTCCACAATT CCCTTATTTG GGTGTGTCGT 60
CCACGAACAA CATGAGTTTG TCGGAGAGGC AAAAAGAAGA AATGTGAGTG TTGAAGCCTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Cel-018459|E3,WD_repeat;UBD,Beta-Prp|Caenorhabditis elegans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0137--Centromere
KW-0158--Chromosome
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0995--Kinetochore
KW-0493--Microtubule
KW-0498--Mitosis
KW-0524--Neurogenesis
KW-0896--Oogenesis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR017252--Dynein_regulator_LIS1
IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08513--LisH
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00667--LisH
SM00320--WD40

Gene Ontology

GO:0005818--C:aster
GO:1904115--C:axon cytoplasm
GO:0005938--C:cell cortex
GO:0005813--C:centrosome
GO:0000777--C:condensed chromosome kinetochore
GO:0005737--C:cytoplasm
GO:0005868--C:cytoplasmic dynein complex
GO:0000776--C:kinetochore
GO:0005874--C:microtubule
GO:0005875--C:microtubule associated complex
GO:0048471--C:perinuclear region of cytoplasm
GO:0045202--C:synapse
GO:0008017--F:microtubule binding
GO:0051301--P:cell division
GO:0051026--P:chiasma assembly
GO:0009792--P:embryo development ending in birth or egg hatching
GO:0043652--P:engulfment of apoptotic cell
GO:0000132--P:establishment of mitotic spindle orientation
GO:0007281--P:germ cell development
GO:0040011--P:locomotion
GO:0007018--P:microtubule-based movement
GO:0007100--P:mitotic centrosome separation
GO:0022008--P:neurogenesis
GO:0048477--P:oogenesis
GO:0035046--P:pronuclear migration
GO:2000574--P:regulation of microtubule motor activity
GO:0008090--P:retrograde axonal transport
GO:0051225--P:spindle assembly
GO:0051932--P:synaptic transmission, GABAergic
GO:0048489--P:synaptic vesicle transport
GO:0047496--P:vesicle transport along microtubule

KEGG cel:CELE_T03F6.5
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001589 Ailuropoda melanoleuca 57.50 6.00e-145 505.00
IUUC-Apl-004024 Anas platyrhynchos 57.66 4.00e-149 519.00
IUUC-Aca-004564 Anolis carolinensis 57.66 3.00e-147 513.00
IUUC-Ago-007862 Ashbya gossypii 26.72 6.00e-37 147.00
IUUC-Acl-008360 Aspergillus clavatus 42.18 2.00e-91 328.00
IUUC-Afl-008502 Aspergillus flavus 42.86 6.00e-84 303.00
IUUC-Afu-008848 Aspergillus fumigatus 42.43 4.00e-94 337.00
IUUC-Ani-009173 Aspergillus nidulans 41.96 2.00e-84 305.00
IUUC-Ang-009873 Aspergillus niger 42.42 6.00e-84 303.00
IUUC-Aor-009973 Aspergillus oryzae 41.06 3.00e-82 297.00
IUUC-Ate-010523 Aspergillus terreus 40.45 6.00e-81 293.00
IUUC-Ame-010969 Astyanax mexicanus 57.42 2.00e-149 520.00
IUUC-Bgr-011972 Blumeria graminis 42.93 1.00e-92 332.00
IUUC-Bta-013106 Bos taurus 57.42 4.00e-149 519.00
IUUC-Bci-013615 Botrytis cinerea 41.65 4.00e-88 317.00
IUUC-Cja-018755 Callithrix jacchus 56.20 1.00e-145 508.00
IUUC-Cfa-020749 Canis familiaris 57.42 4.00e-149 519.00
IUUC-Cpo-022371 Cavia porcellus 57.42 4.00e-149 519.00
IUUC-Cre-022578 Chlamydomonas reinhardtii 33.22 3.00e-45 174.00
IUUC-Csa-023524 Chlorocebus sabaeus 57.68 7.00e-126 442.00
IUUC-Cho-024764 Choloepus hoffmanni 53.13 6.00e-119 419.00
IUUC-Cin-025753 Ciona intestinalis 53.27 1.00e-134 471.00
IUUC-Csv-025817 Ciona savignyi 53.06 4.00e-138 483.00
IUUC-Cgl-026529 Colletotrichum gloeosporioides 43.73 2.00e-85 308.00
IUUC-Cne-027087 Cryptococcus neoformans 45.34 3.00e-92 330.00
IUUC-Dre-028314 Danio rerio 57.42 3.00e-149 520.00
IUUC-Dno-029050 Dasypus novemcinctus 57.66 2.00e-149 520.00
IUUC-Dor-030222 Dipodomys ordii 53.77 4.00e-136 476.00
IUUC-Dse-031164 Dothistroma septosporum 42.30 3.00e-92 331.00
IUUC-Dme-031745 Drosophila melanogaster 56.72 4.00e-140 489.00
IUUC-Ete-032508 Echinops telfairi 57.55 2.00e-100 357.00
IUUC-Eca-034288 Equus caballus 57.50 2.00e-144 504.00
IUUC-Eeu-034984 Erinaceus europaeus 53.53 4.00e-135 473.00
IUUC-Fca-036498 Felis catus 57.42 4.00e-149 519.00
IUUC-Fal-036920 Ficedula albicollis 57.66 4.00e-149 519.00
IUUC-Fox-037996 Fusarium oxysporum 44.01 2.00e-94 337.00
IUUC-Fso-038160 Fusarium solani 40.09 2.00e-88 318.00
IUUC-Gmo-038983 Gadus morhua 56.93 2.00e-148 517.00
IUUC-Ggr-040051 Gaeumannomyces graminis 40.38 5.00e-83 300.00
IUUC-Gga-040623 Gallus gallus 57.66 4.00e-149 519.00
IUUC-Gac-041613 Gasterosteus aculeatus 56.45 7.00e-148 515.00
IUUC-Ggo-045410 Gorilla gorilla 51.76 2.00e-124 437.00
IUUC-Hsa-046358 Homo sapiens 57.42 5.00e-149 519.00
IUUC-Itr-047890 Ictidomys tridecemlineatus 57.42 4.00e-149 519.00
IUUC-Kpa-049351 Komagataella pastoris 29.58 1.00e-41 162.00
IUUC-Lch-049936 Latimeria chalumnae 57.18 3.00e-148 516.00
IUUC-Loc-052476 Lepisosteus oculatus 57.25 2.00e-145 506.00
IUUC-Lma-053170 Leptosphaeria maculans 43.70 6.00e-91 326.00
IUUC-Laf-053713 Loxodonta africana 56.31 6.00e-146 508.00
IUUC-Mcc-054628 Macaca mulatta 57.42 8.00e-149 518.00
IUUC-Meu-055927 Macropus eugenii 50.36 2.00e-81 293.00
IUUC-Mor-056962 Magnaporthe oryzae 40.89 3.00e-83 300.00
IUUC-Mpo-057583 Magnaporthe poae 39.42 1.00e-79 288.00
IUUC-Mla-058819 Melampsora laricipopulina 42.70 3.00e-97 347.00
IUUC-Mga-059945 Meleagris gallopavo 57.66 3.00e-149 520.00
IUUC-Mvi-060403 Microbotryum violaceum 42.66 6.00e-107 379.00
IUUC-Mmr-061289 Microcebus murinus 57.50 6.00e-145 505.00
IUUC-Mdo-061912 Monodelphis domestica 57.66 5.00e-149 519.00
IUUC-Mmu-063253 Mus musculus 57.42 4.00e-149 519.00
IUUC-Mpu-066638 Mustela putorius furo 57.42 4.00e-149 519.00
IUUC-Mlu-067267 Myotis lucifugus 56.72 5.00e-146 509.00
IUUC-Nfi-068571 Neosartorya fischeri 40.24 2.00e-86 311.00
IUUC-Ncr-068895 Neurospora crassa 44.85 3.00e-92 330.00
IUUC-Nle-069087 Nomascus leucogenys 56.38 2.00e-116 410.00
IUUC-Opr-070579 Ochotona princeps 57.66 2.00e-149 520.00
IUUC-Ont-072432 Oreochromis niloticus 56.69 6.00e-149 519.00
IUUC-Oan-073072 Ornithorhynchus anatinus 57.42 4.00e-149 519.00
IUUC-Ocu-074180 Oryctolagus cuniculus 57.66 2.00e-149 520.00
IUUC-Ola-086772 Oryzias latipes 57.18 2.00e-148 517.00
IUUC-Oga-088219 Otolemur garnettii 56.97 1.00e-145 507.00
IUUC-Oar-090394 Ovis aries 57.42 4.00e-149 519.00
IUUC-Ptr-091517 Pan troglodytes 57.42 4.00e-149 519.00
IUUC-Pan-092421 Papio anubis 57.42 8.00e-149 518.00
IUUC-Psi-093370 Pelodiscus sinensis 57.91 2.00e-149 520.00
IUUC-Pma-094319 Petromyzon marinus 57.43 2.00e-122 430.00
IUUC-Pno-094815 Phaeosphaeria nodorum 43.67 6.00e-92 330.00
IUUC-Pfo-097089 Poecilia formosa 57.42 2.00e-149 520.00
IUUC-Pab-098421 Pongo abelii 57.42 4.00e-149 519.00
IUUC-Pca-100120 Procavia capensis 41.98 9.00e-91 325.00
IUUC-Pva-102960 Pteropus vampyrus 57.18 7.00e-148 515.00
IUUC-Pgr-103538 Puccinia graminis 42.73 8.00e-100 355.00
IUUC-Ptt-103990 Puccinia triticina 39.84 1.00e-37 150.00
IUUC-Pte-104261 Pyrenophora teres 43.58 4.00e-92 330.00
IUUC-Pyt-104780 Pyrenophora triticirepentis 43.58 3.00e-92 330.00
IUUC-Rno-105123 Rattus norvegicus 57.42 4.00e-149 519.00
IUUC-Sce-106208 Saccharomyces cerevisiae 26.65 3.00e-29 121.00
IUUC-Sha-107010 Sarcophilus harrisii 57.66 4.00e-149 519.00
IUUC-Sja-107899 Schizosaccharomyces japonicus 34.99 1.00e-64 238.00
IUUC-Ssl-108571 Sclerotinia sclerotiorum 42.37 3.00e-89 320.00
IUUC-Sar-113309 Sorex araneus 56.75 2.00e-142 497.00
IUUC-Sre-115003 Sporisorium reilianum 43.02 8.00e-106 375.00
IUUC-Ssc-116148 Sus scrofa 57.42 4.00e-149 519.00
IUUC-Tgu-117299 Taeniopygia guttata 57.66 5.00e-149 519.00
IUUC-Tru-117721 Takifugu rubripes 56.20 2.00e-147 513.00
IUUC-Tsy-119493 Tarsius syrichta 57.18 4.00e-147 513.00
IUUC-Tni-120355 Tetraodon nigroviridis 55.96 1.00e-146 511.00
IUUC-Tre-121977 Trichoderma reesei 37.00 1.00e-83 302.00
IUUC-Tvi-122661 Trichoderma virens 37.37 2.00e-83 301.00
IUUC-Tme-127031 Tuber melanosporum 44.72 8.00e-93 332.00
IUUC-Tbe-127492 Tupaia belangeri 49.23 2.00e-65 241.00
IUUC-Ttr-128929 Tursiops truncatus 57.42 7.00e-149 518.00
IUUC-Uma-129347 Ustilago maydis 41.88 9.00e-104 369.00
IUUC-Vda-129837 Verticillium dahliae 41.98 3.00e-87 314.00
IUUC-Vpa-130532 Vicugna pacos 49.61 4.00e-112 396.00
IUUC-Xtr-131985 Xenopus tropicalis 56.93 7.00e-149 518.00
IUUC-Xma-133314 Xiphophorus maculatus 57.42 2.00e-149 521.00
IUUC-Yli-134403 Yarrowia lipolytica 36.22 3.00e-72 264.00
Created Date 25-Jun-2017

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