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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Rno-105941
UUCD1 version UUC-RaN-00558
Ensembl Protein ID ENSRNOP00000000543.3
UniProt Accession Q6MGB6; Q4KMC1; Q63510; RING1_RAT
Genbank Protein ID CAE83930.1; AAH98635.2; CAA64746.1
Protein Name E3 ubiquitin-protein ligase RING1; Polycomb complex protein RING1; RING finger protein 1; RING-type E3 ubiquitin transferase RING1
Genbank Nucleotide ID BX883042; BC098635; X95474
Gene Name Ring1; Rnf1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000000467.4 ENSRNOT00000081085.1 ENSRNOP00000073573.1
ENSRNOG00000000467.4 ENSRNOT00000000543.4 ENSRNOP00000000543.3
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNATRANSFACmiRNAMapRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/RING 6.80e-07 30.1 48 88
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C+iCl+++k+   +  C H f+ dC+  ++       s++  CP+Cr
   Q: 48   CPICLDMLKNTMTTKECLHRFCSDCIvTAL------RSGNKECPTCR 88
           **********555555**********7777......**********8 PP
   
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity (By similarity).
 Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity (By similarity).
Protein Sequence
(Fasta)
MTTPANAQNA SKTWELSLYE LHRTPQEAIM DGTEIAVSPR SLHSELMCPI CLDMLKNTMT 60
TKECLHRFCS DCIVTALRSG NKECPTCRKK LVSKRSLRPD PNFDALISKI YPSREEYEAH 120
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Protein Fasta Sequence


>IUUC-Rno-105941|E3,RING|Rattus norvegicus
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Nucleotide Sequence
(Fasta)
CGGGCCTCAG CGCCCGGGCC ATGGCGGCGG CGGTGGCAGC AAGGGTTGCG GCGTGAGTGG 60
CAGCTACGGA CCGAGCAGAC CAGGGCGGCG GAGCCCCGGG GTCCCCGGGG AGAGGCCCGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-105941|E3,RING|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR032443--RAWUL
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF16207--RAWUL
SMART

SM00184--RING
Gene Ontology

GO:0005829--C:cytosol
GO:0016607--C:nuclear speck
GO:0031519--C:PcG protein complex
GO:0035102--C:PRC1 complex
GO:0001739--C:sex chromatin
GO:0003682--F:chromatin binding
GO:0016740--F:transferase activity
GO:0097027--F:ubiquitin-protein transferase activator activity
GO:0008270--F:zinc ion binding
GO:0009952--P:anterior/posterior pattern specification
GO:0048593--P:camera-type eye morphogenesis
GO:0035518--P:histone H2A monoubiquitination
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
KEGG rno:309626
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001831 Ailuropoda melanoleuca 100.00 3.00e-99 355.00
IUUC-Aca-005261 Anolis carolinensis 59.31 8.00e-120 423.00
IUUC-Bta-012493 Bos taurus 100.00 1.00e-83 303.00
IUUC-Cel-018573 Caenorhabditis elegans 50.00 4.00e-15 78.60
IUUC-Cja-019447 Callithrix jacchus 99.41 6.00e-99 354.00
IUUC-Cfa-020721 Canis familiaris 100.00 2.00e-99 355.00
IUUC-Cpo-022273 Cavia porcellus 99.41 5.00e-99 354.00
IUUC-Csa-023422 Chlorocebus sabaeus 99.41 9.00e-99 353.00
IUUC-Dno-028911 Dasypus novemcinctus 100.00 3.00e-99 355.00
IUUC-Dor-030457 Dipodomys ordii 82.94 2.00e-76 279.00
IUUC-Eca-033576 Equus caballus 100.00 3.00e-99 355.00
IUUC-Eeu-034880 Erinaceus europaeus 99.34 5.00e-87 314.00
IUUC-Fca-035789 Felis catus 100.00 3.00e-99 355.00
IUUC-Gma-044107 Glycine max 44.26 8.00e-24 104.00
IUUC-Ggo-045070 Gorilla gorilla 99.41 9.00e-99 353.00
IUUC-Hsa-045680 Homo sapiens 99.41 9.00e-99 353.00
IUUC-Itr-048166 Ictidomys tridecemlineatus 100.00 3.00e-99 355.00
IUUC-Laf-054431 Loxodonta africana 100.00 2.00e-99 355.00
IUUC-Mcc-055268 Macaca mulatta 99.41 9.00e-99 353.00
IUUC-Meu-056000 Macropus eugenii 90.69 4.00e-154 537.00
IUUC-Mmr-061509 Microcebus murinus 99.41 1.00e-98 352.00
IUUC-Mdo-063069 Monodelphis domestica 90.38 3.00e-147 514.00
IUUC-Mmu-063462 Mus musculus 98.52 3.00e-151 527.00
IUUC-Mac-064893 Musa acuminata 46.94 2.00e-24 107.00
IUUC-Mpu-066818 Mustela putorius furo 100.00 3.00e-99 355.00
IUUC-Mlu-067266 Myotis lucifugus 100.00 4.00e-79 288.00
IUUC-Nle-069778 Nomascus leucogenys 99.41 9.00e-99 353.00
IUUC-Opr-070456 Ochotona princeps 80.71 3.00e-56 212.00
IUUC-Oga-088881 Otolemur garnettii 100.00 3.00e-99 355.00
IUUC-Oar-089484 Ovis aries 100.00 3.00e-99 355.00
IUUC-Ptr-091151 Pan troglodytes 99.29 1.00e-80 293.00
IUUC-Pan-092254 Papio anubis 99.41 9.00e-99 353.00
IUUC-Pab-098086 Pongo abelii 98.82 3.00e-98 351.00
IUUC-Pca-100649 Procavia capensis 97.06 2.00e-92 332.00
IUUC-Sha-106734 Sarcophilus harrisii 90.44 3.00e-166 577.00
IUUC-Stu-112805 Solanum tuberosum 51.28 4.00e-20 92.80
IUUC-Ssc-116072 Sus scrofa 100.00 3.00e-99 355.00
IUUC-Ttr-128591 Tursiops truncatus 100.00 2.00e-83 302.00
Created Date 25-Jun-2017

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