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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046757
UUCD1 version UUC-HoS-01261
Ensembl Protein ID ENSP00000275034.3
UniProt Accession Q8WWQ0; A7J992; B2RPK4; Q05CQ9; Q5VVH4; Q66I29; Q69YV1; Q8NBZ5; Q96H52; Q96ME2; Q9H261; PHIP_HUMAN
Genbank Protein ID ABK76299.1; CAC83118.1; CAH70884.1; CAH70884.1; CAI14406.1; CAI14406.1; EAW48718.1; AAH08909.2; AAH21905.1; AAH81569.1; AAI37489.1; BAB71353.1; BAC11417.1; CAH10776.1; AAG45145.1
Protein Name PH-interacting protein; IRS-1 PH domain-binding protein; WD repeat-containing protein 11
Genbank Nucleotide ID DQ924532; AJ303102; AL450327; AL356776; AL356776; AL450327; CH471051; BC008909; BC021905; BC081569; BC137488; AK057039; AK075124; AL161957; AF310250
Gene Name PHIP; WDR11
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000146247.13 ENST00000275034.4 ENSP00000275034.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarmiRNAMapSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
ClinVarGWASdbOMIM
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD WD_repeat 17588513
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 3.20e-34 117.1 181 218
UBD/Beta-Prp 1.00e-51 177.6 280 541
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvll 36
           gH +sv+c+ f  + +++ +GsdD+ +k+W +++g+ll
   Q: 181  GHLSSVYCVTFdRTgRRIFTGSDDCLVKIWATDDGRLL 218
           8**********955599*****************9987 PP
   

   UBD/Beta-Prp
   S: 19   spdksllatgsrdgtikvwdvttgkl.....lrsl.sgheaevtavk..fspdgkilvtgseDrtikvw..dlstgkcvhtlkghedsvlsl 100
           s +k++l ++++dgti  w ++ g+l      +++ +   ++v+ ++  fs  g +l+tgs+D++i+v+     +++ ++ l+ h+d+v s+
   Q: 280  SGSKRYLSSTGADGTICFWLWDAGTLkinprPAKFtERPRPGVQMICssFSAGGMFLATGSTDHIIRVYffGSGQPEKISELEFHTDKVDSI 371
           67899***********999999999988988555547777888765522777888**************777779999************** PP
   S: 101  sfspsgdklvsGshdrtirvwdletgqclee................tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtlt 176
           +fs +++++vsGs+d t+r+w+ + +++ +                  +++++  v++v+++  +n ++++ ++ t+++W++ tg+l++ l 
   Q: 372  QFSNTSNRFVSGSRDGTARIWQFKRREWKSIlldmatrpagqnlqgiEDKITKMKVTMVAWDRHDNTVITAVNNMTLKVWNSYTGQLIHVLM 463
           *****************************99***************888899999************************************* PP
   S: 177  gghtdsvysls...fdsngkelvsgsldgtvklwdlqtgecvrtlnght.....dnvksvrfspnderlvsgssDgsiriW 249
           g h+d v  l+   fd+  + l s+++dg v++wdl +g  +r++ +         v + + sp++++++++ s+g + i+
   Q: 464  G-HEDEVFVLEphpFDP--RVLFSAGHDGNVIVWDLARGVKIRSYFNMIegqghGAVFDCKCSPDGQHFACTDSHGHLLIF 541
           9.*********999999..89******************999998875544445566667777999999999999988887 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization.
 Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization.
Protein Sequence
(Fasta)
MSCERKGLSE LRSELYFLIA RFLEDGPCQQ AAQVLIREVA EKELLPRRTD WTGKEHPRTY 60
QNLVKYYRHL APDHLLQICH RLGPLLEQEI PQSVPGVQTL LGAGRQSLLR TNKSCKHVVW 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046757|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTTGTTTCCT CCTCCTCCTC CTCCGCCTCC GCCGCCGTTG CTTGAATGGT GGAGCCGAAG 60
CTCGGCTCGT GAACACACAC TGACAGCTAT AGGGCAGGCG GCGGCACCGT CCCCGCTTCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046757|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0103--Bromodomain
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
KW-0853--WD repeat
Interpro

IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR028738--PHIP
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00439--Bromodomain
PF00400--WD40
PRINTS

PR00503--BROMODOMAIN
SMART

SM00297--BROMO
SM00320--WD40
Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0005158--F:insulin receptor binding
GO:0070577--F:lysine-acetylated histone binding
GO:0007010--P:cytoskeleton organization
GO:0008286--P:insulin receptor signaling pathway
GO:0043066--P:negative regulation of apoptotic process
GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway
GO:0008284--P:positive regulation of cell proliferation
GO:0043568--P:positive regulation of insulin-like growth factor receptor signaling pathway
GO:0045840--P:positive regulation of mitotic nuclear division
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0022604--P:regulation of cell morphogenesis
GO:0008360--P:regulation of cell shape
GO:0001932--P:regulation of protein phosphorylation
KEGG hsa:55023
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001113 Aegilops tauschii 31.54 5.00e-63 237.00
IUUC-Aml-002299 Ailuropoda melanoleuca 96.30 0.00e+00 3204.00
IUUC-Atr-002600 Amborella trichopoda 31.69 3.00e-71 265.00
IUUC-Apl-003700 Anas platyrhynchos 86.66 0.00e+00 2872.00
IUUC-Aca-004474 Anolis carolinensis 82.64 0.00e+00 2831.00
IUUC-Bta-013125 Bos taurus 95.68 0.00e+00 3113.00
IUUC-Cja-018868 Callithrix jacchus 96.27 0.00e+00 3373.00
IUUC-Cfa-021179 Canis familiaris 95.66 0.00e+00 3175.00
IUUC-Cpo-022077 Cavia porcellus 91.55 0.00e+00 3083.00
IUUC-Csa-023618 Chlorocebus sabaeus 98.96 0.00e+00 3424.00
IUUC-Cho-024794 Choloepus hoffmanni 90.54 0.00e+00 872.00
IUUC-Dre-028029 Danio rerio 80.25 0.00e+00 1352.00
IUUC-Dno-030048 Dasypus novemcinctus 95.52 0.00e+00 3220.00
IUUC-Dor-030195 Dipodomys ordii 85.00 0.00e+00 1466.00
IUUC-Ete-032748 Echinops telfairi 83.44 0.00e+00 1156.00
IUUC-Eca-034274 Equus caballus 97.16 0.00e+00 3175.00
IUUC-Eeu-034688 Erinaceus europaeus 84.89 0.00e+00 1414.00
IUUC-Fca-035451 Felis catus 95.80 0.00e+00 3055.00
IUUC-Fal-037465 Ficedula albicollis 85.62 0.00e+00 2890.00
IUUC-Gmo-039451 Gadus morhua 68.38 0.00e+00 721.00
IUUC-Gga-040798 Gallus gallus 86.50 0.00e+00 2969.00
IUUC-Hvu-047706 Hordeum vulgare 31.84 2.00e-37 149.00
IUUC-Itr-048843 Ictidomys tridecemlineatus 93.89 0.00e+00 1185.00
IUUC-Lch-050646 Latimeria chalumnae 78.51 0.00e+00 2759.00
IUUC-Laf-054140 Loxodonta africana 95.97 0.00e+00 3204.00
IUUC-Mcc-055061 Macaca mulatta 98.74 0.00e+00 3411.00
IUUC-Mtr-058094 Medicago truncatula 32.66 8.00e-73 270.00
IUUC-Mmr-060837 Microcebus murinus 97.80 0.00e+00 1669.00
IUUC-Mdo-061903 Monodelphis domestica 95.60 0.00e+00 1727.00
IUUC-Mmu-063772 Mus musculus 94.89 0.00e+00 3271.00
IUUC-Mpu-066359 Mustela putorius furo 96.36 0.00e+00 2951.00
IUUC-Mlu-067928 Myotis lucifugus 94.79 0.00e+00 3216.00
IUUC-Nle-070094 Nomascus leucogenys 98.68 0.00e+00 3354.00
IUUC-Opr-070971 Ochotona princeps 74.84 0.00e+00 959.00
IUUC-Ont-072221 Oreochromis niloticus 76.03 0.00e+00 1329.00
IUUC-Oan-073185 Ornithorhynchus anatinus 87.52 0.00e+00 2890.00
IUUC-Ocu-074033 Oryctolagus cuniculus 95.13 0.00e+00 2872.00
IUUC-Obr-076619 Oryza brachyantha 30.17 4.00e-71 264.00
IUUC-Ogl-077493 Oryza glaberrima 25.22 7.00e-35 143.00
IUUC-Ogu-078641 Oryza glumaepatula 24.28 1.00e-29 126.00
IUUC-Oin-079669 Oryza indica 31.13 3.00e-52 199.00
IUUC-Olo-080755 Oryza longistaminata 31.65 4.00e-54 207.00
IUUC-Oni-082991 Oryza nivara 27.78 2.00e-39 159.00
IUUC-Opu-083233 Oryza punctata 29.74 6.00e-66 246.00
IUUC-Oga-088578 Otolemur garnettii 96.65 0.00e+00 3162.00
IUUC-Oar-090247 Ovis aries 96.08 0.00e+00 3118.00
IUUC-Ptr-091266 Pan troglodytes 99.55 0.00e+00 3298.00
IUUC-Pan-092734 Papio anubis 99.07 0.00e+00 3421.00
IUUC-Pfo-096191 Poecilia formosa 72.54 0.00e+00 2059.00
IUUC-Pab-098402 Pongo abelii 99.67 0.00e+00 3405.00
IUUC-Pop-099185 Populus trichocarpa 35.42 2.00e-70 262.00
IUUC-Pca-101128 Procavia capensis 84.09 0.00e+00 2860.00
IUUC-Ppe-101849 Prunus persica 31.70 4.00e-75 277.00
IUUC-Pva-103058 Pteropus vampyrus 95.11 0.00e+00 1575.00
IUUC-Rno-106013 Rattus norvegicus 93.41 0.00e+00 3133.00
IUUC-Sha-107496 Sarcophilus harrisii 91.15 0.00e+00 3092.00
IUUC-Sar-113520 Sorex araneus 90.91 0.00e+00 1538.00
IUUC-Sbi-114195 Sorghum bicolor 30.08 7.00e-60 225.00
IUUC-Ssc-115461 Sus scrofa 92.76 0.00e+00 3144.00
IUUC-Tgu-116821 Taeniopygia guttata 86.02 0.00e+00 2932.00
IUUC-Tsy-119132 Tarsius syrichta 85.22 0.00e+00 2585.00
IUUC-Tae-125478 Triticum aestivum 31.56 2.00e-72 268.00
IUUC-Tur-126809 Triticum urartu 31.23 3.00e-70 261.00
IUUC-Tbe-127479 Tupaia belangeri 93.19 0.00e+00 1463.00
IUUC-Ttr-128427 Tursiops truncatus 90.89 0.00e+00 3058.00
IUUC-Vpa-130160 Vicugna pacos 93.31 0.00e+00 3045.00
IUUC-Vvi-131332 Vitis vinifera 31.96 6.00e-78 286.00
IUUC-Xtr-132717 Xenopus tropicalis 74.84 0.00e+00 2577.00
IUUC-Xma-134120 Xiphophorus maculatus 78.04 0.00e+00 1288.00
Created Date 25-Jun-2017

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