iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000141293.15	ENST00000336915.10	ENSP00000338171.6
ENSG00000141293.15	ENST00000584709.5	ENSP00000463284.1
ENSG00000141293.15	ENST00000581400.2	ENSP00000462360.1
ENSG00000141293.15	ENST00000581419.1	ENSP00000462437.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	CircNet	microRNA
TRANSFAC	TargetScan	RepTar	miRNAMap
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
GWASdb	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	HPRD
Phospho.ELM	UniProt
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	5.20e-10	40.8	299	352

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 6    vqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
            q l+d  + + deL++++Gd +++++ke +  gW++g  el+   G++P+ + + 
   Q: 299  YQGLWDCHGDQPDELSFQRGDLIRILSKEYNMYGWWVG--ELNSLVGIVPKEYLTT 352
           67789999999***************************..9***********9875 PP

Organism

Homo sapiens

Functional Description
(View)

Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells.

Protein Sequence
(Fasta)

MQAAALPEEI RWLLEDAEEF LAEGLRNENL SAVARDHRDH ILRGFQQIKA RYYWDFQPQG 60
GDIGQDSSDD NHSGTLGLSL TSDAPFLSDY QDEGMEDIVK GAQELDNVIK QGYLEKKSKD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCGGGGACC CACGGCCCCG CCCCGCGGCC GGGCTGGGCG GGCGGCGACC GCGGCTGAGG 60
TACAGGTGCC TCGCGGTGCA GCCGGGTCGC CTTCCAGCCC GTCCGCCTCC CGACCAGGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-1064--Adaptive immunity
KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0391--Immunity
KW-0472--Membrane
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR011993--PH_dom-like
IPR001849--PH_domain
IPR001452--SH3_domain

PROSITE

PS50003--PH_DOMAIN
PS50002--SH3

Pfam

PF00169--PH
PF00018--SH3_1

PRINTS

PR00452--SH3DOMAIN

SMART

SM00233--PH
SM00326--SH3

Gene Ontology

GO:0005911--C:cell-cell junction
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0042101--C:T cell receptor complex
GO:0019901--F:protein kinase binding
GO:0019903--F:protein phosphatase binding
GO:0042169--F:SH2 domain binding
GO:0017124--F:SH3 domain binding
GO:0005070--F:SH3/SH2 adaptor activity
GO:0002250--P:adaptive immune response
GO:0045785--P:positive regulation of cell adhesion
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0072659--P:protein localization to plasma membrane
GO:0050852--P:T cell receptor signaling pathway

KEGG

hsa:8631

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001694	Ailuropoda melanoleuca	85.28	2.00e-120	425.00
IUUC-Apl-003847	Anas platyrhynchos	57.72	1.00e-76	279.00
IUUC-Bta-013317	Bos taurus	84.13	2.00e-116	411.00
IUUC-Cja-019106	Callithrix jacchus	95.38	4.00e-164	570.00
IUUC-Cpo-021443	Cavia porcellus	73.33	1.00e-103	369.00
IUUC-Dre-027975	Danio rerio	51.38	6.00e-59	221.00
IUUC-Dno-029749	Dasypus novemcinctus	91.39	6.00e-124	436.00
IUUC-Dor-031025	Dipodomys ordii	80.97	3.00e-152	531.00
IUUC-Eca-033429	Equus caballus	81.63	3.00e-69	254.00
IUUC-Gac-042564	Gasterosteus aculeatus	45.30	2.00e-70	259.00
IUUC-Ggo-044941	Gorilla gorilla	98.89	0.00e+00	649.00
IUUC-Laf-054473	Loxodonta africana	67.77	5.00e-95	340.00
IUUC-Meu-055974	Macropus eugenii	72.02	2.00e-133	468.00
IUUC-Mdo-062722	Monodelphis domestica	72.04	5.00e-140	490.00
IUUC-Mlu-067387	Myotis lucifugus	85.54	2.00e-104	371.00
IUUC-Nle-069187	Nomascus leucogenys	98.61	9.00e-179	619.00
IUUC-Oan-073286	Ornithorhynchus anatinus	66.31	1.00e-94	339.00
IUUC-Oar-089820	Ovis aries	84.87	1.00e-119	422.00
IUUC-Ptr-090625	Pan troglodytes	99.72	0.00e+00	627.00
IUUC-Psi-093355	Pelodiscus sinensis	61.99	6.00e-81	293.00
IUUC-Pab-098125	Pongo abelii	97.41	7.00e-169	586.00
IUUC-Pca-100104	Procavia capensis	84.48	3.00e-151	527.00
IUUC-Pva-102738	Pteropus vampyrus	87.40	3.00e-172	597.00
IUUC-Sha-107032	Sarcophilus harrisii	69.66	1.00e-98	352.00
IUUC-Ssc-115515	Sus scrofa	87.27	2.00e-118	418.00
IUUC-Tru-117634	Takifugu rubripes	50.58	9.00e-70	257.00
IUUC-Tni-119940	Tetraodon nigroviridis	48.42	2.00e-72	265.00
IUUC-Vpa-130355	Vicugna pacos	88.51	2.00e-160	558.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence