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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045884
Ensembl Protein ID ENSP00000233055.4
UniProt Accession Q8IWB7; Q53S17; Q9H9D5; Q9P2B3; WDFY1_HUMAN
Genbank Protein ID CAC83947.1; AAL04161.1; BAA92673.1; BAB14294.1; AAY14924.1; EAW70817.1; AAH40525.1; AAH65934.1
Protein Name WD repeat and FYVE domain-containing protein 1; FENS-1; Phosphoinositide-binding protein 1; WD40- and FYVE domain-containing protein 1; Zinc finger FYVE domain-containing protein 17
Genbank Nucleotide ID AJ310568; AF411977; AB037856; AK022888; AC073641; CH471063; BC040525; BC065934
Gene Name WDFY1; KIAA1435; WDF1; ZFYVE17
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000085449.14 ENST00000233055.8 ENSP00000233055.4
ENSG00000085449.14 ENST00000429915.1 ENSP00000395416.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexMenthaInWeb_IM
Disease-associated Variation
GWAS Central
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMHPRD
UniProtPHOSIDABioGRID
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 9.80e-18 65.2 240 271
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDl 30
           gH d+v +l++   ++ lvs+s Dg i vW++
   Q: 240  GHHDKVQSLCYlqLTRQLVSCSSDGGIAVWNM 271
           899*******9884489*************97 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Positively regulates TLR3- and TLR4-mediated signaling pathways by bridging the interaction between TLR3 or TLR4 and TICAM1. Promotes TLR3/4 ligand-induced activation of transcription factors IRF3 and NF-kappa-B, as well as the production of IFN-beta and inflammatory cytokines (PubMed:25736436).
 Positively regulates TLR3- and TLR4-mediated signaling pathways by bridging the interaction between TLR3 or TLR4 and TICAM1. Promotes TLR3/4 ligand-induced activation of transcription factors IRF3 and NF-kappa-B, as well as the production of IFN-beta and inflammatory cytokines (PubMed:25736436).
Protein Sequence
(Fasta)
MAAEIHSRPQ SSRPVLLSKI EGHQDAVTAA LLIPKEDGVI TASEDRTIRV WLKRDSGQYW 60
PSIYHTMASP CSAMAYHHDS RRIFVGQDNG AVMEFHVSED FNKMNFIKTY PAHQNRVSAI 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045884|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AAGAGGCCCC AGCAGCCGAA GGGAAACCGG CGCGTCCCCC GCCCGCCCAG GCGTCAGCTG 60
ATGGGCTGCC TGCCGAGGAG GCCGCAGCAG TCGCCGCGCG AACATGGCGG CCGAAATCCA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045884|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0967--Endosome
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR000306--Znf_FYVE
IPR017455--Znf_FYVE-rel
IPR011011--Znf_FYVE_PHD
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
PS50178--ZF_FYVE
Pfam

PF01363--FYVE
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00064--FYVE
SM00320--WD40
Gene Ontology

GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0005634--C:nucleus
GO:0005545--F:1-phosphatidylinositol binding
GO:0008270--F:zinc ion binding
GO:0034141--P:positive regulation of toll-like receptor 3 signaling pathway
GO:0034145--P:positive regulation of toll-like receptor 4 signaling pathway
KEGG hsa:57590
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001526 Ailuropoda melanoleuca 96.28 0.00e+00 818.00
IUUC-Apl-003661 Anas platyrhynchos 91.80 0.00e+00 730.00
IUUC-Aca-005225 Anolis carolinensis 90.93 0.00e+00 785.00
IUUC-Ame-011044 Astyanax mexicanus 76.28 0.00e+00 661.00
IUUC-Bta-012602 Bos taurus 97.80 0.00e+00 851.00
IUUC-Cja-019529 Callithrix jacchus 98.78 0.00e+00 854.00
IUUC-Cfa-020512 Canis familiaris 96.72 0.00e+00 750.00
IUUC-Cpo-022239 Cavia porcellus 95.85 0.00e+00 825.00
IUUC-Csa-023535 Chlorocebus sabaeus 98.55 0.00e+00 715.00
IUUC-Cho-024858 Choloepus hoffmanni 79.51 0.00e+00 656.00
IUUC-Dre-028520 Danio rerio 79.90 0.00e+00 686.00
IUUC-Dno-030005 Dasypus novemcinctus 98.29 0.00e+00 849.00
IUUC-Dor-030500 Dipodomys ordii 96.64 5.00e-177 613.00
IUUC-Ete-032870 Echinops telfairi 80.84 3.00e-147 514.00
IUUC-Eca-033284 Equus caballus 94.89 0.00e+00 813.00
IUUC-Fca-036212 Felis catus 97.80 0.00e+00 757.00
IUUC-Fal-037595 Ficedula albicollis 91.91 0.00e+00 811.00
IUUC-Gmo-038664 Gadus morhua 81.33 0.00e+00 730.00
IUUC-Gga-040400 Gallus gallus 92.16 0.00e+00 811.00
IUUC-Gac-041434 Gasterosteus aculeatus 82.11 0.00e+00 736.00
IUUC-Itr-048815 Ictidomys tridecemlineatus 99.06 0.00e+00 666.00
IUUC-Lch-049995 Latimeria chalumnae 87.80 0.00e+00 777.00
IUUC-Loc-052075 Lepisosteus oculatus 85.43 0.00e+00 753.00
IUUC-Laf-054345 Loxodonta africana 96.83 0.00e+00 846.00
IUUC-Mcc-055293 Macaca mulatta 98.54 0.00e+00 847.00
IUUC-Mga-059585 Meleagris gallopavo 90.96 0.00e+00 727.00
IUUC-Mmr-061268 Microcebus murinus 98.54 0.00e+00 854.00
IUUC-Mdo-061857 Monodelphis domestica 92.65 0.00e+00 815.00
IUUC-Mmu-063789 Mus musculus 97.80 0.00e+00 848.00
IUUC-Mpu-066391 Mustela putorius furo 97.80 0.00e+00 846.00
IUUC-Mlu-067636 Myotis lucifugus 96.16 0.00e+00 751.00
IUUC-Nle-068974 Nomascus leucogenys 99.27 0.00e+00 854.00
IUUC-Opr-070553 Ochotona princeps 84.39 0.00e+00 708.00
IUUC-Oan-073659 Ornithorhynchus anatinus 94.74 0.00e+00 694.00
IUUC-Ocu-074034 Oryctolagus cuniculus 98.05 0.00e+00 850.00
IUUC-Ola-087030 Oryzias latipes 81.86 0.00e+00 736.00
IUUC-Oga-087962 Otolemur garnettii 97.81 0.00e+00 762.00
IUUC-Oar-089377 Ovis aries 97.80 0.00e+00 851.00
IUUC-Ptr-090728 Pan troglodytes 99.51 0.00e+00 857.00
IUUC-Pan-092130 Papio anubis 98.29 0.00e+00 847.00
IUUC-Psi-093886 Pelodiscus sinensis 92.56 0.00e+00 730.00
IUUC-Pfo-097254 Poecilia formosa 83.41 0.00e+00 743.00
IUUC-Pab-097594 Pongo abelii 99.76 0.00e+00 857.00
IUUC-Pca-100741 Procavia capensis 87.64 0.00e+00 658.00
IUUC-Pva-102441 Pteropus vampyrus 95.07 0.00e+00 701.00
IUUC-Rno-105767 Rattus norvegicus 97.07 0.00e+00 846.00
IUUC-Sha-106731 Sarcophilus harrisii 93.11 0.00e+00 730.00
IUUC-Ssc-115316 Sus scrofa 97.16 1.00e-124 439.00
IUUC-Tgu-116691 Taeniopygia guttata 91.91 0.00e+00 810.00
IUUC-Tru-118169 Takifugu rubripes 82.60 0.00e+00 738.00
IUUC-Tsy-119047 Tarsius syrichta 84.89 0.00e+00 633.00
IUUC-Tni-120708 Tetraodon nigroviridis 83.37 0.00e+00 736.00
IUUC-Tbe-127442 Tupaia belangeri 98.08 0.00e+00 760.00
IUUC-Ttr-128779 Tursiops truncatus 86.59 0.00e+00 733.00
IUUC-Vpa-130488 Vicugna pacos 94.71 8.00e-120 422.00
IUUC-Xtr-131994 Xenopus tropicalis 81.42 0.00e+00 728.00
Created Date 25-Jun-2017

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