iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Protein 3D Structure
PDB	MMDB
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	3.00e-32	110.6	157	209

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 4    ekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFve 60
           + vq+l+d+++q+++eL +k+Gdv+++i  ++ d +W++g  +l+++rG+fP+n+v 
   Q: 157  KFVQALFDFNPQESGELAFKRGDVITLI--NKDDPNWWEG--QLNNRRGIFPSNYVC 209
           679*************************..7889******..8************96 PP

Organism

Caenorhabditis elegans

Functional Description
(View)

Adapter protein which modulates signaling mediated by several receptor tyrosine kinases such as egl-15 and let-23 probably acting upstream of let-60/ras. Negatively regulates vulva induction probably downstream of let-23 (PubMed:1372395, PubMed:16547100). Involved in sex myoblast migration (PubMed:1372395). Negatively regulates fluid homeostasis probably downstream of egl-15 (PubMed:1372395, PubMed:11689700). During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles probably downstream of egl-15 (PubMed:16495308). Involved in let-23-mediated regulation of fertility independently of let-60/Ras (PubMed:16547100). Negatively regulates daf-2-mediated repression of dauer formation (PubMed:16547100). Plays a role in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nicotine (PubMed:15990870). Regulates synaptic levels of nAchR subunit lev-1 in the nerve cord (PubMed:15990870). May play a role in oocyte development upstream of let-60/Ras and the MAP kinase pathway (PubMed:12169634).

Protein Sequence
(Fasta)

MEAVAEHDFQ AGSPDELSFK RGNTLKVLNK DEDPHWYKAE LDGNEGFIPS NYIRMTECNW 60
YLGKITRNDA EVLLKKPTVR DGHFLVRQCE SSPGEFSISV RFQDSVQHFK VLRDQNGKYY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGTAGCGAG ACGATGGAGG CGGTCGCCGA GCATGATTTC CAGGCGGGAT CACCTGATGA 60
GTTGTCTTTC AAGAGAGGAA ACACGCTAAA AGTTTGTTCA ACAATATCAT AACCGGGCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0727--SH2 domain
KW-0728--SH3 domain

Interpro

IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50001--SH2
PS50002--SH3

Pfam

PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005154--F:epidermal growth factor receptor binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005070--F:SH3/SH2 adaptor activity
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0045087--P:innate immune response
GO:0030539--P:male genitalia development
GO:0007517--P:muscle organ development
GO:0002119--P:nematode larval development
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0031344--P:regulation of cell projection organization
GO:0042127--P:regulation of cell proliferation
GO:0040028--P:regulation of vulval development
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

cel:CELE_C14F5.5

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001277	Ailuropoda melanoleuca	51.85	5.00e-62	229.00
IUUC-Apl-003322	Anas platyrhynchos	57.07	2.00e-61	226.00
IUUC-Aca-005193	Anolis carolinensis	58.53	3.00e-72	263.00
IUUC-Aor-009970	Aspergillus oryzae	50.94	3.00e-11	62.00
IUUC-Ame-010929	Astyanax mexicanus	57.60	3.00e-71	259.00
IUUC-Bta-012932	Bos taurus	58.06	4.00e-72	262.00
IUUC-Bci-013975	Botrytis cinerea	54.00	1.00e-10	59.70
IUUC-Cja-019225	Callithrix jacchus	58.06	4.00e-72	262.00
IUUC-Cfa-020887	Canis familiaris	58.06	4.00e-72	262.00
IUUC-Cpo-022488	Cavia porcellus	58.06	4.00e-72	262.00
IUUC-Csa-023326	Chlorocebus sabaeus	58.06	4.00e-72	262.00
IUUC-Cho-024953	Choloepus hoffmanni	47.93	1.00e-52	197.00
IUUC-Cin-025144	Ciona intestinalis	54.72	1.00e-66	244.00
IUUC-Csv-026210	Ciona savignyi	55.29	8.00e-67	245.00
IUUC-Dre-028095	Danio rerio	58.06	1.00e-71	261.00
IUUC-Dno-029187	Dasypus novemcinctus	58.06	1.00e-71	261.00
IUUC-Dor-030763	Dipodomys ordii	58.06	4.00e-72	262.00
IUUC-Dme-031741	Drosophila melanogaster	61.03	7.00e-77	278.00
IUUC-Ete-032354	Echinops telfairi	43.32	1.00e-44	171.00
IUUC-Eca-033222	Equus caballus	58.06	4.00e-72	262.00
IUUC-Eeu-034513	Erinaceus europaeus	41.94	1.00e-44	171.00
IUUC-Fca-036294	Felis catus	58.06	4.00e-72	262.00
IUUC-Fal-037130	Ficedula albicollis	58.06	9.00e-72	261.00
IUUC-Gmo-039546	Gadus morhua	58.06	1.00e-71	261.00
IUUC-Gga-041139	Gallus gallus	58.06	3.00e-72	263.00
IUUC-Gac-041968	Gasterosteus aculeatus	58.06	1.00e-71	261.00
IUUC-Ggo-044562	Gorilla gorilla	58.06	4.00e-72	262.00
IUUC-Hsa-046730	Homo sapiens	58.06	4.00e-72	262.00
IUUC-Itr-049025	Ictidomys tridecemlineatus	58.06	4.00e-72	262.00
IUUC-Lch-050230	Latimeria chalumnae	60.16	9.00e-41	159.00
IUUC-Loc-052723	Lepisosteus oculatus	58.53	3.00e-72	263.00
IUUC-Laf-053774	Loxodonta africana	57.60	1.00e-71	260.00
IUUC-Mcc-054603	Macaca mulatta	58.06	4.00e-72	262.00
IUUC-Meu-056173	Macropus eugenii	47.91	7.00e-55	205.00
IUUC-Mga-059950	Meleagris gallopavo	58.06	3.00e-72	263.00
IUUC-Mvi-060309	Microbotryum violaceum	50.94	6.00e-11	62.40
IUUC-Mmr-060878	Microcebus murinus	58.06	4.00e-72	262.00
IUUC-Mdo-062454	Monodelphis domestica	58.14	1.00e-71	261.00
IUUC-Mmu-063913	Mus musculus	58.53	2.00e-72	263.00
IUUC-Mpu-066125	Mustela putorius furo	58.06	4.00e-72	262.00
IUUC-Mlu-068007	Myotis lucifugus	58.06	4.00e-72	262.00
IUUC-Nle-069101	Nomascus leucogenys	58.06	4.00e-72	262.00
IUUC-Opr-071075	Ochotona princeps	58.06	4.00e-72	262.00
IUUC-Ont-072253	Oreochromis niloticus	57.60	5.00e-71	259.00
IUUC-Oan-073107	Ornithorhynchus anatinus	45.37	2.00e-49	187.00
IUUC-Ocu-074583	Oryctolagus cuniculus	58.06	4.00e-72	262.00
IUUC-Ola-086586	Oryzias latipes	62.50	2.00e-51	194.00
IUUC-Oga-089047	Otolemur garnettii	58.06	4.00e-72	262.00
IUUC-Oar-089904	Ovis aries	53.46	3.00e-63	233.00
IUUC-Ptr-090678	Pan troglodytes	58.06	4.00e-72	262.00
IUUC-Pan-092090	Papio anubis	58.06	4.00e-72	262.00
IUUC-Psi-093765	Pelodiscus sinensis	58.06	5.00e-72	262.00
IUUC-Pma-094650	Petromyzon marinus	59.36	2.00e-72	263.00
IUUC-Pfo-096131	Poecilia formosa	58.99	7.00e-73	265.00
IUUC-Pab-098709	Pongo abelii	58.06	4.00e-72	262.00
IUUC-Pca-100581	Procavia capensis	56.54	6.00e-61	225.00
IUUC-Pva-103066	Pteropus vampyrus	58.06	4.00e-72	262.00
IUUC-Rno-105224	Rattus norvegicus	58.06	4.00e-72	262.00
IUUC-Sce-106302	Saccharomyces cerevisiae	48.15	7.00e-13	65.90
IUUC-Sha-107247	Sarcophilus harrisii	57.07	2.00e-61	226.00
IUUC-Sja-107745	Schizosaccharomyces japonicus	42.31	1.00e-10	58.20
IUUC-Ssl-108415	Sclerotinia sclerotiorum	56.00	2.00e-11	62.40
IUUC-Sar-113277	Sorex araneus	48.85	3.00e-56	209.00
IUUC-Ssc-115478	Sus scrofa	58.06	4.00e-72	262.00
IUUC-Tgu-117479	Taeniopygia guttata	58.06	1.00e-71	261.00
IUUC-Tru-118451	Takifugu rubripes	55.46	9.00e-65	238.00
IUUC-Tsy-119029	Tarsius syrichta	58.44	1.00e-45	173.00
IUUC-Tni-120563	Tetraodon nigroviridis	43.46	3.00e-46	176.00
IUUC-Tbe-128097	Tupaia belangeri	58.06	9.00e-72	261.00
IUUC-Ttr-128195	Tursiops truncatus	50.93	7.00e-61	225.00
IUUC-Uma-129575	Ustilago maydis	54.00	6.00e-12	64.30
IUUC-Vpa-130754	Vicugna pacos	58.06	4.00e-72	262.00
IUUC-Xtr-132275	Xenopus tropicalis	55.46	1.00e-70	257.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence