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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046172
UUCD1 version UUC-HoS-00125
Ensembl Protein ID ENSP00000356475.2
UniProt Accession Q149N8; Q149N9; Q5VV79; Q68DS5; Q7Z5J5; Q8IVE8; Q8IWQ9; Q8N1S8; Q8NBR7; SHPRH_HUMAN
Genbank Protein ID AAO26201.1; AAO06907.1; CAH18145.1; CAI41120.1; CAI41120.1; CAH70765.1; CAH70765.1; AAI13090.1; AAI17686.1; AAI17687.1; BAC11544.1; BAC04459.1; BAC23119.1
Protein Name E3 ubiquitin-protein ligase SHPRH; RING-type E3 ubiquitin transferase SHPRH; SNF2, histone-linker, PHD and RING finger domain-containing helicase
Genbank Nucleotide ID AY161136; AY163808; CR749290; AL356599; AL451145; AL451145; AL356599; BC113089; BC117685; BC117686; AK075318; AK094944; AB095943
Gene Name SHPRH; KIAA2023
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000146414.15 ENST00000417762.5 ENSP00000403790.1
ENSG00000146414.15 ENST00000367505.6 ENSP00000356475.2
ENSG00000146414.15 ENST00000438092.6 ENSP00000412797.2
ENSG00000146414.15 ENST00000433355.6 ENSP00000408019.2
ENSG00000146414.15 ENST00000519632.5 ENSP00000430528.1
ENSG00000146414.15 ENST00000521977.1 ENSP00000429548.1
ENSG00000146414.15 ENST00000629427.2 ENSP00000486723.1
ENSG00000146414.15 ENST00000367503.7 ENSP00000356473.4
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtBioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 18316726
Classification
Family E-value Score Start End
E3 activity/RING/RING 0.0002 23.5 1432 1479
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadCl....qkw.pglknssskefrCPlCr 46
           C+iC   + +++ vl CgH+f+ +C+    +++ +g   s + +++C +Cr
   Q: 1432 CPICARQLGKQWAVLTCGHCFCNECIsiiiEQYsVG---SHRSSIKCAICR 1479
           ********999**************95556666445...556666676775 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'.
 E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'.
Protein Sequence
(Fasta)
MSSRRKRAPP VRVDEEKRQQ LHWNMHEDRR NEPIIISDDD EQPCPGSDTS SAHYIILSDS 60
LKEEVAHRDK KRCSKVVSFS KPIEKEETVG IFSPLSVKLN IVISPYHFDN SWKAFLGELT 120
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Protein Fasta Sequence


>IUUC-Hsa-046172|E3,RING|Homo sapiens
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Nucleotide Sequence
(Fasta)
ACTCATGAAG CCAGCGCAGG AGAAAGGGGG CGGGGTGCTC TGACGAGCGC GTTCGCCTTG 60
ACCCCACGCT ACAGCGCGCG CCCGGCAGCT AGGCGCTGTG GTTTCTGGGT CTCCCGGGGG 120
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Nucleotide Fasta Sequence


>IUUC-Hsa-046172|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0347--Helicase
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR014001--Helicase_ATP-bd
IPR001650--Helicase_C
IPR005818--Histone_H1/H5_H15
IPR027417--P-loop_NTPase
IPR000330--SNF2_N
IPR011990--TPR-like_helical_dom
IPR011991--WHTH_DNA-bd_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS51504--H15
PS51192--HELICASE_ATP_BIND_1
PS51194--HELICASE_CTER
PS01359--ZF_PHD_1
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00271--Helicase_C
PF00538--Linker_histone
PF00176--SNF2_N
SMART

SM00487--DEXDc
SM00526--H15
SM00490--HELICc
SM00249--PHD
SM00184--RING
Gene Ontology

GO:0000786--C:nucleosome
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0003677--F:DNA binding
GO:0004386--F:helicase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0006281--P:DNA repair
GO:0006334--P:nucleosome assembly
GO:0000209--P:protein polyubiquitination
KEGG hsa:257218
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Atr-002896 Amborella trichopoda 40.50 7.00e-89 323.00
IUUC-Apl-003428 Anas platyrhynchos 71.41 0.00e+00 2399.00
IUUC-Aca-004510 Anolis carolinensis 63.37 0.00e+00 1970.00
IUUC-Aly-005691 Arabidopsis lyrata 32.92 6.00e-151 529.00
IUUC-Ath-007139 Arabidopsis thaliana 32.96 6.00e-148 519.00
IUUC-Ago-007786 Ashbya gossypii 27.76 4.00e-27 118.00
IUUC-Acl-008380 Aspergillus clavatus 29.49 1.00e-29 126.00
IUUC-Afu-008890 Aspergillus fumigatus 34.91 4.00e-36 147.00
IUUC-Ani-009351 Aspergillus nidulans 31.91 3.00e-31 131.00
IUUC-Ang-009583 Aspergillus niger 35.74 2.00e-35 145.00
IUUC-Aor-009893 Aspergillus oryzae 32.61 4.00e-32 134.00
IUUC-Ate-010385 Aspergillus terreus 33.55 1.00e-39 159.00
IUUC-Ame-011882 Astyanax mexicanus 62.22 0.00e+00 2068.00
IUUC-Bgr-012295 Blumeria graminis 35.06 9.00e-42 166.00
IUUC-Bta-012528 Bos taurus 90.35 0.00e+00 3067.00
IUUC-Bci-013701 Botrytis cinerea 35.90 3.00e-37 151.00
IUUC-Bdi-014034 Brachypodium distachyon 38.33 2.00e-75 278.00
IUUC-Bol-015555 Brassica oleracea 34.09 1.00e-145 511.00
IUUC-Bra-016916 Brassica rapa 34.09 1.00e-158 555.00
IUUC-Cja-019391 Callithrix jacchus 95.64 0.00e+00 3218.00
IUUC-Cfa-020732 Canis familiaris 92.53 0.00e+00 3135.00
IUUC-Cpo-021641 Cavia porcellus 86.73 0.00e+00 2917.00
IUUC-Cre-022879 Chlamydomonas reinhardtii 29.79 1.00e-22 102.00
IUUC-Csa-023937 Chlorocebus sabaeus 98.10 0.00e+00 3317.00
IUUC-Cho-024617 Choloepus hoffmanni 71.04 2.00e-108 388.00
IUUC-Cgl-026624 Colletotrichum gloeosporioides 36.68 2.00e-39 158.00
IUUC-Cme-027178 Cyanidioschyzon merolae 33.64 1.00e-131 464.00
IUUC-Dre-028441 Danio rerio 62.48 0.00e+00 2057.00
IUUC-Dno-029395 Dasypus novemcinctus 81.95 0.00e+00 2775.00
IUUC-Dse-031372 Dothistroma septosporum 34.00 9.00e-41 163.00
IUUC-Dme-031785 Drosophila melanogaster 30.86 2.00e-116 414.00
IUUC-Ete-032502 Echinops telfairi 78.40 0.00e+00 1479.00
IUUC-Eca-033455 Equus caballus 87.34 0.00e+00 2927.00
IUUC-Eeu-034956 Erinaceus europaeus 86.26 0.00e+00 1998.00
IUUC-Fca-035984 Felis catus 90.56 0.00e+00 2502.00
IUUC-Fal-036811 Ficedula albicollis 70.97 0.00e+00 2365.00
IUUC-Fox-038048 Fusarium oxysporum 44.97 1.00e-32 136.00
IUUC-Fso-038224 Fusarium solani 34.30 2.00e-37 151.00
IUUC-Gmo-039126 Gadus morhua 75.41 0.00e+00 1645.00
IUUC-Ggr-040102 Gaeumannomyces graminis 29.94 8.00e-28 120.00
IUUC-Gga-041238 Gallus gallus 71.76 0.00e+00 2400.00
IUUC-Gac-041614 Gasterosteus aculeatus 62.49 0.00e+00 2053.00
IUUC-Gma-043259 Glycine max 40.60 4.00e-78 287.00
IUUC-Ggo-045213 Gorilla gorilla 96.62 0.00e+00 3231.00
IUUC-Hvu-047286 Hordeum vulgare 38.50 6.00e-34 139.00
IUUC-Itr-048880 Ictidomys tridecemlineatus 90.75 0.00e+00 3028.00
IUUC-Kpa-049196 Komagataella pastoris 26.56 6.00e-24 107.00
IUUC-Lch-050648 Latimeria chalumnae 64.69 0.00e+00 1964.00
IUUC-Lpe-050871 Leersia perrieri 38.48 2.00e-77 285.00
IUUC-Loc-051862 Lepisosteus oculatus 63.63 0.00e+00 2086.00
IUUC-Lma-053266 Leptosphaeria maculans 29.67 2.00e-25 112.00
IUUC-Laf-053851 Loxodonta africana 89.82 0.00e+00 3010.00
IUUC-Mcc-055066 Macaca mulatta 98.04 0.00e+00 3313.00
IUUC-Meu-056104 Macropus eugenii 79.73 0.00e+00 716.00
IUUC-Mor-057226 Magnaporthe oryzae 28.33 1.00e-31 132.00
IUUC-Mpo-057528 Magnaporthe poae 28.10 1.00e-28 122.00
IUUC-Mtr-058336 Medicago truncatula 39.91 6.00e-80 293.00
IUUC-Mga-059775 Meleagris gallopavo 71.47 0.00e+00 2387.00
IUUC-Mvi-060213 Microbotryum violaceum 31.87 3.00e-28 122.00
IUUC-Mdo-062943 Monodelphis domestica 76.42 0.00e+00 2528.00
IUUC-Mmu-064115 Mus musculus 85.41 0.00e+00 2883.00
IUUC-Mac-064445 Musa acuminata 41.19 3.00e-89 323.00
IUUC-Mpu-066850 Mustela putorius furo 92.59 0.00e+00 3140.00
IUUC-Mlu-067610 Myotis lucifugus 90.44 0.00e+00 3057.00
IUUC-Nfi-068264 Neosartorya fischeri 34.91 4.00e-36 147.00
IUUC-Ncr-068745 Neurospora crassa 37.45 4.00e-35 144.00
IUUC-Nle-070055 Nomascus leucogenys 99.23 0.00e+00 3330.00
IUUC-Ont-071526 Oreochromis niloticus 63.44 0.00e+00 2074.00
IUUC-Oan-073609 Ornithorhynchus anatinus 83.88 0.00e+00 1368.00
IUUC-Ocu-074042 Oryctolagus cuniculus 88.59 0.00e+00 3013.00
IUUC-Oba-075121 Oryza barthii 39.05 1.00e-75 279.00
IUUC-Obr-076312 Oryza brachyantha 30.13 6.00e-128 452.00
IUUC-Ogl-077560 Oryza glaberrima 39.05 2.00e-75 278.00
IUUC-Ogu-078746 Oryza glumaepatula 39.05 2.00e-76 281.00
IUUC-Oin-080153 Oryza indica 30.18 2.00e-110 394.00
IUUC-Olo-080436 Oryza longistaminata 30.54 2.00e-126 447.00
IUUC-Oni-082845 Oryza nivara 39.26 2.00e-75 278.00
IUUC-Opu-083321 Oryza punctata 30.90 6.00e-134 473.00
IUUC-Oru-084329 Oryza rufipogon 39.05 8.00e-76 280.00
IUUC-Osa-085508 Oryza sativa 38.74 6.00e-32 130.00
IUUC-Olu-087671 Ostreococcus lucimarinus 32.09 4.00e-140 493.00
IUUC-Oar-090005 Ovis aries 90.57 0.00e+00 3078.00
IUUC-Pan-092723 Papio anubis 96.50 0.00e+00 3218.00
IUUC-Psi-093870 Pelodiscus sinensis 73.17 0.00e+00 2441.00
IUUC-Pma-094750 Petromyzon marinus 70.94 4.00e-100 357.00
IUUC-Pno-095005 Phaeosphaeria nodorum 29.45 2.00e-32 135.00
IUUC-Ppa-095619 Physcomitrella patens 30.48 2.00e-80 294.00
IUUC-Pfo-096833 Poecilia formosa 63.37 0.00e+00 2102.00
IUUC-Pab-098544 Pongo abelii 99.35 0.00e+00 3341.00
IUUC-Pop-099540 Populus trichocarpa 41.53 1.00e-91 332.00
IUUC-Ppe-102038 Prunus persica 40.51 1.00e-92 335.00
IUUC-Pte-104081 Pyrenophora teres 29.60 2.00e-31 132.00
IUUC-Pyt-104477 Pyrenophora triticirepentis 30.50 8.00e-34 140.00
IUUC-Rno-104959 Rattus norvegicus 84.35 0.00e+00 2828.00
IUUC-Sha-107078 Sarcophilus harrisii 75.77 0.00e+00 2496.00
IUUC-Sja-107755 Schizosaccharomyces japonicus 30.46 1.00e-36 149.00
IUUC-Spo-108132 Schizosaccharomyces pombe 38.13 2.00e-41 164.00
IUUC-Ssl-108615 Sclerotinia sclerotiorum 28.95 2.00e-32 135.00
IUUC-Smo-108991 Selaginella moellendorffii 35.60 5.00e-171 596.00
IUUC-Sit-110047 Setaria italica 31.94 5.00e-48 187.00
IUUC-Sly-111232 Solanum lycopersicum 39.09 1.00e-81 298.00
IUUC-Sar-113738 Sorex araneus 80.00 0.00e+00 2707.00
IUUC-Sbi-114485 Sorghum bicolor 33.96 7.00e-59 223.00
IUUC-Ssc-116362 Sus scrofa 91.36 0.00e+00 3079.00
IUUC-Tgu-117188 Taeniopygia guttata 71.03 0.00e+00 2367.00
IUUC-Tru-117637 Takifugu rubripes 63.16 0.00e+00 2069.00
IUUC-Tni-119701 Tetraodon nigroviridis 62.99 0.00e+00 2075.00
IUUC-Tca-121831 Theobroma cacao 41.94 2.00e-94 341.00
IUUC-Tre-122005 Trichoderma reesei 32.48 6.00e-28 120.00
IUUC-Tvi-122328 Trichoderma virens 32.72 2.00e-29 125.00
IUUC-Tae-123569 Triticum aestivum 30.14 2.00e-128 454.00
IUUC-Tur-125964 Triticum urartu 37.58 3.00e-72 267.00
IUUC-Tbe-127799 Tupaia belangeri 78.19 0.00e+00 1697.00
IUUC-Vda-129795 Verticillium dahliae 30.77 2.00e-27 118.00
IUUC-Vvi-131682 Vitis vinifera 42.06 3.00e-94 340.00
IUUC-Xtr-132232 Xenopus tropicalis 63.54 0.00e+00 2082.00
IUUC-Xma-133291 Xiphophorus maculatus 62.36 0.00e+00 2018.00
IUUC-Yli-134508 Yarrowia lipolytica 27.76 8.00e-28 120.00
IUUC-Zma-135327 Zea mays 38.38 5.00e-75 276.00
Created Date 25-Jun-2017

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