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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063900
UUCD1 version UUC-MuM-00877
Ensembl Protein ID ENSMUSP00000034739.5
UniProt Accession Q99ML9; Q3UVL7; Q6NSW2; Q7TMR3; Q8C881; Q8CBC0; RN111_MOUSE
Genbank Protein ID AAK38272.1; BAC33245.1; BAC29394.1; BAE23252.1; AAH54842.1; AAH69835.1
Protein Name E3 ubiquitin-protein ligase Arkadia; RING finger protein 111; RING-type E3 ubiquitin transferase Arkadia
Genbank Nucleotide ID AF330197; AK048110; AK036351; AK137148; BC054842; BC069835
Gene Name Rnf111
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000032217.13 ENSMUST00000215848.1 ENSMUSP00000149445.1
ENSMUSG00000032217.13 ENSMUST00000034739.11 ENSMUSP00000034739.5
ENSMUSG00000032217.13 ENSMUST00000213647.1 ENSMUSP00000149501.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitecircBasemiRTarBasemicroRNA
TRANSFACRepTarmiRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexMentha
Post-translational Modifications (PTMs)
BioGRID
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/RING 7.70e-07 30.7 937 978
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdg..plvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iCl+ +++g  ++ lpC H+fh+ C+ +w        ++ +CP+Cr
   Q: 937  CTICLSILEEGedVRRLPCMHLFHQVCVDQW------LITNKKCPICR 978
           9*****9944444******************......**********8 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase required for mesoderm patterning during embryonic development (PubMed:11298452). Acts as an enhancer of the transcriptional responses of the SMAD2/SMAD3 effectors, which are activated downstream of BMP (PubMed:14657019). Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD7, inducing their proteasomal degradation and thereby enhancing the transcriptional activity of TGF-beta and BMP (PubMed:14657019). In addition to enhance transcription of SMAD2/SMAD3 effectors, also regulates their turnover by mediating their ubiquitination and subsequent degradation, coupling their activation with degradation, thereby ensuring that only effectors 'in use' are degraded (By similarity). Activates SMAD3/SMAD4-dependent transcription by triggering signal-induced degradation of SNON isoform of SKIL (By similarity). Associates with UBE2D2 as an E2 enzyme (By similarity). Specifically binds polysumoylated chains via SUMO interaction motifs (SIMs) and mediates ubiquitination of sumoylated substrates (PubMed:23530056). Catalyzes 'Lys-63'-linked ubiquitination of sumoylated XPC in response to UV irradiation, promoting nucleotide excision repair (By similarity). Mediates ubiquitination and degradation of sumoylated PML (PubMed:23530056). The regulation of the BMP-SMAD signaling is however independent of sumoylation and is not dependent of SUMO interaction motifs (SIMs) (PubMed:23530056).
 E3 ubiquitin-protein ligase required for mesoderm patterning during embryonic development (PubMed:11298452). Acts as an enhancer of the transcriptional responses of the SMAD2/SMAD3 effectors, which are activated downstream of BMP (PubMed:14657019). Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD7, inducing their proteasomal degradation and thereby enhancing the transcriptional activity of TGF-beta and BMP (PubMed:14657019). In addition to enhance transcription of SMAD2/SMAD3 effectors, also regulates their turnover by mediating their ubiquitination and subsequent degradation, coupling their activation with degradation, thereby ensuring that only effectors 'in use' are degraded (By similarity). Activates SMAD3/SMAD4-dependent transcription by triggering signal-induced degradation of SNON isoform of SKIL (By similarity). Associates with UBE2D2 as an E2 enzyme (By similarity). Specifically binds polysumoylated chains via SUMO interaction motifs (SIMs) and mediates ubiquitination of sumoylated substrates (PubMed:23530056). Catalyzes 'Lys-63'-linked ubiquitination of sumoylated XPC in response to UV irradiation, promoting nucleotide excision repair (By similarity). Mediates ubiquitination and degradation of sumoylated PML (PubMed:23530056). The regulation of the BMP-SMAD signaling is however independent of sumoylation and is not dependent of SUMO interaction motifs (SIMs) (PubMed:23530056).
Protein Sequence
(Fasta)
MSQWTPEFNE LYTLKVAMKS GTPDAPTTQE SLKAVLLHPQ PLGATKSFPA EVEMINSKVG 60
NEFSHLCDDS QKQEKDMTGN QQEQEKSGVV RKKRKSQQAG PSYVQNCVKE NQEILGRRQQ 120
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Protein Fasta Sequence


>IUUC-Mmu-063900|E3,RING|Mus musculus
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Nucleotide Sequence
(Fasta)
CGACGGCGAT GGTGGCGGGG CGCTGGTGCT GCGCGGCGTA AGGCACGCCG GCCGTTCAGG 60
GTCGCGAGCG CGCGTGGGCC GCGATCGGGT GCTCGGAGCC GGGTCCAGCC GAGCCAGGCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063900|E3,RING|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0227--DNA damage
KW-0234--DNA repair
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR029306--RNF111_N
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF15303--RNF111_N
PF13639--zf-RING_2
SMART

SM00184--RING
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0016605--C:PML body
GO:0043234--C:protein complex
GO:0032184--F:SUMO polymer binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006281--P:DNA repair
GO:0007389--P:pattern specification process
GO:0031398--P:positive regulation of protein ubiquitination
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0030511--P:positive regulation of transforming growth factor beta receptor signaling pathway
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030579--P:ubiquitin-dependent SMAD protein catabolic process
KEGG mmu:93836
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000605 Aegilops tauschii 50.94 1.00e-13 69.70
IUUC-Aml-001378 Ailuropoda melanoleuca 88.82 0.00e+00 1334.00
IUUC-Apl-003634 Anas platyrhynchos 78.49 0.00e+00 1184.00
IUUC-Aca-004574 Anolis carolinensis 74.36 1.00e-123 436.00
IUUC-Ath-007520 Arabidopsis thaliana 35.51 3.00e-15 75.50
IUUC-Acl-008067 Aspergillus clavatus 44.64 2.00e-10 61.20
IUUC-Ang-009544 Aspergillus niger 53.33 3.00e-10 60.80
IUUC-Ate-010250 Aspergillus terreus 51.11 6.00e-10 59.70
IUUC-Bta-012823 Bos taurus 88.83 0.00e+00 1360.00
IUUC-Bdi-014777 Brachypodium distachyon 59.09 4.00e-13 67.80
IUUC-Cja-018850 Callithrix jacchus 86.85 0.00e+00 1214.00
IUUC-Cfa-021062 Canis familiaris 89.02 0.00e+00 1332.00
IUUC-Cpo-021467 Cavia porcellus 83.89 0.00e+00 1273.00
IUUC-Csa-024048 Chlorocebus sabaeus 89.63 0.00e+00 1329.00
IUUC-Cho-024278 Choloepus hoffmanni 79.76 1.00e-120 427.00
IUUC-Dre-028323 Danio rerio 51.13 8.00e-152 531.00
IUUC-Dno-028850 Dasypus novemcinctus 83.81 0.00e+00 1239.00
IUUC-Dme-031973 Drosophila melanogaster 38.24 2.00e-25 112.00
IUUC-Ete-032985 Echinops telfairi 87.46 3.00e-114 406.00
IUUC-Eca-033659 Equus caballus 89.53 0.00e+00 1392.00
IUUC-Eeu-034773 Erinaceus europaeus 79.06 0.00e+00 694.00
IUUC-Fca-035560 Felis catus 88.92 0.00e+00 1293.00
IUUC-Fal-037598 Ficedula albicollis 77.29 0.00e+00 1177.00
IUUC-Gmo-038696 Gadus morhua 71.15 2.00e-66 246.00
IUUC-Gga-040900 Gallus gallus 79.50 0.00e+00 1179.00
IUUC-Gac-041830 Gasterosteus aculeatus 52.37 5.00e-166 578.00
IUUC-Gma-043396 Glycine max 50.00 6.00e-14 70.50
IUUC-Ggo-044921 Gorilla gorilla 89.23 0.00e+00 1401.00
IUUC-Hsa-046529 Homo sapiens 90.04 0.00e+00 1404.00
IUUC-Itr-048765 Ictidomys tridecemlineatus 91.24 0.00e+00 1336.00
IUUC-Lch-049512 Latimeria chalumnae 68.94 0.00e+00 950.00
IUUC-Lpe-050764 Leersia perrieri 52.94 1.00e-12 66.20
IUUC-Loc-052174 Lepisosteus oculatus 55.76 0.00e+00 664.00
IUUC-Laf-053804 Loxodonta africana 88.02 0.00e+00 1232.00
IUUC-Mcc-055297 Macaca mulatta 89.33 0.00e+00 1358.00
IUUC-Meu-056052 Macropus eugenii 80.81 8.00e-119 421.00
IUUC-Mtr-058136 Medicago truncatula 55.32 3.00e-13 67.80
IUUC-Mga-059350 Meleagris gallopavo 79.30 0.00e+00 1203.00
IUUC-Mmr-061666 Microcebus murinus 89.33 0.00e+00 1356.00
IUUC-Mdo-061958 Monodelphis domestica 81.89 0.00e+00 1223.00
IUUC-Mac-065281 Musa acuminata 32.52 2.00e-11 61.20
IUUC-Mpu-066492 Mustela putorius furo 88.52 0.00e+00 1333.00
IUUC-Mlu-067464 Myotis lucifugus 88.05 0.00e+00 1299.00
IUUC-Nfi-068528 Neosartorya fischeri 51.11 7.00e-10 59.70
IUUC-Nle-070038 Nomascus leucogenys 88.83 0.00e+00 1397.00
IUUC-Opr-070924 Ochotona princeps 80.72 0.00e+00 773.00
IUUC-Ont-072297 Oreochromis niloticus 52.75 1.00e-100 361.00
IUUC-Oan-072897 Ornithorhynchus anatinus 62.84 0.00e+00 813.00
IUUC-Ocu-074713 Oryctolagus cuniculus 88.02 0.00e+00 1343.00
IUUC-Oba-074994 Oryza barthii 32.46 5.00e-13 69.30
IUUC-Obr-076337 Oryza brachyantha 32.11 3.00e-13 70.10
IUUC-Ogl-077817 Oryza glaberrima 32.46 5.00e-13 69.30
IUUC-Ogu-077954 Oryza glumaepatula 32.46 5.00e-13 69.30
IUUC-Oin-079127 Oryza indica 34.62 7.00e-13 69.30
IUUC-Olo-080304 Oryza longistaminata 32.46 5.00e-13 69.30
IUUC-Ome-081451 Oryza meridionalis 34.62 8.00e-13 69.30
IUUC-Oni-082765 Oryza nivara 32.46 6.00e-13 69.30
IUUC-Opu-084108 Oryza punctata 34.62 6.00e-13 69.70
IUUC-Oru-084289 Oryza rufipogon 32.46 6.00e-13 69.30
IUUC-Osa-085712 Oryza sativa 32.46 6.00e-13 69.30
IUUC-Ola-087455 Oryzias latipes 51.56 5.00e-173 601.00
IUUC-Oga-088809 Otolemur garnettii 89.46 0.00e+00 1409.00
IUUC-Oar-090286 Ovis aries 87.73 0.00e+00 1365.00
IUUC-Ptr-091451 Pan troglodytes 89.23 0.00e+00 1398.00
IUUC-Pan-092593 Papio anubis 89.95 0.00e+00 1345.00
IUUC-Psi-093662 Pelodiscus sinensis 77.53 0.00e+00 1149.00
IUUC-Pfo-096611 Poecilia formosa 51.38 2.00e-169 589.00
IUUC-Pab-097885 Pongo abelii 88.83 0.00e+00 1360.00
IUUC-Pca-100561 Procavia capensis 77.53 0.00e+00 693.00
IUUC-Pva-102891 Pteropus vampyrus 89.05 0.00e+00 1430.00
IUUC-Rno-105327 Rattus norvegicus 96.26 0.00e+00 1484.00
IUUC-Sha-107401 Sarcophilus harrisii 82.18 0.00e+00 1233.00
IUUC-Sit-109909 Setaria italica 50.00 6.00e-14 70.50
IUUC-Sar-113238 Sorex araneus 80.40 0.00e+00 788.00
IUUC-Sbi-114185 Sorghum bicolor 50.94 4.00e-14 70.90
IUUC-Ssc-116436 Sus scrofa 89.05 0.00e+00 1382.00
IUUC-Tgu-116470 Taeniopygia guttata 77.66 0.00e+00 1118.00
IUUC-Tru-118054 Takifugu rubripes 49.47 2.00e-157 550.00
IUUC-Tni-120063 Tetraodon nigroviridis 50.54 1.00e-168 587.00
IUUC-Tae-125027 Triticum aestivum 58.33 2.00e-14 72.40
IUUC-Tur-126415 Triticum urartu 53.70 5.00e-14 70.50
IUUC-Tbe-128026 Tupaia belangeri 83.56 0.00e+00 1147.00
IUUC-Ttr-128623 Tursiops truncatus 85.51 0.00e+00 1279.00
IUUC-Uma-129481 Ustilago maydis 35.53 5.00e-10 61.60
IUUC-Vpa-130662 Vicugna pacos 85.40 0.00e+00 1354.00
Created Date 25-Jun-2017

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