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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063638
UUCD1 version UUC-MuM-01194
Ensembl Protein ID ENSMUSP00000122199.1
UniProt Accession Q91W36; UBP3_MOUSE
Genbank Protein ID BAC27276.1; AAH17156.1
Protein Name Ubiquitin carboxyl-terminal hydrolase 3; Deubiquitinating enzyme 3; Ubiquitin thioesterase 3; Ubiquitin-specific-processing protease 3
Genbank Nucleotide ID AK031141; BC017156
Gene Name Usp3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000032376.12 ENSMUST00000127569.7 ENSMUSP00000122199.1
ENSMUSG00000032376.12 ENSMUST00000139547.7 ENSMUSP00000115620.1
ENSMUSG00000032376.12 ENSMUST00000098613.8 ENSMUSP00000096213.2
ENSMUSG00000032376.12 ENSMUST00000174387.1 ENSMUSP00000134472.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
circBasemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDMentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 4.00e-99 333.1 159 510
UBD/ZnF/ZnF_UBP 8.70e-27 94.3 27 104
Active Site
Position(s) Description Evidence
168 Nucleophile ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
471 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle...........kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalk 78
           tGl+NlgNtC+mN++LQ+Lsni+++ ++++e             +++ + +++ +++ +l+++++k + +lw+++++a+sp++l+ +++
   Q: 159  TGLRNLGNTCFMNAILQSLSNIEQFCCYFKElpavelrngktAGRRTYHTRSQGDSNVSLVEEFRKTLCALWQGSQTAFSPESLFYVVW 247
           7******************************888888777775555555556688999******************************* PP
   S: 79   keaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssree 167
           k+ ++f+gy+qqDa+Ef+++lld+l+ el+   n    ++  +++s+ls  +++   +  +++++ +F+g l++++ cl c+++s +++
   Q: 248  KIMPNFRGYQQQDAHEFMRYLLDHLHLELQGGFNGVSRSAILQENSTLS-ASNKCCINGASTVVTAIFGGILQNEVNCLICGTESRKFD 335
           *****************************77444444444444444444.45688899999**************************** PP
   S: 168  pfldlslpvpgkeetkke.........slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksre 247
           pfldlsl++p++  +k +         sl+dcL+sft  eel++ + y c kckkkq+++kk++++klP+ L+lhLkRf+++   + r+
   Q: 336  PFLDLSLDIPSQFRSKRSknqengpvcSLRDCLRSFTDLEELDETELYMCHKCKKKQKSTKKFWIQKLPKALCLHLKRFHWTA--YLRN 422
           **********77655555678899999****************************************************7755..799* PP
   S: 248  kinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlf 334
           k++++v+fpl+ Ld++ ++ +pe++  +++ Y+L avvvH+G +++sGHY+ay+ + +g+W++f+Ds+Vt+++ee+v +   ++aY+lf
   Q: 423  KVDTYVQFPLRgLDMKCYLLEPENSGPDSCLYDLAAVVVHHGsGVGSGHYTAYAVH-EGRWFHFNDSTVTVTDEETVGK---AKAYILF 507
           ********************************************************.9*********************...******* PP
   S: 335  Ykr 337
           Y +
   Q: 508  YVE 510
           *76 PP
   

   UBD/ZnF/ZnF_UBP
   S: 1    kkcsvcdktenlWlcLtcgsvgCGRyvegHalkHyeetqhpl................vlslstlsvycYacddyvhr 62
           ++csvc++++++W+cLtc+sv+CGRyv+gHa+kHye++q pl                ++++s++s+ycY+cdd+v++
   Q: 27   WCCSVCRSNKSPWVCLTCSSVHCGRYVNGHAKKHYEDAQIPLlnhkrsekqekaqhtvCMDCSSYSTYCYRCDDFVVN 104
           9***************************************************************************85 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin (By similarity).
 Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin (By similarity).
Protein Sequence
(Fasta)
MECPHLSSSV CIAPDSAKFP NGSPSSWCCS VCRSNKSPWV CLTCSSVHCG RYVNGHAKKH 60
YEDAQIPLLN HKRSEKQEKA QHTVCMDCSS YSTYCYRCDD FVVNDTKLGL VQKVREHLQN 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063638|DUB,USP;UBD,ZnF_UBP|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGCGGGGCCG CCGGAGAAGG CGGAAGCCTA CTGTCCCTGG GCGGCGGCAG AACCAGGAGT 60
CCGGATTTTC ACGTTCTCCG GAGCGGGGCG CCGGGAGACG GCGGATGGCA AAACCCGGCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063638|DUB,USP;UBD,ZnF_UBP|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0131--Cell cycle
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP
PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP
Pfam

PF00443--UCH
PF02148--zf-UBP
SMART

SM00290--ZnF_UBP
Gene Ontology

GO:0070938--C:contractile ring
GO:0000790--C:nuclear chromatin
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0001046--F:core promoter sequence-specific DNA binding
GO:0042393--F:histone binding
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0006281--P:DNA repair
GO:0016578--P:histone deubiquitination
GO:0000278--P:mitotic cell cycle
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0031647--P:regulation of protein stability
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG mmu:235441
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001537 Ailuropoda melanoleuca 96.35 0.00e+00 942.00
IUUC-Apl-003358 Anas platyrhynchos 94.29 0.00e+00 888.00
IUUC-Aca-004454 Anolis carolinensis 90.62 0.00e+00 815.00
IUUC-Ame-011544 Astyanax mexicanus 76.32 0.00e+00 735.00
IUUC-Bta-012738 Bos taurus 96.16 0.00e+00 922.00
IUUC-Cel-018186 Caenorhabditis elegans 36.49 3.00e-54 206.00
IUUC-Cja-018893 Callithrix jacchus 97.31 0.00e+00 945.00
IUUC-Cfa-020607 Canis familiaris 96.35 0.00e+00 925.00
IUUC-Cpo-021828 Cavia porcellus 95.38 0.00e+00 916.00
IUUC-Csa-023884 Chlorocebus sabaeus 97.41 0.00e+00 771.00
IUUC-Cho-024863 Choloepus hoffmanni 86.15 0.00e+00 799.00
IUUC-Dre-028452 Danio rerio 73.66 0.00e+00 746.00
IUUC-Dno-029531 Dasypus novemcinctus 95.71 0.00e+00 860.00
IUUC-Dor-030913 Dipodomys ordii 89.52 3.00e-177 614.00
IUUC-Ete-032611 Echinops telfairi 90.58 0.00e+00 872.00
IUUC-Eca-033622 Equus caballus 96.33 0.00e+00 861.00
IUUC-Eeu-035268 Erinaceus europaeus 91.41 0.00e+00 790.00
IUUC-Fca-035801 Felis catus 95.71 0.00e+00 892.00
IUUC-Fal-036749 Ficedula albicollis 94.50 0.00e+00 851.00
IUUC-Gmo-039598 Gadus morhua 76.71 0.00e+00 768.00
IUUC-Gga-040883 Gallus gallus 94.49 0.00e+00 854.00
IUUC-Gac-042235 Gasterosteus aculeatus 75.05 0.00e+00 734.00
IUUC-Ggo-044767 Gorilla gorilla 91.04 0.00e+00 830.00
IUUC-Hsa-046581 Homo sapiens 96.54 0.00e+00 962.00
IUUC-Itr-047898 Ictidomys tridecemlineatus 96.92 0.00e+00 930.00
IUUC-Lch-049732 Latimeria chalumnae 89.42 0.00e+00 902.00
IUUC-Loc-052371 Lepisosteus oculatus 88.27 0.00e+00 894.00
IUUC-Laf-054565 Loxodonta africana 96.15 0.00e+00 925.00
IUUC-Mcc-055522 Macaca mulatta 96.92 0.00e+00 967.00
IUUC-Meu-056754 Macropus eugenii 86.03 3.00e-176 611.00
IUUC-Mga-060095 Meleagris gallopavo 94.36 0.00e+00 636.00
IUUC-Mmr-060839 Microcebus murinus 96.73 0.00e+00 927.00
IUUC-Mdo-062339 Monodelphis domestica 96.55 0.00e+00 751.00
IUUC-Mpu-066647 Mustela putorius furo 96.55 0.00e+00 749.00
IUUC-Mlu-067921 Myotis lucifugus 94.90 0.00e+00 875.00
IUUC-Nle-069752 Nomascus leucogenys 97.31 0.00e+00 969.00
IUUC-Opr-070636 Ochotona princeps 82.12 0.00e+00 728.00
IUUC-Ont-071638 Oreochromis niloticus 75.58 0.00e+00 692.00
IUUC-Oan-073417 Ornithorhynchus anatinus 89.04 0.00e+00 879.00
IUUC-Ocu-074620 Oryctolagus cuniculus 96.15 0.00e+00 925.00
IUUC-Ola-087281 Oryzias latipes 77.65 3.00e-179 620.00
IUUC-Olu-087697 Ostreococcus lucimarinus 39.67 1.00e-47 183.00
IUUC-Oga-088448 Otolemur garnettii 95.77 0.00e+00 953.00
IUUC-Oar-090132 Ovis aries 96.15 0.00e+00 926.00
IUUC-Ptr-090696 Pan troglodytes 96.54 0.00e+00 902.00
IUUC-Pan-092124 Papio anubis 96.54 0.00e+00 962.00
IUUC-Psi-093801 Pelodiscus sinensis 94.71 0.00e+00 739.00
IUUC-Pma-094472 Petromyzon marinus 72.37 2.00e-94 338.00
IUUC-Pfo-096330 Poecilia formosa 78.40 0.00e+00 776.00
IUUC-Pab-098191 Pongo abelii 97.12 0.00e+00 968.00
IUUC-Pca-100341 Procavia capensis 95.85 0.00e+00 722.00
IUUC-Pva-103177 Pteropus vampyrus 95.96 0.00e+00 912.00
IUUC-Rno-105048 Rattus norvegicus 98.28 0.00e+00 913.00
IUUC-Sha-107429 Sarcophilus harrisii 95.17 0.00e+00 862.00
IUUC-Sar-113024 Sorex araneus 94.46 0.00e+00 805.00
IUUC-Ssc-115749 Sus scrofa 96.44 2.00e-151 527.00
IUUC-Tgu-117277 Taeniopygia guttata 94.29 0.00e+00 885.00
IUUC-Tru-117844 Takifugu rubripes 77.74 0.00e+00 771.00
IUUC-Tsy-119456 Tarsius syrichta 94.48 0.00e+00 860.00
IUUC-Tni-120251 Tetraodon nigroviridis 74.14 0.00e+00 788.00
IUUC-Tbe-127423 Tupaia belangeri 91.35 0.00e+00 849.00
IUUC-Ttr-128401 Tursiops truncatus 89.37 0.00e+00 779.00
IUUC-Vpa-130549 Vicugna pacos 88.32 2.00e-164 571.00
IUUC-Xtr-131892 Xenopus tropicalis 82.80 0.00e+00 795.00
Created Date 25-Jun-2017

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