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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046396
UUCD1 version UUC-HoS-00211
Ensembl Protein ID ENSP00000264346.7
UniProt Accession Q8IVU3; B4DIY5; Q5GC90; Q5GRH3; Q5HYM6; Q5JPB6; Q6PIF4; Q8NAN3; Q9NWS4; HERC6_HUMAN
Genbank Protein ID AAQ14893.1; AAV66895.1; BAA91303.1; BAC03879.1; BAG58647.1; AAH35775.2; AAH42047.2; CAI46151.1; CAI46056.1
Protein Name Probable E3 ubiquitin-protein ligase HERC6; HECT domain and RCC1-like domain-containing protein 6; HECT-type E3 ubiquitin transferase HERC6
Genbank Nucleotide ID AF336798; AY653201; AK000644; AK092403; AK295832; BC035775; BC042047; AL833664; BX647121
Gene Name HERC6
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000138642.14 ENST00000380265.9 ENSP00000369617.5
ENSG00000138642.14 ENST00000264346.11 ENSP00000264346.7
ENSG00000138642.14 ENST00000504905.5 ENSP00000425504.1
ENSG00000138642.14 ENST00000502870.1 ENSP00000425060.1
ENSG00000138642.14 ENST00000273960.7 ENSP00000273960.4
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
THPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanmiRecordsRepTarSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDBioGRIDmUbiSiDa
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/HECT HECT 20133869
Classification
Family E-value Score Start End
E3 activity/HECT 5.90e-91 307.0 695 1014
Active Site
Position(s) Description Evidence
985 Glycyl thioester intermediate {ECO:0000255|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlpl 92
            d+ k+l vef +E + + gGv++ef++++++e+ +p++g+f+y e ++++++p++ +     e+ ++F  +G+l+g++l++ ++ +lp+
   Q: 695  TDFCKVLVVEFINEICPESGGVSSEFFHCMFEEMTKPEYGMFMYPEMGSCMWFPAKPKP----EKKRYFL-FGMLCGLSLFNLNVANLPF 779
           688899*************************************************9885....7889995.5****************** PP
   S: 93   sksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrl 182
           + ++yk+ll++k sledl+e+ p l ksl+e+++ a +di ++ l+++fs++     ++++++L+p+G +ipV ++Nk++Yv+++++y++
   Q: 780  PLALYKKLLDQKPSLEDLKELSPRLGKSLQEVLDDAADDIGDA-LCIRFSIH----WDQNDVDLIPNGISIPVDQTNKRDYVSKYIDYIF 864
           ***********************************99999998.*****955....5779999*************************** PP
   S: 183  kegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgss 272
           + ++k  +e+f++Gf++v+++e+l+ F +eel + i G++++d+++++++ ky++gy++++p+iq Fw+++++++ +e+k+fL F+Tg++
   Q: 865  NVSVKAVYEEFQRGFYRVCEKEILRHFYPEELMTAIIGNTDYDWKQFEQNSKYEQGYQKSHPTIQLFWKAFHKLTLDEKKKFLFFLTGRD 954
           ****************************************************************************************** PP
   S: 273  rlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgF 333
           rl ++G+++++  +f +++  s+++ P+s TC n L LP+Ys++e ++e L++Ai++++gF
   Q: 955  RLHARGIQKME-IVFRCPETFSERDHPTSITCHNILSLPKYSTMERMEEALQVAINNNRGF 1014
           ***********.77888889****************************************9 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
 E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
Protein Sequence
(Fasta)
MYFCWGADSR ELQRRRTAGS PGAELLQAAS GERHSLLLLT NHRVLSCGDN SRGQLGRRGA 60
QRGELPEPIQ ALETLIVDLV SCGKEHSLAV CHKGRVFAWG AGSEGQLGIG EFKEISFTPK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046396|E3,HECT|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGCACTTGAA GTTCAGGCAG CGAGAGTTGA CATGGGGCCA GGGCTGCGCC CCTGGGGCGG 60
GTTGAAGACA GGGTGAGTCT CTTGATATTC AGGAAATCAT CGCGCACCCA GTCACCAGCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046396|E3,HECT|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3
Pfam

PF00632--HECT
PF00415--RCC1
PRINTS

PR00633--RCCNDNSATION
SMART

SM00119--HECTc
Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0002244--P:hematopoietic progenitor cell differentiation
GO:0000209--P:protein polyubiquitination
KEGG hsa:55008
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001374 Ailuropoda melanoleuca 73.16 0.00e+00 1410.00
IUUC-Aca-004663 Anolis carolinensis 46.88 0.00e+00 873.00
IUUC-Bta-013080 Bos taurus 73.73 0.00e+00 1459.00
IUUC-Cja-018891 Callithrix jacchus 86.85 0.00e+00 1764.00
IUUC-Cfa-020763 Canis familiaris 72.49 0.00e+00 1367.00
IUUC-Cpo-022346 Cavia porcellus 70.52 0.00e+00 1447.00
IUUC-Csa-023049 Chlorocebus sabaeus 95.29 0.00e+00 1998.00
IUUC-Dno-029093 Dasypus novemcinctus 76.42 0.00e+00 1560.00
IUUC-Eca-034098 Equus caballus 77.28 0.00e+00 1486.00
IUUC-Eeu-035028 Erinaceus europaeus 59.54 1.00e-167 584.00
IUUC-Fca-036283 Felis catus 74.52 0.00e+00 1439.00
IUUC-Ggo-045553 Gorilla gorilla 94.41 0.00e+00 1937.00
IUUC-Loc-052700 Lepisosteus oculatus 41.84 0.00e+00 802.00
IUUC-Laf-054433 Loxodonta africana 71.95 0.00e+00 1506.00
IUUC-Mcc-055014 Macaca mulatta 90.77 0.00e+00 1922.00
IUUC-Mdo-061839 Monodelphis domestica 57.28 0.00e+00 1055.00
IUUC-Mmu-064378 Mus musculus 66.31 0.00e+00 1306.00
IUUC-Mpu-066293 Mustela putorius furo 71.75 0.00e+00 1362.00
IUUC-Mlu-067407 Myotis lucifugus 73.11 0.00e+00 1436.00
IUUC-Nle-069978 Nomascus leucogenys 95.68 0.00e+00 2006.00
IUUC-Opr-070190 Ochotona princeps 60.31 0.00e+00 721.00
IUUC-Ocu-074640 Oryctolagus cuniculus 70.53 0.00e+00 874.00
IUUC-Oga-088780 Otolemur garnettii 71.47 0.00e+00 1431.00
IUUC-Oar-090307 Ovis aries 74.25 0.00e+00 1458.00
IUUC-Ptr-091567 Pan troglodytes 97.45 0.00e+00 2015.00
IUUC-Pan-091802 Papio anubis 89.82 0.00e+00 1865.00
IUUC-Pab-098024 Pongo abelii 78.56 0.00e+00 1546.00
IUUC-Pva-102382 Pteropus vampyrus 69.64 0.00e+00 1356.00
IUUC-Rno-105768 Rattus norvegicus 62.02 0.00e+00 1235.00
IUUC-Sha-106525 Sarcophilus harrisii 54.97 0.00e+00 1122.00
IUUC-Sar-113014 Sorex araneus 60.36 4.00e-158 551.00
IUUC-Tsy-119565 Tarsius syrichta 78.65 4.00e-176 612.00
IUUC-Vpa-130214 Vicugna pacos 71.98 0.00e+00 1308.00
Created Date 25-Jun-2017

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