iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Mmu-063805

Ensembl Protein ID

ENSMUSP00000039668.3

UniProt Accession

Q571K4; TAB3_MOUSE

Genbank Protein ID

BAD90370.1

Protein Name

TGF-beta-activated kinase 1 and MAP3K7-binding protein 3; Mitogen-activated protein kinase kinase kinase 7-interacting protein 3; TAK1-binding protein 3; TGF-beta-activated kinase 1-binding protein 3

Genbank Nucleotide ID

AK220185

Gene Name

Tab3; Kiaa4135; Map3k7ip3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000035476.9	ENSMUST00000048250.9	ENSMUSP00000039668.3

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
miRNAMap	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/ZnF/NZF	NZF	19927120

Classification

Family	E-value	Score	Start	End
UBD/ZnF/NZF	8.30e-14	51.9	688	715
UBD/Alpha-Helix/CUE	8.20e-06	26.9	12	50

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/ZnF/NZF

   S: 2    eaqWaCsaCTflNePeavkCemCsrpRg 29
           +a+W+C++CTflN+P++++Ce+C++pR+
   Q: 688  GAPWNCDSCTFLNHPALNRCEQCEMPRY 715
           78*************************7 PP

UBD/Alpha-Helix/CUE

   S: 5    aleqLkeiFPnldysviqvvLeantgsleaavnnLLegs 43
            l+ L++ FP+ ++ v+ +++++n+++lea++ +L ++s
   Q: 12   VLHDLRQRFPEIPEGVVSQCMLQNNNNLEACCRALSQES 50
           699*********************************987 PP

Organism

Mus musculus

Functional Description
(View)

Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL-1 and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor (By similarity).

Protein Sequence
(Fasta)

MAQNSPQLDI QVLHDLRQRF PEIPEGVVSQ CMLQNNNNLE ACCRALSQES SKYLYMEYHS 60
PEDNRMNRNR LLHINLGIHS PSSYHPGDGA HLNGGRTLVH SSSDGHIDPQ HTAGKQLICL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGGCTCACA CCGGATCTGC CCTCGGCACG GCGCGCAGTC AAGGGGGTTC GGCCGGGGAA 60
GCCGTGCCCG CCCGGACCCC CCGTGGGAGC CTGCGGACGG ACCGAGGGCC GGGCGGAGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003892--CUE
IPR001876--Znf_RanBP2

PROSITE

PS51140--CUE
PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2

Pfam

PF02845--CUE

SMART

SM00546--CUE
SM00547--ZnF_RBZ

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0008270--F:zinc ion binding

KEGG

mmu:66724

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001479	Ailuropoda melanoleuca	94.00	0.00e+00	1080.00
IUUC-Atr-002761	Amborella trichopoda	54.17	4.00e-04	38.90
IUUC-Apl-003957	Anas platyrhynchos	82.21	0.00e+00	887.00
IUUC-Aca-005020	Anolis carolinensis	76.11	0.00e+00	820.00
IUUC-Ame-011322	Astyanax mexicanus	46.21	6.00e-73	268.00
IUUC-Bta-012378	Bos taurus	95.42	1.00e-140	492.00
IUUC-Cja-018917	Callithrix jacchus	94.83	0.00e+00	1094.00
IUUC-Cfa-020333	Canis familiaris	94.70	0.00e+00	1097.00
IUUC-Cpo-022384	Cavia porcellus	92.21	0.00e+00	1100.00
IUUC-Csa-023536	Chlorocebus sabaeus	94.27	0.00e+00	1035.00
IUUC-Csv-025843	Ciona savignyi	34.96	4.00e-14	70.90
IUUC-Dre-028192	Danio rerio	49.34	8.00e-70	258.00
IUUC-Dno-029493	Dasypus novemcinctus	93.98	0.00e+00	1045.00
IUUC-Dme-031784	Drosophila melanogaster	54.55	3.00e-04	40.80
IUUC-Ete-032743	Echinops telfairi	91.33	0.00e+00	1080.00
IUUC-Eca-033530	Equus caballus	94.42	0.00e+00	1090.00
IUUC-Eeu-035002	Erinaceus europaeus	94.28	0.00e+00	920.00
IUUC-Fca-035595	Felis catus	94.28	0.00e+00	1072.00
IUUC-Fal-036772	Ficedula albicollis	79.45	0.00e+00	882.00
IUUC-Gga-040397	Gallus gallus	82.64	2.00e-141	496.00
IUUC-Gac-042605	Gasterosteus aculeatus	55.41	2.00e-61	230.00
IUUC-Ggo-045454	Gorilla gorilla	94.55	0.00e+00	1058.00
IUUC-Hsa-046688	Homo sapiens	94.83	0.00e+00	1061.00
IUUC-Itr-048163	Ictidomys tridecemlineatus	94.70	0.00e+00	1098.00
IUUC-Lch-049632	Latimeria chalumnae	57.78	2.00e-169	589.00
IUUC-Laf-054539	Loxodonta africana	95.26	0.00e+00	1101.00
IUUC-Mcc-055842	Macaca mulatta	94.55	0.00e+00	1040.00
IUUC-Mla-058933	Melampsora laricipopulina	43.59	1.00e-01	30.80
IUUC-Mga-059642	Meleagris gallopavo	79.28	0.00e+00	853.00
IUUC-Mmr-061140	Microcebus murinus	95.12	0.00e+00	1097.00
IUUC-Mdo-062726	Monodelphis domestica	87.59	0.00e+00	1048.00
IUUC-Mpu-066164	Mustela putorius furo	94.27	0.00e+00	1097.00
IUUC-Mlu-066947	Myotis lucifugus	91.20	0.00e+00	1006.00
IUUC-Nle-069044	Nomascus leucogenys	94.69	0.00e+00	1060.00
IUUC-Opr-071211	Ochotona princeps	87.61	0.00e+00	697.00
IUUC-Ont-071714	Oreochromis niloticus	50.96	1.00e-67	251.00
IUUC-Oan-072910	Ornithorhynchus anatinus	77.82	5.00e-98	351.00
IUUC-Ocu-074006	Oryctolagus cuniculus	94.84	0.00e+00	1087.00
IUUC-Ola-087258	Oryzias latipes	61.96	4.00e-71	262.00
IUUC-Oga-088238	Otolemur garnettii	94.14	0.00e+00	1054.00
IUUC-Oar-090069	Ovis aries	93.44	0.00e+00	1063.00
IUUC-Ptr-091494	Pan troglodytes	94.83	0.00e+00	1061.00
IUUC-Pan-092668	Papio anubis	94.41	0.00e+00	1035.00
IUUC-Psi-093369	Pelodiscus sinensis	80.56	0.00e+00	914.00
IUUC-Pfo-096048	Poecilia formosa	47.18	2.00e-72	266.00
IUUC-Pab-097899	Pongo abelii	94.61	2.00e-151	529.00
IUUC-Pca-100126	Procavia capensis	90.63	0.00e+00	950.00
IUUC-Pva-103031	Pteropus vampyrus	91.04	0.00e+00	999.00
IUUC-Rno-105308	Rattus norvegicus	96.65	0.00e+00	1130.00
IUUC-Sha-107639	Sarcophilus harrisii	87.87	0.00e+00	1031.00
IUUC-Stu-112451	Solanum tuberosum	33.33	8.00e-04	38.50
IUUC-Sar-113032	Sorex araneus	91.42	1.00e-169	589.00
IUUC-Ssc-115940	Sus scrofa	94.00	0.00e+00	1081.00
IUUC-Tgu-116804	Taeniopygia guttata	85.44	0.00e+00	820.00
IUUC-Tru-118326	Takifugu rubripes	45.83	3.00e-55	209.00
IUUC-Tsy-119508	Tarsius syrichta	90.39	6.00e-152	531.00
IUUC-Tni-120668	Tetraodon nigroviridis	42.31	5.00e-73	268.00
IUUC-Tbe-127935	Tupaia belangeri	94.52	1.00e-162	566.00
IUUC-Ttr-128906	Tursiops truncatus	91.07	0.00e+00	1060.00
IUUC-Vpa-130231	Vicugna pacos	85.89	5.00e-138	484.00
IUUC-Xtr-131801	Xenopus tropicalis	66.94	0.00e+00	787.00
IUUC-Xma-133288	Xiphophorus maculatus	54.13	2.00e-70	260.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence