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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-064056
UUCD1 version UUC-MuM-01074
Ensembl Protein ID ENSMUSP00000086716.4
UniProt Accession P70398; E9QLY0; Q62497; USP9X_MOUSE
Genbank Protein ID AAB07731.1; CAB01555.1
Protein Name Probable ubiquitin carboxyl-terminal hydrolase FAF-X; Deubiquitinating enzyme FAF-X; Fat facets homolog; Fat facets protein-related, X-linked; Ubiquitin carboxyl-terminal hydrolase FAM; Ubiquitin thioesterase FAF-X; Ubiquitin-specific protease 9, X chromosome; Ubiquitin-specific-processing protease FAF-X
Genbank Nucleotide ID U67874; AL669967
Gene Name Usp9x; Fafl; Fam
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000031010.17 ENSMUST00000089302.10 ENSMUSP00000086716.4
ENSMUSG00000031010.17 ENSMUST00000149021.2 ENSMUSP00000133948.1
ENSMUSG00000031010.17 ENSMUST00000133997.3 ENSMUSP00000134612.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitecircBasemicroRNATRANSFAC
RepTarmiRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
Phospho.ELMUniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
DUB/USP USP 11825870
Classification
Family E-value Score Start End
DUB/USP 2.10e-84 284.7 1557 1956
Active Site
Position(s) Description Evidence
1566 Nucleophile ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
1879 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle................kkkeklneenp............................. 42
           +GlkN g+tCYmNSv+Q+L++ip++r+ +l                 k         +                             
   Q: 1557 VGLKNAGATCYMNSVIQQLYMIPSIRNGILAiegtgsdvdddmsgdeK---------Qdnesnvdprddvfgypqqfedkpplskte 1634
           6******************************98888877766654431.........033333455677777777777777777777 PP
   S: 43   ..kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedksels 127
             ke +  +l++lq +f +l  s+ +++ pr ++k+++ + e ++  eq+Da Ef++ l+d+l+e+l                    
   Q: 1635 drKEYNIGVLRHLQVIFGHLAASRLQYYVPRGFWKQFRLWGEPVNLREQHDALEFFNSLVDSLDEAL-------------------- 1701
           7677777************************************************************.................... PP
   S: 128  deaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkkeslqdcLesftkeeelegenkyycekckkk 214
                 k   ++ ++s++++g++ +q +c+ c ++++ ee+f++l++++++++     +l d+Le+++k + leg+n+y+cekc+kk
   Q: 1702 ------KALGHPAMLSKVLGGSFADQKICQGCPHRYECEESFTTLNVDIRNHQ-----NLLDSLEQYVKGDLLEGANAYHCEKCNKK 1777
           ......67999******************************************.....9**************************** PP
   S: 215  qeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts......................peekqkekkkYe 279
           ++++k+l +kklP+vL ++LkRf ++ e+++ +k+n+++efp+eLd++p+++                       +e++++ ++kY+
   Q: 1778 VDTVKRLLIKKLPPVLAIQLKRFDYDWERECAIKFNDYFEFPRELDMEPYTVAgvaklegdnvnpesqliqqneqSESEKAGSTKYR 1864
           *****************************************************99999999999888888776654444444***** PP
   S: 280  LiavvvHsGslssGHYvayvkn......ekgkWllfdDskVtevkeeevleetg...........................staYvl 333
           L++v+vHsG++s+GHY++y+ +      ek++W++fdD  Vte+k+++ +e+++                           ++aY+l
   Q: 1865 LVGVLVHSGQASGGHYYSYIIQrnggdgEKNRWYKFDDGDVTECKMDDDEEMKNqcfggeymgevfdhmmkrmsyrrqkrwWNAYIL 1951
           **********************6666655666*******************9999******************************** PP
   S: 334  fYkrr 338
           fY+r+
   Q: 1952 FYERM 1956
           ***96 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Regulates chromosome alignment and segregation in mitosis by regulating the localization of BIRC5/survivin to mitotic centromeres. Specifically hydrolyzes both 'Lys-29'- and 'Lys-33'-linked polyubiquitins chains. Specifically deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33 (By similarity). Involved in axonal growth and neuronal cell migration.
 Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Regulates chromosome alignment and segregation in mitosis by regulating the localization of BIRC5/survivin to mitotic centromeres. Specifically hydrolyzes both 'Lys-29'- and 'Lys-33'-linked polyubiquitins chains. Specifically deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33 (By similarity). Involved in axonal growth and neuronal cell migration.
Protein Sequence
(Fasta)
MTATTRGSPV GGNDNQGQAP DGQSQPPLQQ NQTSSPDSSN ENSPATPPDE QGQGDAPPQI 60
EDEEPAFPHT DLAKLDDMIN RPRWVVPVLP KGELEVLLEA AIDLSKKGLD VKSEACQRFF 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064056|DUB,USP|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGGCGGTGCT GAGACTAGTG GGAGTCTGCG CTGCCGCTGC TGTTGCTGCC GCCGTCGCCG 60
CCGCCTCCGA CACTGCCACC GCCACCGCCA CCACCACCGG CCGTGCGGGT TTTCTTTCTT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064056|DUB,USP|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0966--Cell projection
KW-0159--Chromosome partition
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0498--Mitosis
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
Pfam

PF00443--UCH
Gene Ontology

GO:0045177--C:apical part of cell
GO:0005737--C:cytoplasm
GO:0030426--C:growth cone
GO:0016020--C:membrane
GO:0070410--F:co-SMAD binding
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0048675--P:axon extension
GO:0030509--P:BMP signaling pathway
GO:0051301--P:cell division
GO:0071560--P:cellular response to transforming growth factor beta stimulus
GO:0021698--P:cerebellar cortex structural organization
GO:0007059--P:chromosome segregation
GO:0021766--P:hippocampus development
GO:0001701--P:in utero embryonic development
GO:0007067--P:mitotic nuclear division
GO:0001764--P:neuron migration
GO:1990138--P:neuron projection extension
GO:0009791--P:post-embryonic development
GO:0016579--P:protein deubiquitination
GO:0007179--P:transforming growth factor beta receptor signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG mmu:22284
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001640 Ailuropoda melanoleuca 98.36 0.00e+00 4993.00
IUUC-Apl-003592 Anas platyrhynchos 94.76 0.00e+00 4821.00
IUUC-Aca-004939 Anolis carolinensis 94.48 0.00e+00 4779.00
IUUC-Ame-011772 Astyanax mexicanus 87.63 0.00e+00 4522.00
IUUC-Bta-012775 Bos taurus 97.96 0.00e+00 4953.00
IUUC-Cja-019464 Callithrix jacchus 98.08 0.00e+00 4884.00
IUUC-Cfa-020569 Canis familiaris 98.09 0.00e+00 3218.00
IUUC-Csa-023405 Chlorocebus sabaeus 98.47 0.00e+00 4944.00
IUUC-Cho-024524 Choloepus hoffmanni 93.22 0.00e+00 797.00
IUUC-Cin-025551 Ciona intestinalis 63.75 5.00e-143 500.00
IUUC-Csv-025956 Ciona savignyi 53.74 0.00e+00 2499.00
IUUC-Dre-028329 Danio rerio 88.01 0.00e+00 4554.00
IUUC-Dno-028936 Dasypus novemcinctus 98.32 0.00e+00 4997.00
IUUC-Dor-030352 Dipodomys ordii 93.72 0.00e+00 2241.00
IUUC-Dme-032160 Drosophila melanogaster 47.84 0.00e+00 2165.00
IUUC-Ete-032287 Echinops telfairi 96.30 0.00e+00 2757.00
IUUC-Eca-033352 Equus caballus 97.08 0.00e+00 4979.00
IUUC-Eeu-034907 Erinaceus europaeus 86.52 0.00e+00 1834.00
IUUC-Fca-035458 Felis catus 97.67 0.00e+00 5012.00
IUUC-Fal-036924 Ficedula albicollis 94.62 0.00e+00 4725.00
IUUC-Gmo-039578 Gadus morhua 89.45 0.00e+00 4460.00
IUUC-Gga-040978 Gallus gallus 94.83 0.00e+00 4824.00
IUUC-Gac-041970 Gasterosteus aculeatus 90.18 0.00e+00 4558.00
IUUC-Ggo-045575 Gorilla gorilla 97.78 0.00e+00 4962.00
IUUC-Hsa-046295 Homo sapiens 97.86 0.00e+00 4967.00
IUUC-Itr-048768 Ictidomys tridecemlineatus 98.71 0.00e+00 5004.00
IUUC-Lch-050493 Latimeria chalumnae 92.07 0.00e+00 4628.00
IUUC-Loc-052667 Lepisosteus oculatus 89.50 0.00e+00 4662.00
IUUC-Laf-054094 Loxodonta africana 97.67 0.00e+00 4984.00
IUUC-Mcc-054861 Macaca mulatta 97.33 0.00e+00 4924.00
IUUC-Meu-056849 Macropus eugenii 82.60 0.00e+00 1409.00
IUUC-Mga-060159 Meleagris gallopavo 94.64 0.00e+00 4818.00
IUUC-Mmr-060732 Microcebus murinus 98.32 0.00e+00 4998.00
IUUC-Mdo-062274 Monodelphis domestica 94.95 0.00e+00 4891.00
IUUC-Mpu-066669 Mustela putorius furo 98.39 0.00e+00 4998.00
IUUC-Mlu-067516 Myotis lucifugus 97.50 0.00e+00 4951.00
IUUC-Nle-069664 Nomascus leucogenys 98.59 0.00e+00 3662.00
IUUC-Opr-070185 Ochotona princeps 87.53 0.00e+00 794.00
IUUC-Ont-072119 Oreochromis niloticus 89.42 0.00e+00 4570.00
IUUC-Oan-073154 Ornithorhynchus anatinus 94.52 0.00e+00 4869.00
IUUC-Ocu-074485 Oryctolagus cuniculus 98.17 0.00e+00 5039.00
IUUC-Ola-086350 Oryzias latipes 89.83 0.00e+00 4488.00
IUUC-Oga-088328 Otolemur garnettii 97.39 0.00e+00 5036.00
IUUC-Oar-090098 Ovis aries 97.28 0.00e+00 4973.00
IUUC-Pan-091741 Papio anubis 98.38 0.00e+00 3784.00
IUUC-Psi-093040 Pelodiscus sinensis 94.68 0.00e+00 4809.00
IUUC-Pfo-096871 Poecilia formosa 88.71 0.00e+00 4551.00
IUUC-Pab-098374 Pongo abelii 98.43 0.00e+00 4939.00
IUUC-Pca-100801 Procavia capensis 88.94 0.00e+00 2415.00
IUUC-Pva-102992 Pteropus vampyrus 92.20 0.00e+00 2412.00
IUUC-Rno-105377 Rattus norvegicus 99.65 0.00e+00 5052.00
IUUC-Sha-106648 Sarcophilus harrisii 92.29 0.00e+00 4709.00
IUUC-Smo-108879 Selaginella moellendorffii 28.05 0.00e+00 811.00
IUUC-Sar-113729 Sorex araneus 94.10 0.00e+00 3136.00
IUUC-Ssc-116261 Sus scrofa 91.87 0.00e+00 4767.00
IUUC-Tgu-117126 Taeniopygia guttata 94.79 0.00e+00 4824.00
IUUC-Tru-117676 Takifugu rubripes 89.81 0.00e+00 4561.00
IUUC-Tsy-119209 Tarsius syrichta 86.50 0.00e+00 2670.00
IUUC-Tni-120207 Tetraodon nigroviridis 88.44 0.00e+00 2036.00
IUUC-Tbe-128033 Tupaia belangeri 98.62 0.00e+00 1055.00
IUUC-Ttr-128742 Tursiops truncatus 96.44 0.00e+00 4911.00
IUUC-Vpa-130581 Vicugna pacos 94.48 0.00e+00 4766.00
IUUC-Xtr-132145 Xenopus tropicalis 92.33 0.00e+00 4737.00
Created Date 25-Jun-2017

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