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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Rno-105121
UUCD1 version UUC-RaN-00519
Ensembl Protein ID ENSRNOP00000072621.1
UniProt Accession P62870; Q63529; Q80W20; ELOB_RAT
Genbank Protein ID AAA80968.1; AAH58463.1
Protein Name Elongin-B; Elongin 18 kDa subunit; RNA polymerase II transcription factor SIII subunit B; SIII p18; Transcription elongation factor B polypeptide 2
Genbank Nucleotide ID L42855; BC058463
Gene Name Tceb2; Elob
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000004814.6 ENSRNOT00000087768.1 ENSRNOP00000072621.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNATRANSFACRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
PhosphositePlusdbPTM
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
ULD/UDP/UBQ/UBQ_Other 6.80e-10 39.1 18 61
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   ULD/UDP/UBQ/UBQ_Other
   S: 17   vnpsdtVaeLKekiekklgippeqqrLiykGkiLeddktLadyg 60
            ++s+tV eLK+ +e+ l+ ppe+qrL+ ++++L+d+ktL+++g
   Q: 18   AKESSTVFELKRIVEGILKRPPEEQRLYKDDQLLDDGKTLGECG 61
           3799***************************************8 PP
   
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.
 The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.
Protein Sequence
(Fasta)
MDVFLMIRRH KTTIFTDAKE SSTVFELKRI VEGILKRPPE EQRLYKDDQL LDDGKTLGEC 60
GFTSQTARPQ APATVGLAFR ADDTFEALRI EPFSSPPELP DVMKPQDSGG SANEQAVQ 118
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-105121|ULD,UBQ_Other|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCGGCCGCGC CGGCGCGTCG AGCCAGAAGC AGCCGCCGGG ATGGTGAGCG GGCGCGGGGG 60
GGAGGGGCGA CGGGGCCGGG GGCGGCGGGG GCTCCGGGGC CACGCCGGGG GCCGCGGGCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-105121|ULD,UBQ_Other|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
Interpro

IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom
PROSITE

PS50053--UBIQUITIN_2
Pfam

PF00240--ubiquitin
SMART

SM00213--UBQ
Gene Ontology

GO:0070449--C:elongin complex
GO:0005667--C:transcription factor complex
GO:0030891--C:VCB complex
GO:0032403--F:protein complex binding
GO:0003713--F:transcription coactivator activity
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0016567--P:protein ubiquitination
GO:0006351--P:transcription, DNA-templated
KEGG rno:81807
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001280 Ailuropoda melanoleuca 94.96 2.00e-62 229.00
IUUC-Atr-002796 Amborella trichopoda 28.70 3.00e-06 43.10
IUUC-Aca-004530 Anolis carolinensis 88.98 3.00e-57 213.00
IUUC-Ame-011292 Astyanax mexicanus 88.24 1.00e-58 217.00
IUUC-Bta-012458 Bos taurus 96.61 8.00e-64 234.00
IUUC-Cel-018575 Caenorhabditis elegans 38.53 1.00e-16 77.80
IUUC-Cja-019950 Callithrix jacchus 96.58 1.00e-62 230.00
IUUC-Cfa-020172 Canis familiaris 96.15 5.00e-40 155.00
IUUC-Cpo-022344 Cavia porcellus 99.15 1.00e-64 237.00
IUUC-Csa-024213 Chlorocebus sabaeus 97.44 4.00e-63 232.00
IUUC-Csv-026001 Ciona savignyi 56.41 3.00e-35 140.00
IUUC-Dre-027429 Danio rerio 86.55 8.00e-57 211.00
IUUC-Dno-029254 Dasypus novemcinctus 96.58 4.00e-63 232.00
IUUC-Dme-031644 Drosophila melanogaster 55.08 8.00e-32 128.00
IUUC-Eeu-034507 Erinaceus europaeus 67.07 2.00e-27 113.00
IUUC-Fca-036342 Felis catus 97.44 2.00e-63 233.00
IUUC-Gmo-039577 Gadus morhua 87.39 3.00e-47 179.00
IUUC-Gac-041786 Gasterosteus aculeatus 84.03 2.00e-56 210.00
IUUC-Gma-044029 Glycine max 31.18 6.00e-07 46.20
IUUC-Ggo-044725 Gorilla gorilla 96.58 2.00e-62 231.00
IUUC-Hsa-046790 Homo sapiens 97.46 9.00e-64 234.00
IUUC-Laf-054303 Loxodonta africana 97.44 1.00e-63 233.00
IUUC-Mcc-054748 Macaca mulatta 96.58 5.00e-63 232.00
IUUC-Mtr-058736 Medicago truncatula 32.26 1.00e-07 47.80
IUUC-Mmr-061528 Microcebus murinus 97.44 2.00e-63 233.00
IUUC-Mdo-062545 Monodelphis domestica 92.31 2.00e-60 223.00
IUUC-Mmu-064363 Mus musculus 100.00 7.00e-66 241.00
IUUC-Mpu-066915 Mustela putorius furo 96.58 4.00e-63 232.00
IUUC-Mlu-067606 Myotis lucifugus 92.86 8.00e-41 157.00
IUUC-Nle-069340 Nomascus leucogenys 96.58 1.00e-62 231.00
IUUC-Ont-071550 Oreochromis niloticus 86.44 2.00e-57 213.00
IUUC-Oan-073548 Ornithorhynchus anatinus 95.80 5.00e-53 199.00
IUUC-Ocu-074024 Oryctolagus cuniculus 97.35 4.00e-61 225.00
IUUC-Ola-086438 Oryzias latipes 85.59 7.00e-56 209.00
IUUC-Oar-090425 Ovis aries 96.58 4.00e-63 232.00
IUUC-Ptr-090487 Pan troglodytes 96.61 2.00e-63 234.00
IUUC-Pan-092779 Papio anubis 96.61 2.00e-63 234.00
IUUC-Pfo-097197 Poecilia formosa 85.71 1.00e-56 211.00
IUUC-Pab-098035 Pongo abelii 96.61 2.00e-63 234.00
IUUC-Pop-099504 Populus trichocarpa 27.47 8.00e-05 38.10
IUUC-Sha-107566 Sarcophilus harrisii 93.22 2.00e-61 226.00
IUUC-Sar-113663 Sorex araneus 45.78 4.00e-18 82.40
IUUC-Ssc-115270 Sus scrofa 96.61 8.00e-64 234.00
IUUC-Tru-118420 Takifugu rubripes 84.87 1.00e-56 211.00
IUUC-Tni-120611 Tetraodon nigroviridis 84.21 5.00e-53 198.00
IUUC-Tca-121839 Theobroma cacao 27.96 8.00e-06 41.60
IUUC-Ttr-128410 Tursiops truncatus 95.76 5.00e-63 233.00
Created Date 25-Jun-2017

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