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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063129
UUCD1 version UUC-MuM-00899
Ensembl Protein ID ENSMUSP00000017839.2
UniProt Accession Q9CWS1; Q3UBK5; Q8R161; Q9DCH3; RN135_MOUSE
Genbank Protein ID BAB22354.1; BAB26931.1; BAE29959.1; BAE30944.1; CAI25292.1; AAH25209.1; AAH96385.1; AAI32308.1
Protein Name E3 ubiquitin-protein ligase RNF135; RING finger protein 135; RING-type E3 ubiquitin transferase RNF135
Genbank Nucleotide ID AK002781; AK010429; AK150921; AK152096; AL591426; BC025209; BC096385; BC132307
Gene Name Rnf135
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000020707.6 ENSMUST00000017839.2 ENSMUSP00000017839.2
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarRAID2
Protein-protein Interaction
IIDiRefIndexHINT
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 56.52 4.00e-126 449.00 IUUC-Hsa-046550
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Acts as an E2-dependent E3 ubiquitin-protein ligase, involved in innate immune defense against viruses. Ubiquitinates DDX58 and is required for full activation of the DDX58 signaling resulting in interferon beta production.
 Acts as an E2-dependent E3 ubiquitin-protein ligase, involved in innate immune defense against viruses. Ubiquitinates DDX58 and is required for full activation of the DDX58 signaling resulting in interferon beta production.
Protein Sequence
(Fasta)
MAAVCSGNAV PVWLSEDDLS CIICQGLLDQ PTTLPCGHSF CLRCLHDLWV SKRGAVDGCP 60
WACPICRKGP LTKPKLHKNP LLQDLVDKYL QAAREVEAGS EPEPAPAPRS APQVTVQKST 120
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Protein Fasta Sequence


>IUUC-Mmu-063129|E3,RING|Mus musculus
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Nucleotide Sequence
(Fasta)
AGTGTTGCCG GGGAAGTTAG TAGGACAAGG CGGAACCTAA GGGTGCTTCC TGGCTGTCGC 60
CTAATTATGG CGGCCGTTTG TTCTGGCAAT GCAGTCCCCG TGTGGCTGAG CGAGGACGAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063129|E3,RING|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0391--Immunity
KW-0399--Innate immunity
KW-0479--Metal-binding
KW-0675--Receptor
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR003877--SPRY_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50188--B302_SPRY
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00622--SPRY
PRINTS

PR01407--BUTYPHLNCDUF
SMART

SM00184--RING
SM00449--SPRY
Gene Ontology

GO:0005737--C:cytoplasm
GO:0042802--F:identical protein binding
GO:0043021--F:ribonucleoprotein complex binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0045087--P:innate immune response
GO:0032728--P:positive regulation of interferon-beta production
GO:0016567--P:protein ubiquitination
GO:0045088--P:regulation of innate immune response
KEGG mmu:71956
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002251 Ailuropoda melanoleuca 51.60 9.00e-82 296.00
IUUC-Apl-003301 Anas platyrhynchos 45.16 2.00e-39 155.00
IUUC-Aca-004520 Anolis carolinensis 36.14 2.00e-30 125.00
IUUC-Bta-012846 Bos taurus 51.39 5.00e-107 381.00
IUUC-Cja-019096 Callithrix jacchus 55.95 5.00e-117 414.00
IUUC-Cfa-020135 Canis familiaris 56.92 2.00e-73 270.00
IUUC-Cpo-022042 Cavia porcellus 48.70 2.00e-95 342.00
IUUC-Csa-024154 Chlorocebus sabaeus 55.45 3.00e-122 432.00
IUUC-Cho-024619 Choloepus hoffmanni 50.49 8.00e-73 266.00
IUUC-Dre-027925 Danio rerio 43.20 1.00e-23 104.00
IUUC-Dno-028856 Dasypus novemcinctus 51.67 3.00e-105 375.00
IUUC-Eca-033795 Equus caballus 50.36 1.00e-102 366.00
IUUC-Eeu-035078 Erinaceus europaeus 52.00 4.00e-115 408.00
IUUC-Fca-035503 Felis catus 64.29 8.00e-72 262.00
IUUC-Fal-036914 Ficedula albicollis 48.09 8.00e-32 129.00
IUUC-Ggo-045197 Gorilla gorilla 56.55 2.00e-105 375.00
IUUC-Hsa-046550 Homo sapiens 57.67 1.00e-132 466.00
IUUC-Itr-049007 Ictidomys tridecemlineatus 52.11 8.00e-121 427.00
IUUC-Laf-053812 Loxodonta africana 53.56 8.00e-114 403.00
IUUC-Mcc-055777 Macaca mulatta 54.99 7.00e-120 424.00
IUUC-Meu-056473 Macropus eugenii 48.59 2.00e-40 160.00
IUUC-Mmr-061016 Microcebus murinus 55.61 1.00e-119 422.00
IUUC-Mpu-065938 Mustela putorius furo 53.19 4.00e-107 381.00
IUUC-Mlu-067911 Myotis lucifugus 46.45 4.00e-99 355.00
IUUC-Opr-071118 Ochotona princeps 46.43 2.00e-61 229.00
IUUC-Oan-073277 Ornithorhynchus anatinus 38.48 6.00e-63 234.00
IUUC-Ocu-074512 Oryctolagus cuniculus 58.75 8.00e-95 340.00
IUUC-Oga-089086 Otolemur garnettii 58.71 1.00e-130 459.00
IUUC-Oar-089493 Ovis aries 58.90 3.00e-72 264.00
IUUC-Ptr-090466 Pan troglodytes 56.51 8.00e-128 450.00
IUUC-Pan-091817 Papio anubis 55.22 8.00e-120 423.00
IUUC-Psi-093151 Pelodiscus sinensis 35.22 5.00e-46 179.00
IUUC-Pab-098342 Pongo abelii 56.98 1.00e-131 463.00
IUUC-Pca-101052 Procavia capensis 46.04 4.00e-49 187.00
IUUC-Pva-103178 Pteropus vampyrus 53.82 3.00e-84 305.00
IUUC-Rno-105519 Rattus norvegicus 77.99 2.00e-173 602.00
IUUC-Sre-115193 Sporisorium reilianum 33.33 1.00e-08 55.50
IUUC-Ssc-115925 Sus scrofa 49.65 1.00e-105 376.00
IUUC-Tgu-116757 Taeniopygia guttata 49.62 4.00e-33 133.00
IUUC-Ttr-128972 Tursiops truncatus 45.88 3.00e-33 135.00
IUUC-Uma-129518 Ustilago maydis 37.80 1.00e-08 55.80
Created Date 25-Jun-2017

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