iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC	RAID2
Protein-protein Interaction
IID	PINA	HINT
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	2.30e-07	31.6	380	419

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC e  kd +++ pCgH+++++Cl  w    + +s  + CP Cr
   Q: 380  CKICAENDKD-VKIEPCGHLMCTSCLTSW----Q-ESEGQGCPFCR 419
           99********.******************....5.555555****8 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MAGNVKKSSG AGGSGSGGSG AGGLIGLMKD AFQPHHHHHH HLSPHPPCTV DKKMVEKCWK 60
LMDKVVRLCQ NPKLALKNSP PYILDLLPDT YQHLRTVLSR YEGKMETLGE NEYFRVFMEN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTGTGAGCG CCGGCGGTGG CTGCCGGAGA GGCCCCTCCT TCTCGCCCCG CTCCATTCCC 60
TCGCTCGCGG CCGAGCGGGC TCCCGACCCT CCGCTGGCCA TGGCCGGCAA CGTGAAGAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR024162--Adaptor_Cbl
IPR014741--Adaptor_Cbl_EF_hand-like
IPR003153--Adaptor_Cbl_N_hlx
IPR014742--Adaptor_Cbl_SH2-like
IPR024159--Cbl_PTB
IPR011992--EF-hand-dom_pair
IPR000980--SH2
IPR015940--UBA
IPR009060--UBA-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51506--CBL_PTB
PS50030--UBA
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF02262--Cbl_N
PF02761--Cbl_N2
PF02762--Cbl_N3
PF00627--UBA

SMART

SM00184--RING
SM00165--UBA

Gene Ontology

GO:0030424--C:axon
GO:0005829--C:cytosol
GO:0016600--C:flotillin complex
GO:0005925--C:focal adhesion
GO:0030426--C:growth cone
GO:0045121--C:membrane raft
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0005509--F:calcium ion binding
GO:0005154--F:epidermal growth factor receptor binding
GO:0036312--F:phosphatidylinositol 3-kinase regulatory subunit binding
GO:0019901--F:protein kinase binding
GO:1990782--F:protein tyrosine kinase binding
GO:0030971--F:receptor tyrosine kinase binding
GO:0017124--F:SH3 domain binding
GO:0004871--F:signal transducer activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0071364--P:cellular response to epidermal growth factor stimulus
GO:1990090--P:cellular response to nerve growth factor stimulus
GO:0090650--P:cellular response to oxygen-glucose deprivation
GO:0036120--P:cellular response to platelet-derived growth factor stimulus
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0008584--P:male gonad development
GO:0043303--P:mast cell degranulation
GO:0043066--P:negative regulation of apoptotic process
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:1901215--P:negative regulation of neuron death
GO:0070997--P:neuron death
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0048260--P:positive regulation of receptor-mediated endocytosis
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0006508--P:proteolysis
GO:0014823--P:response to activity
GO:0046677--P:response to antibiotic
GO:0045471--P:response to ethanol
GO:0010332--P:response to gamma radiation
GO:0042594--P:response to starvation
GO:0033574--P:response to testosterone

KEGG

rno:500985

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002357	Ailuropoda melanoleuca	90.62	0.00e+00	1463.00
IUUC-Apl-004041	Anas platyrhynchos	83.70	0.00e+00	1379.00
IUUC-Aca-004899	Anolis carolinensis	81.44	0.00e+00	1265.00
IUUC-Ame-010746	Astyanax mexicanus	58.82	1.00e-179	622.00
IUUC-Bta-012759	Bos taurus	90.47	0.00e+00	1519.00
IUUC-Cja-019207	Callithrix jacchus	89.98	0.00e+00	1529.00
IUUC-Cfa-020897	Canis familiaris	89.77	0.00e+00	1493.00
IUUC-Cpo-021453	Cavia porcellus	91.78	0.00e+00	1518.00
IUUC-Csa-023136	Chlorocebus sabaeus	90.51	0.00e+00	1516.00
IUUC-Cho-024282	Choloepus hoffmanni	81.57	0.00e+00	1208.00
IUUC-Cin-025574	Ciona intestinalis	71.28	9.00e-178	616.00
IUUC-Csv-025938	Ciona savignyi	69.62	5.00e-173	600.00
IUUC-Dre-027644	Danio rerio	68.65	0.00e+00	1031.00
IUUC-Dno-030025	Dasypus novemcinctus	92.14	0.00e+00	1484.00
IUUC-Dme-032213	Drosophila melanogaster	74.55	0.00e+00	643.00
IUUC-Ete-033118	Echinops telfairi	77.25	0.00e+00	783.00
IUUC-Eca-033900	Equus caballus	92.38	0.00e+00	1482.00
IUUC-Eeu-035142	Erinaceus europaeus	85.71	0.00e+00	952.00
IUUC-Fca-035455	Felis catus	90.11	0.00e+00	1493.00
IUUC-Fal-037182	Ficedula albicollis	94.81	0.00e+00	901.00
IUUC-Gmo-038698	Gadus morhua	86.63	0.00e+00	867.00
IUUC-Gga-040438	Gallus gallus	82.57	0.00e+00	1394.00
IUUC-Gac-042166	Gasterosteus aculeatus	75.87	0.00e+00	884.00
IUUC-Ggo-045618	Gorilla gorilla	91.05	0.00e+00	1530.00
IUUC-Hsa-046177	Homo sapiens	91.05	0.00e+00	1524.00
IUUC-Itr-048795	Ictidomys tridecemlineatus	95.92	0.00e+00	1003.00
IUUC-Lch-050095	Latimeria chalumnae	73.65	0.00e+00	1165.00
IUUC-Loc-052570	Lepisosteus oculatus	71.69	0.00e+00	1119.00
IUUC-Laf-054008	Loxodonta africana	88.96	0.00e+00	1499.00
IUUC-Mcc-054676	Macaca mulatta	90.40	0.00e+00	1513.00
IUUC-Mga-059239	Meleagris gallopavo	82.54	0.00e+00	1401.00
IUUC-Mmr-060907	Microcebus murinus	89.19	0.00e+00	1483.00
IUUC-Mdo-062595	Monodelphis domestica	87.75	0.00e+00	1408.00
IUUC-Mmu-063725	Mus musculus	97.70	0.00e+00	1688.00
IUUC-Mpu-066771	Mustela putorius furo	90.40	0.00e+00	1506.00
IUUC-Mlu-067206	Myotis lucifugus	77.36	0.00e+00	1097.00
IUUC-Nle-069285	Nomascus leucogenys	88.67	0.00e+00	1432.00
IUUC-Opr-071026	Ochotona princeps	91.30	0.00e+00	1472.00
IUUC-Ont-071954	Oreochromis niloticus	68.76	0.00e+00	1040.00
IUUC-Ocu-074657	Oryctolagus cuniculus	91.20	0.00e+00	1455.00
IUUC-Ola-087165	Oryzias latipes	66.04	0.00e+00	1054.00
IUUC-Oga-088198	Otolemur garnettii	79.61	0.00e+00	1298.00
IUUC-Oar-090258	Ovis aries	90.06	0.00e+00	1450.00
IUUC-Ptr-090710	Pan troglodytes	91.05	0.00e+00	1524.00
IUUC-Pan-092785	Papio anubis	90.62	0.00e+00	1518.00
IUUC-Pfo-096990	Poecilia formosa	90.11	0.00e+00	817.00
IUUC-Pab-098526	Pongo abelii	90.28	0.00e+00	1517.00
IUUC-Pca-100984	Procavia capensis	75.38	6.00e-160	557.00
IUUC-Pva-102352	Pteropus vampyrus	95.40	0.00e+00	892.00
IUUC-Sha-107588	Sarcophilus harrisii	85.88	0.00e+00	1216.00
IUUC-Sar-112959	Sorex araneus	86.84	0.00e+00	1407.00
IUUC-Ssc-115261	Sus scrofa	91.50	0.00e+00	1528.00
IUUC-Tgu-116580	Taeniopygia guttata	80.73	0.00e+00	1310.00
IUUC-Tru-118731	Takifugu rubripes	67.94	0.00e+00	1027.00
IUUC-Tsy-118982	Tarsius syrichta	84.28	0.00e+00	1021.00
IUUC-Tni-120725	Tetraodon nigroviridis	68.64	0.00e+00	1028.00
IUUC-Tbe-128018	Tupaia belangeri	94.78	0.00e+00	1148.00
IUUC-Ttr-128927	Tursiops truncatus	91.83	0.00e+00	1538.00
IUUC-Vpa-130369	Vicugna pacos	91.09	0.00e+00	1414.00
IUUC-Xtr-132474	Xenopus tropicalis	73.73	0.00e+00	1150.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence