iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000170236.14	ENST00000532404.5	ENSP00000434676.1
ENSG00000170236.14	ENST00000559105.5	ENSP00000453946.1
ENSG00000170236.14	ENST00000529349.1	ENSP00000434014.1
ENSG00000170236.14	ENST00000616326.1	ENSP00000483490.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	CircNet	microRNA
TRANSFAC	RepTar	miRcode	RAID2
Protein-protein Interaction
HINT	InWeb_IM
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.00e-70	238.8	44	338

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenp....kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgy 87
           tGl NlgNtC +N++ QcL +i +l e++l+ k+  +l+++ +    +++  e++++++ l++ +w +++  vsp+ +++al+++ + f++ 
   Q: 44   TGLWNLGNTCCVNAISQCLCSILPLVEYFLTgKYITALQNKTYpfllPSDCSEVATAFAYLMTDMWLGDSDCVSPEIFWSALGNLYPAFTKK 135
           7******************************644455544444666677888**************************************** PP
   S: 88   eqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgk 179
           +qqDaqEfl ++l++l+e+lkk    ++++ ++  ++ +++   +k  + ++s+i++lF+ ql  +i+cl+c++ + ++e f+ +slp+p+k
   Q: 136  MQQDAQEFLICVLNELHEALKK---YHYSRRRS-YEKGSTQRCCRKWITTETSIITQLFEEQLNYSIVCLKCEKCTYKNEVFTVFSLPIPSK 223
           ********************44...34444433.4455566677899999****************************************** PP
   S: 180  eetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefple.Ldlspfctspee 270
            e+   sl+dcL+ f++++ l+ +n+++c+ c+ kqe+  + +++k P+++i+hLkRf  + ++  ++k+ + +++pl+ Ldl+p+ +s  +
   Q: 224  YEC---SLRDCLQCFFQQDALTWNNEIHCSFCETKQETAVRASISKAPKIIIFHLKRF--DIQGTTKRKLRTDIHYPLTnLDLTPYICSIFR 310
           ***...****************************************************..66778999*********************665 PP
   S: 271  kqkekkkYeLiavvvHsGslssGHYvayvkn 301
           k   + kY+L+avv+H G l++GHY+a++kn
   Q: 311  K---YPKYNLCAVVNHFGDLDGGHYTAFCKN 338
           5...8*************************9 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MTSQPSLPAD DFDIYHVLAE CTDYYDTLPV KEADGNQPHF QGVTGLWNLG NTCCVNAISQ 60
CLCSILPLVE YFLTGKYITA LQNKTYPFLL PSDCSEVATA FAYLMTDMWL GDSDCVSPEI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGAAAATCCA AGTTGGAGTG GTGCCTGATA CAGGTGAAAA TCAGTTCGCA GCTACTGGAA 60
GAGAGAGGAG CATATCAATT GTTTAAAACA AAAAGCCAGC GTTAACAGGC TCAGAGAAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002089	Ailuropoda melanoleuca	82.22	6.00e-164	570.00
IUUC-Aca-005256	Anolis carolinensis	43.77	2.00e-74	273.00
IUUC-Bta-012753	Bos taurus	76.38	6.00e-150	523.00
IUUC-Cfa-020054	Canis familiaris	79.88	4.00e-162	563.00
IUUC-Cpo-021375	Cavia porcellus	73.15	2.00e-140	492.00
IUUC-Csa-023902	Chlorocebus sabaeus	84.72	6.00e-110	389.00
IUUC-Cho-024755	Choloepus hoffmanni	72.89	1.00e-138	486.00
IUUC-Dor-030311	Dipodomys ordii	86.74	9.00e-91	327.00
IUUC-Ete-032570	Echinops telfairi	59.08	5.00e-97	347.00
IUUC-Eca-034343	Equus caballus	81.92	9.00e-163	566.00
IUUC-Eeu-034510	Erinaceus europaeus	81.54	4.00e-156	543.00
IUUC-Fca-035920	Felis catus	80.17	8.00e-162	563.00
IUUC-Fal-036903	Ficedula albicollis	54.15	1.00e-87	316.00
IUUC-Gac-042261	Gasterosteus aculeatus	41.29	8.00e-56	210.00
IUUC-Ggo-045650	Gorilla gorilla	92.99	9.00e-81	293.00
IUUC-Itr-048167	Ictidomys tridecemlineatus	84.84	3.00e-172	597.00
IUUC-Lch-049925	Latimeria chalumnae	50.96	1.00e-86	313.00
IUUC-Loc-051880	Lepisosteus oculatus	44.59	2.00e-60	227.00
IUUC-Laf-054494	Loxodonta africana	82.51	6.00e-168	583.00
IUUC-Mcc-055507	Macaca mulatta	89.21	0.00e+00	627.00
IUUC-Meu-055906	Macropus eugenii	73.21	6.00e-145	506.00
IUUC-Mmr-061564	Microcebus murinus	63.27	2.00e-109	388.00
IUUC-Mdo-061800	Monodelphis domestica	71.94	2.00e-141	494.00
IUUC-Mmu-063618	Mus musculus	75.51	3.00e-149	521.00
IUUC-Mpu-066699	Mustela putorius furo	82.51	2.00e-166	578.00
IUUC-Mlu-067672	Myotis lucifugus	78.72	1.00e-157	549.00
IUUC-Opr-070949	Ochotona princeps	80.69	1.00e-149	522.00
IUUC-Ont-072200	Oreochromis niloticus	42.26	9.00e-52	197.00
IUUC-Oan-073725	Ornithorhynchus anatinus	60.69	7.00e-116	410.00
IUUC-Ocu-074021	Oryctolagus cuniculus	86.01	5.00e-174	603.00
IUUC-Oga-088258	Otolemur garnettii	81.63	5.00e-159	553.00
IUUC-Oar-089881	Ovis aries	79.88	3.00e-159	554.00
IUUC-Ptr-090988	Pan troglodytes	94.72	0.00e+00	658.00
IUUC-Pan-091773	Papio anubis	88.34	2.00e-178	618.00
IUUC-Psi-093243	Pelodiscus sinensis	68.75	1.00e-112	399.00
IUUC-Pab-097713	Pongo abelii	90.67	0.00e+00	635.00
IUUC-Pca-100226	Procavia capensis	65.89	1.00e-127	449.00
IUUC-Pva-103172	Pteropus vampyrus	84.80	5.00e-171	593.00
IUUC-Rno-105950	Rattus norvegicus	76.97	3.00e-152	531.00
IUUC-Sha-107026	Sarcophilus harrisii	71.39	3.00e-138	484.00
IUUC-Ssc-116383	Sus scrofa	82.22	4.00e-166	577.00
IUUC-Tgu-116511	Taeniopygia guttata	52.92	1.00e-83	303.00
IUUC-Tsy-119444	Tarsius syrichta	92.98	3.00e-61	228.00
IUUC-Tbe-127808	Tupaia belangeri	81.29	2.00e-60	226.00
IUUC-Ttr-129046	Tursiops truncatus	81.92	3.00e-163	567.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence