iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA
DNA & RNA Element
UTRdb	AREsite	microRNA	TRANSFAC
RepTar	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Post-translational Modifications (PTMs)
CPLM	BioGRID
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	6.30e-10	41.1	20	48

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkw 29
           CaiCl+ fkd p++ +CgH f++ C+ q w
   Q: 20   CAICLDYFKD-PVSISCGHNFCRGCVtQLW 48
           **********.**************98999 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MAGYATTPSP MQTLQEEAVC AICLDYFKDP VSISCGHNFC RGCVTQLWSK EDEEDQNEEE 60
DEWEEEEDEE AVGAMDGWDG SIREVLYRGN ADEELFQDQD DDELWLGDSG ITNWDNVDYM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCTCGGGCAG GGTAGCCAGC GGCTGCATCT GAGGCGGACG CCGCAGTGTA GGGCACACCC 60
TGAGGGTAGC GAGAGACGTG ACAGGACCGA GCAGCTGGGG GCTGCAGCCT GCTCTGTCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00643--zf-B_box

SMART

SM00336--BBOX
SM00184--RING

Gene Ontology

GO:0005622--C:intracellular
GO:0008270--F:zinc ion binding
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity

KEGG

hsa:84851

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Bta-013348	Bos taurus	70.46	4.00e-89	321.00
IUUC-Cfa-020624	Canis familiaris	74.26	4.00e-104	370.00
IUUC-Csa-023996	Chlorocebus sabaeus	92.99	4.00e-108	384.00
IUUC-Dno-029560	Dasypus novemcinctus	67.86	3.00e-89	321.00
IUUC-Eeu-035330	Erinaceus europaeus	62.34	2.00e-34	139.00
IUUC-Fca-035760	Felis catus	73.85	3.00e-96	345.00
IUUC-Ggo-044507	Gorilla gorilla	95.62	9.00e-120	422.00
IUUC-Mcc-055238	Macaca mulatta	92.93	8.00e-126	442.00
IUUC-Oar-090240	Ovis aries	73.90	8.00e-94	336.00
IUUC-Ptr-090708	Pan troglodytes	85.23	8.00e-119	419.00
IUUC-Pan-092603	Papio anubis	93.04	1.00e-120	426.00
IUUC-Pab-097933	Pongo abelii	95.27	1.00e-107	382.00
IUUC-Ssc-116255	Sus scrofa	72.64	8.00e-97	346.00
IUUC-Ttr-128855	Tursiops truncatus	66.95	6.00e-63	234.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence