• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063956
UUCD1 version UUC-MuM-01134
Ensembl Protein ID ENSMUSP00000034349.9
UniProt Accession Q8VBW6; Q8CFL6; ULA1_MOUSE
Genbank Protein ID AAH19163.1; AAH21510.1; AAH23680.1; AAH23897.1; AAH27124.1
Protein Name NEDD8-activating enzyme E1 regulatory subunit; Amyloid beta precursor protein-binding protein 1, 59 kDa; Amyloid protein-binding protein 1
Genbank Nucleotide ID BC019163; BC021510; BC023680; BC023897; BC027124
Gene Name Nae1; Appbp1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000031878.18 ENSMUST00000162466.7 ENSMUSP00000125456.1
ENSMUSG00000031878.18 ENSMUST00000034349.9 ENSMUSP00000034349.9
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarmiRNAMap
RAID2
Protein-protein Interaction
IIDMentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMUniProt
mUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E1 5.40e-131 438.7 13 525
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E1
   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvn 89
           YDRQ+rlwG+++qe+l+sa+v+l++a+++G+E+lKnLvl G+gs+t++D++ v+ ++ +++F+++++++gk++A++a+e+l+eln+dv+
   Q: 13   YDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGIGSFTIIDGNLVSGEDAGNNFFLQKSSIGKNRAQAAMEFLQELNSDVS 101
           ***************************************************************************************** PP
   S: 90   veaheesiteleeeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dppqktiPfc 174
           ++++ees+++l ++++ Ff++f++Vv+++  +++ ++++++++n ++pl++++t+Gl+G++r+iik++++++s++d   +++++++Pf+
   Q: 102  GSFVEESPENLLDNDPsFFCRFTIVVATQLLESTLLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDnalEDLRLDKPFP 190
           ***************************************************************************************** PP
   S: 175  tlketpn.........aaehtiewavlfnklleeeageeevlekldseekeegkdkvkselks......edeenfeeaieiavkafakt 248
           +l+e+ +         +++++++w+v+++k+l++++ e++++ +++++eke+++d++++++ +      edeenfeeai+++++a+++t
   Q: 191  ELREHLQsydldhmekKDHSHTPWIVIIAKYLAQWYNETNGRIPKSYKEKEDFRDLIRQGILKnengapEDEENFEEAIKNVNTALNTT 279
           *****66666666666***********************************************9************************* PP
   S: 249  tins.ikqllksfecdivtkskspfwv.............................................................. 274
           +i+s i++++++++c ++tk+++ fw+                                                              
   Q: 280  QIPSsIEDIFNDDRCINITKQTPTFWIlaralkefvakegqgnlpvrgtipdmiadsnkyiklqnvyrekakkdaaavgnhvakllqsv 368
           ***************************************************************************************** PP
   S: 275  .............sfcsnaealqvp...........ekvekdeevvkasap.....lylllralerfekkkgrkpgelsfekddds..a 332
                         +csn++ l+v            ++v+kde+++++++p     lyl+lra++rf+k++gr+pg++++++++d+  +
   Q: 369  gqapesisekelkLLCSNSAFLRVVrcrslaeeyglDTVNKDEIISSMDNPdneivLYLMLRAVDRFHKQHGRYPGVSNYQVEEDIgkL 457
           *************99********7777777888888**************9***********************************999 PP
   S: 333  vdlvtaaanlraeslgiepkldddlikeiagniipaiattnavvgGlaaqEviKvvsgkfeplknfflfdae 404
            +++t ++    +++g++ +++dd+++e++++++++ +t++a++gG+aaqEviK+++++f+ ++n++++ ++
   Q: 458  KSCLTGFL----QEYGLSVMVKDDYVHEFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGM 525
           ********....********************************************************9776 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation (By similarity).
 Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation (By similarity).
Protein Sequence
(Fasta)
MAQPGKILKE QKYDRQLRLW GDHGQEALES AHVCLINATA TGTEILKNLV LPGIGSFTII 60
DGNLVSGEDA GNNFFLQKSS IGKNRAQAAM EFLQELNSDV SGSFVEESPE NLLDNDPSFF 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063956|E1,E1_ThiF|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGTGCGCCTG CGTGAGGCCG AGTGGGTGGC GGCCTCCTTA GGCGGCTTTG CTGTTCGCGG 60
GCCAGGCGCG GCCATGGCGC AGCCAGGGAA GATACTCAAG GAGCAAAAGT ACGACCGGCA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063956|E1,E1_ThiF|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0053--Apoptosis
KW-0131--Cell cycle
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
Pfam

PF00899--ThiF
Gene Ontology

GO:0005886--C:plasma membrane
GO:0019781--F:NEDD8 activating enzyme activity
GO:0046982--F:protein heterodimerization activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0033314--P:mitotic DNA replication checkpoint
GO:0051402--P:neuron apoptotic process
GO:0045116--P:protein neddylation
GO:0042981--P:regulation of apoptotic process
GO:0043523--P:regulation of neuron apoptotic process
KEGG mmu:234664
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000764 Aegilops tauschii 41.97 7.00e-125 441.00
IUUC-Aml-002333 Ailuropoda melanoleuca 96.27 0.00e+00 1079.00
IUUC-Atr-002644 Amborella trichopoda 40.75 2.00e-114 406.00
IUUC-Apl-003446 Anas platyrhynchos 84.78 0.00e+00 923.00
IUUC-Aca-004450 Anolis carolinensis 80.49 0.00e+00 919.00
IUUC-Aly-006187 Arabidopsis lyrata 40.19 3.00e-126 445.00
IUUC-Ath-007600 Arabidopsis thaliana 40.75 1.00e-127 449.00
IUUC-Ago-007900 Ashbya gossypii 26.56 2.00e-40 159.00
IUUC-Acl-008333 Aspergillus clavatus 34.53 6.00e-82 298.00
IUUC-Afl-008529 Aspergillus flavus 36.38 3.00e-87 316.00
IUUC-Afu-009071 Aspergillus fumigatus 33.87 2.00e-82 300.00
IUUC-Ani-009443 Aspergillus nidulans 33.69 1.00e-79 290.00
IUUC-Ang-009669 Aspergillus niger 33.51 3.00e-83 302.00
IUUC-Aor-009914 Aspergillus oryzae 35.70 5.00e-84 305.00
IUUC-Ate-010450 Aspergillus terreus 34.53 1.00e-84 307.00
IUUC-Ame-011183 Astyanax mexicanus 72.59 0.00e+00 833.00
IUUC-Bgr-012111 Blumeria graminis 33.51 3.00e-67 249.00
IUUC-Bta-012583 Bos taurus 97.19 0.00e+00 1088.00
IUUC-Bci-013892 Botrytis cinerea 33.33 6.00e-68 251.00
IUUC-Bdi-014592 Brachypodium distachyon 42.94 9.00e-128 450.00
IUUC-Bol-016399 Brassica oleracea 39.89 5.00e-124 437.00
IUUC-Bra-017506 Brassica rapa 38.99 9.00e-121 427.00
IUUC-Cel-018456 Caenorhabditis elegans 36.48 4.00e-93 335.00
IUUC-Cja-020007 Callithrix jacchus 96.46 0.00e+00 1082.00
IUUC-Cfa-020324 Canis familiaris 96.82 0.00e+00 1083.00
IUUC-Cpo-022248 Cavia porcellus 64.88 0.00e+00 634.00
IUUC-Csa-023149 Chlorocebus sabaeus 97.57 0.00e+00 926.00
IUUC-Cho-024537 Choloepus hoffmanni 85.03 0.00e+00 805.00
IUUC-Cin-025763 Ciona intestinalis 49.91 2.00e-156 545.00
IUUC-Csv-026113 Ciona savignyi 46.11 3.00e-146 511.00
IUUC-Cgl-026428 Colletotrichum gloeosporioides 31.99 2.00e-66 246.00
IUUC-Cne-026884 Cryptococcus neoformans 29.89 3.00e-72 266.00
IUUC-Cme-027210 Cyanidioschyzon merolae 27.11 4.00e-19 89.70
IUUC-Dre-028140 Danio rerio 73.41 0.00e+00 853.00
IUUC-Dno-030033 Dasypus novemcinctus 96.19 0.00e+00 952.00
IUUC-Dor-030513 Dipodomys ordii 67.41 3.00e-114 405.00
IUUC-Dse-031536 Dothistroma septosporum 35.12 8.00e-87 314.00
IUUC-Dme-031683 Drosophila melanogaster 45.03 1.00e-128 453.00
IUUC-Ete-032420 Echinops telfairi 82.95 0.00e+00 885.00
IUUC-Eca-033992 Equus caballus 97.30 0.00e+00 911.00
IUUC-Eeu-034713 Erinaceus europaeus 80.31 5.00e-118 417.00
IUUC-Fca-036548 Felis catus 95.69 0.00e+00 1071.00
IUUC-Fal-037600 Ficedula albicollis 81.42 0.00e+00 892.00
IUUC-Fox-038037 Fusarium oxysporum 34.06 2.00e-77 283.00
IUUC-Fso-038387 Fusarium solani 35.05 1.00e-78 286.00
IUUC-Gmo-038562 Gadus morhua 71.97 0.00e+00 828.00
IUUC-Ggr-040005 Gaeumannomyces graminis 33.82 6.00e-74 271.00
IUUC-Gga-041129 Gallus gallus 85.05 0.00e+00 949.00
IUUC-Gac-042558 Gasterosteus aculeatus 72.50 0.00e+00 832.00
IUUC-Gma-043610 Glycine max 40.78 4.00e-121 428.00
IUUC-Ggo-045611 Gorilla gorilla 96.46 0.00e+00 1079.00
IUUC-Hsa-046563 Homo sapiens 97.00 0.00e+00 1083.00
IUUC-Hvu-047790 Hordeum vulgare 37.60 5.00e-77 281.00
IUUC-Itr-048066 Ictidomys tridecemlineatus 96.44 0.00e+00 1083.00
IUUC-Kpa-049309 Komagataella pastoris 35.29 2.00e-82 299.00
IUUC-Lch-050038 Latimeria chalumnae 76.04 0.00e+00 855.00
IUUC-Lpe-051535 Leersia perrieri 41.05 7.00e-111 394.00
IUUC-Loc-051917 Lepisosteus oculatus 69.37 0.00e+00 793.00
IUUC-Lma-053112 Leptosphaeria maculans 35.40 2.00e-89 323.00
IUUC-Laf-053690 Loxodonta africana 95.51 0.00e+00 1075.00
IUUC-Mcc-055117 Macaca mulatta 95.35 0.00e+00 1069.00
IUUC-Meu-056761 Macropus eugenii 75.88 0.00e+00 820.00
IUUC-Mor-057230 Magnaporthe oryzae 34.17 2.00e-79 290.00
IUUC-Mpo-057514 Magnaporthe poae 33.63 2.00e-71 263.00
IUUC-Mtr-058551 Medicago truncatula 40.11 7.00e-118 417.00
IUUC-Mla-059183 Melampsora laricipopulina 37.16 7.00e-97 347.00
IUUC-Mga-060144 Meleagris gallopavo 83.90 0.00e+00 922.00
IUUC-Mvi-060221 Microbotryum violaceum 35.62 7.00e-82 298.00
IUUC-Mmr-061325 Microcebus murinus 94.23 0.00e+00 1058.00
IUUC-Mdo-062532 Monodelphis domestica 90.62 0.00e+00 1019.00
IUUC-Mac-064521 Musa acuminata 40.93 1.00e-123 436.00
IUUC-Mpu-066716 Mustela putorius furo 95.82 0.00e+00 1017.00
IUUC-Mlu-067459 Myotis lucifugus 94.78 0.00e+00 1057.00
IUUC-Nfi-068245 Neosartorya fischeri 34.23 1.00e-82 300.00
IUUC-Ncr-068910 Neurospora crassa 34.73 3.00e-78 285.00
IUUC-Nle-070034 Nomascus leucogenys 94.86 0.00e+00 1040.00
IUUC-Opr-070552 Ochotona princeps 86.43 0.00e+00 887.00
IUUC-Ont-071426 Oreochromis niloticus 73.91 0.00e+00 854.00
IUUC-Oan-073389 Ornithorhynchus anatinus 83.82 0.00e+00 781.00
IUUC-Ocu-074911 Oryctolagus cuniculus 95.13 0.00e+00 1074.00
IUUC-Oba-075437 Oryza barthii 42.37 7.00e-118 417.00
IUUC-Obr-076684 Oryza brachyantha 42.56 3.00e-113 402.00
IUUC-Ogl-077170 Oryza glaberrima 42.37 7.00e-118 417.00
IUUC-Ogu-078844 Oryza glumaepatula 43.11 4.00e-111 395.00
IUUC-Oin-079105 Oryza indica 42.37 2.00e-117 416.00
IUUC-Olo-080943 Oryza longistaminata 39.84 1.00e-105 376.00
IUUC-Oni-082891 Oryza nivara 39.50 4.00e-111 395.00
IUUC-Opu-083457 Oryza punctata 42.37 3.00e-117 415.00
IUUC-Oru-084960 Oryza rufipogon 39.84 1.00e-105 377.00
IUUC-Osa-085358 Oryza sativa 42.56 5.00e-118 418.00
IUUC-Ola-086420 Oryzias latipes 71.58 8.00e-169 586.00
IUUC-Olu-087625 Ostreococcus lucimarinus 31.76 1.00e-61 231.00
IUUC-Oga-088810 Otolemur garnettii 95.69 0.00e+00 1073.00
IUUC-Oar-089196 Ovis aries 97.02 0.00e+00 1085.00
IUUC-Ptr-090617 Pan troglodytes 97.19 0.00e+00 1085.00
IUUC-Pan-092761 Papio anubis 97.19 0.00e+00 1089.00
IUUC-Psi-093191 Pelodiscus sinensis 86.27 0.00e+00 960.00
IUUC-Pma-094380 Petromyzon marinus 62.07 0.00e+00 663.00
IUUC-Pno-095084 Phaeosphaeria nodorum 33.21 9.00e-78 285.00
IUUC-Ppa-095875 Physcomitrella patens 40.04 1.00e-120 426.00
IUUC-Pfo-096467 Poecilia formosa 73.16 0.00e+00 836.00
IUUC-Pab-098255 Pongo abelii 96.40 0.00e+00 902.00
IUUC-Pop-099722 Populus trichocarpa 40.56 1.00e-124 440.00
IUUC-Pca-100807 Procavia capensis 77.74 6.00e-116 410.00
IUUC-Ppe-101280 Prunus persica 40.04 7.00e-124 437.00
IUUC-Pva-102333 Pteropus vampyrus 91.62 0.00e+00 1016.00
IUUC-Pgr-103401 Puccinia graminis 31.79 6.00e-82 298.00
IUUC-Ptt-103889 Puccinia triticina 27.50 3.00e-59 223.00
IUUC-Pte-104355 Pyrenophora teres 36.19 2.00e-91 330.00
IUUC-Pyt-104545 Pyrenophora triticirepentis 36.19 1.00e-92 333.00
IUUC-Rno-105810 Rattus norvegicus 97.57 0.00e+00 1086.00
IUUC-Sce-106397 Saccharomyces cerevisiae 26.70 7.00e-37 148.00
IUUC-Sha-106770 Sarcophilus harrisii 88.69 6.00e-153 533.00
IUUC-Sja-107926 Schizosaccharomyces japonicus 32.77 6.00e-78 285.00
IUUC-Spo-108276 Schizosaccharomyces pombe 34.89 1.00e-83 303.00
IUUC-Ssl-108387 Sclerotinia sclerotiorum 33.33 8.00e-71 261.00
IUUC-Smo-109296 Selaginella moellendorffii 42.61 6.00e-125 441.00
IUUC-Sit-110157 Setaria italica 44.03 2.00e-134 472.00
IUUC-Sly-111105 Solanum lycopersicum 39.75 9.00e-123 433.00
IUUC-Stu-112469 Solanum tuberosum 40.26 6.00e-125 441.00
IUUC-Sar-113083 Sorex araneus 72.67 0.00e+00 746.00
IUUC-Sbi-113813 Sorghum bicolor 44.03 2.00e-133 469.00
IUUC-Sre-115058 Sporisorium reilianum 38.89 3.00e-86 312.00
IUUC-Tgu-116772 Taeniopygia guttata 80.08 0.00e+00 884.00
IUUC-Tru-118686 Takifugu rubripes 71.83 0.00e+00 837.00
IUUC-Tsy-119111 Tarsius syrichta 88.34 7.00e-148 517.00
IUUC-Tni-120231 Tetraodon nigroviridis 66.04 0.00e+00 750.00
IUUC-Tca-121491 Theobroma cacao 40.22 3.00e-117 415.00
IUUC-Tre-122103 Trichoderma reesei 37.02 7.00e-84 304.00
IUUC-Tvi-122672 Trichoderma virens 36.95 2.00e-77 283.00
IUUC-Tae-125316 Triticum aestivum 42.56 6.00e-127 447.00
IUUC-Tur-126487 Triticum urartu 41.22 1.00e-120 426.00
IUUC-Tme-127097 Tuber melanosporum 39.63 1.00e-96 347.00
IUUC-Ttr-128465 Tursiops truncatus 89.94 0.00e+00 993.00
IUUC-Uma-129645 Ustilago maydis 33.50 3.00e-90 325.00
IUUC-Vda-129989 Verticillium dahliae 31.10 9.00e-57 214.00
IUUC-Vpa-130529 Vicugna pacos 92.36 0.00e+00 1024.00
IUUC-Vvi-131059 Vitis vinifera 40.97 8.00e-123 434.00
IUUC-Xtr-132002 Xenopus tropicalis 78.84 0.00e+00 909.00
IUUC-Xma-133930 Xiphophorus maculatus 73.19 0.00e+00 838.00
IUUC-Yli-134505 Yarrowia lipolytica 35.81 4.00e-87 315.00
IUUC-Zma-135895 Zea mays 44.27 1.00e-132 466.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved